{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:16:03Z","timestamp":1793394963383,"version":"4.5.0"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,15]]},"DOI":"10.1093\/hmg\/ddq322","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T08:38:37Z","timestamp":1280392717000},"page":"4043-4058","source":"Crossref","is-referenced-by-count":87,"title":["Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma"],"prefix":"10.1093","volume":"19","author":[{"given":"Ming-Chang","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung-Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maw-Rong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Shuo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Han","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jheng-Jie","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Pang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Ru","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yau-Sheng","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuang","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,28]]},"reference":[{"key":"key\n\t\t\t\t20170522173122_DDQ322C1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","author":"Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0166-2236(99)01415-0","article-title":"Recent advances in understanding the pathogenesis of Huntington's disease","volume":"22","author":"Reddy","year":"1999","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C4","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1091\/mbc.12.5.1393","article-title":"Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation","volume":"12","author":"Waelter","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C5","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1093\/hmg\/9.13.2009","article-title":"Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity","volume":"9","author":"Jana","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1083\/jcb.153.2.283","article-title":"Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression","volume":"153","author":"Suhr","year":"2001","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C7","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.100110097","article-title":"The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription","volume":"97","author":"Steffan","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C8","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease","volume":"296","author":"Dunah","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C9","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1074\/jbc.M413279200","article-title":"cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues","volume":"280","author":"Chiang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/hmg\/ddl481","article-title":"Dysregulation of C\/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease","volume":"16","author":"Chiang","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C11","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1093\/hmg\/ddp230","article-title":"The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin\u2013proteasome system","volume":"18","author":"Chiang","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C12","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0140-6736(72)91092-6","article-title":"Increased frequency of diabetes mellitus in patients with Huntington's chorea","volume":"1","author":"Podolsky","year":"1972","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C13","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/brain\/awl027","article-title":"Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles","volume":"129","author":"Underwood","year":"2006","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C14","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/hmg\/ddm170","article-title":"Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation","volume":"16","author":"Valenza","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBPalpha induces adipogenesis through PPARgamma: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C16","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.M804291200","article-title":"Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease","volume":"283","author":"Quintanilla","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C17","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C18","doi-asserted-by":"crossref","first-page":"18779","DOI":"10.1074\/jbc.272.30.18779","article-title":"The organization, promoter analysis, and expression of the human PPARgamma gene","volume":"272","author":"Fajas","year":"1997","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C19","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1038\/oby.2008.326","article-title":"Subcutaneous abdominal adipose tissue subcompartments: potential role in rosiglitazone effects","volume":"16","author":"Walker","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1471-4159.2005.03029.x","article-title":"CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model","volume":"93","author":"Chou","year":"2005","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C21","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1073\/pnas.0536856100","article-title":"Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice","volume":"100","author":"Duan","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C22","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1001\/archneur.65.4.476","article-title":"Glucose homeostasis in Huntington disease: abnormalities in insulin sensitivity and early-phase insulin secretion","volume":"65","author":"Lalic","year":"2008","journal-title":"Arch. Neurol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C23","first-page":"891","article-title":"Insulin resistance and PPAR insulin sensitizers","volume":"7","author":"Bhatia","year":"2006","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2337\/diabetes.48.3.649","article-title":"Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes","volume":"48","author":"Hurlbert","year":"1999","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.chroma.2005.08.033","article-title":"Solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry for determination of trace rosiglitazone in urine","volume":"1097","author":"Chou","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","article-title":"Delaying the onset of Huntington's in mice","volume":"404","author":"van Dellen","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C27","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1210\/me.2009-0073","article-title":"Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity","volume":"23","author":"Tsai","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C28","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1212\/01.wnl.0000334276.09729.0e","article-title":"Weight loss in Huntington disease increases with higher CAG repeat number","volume":"71","author":"Aziz","year":"2008","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/hmg\/10.2.145","article-title":"Abnormalities in the functioning of adipocytes from R6\/2 mice that are transgenic for the Huntington's disease mutation","volume":"10","author":"Fain","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C30","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/hmg\/ddn428","article-title":"Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models","volume":"18","author":"Phan","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C31","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/en.2006-0070","article-title":"Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation","volume":"147","author":"Hondares","year":"2006","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C32","doi-asserted-by":"crossref","first-page":"30614","DOI":"10.1074\/jbc.M304654200","article-title":"Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect","volume":"278","author":"Armoni","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","article-title":"Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator","volume":"24","author":"Puigserver","year":"2003","journal-title":"Endocr. Rev."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C34","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPARgamma","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C35","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1073\/pnas.90.23.11346","article-title":"Transgenic mice expressing the human GLUT4\/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control","volume":"90","author":"Liu","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C37","doi-asserted-by":"crossref","first-page":"22464","DOI":"10.1074\/jbc.M800842200","article-title":"PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle","volume":"283","author":"Pagel-Langenickel","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C38","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/MCB.23.3.1085-1094.2003","article-title":"Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone","volume":"23","author":"Wilson-Fritch","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C39","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1101\/gad.1263305","article-title":"Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes","volume":"19","author":"Guan","year":"2005","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C40","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.tcb.2004.10.006","article-title":"The ubiquitin\u2013proteasome pathway in Parkinson's disease and other neurodegenerative diseases","volume":"14","author":"Ross","year":"2004","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02705243","article-title":"The ubiquitin\u2013proteasome system","volume":"31","author":"Nandi","year":"2006","journal-title":"J. Biosci."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C42","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature06022","article-title":"Global changes to the ubiquitin system in Huntington's disease","volume":"448","author":"Bennett","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C43","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.freeradbiomed.2008.06.007","article-title":"Mitochondria and ubiquitin\u2013proteasomal system interplay: relevance to Parkinson's disease","volume":"45","author":"Domingues","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C44","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1046\/j.1471-4159.2003.02105.x","article-title":"Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease","volume":"87","author":"Zhang","year":"2003","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C45","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nbd.2008.01.015","article-title":"Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease","volume":"30","author":"Duan","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C46","first-page":"1305","article-title":"Identification of a functional peroxisome proliferator activated receptor response element in the 3\u2032 untranslated region of the human bcl-2 gene","volume":"24","author":"Butts","year":"2004","journal-title":"Int. J. Oncol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C47","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuint.2006.03.020","article-title":"PPARgamma as a therapeutic target in central nervous system diseases","volume":"49","author":"Sundararajan","year":"2006","journal-title":"Neurochem. Int."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.expneurol.2006.04.006","article-title":"PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease","volume":"199","author":"Landreth","year":"2006","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C50","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1042\/BST0341341","article-title":"PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases","volume":"34","author":"Bordet","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C51","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biochi.2004.10.021","article-title":"PPAR gamma, 10 years later","volume":"87","author":"Lazar","year":"2005","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C52","doi-asserted-by":"crossref","first-page":"37006","DOI":"10.1074\/jbc.M700447200","article-title":"Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis","volume":"282","author":"Fuenzalida","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C53","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jcp.21730","article-title":"Rosiglitazone and PPAR-gamma overexpression protect mitochondrial membrane potential and prevent apoptosis by upregulating anti-apoptotic Bcl-2 family proteins","volume":"220","author":"Wu","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C54","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1523\/JNEUROSCI.20-12-04389.2000","article-title":"Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease","volume":"20","author":"Ferrante","year":"2000","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C55","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.nbd.2009.06.011","article-title":"Y-27632 improves rotarod performance and reduces huntingtin levels in R6\/2 mice","volume":"36","author":"Li","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C56","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.expneurol.2005.07.021","article-title":"Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease","volume":"196","author":"Van Raamsdonk","year":"2005","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C57","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1471-4159.2005.03357.x","article-title":"Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease","volume":"95","author":"Van Raamsdonk","year":"2005","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C58","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/mds.870110509","article-title":"Characteristics of individuals with Huntington disease in long-term care","volume":"11","author":"Nance","year":"1996","journal-title":"Mov. Disord."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C59","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/archneur.1991.00530200036015","article-title":"Factors associated with slow progression in Huntington's disease","volume":"48","author":"Myers","year":"1991","journal-title":"Arch. Neurol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C60","doi-asserted-by":"crossref","first-page":"1935S","DOI":"10.1093\/jn\/136.7.1935S","article-title":"Adipose tissue and adipokines\u2014energy regulation from the human perspective","volume":"136","author":"Trayhurn","year":"2006","journal-title":"J. Nutr."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C61","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1101\/gad.14.11.1293","article-title":"Transcriptional regulation of adipogenesis","volume":"14","author":"Rosen","year":"2000","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C62","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/diabetes.47.4.507","article-title":"PPAR-gamma: adipogenic regulator and thiazolidinedione receptor","volume":"47","author":"Spiegelman","year":"1998","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tcm.2005.04.002","article-title":"PPARgamma: a critical determinant of body fat distribution in humans and mice","volume":"15","author":"Tsai","year":"2005","journal-title":"Trends Cardiovasc. Med."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C64","doi-asserted-by":"crossref","first-page":"15712","DOI":"10.1073\/pnas.2536828100","article-title":"Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle","volume":"100","author":"He","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C65","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1056\/NEJM199907223410406","article-title":"Glucose transporters and insulin action\u2014implications for insulin resistance and diabetes mellitus","volume":"341","author":"Shepherd","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C66","doi-asserted-by":"crossref","first-page":"33609","DOI":"10.1074\/jbc.R300019200","article-title":"Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis","volume":"278","author":"Minokoshi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C67","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.plefa.2005.04.008","article-title":"The effect of PPARgamma ligands on the adipose tissue in insulin resistance","volume":"73","author":"Hammarstedt","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C68","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C69","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cmet.2006.10.004","article-title":"Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration","volume":"4","author":"Weydt","year":"2006","journal-title":"Cell Metab."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1750-1326-4-10","article-title":"PGC-1alpha as modifier of onset age in Huntington disease","volume":"4","author":"Taherzadeh-Fard","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C71","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1093\/hmg\/ddp243","article-title":"Impaired PGC-1alpha function in muscle in Huntington's disease","volume":"18","author":"Chaturvedi","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C72","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0896-6273(01)00177-5","article-title":"Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases","volume":"29","author":"Sherman","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C73","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pharmthera.2007.04.001","article-title":"Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease","volume":"114","author":"Sun","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C74","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pneurobio.2008.03.001","article-title":"The neuronal ubiquitin\u2013proteasome system: murine models and their neurological phenotype","volume":"85","author":"van Tijn","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C75","first-page":"CD006455","article-title":"Therapeutic interventions for disease progression in Huntington's disease","author":"Mestre","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C76","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00221-005-2357-z","article-title":"Atypical diabetes associated with inclusion formation in the R6\/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents","volume":"166","author":"Hunt","year":"2005","journal-title":"Exp. Brain Res."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C77","doi-asserted-by":"crossref","first-page":"e7868","DOI":"10.1371\/journal.pone.0007868","article-title":"Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus","volume":"4","author":"Lee","year":"2009","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C78","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/exnr.2001.7679","article-title":"Behavioral and histological outcomes following graded spinal cord contusion injury in the C57Bl\/6 mouse","volume":"169","author":"Ma","year":"2001","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C79","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C80","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1074\/mcp.M600356-MCP200","article-title":"Systematic uncovering of multiple pathways underlying the pathology of Huntington disease by an acid-cleavable isotope-coded affinity tag approach","volume":"6","author":"Chiang","year":"2007","journal-title":"Mol. Cell Proteomics"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C81","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0076-6879(99)09026-6","article-title":"Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates","volume":"309","author":"Wanker","year":"1999","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C82","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0014-5793(98)01098-9","article-title":"Expression of type VI adenylyl cyclase in the central nervous system: implication for a potential regulator of multiple signals in different neurotransmitter systems","volume":"436","author":"Liu","year":"1998","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C83","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/exnr.2000.7551","article-title":"ST14A cells have properties of a medium-size spiny neuron","volume":"167","author":"Ehrlich","year":"2001","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t20170522173122_DDQ322C84","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/cyto.a.20033","article-title":"Efficacy of MitoTracker Green and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues","volume":"61","author":"Pendergrass","year":"2004","journal-title":"Cytometry A"},{"key":"key\n\t\t\t\t20170522173122_DDQ322C85","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group","volume":"11","author":"Huntington Study Group","year":"1996","journal-title":"Mov. Disord."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/19\/20\/4043\/13911247\/ddq322.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T12:52:13Z","timestamp":1685710333000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddq322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,28]]},"references-count":85,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2010,7,28]]},"published-print":{"date-parts":[[2010,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddq322","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7,28]]}}}