{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:42:59Z","timestamp":1787240579772,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"DOI":"10.1093\/hmg\/ddq384","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T20:35:43Z","timestamp":1284582943000},"page":"4560-4572","source":"Crossref","is-referenced-by-count":45,"title":["Functional interactions between the LRP6 WNT co-receptor and folate supplementation"],"prefix":"10.1093","volume":"19","author":[{"given":"Jason D.","family":"Gray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghunwa","family":"Nakouzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Slowinska-Castaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Eudes","family":"Dazard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sunil Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H.","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Elizabeth Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,9,15]]},"reference":[{"key":"key\n\t\t\t\t20170522141353_DDQ384C1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/bdra.20333","article-title":"Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects","volume":"79","author":"Harris","year":"2007","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/bdra.20676","article-title":"An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure","volume":"88","author":"Harris","year":"2010","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C3","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/bdra.20542","article-title":"Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice","volume":"85","author":"Gray","year":"2009","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C4","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1093\/hmg\/8.12.2199","article-title":"Crooked tail (Cd) models human folate-responsive neural tube defects","volume":"8","author":"Carter","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C5","doi-asserted-by":"crossref","first-page":"12843","DOI":"10.1073\/pnas.0501963102","article-title":"Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6","volume":"102","author":"Carter","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2121-4-4","article-title":"Wnt\/Wingless signaling through beta-catenin requires the function of both LRP\/Arrow and frizzled classes of receptors","volume":"4","author":"Schweizer","year":"2003","journal-title":"BMC Cell Biol."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35035124","article-title":"An LDL-receptor-related protein mediates Wnt signalling in mice","volume":"407","author":"Pinson","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C8","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1242\/dev.01405","article-title":"Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis","volume":"131","author":"Kokubu","year":"2004","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C9","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1093\/hmg\/ddl415","article-title":"Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice","volume":"15","author":"Ernest","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nrg1181","article-title":"The genetic basis of mammalian neurulation","volume":"4","author":"Copp","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/bdrc.20100","article-title":"Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression","volume":"81","author":"Beaudin","year":"2007","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C12","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C13","doi-asserted-by":"crossref","first-page":"pe3","DOI":"10.1126\/scisignal.253pe3","article-title":"Growth and patterning in the limb: signaling gradients make the decision","volume":"2","author":"Yang","year":"2009","journal-title":"Sci. Signal"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10456-008-9095-3","article-title":"Wnt\/Frizzled signaling in angiogenesis","volume":"11","author":"Zerlin","year":"2008","journal-title":"Angiogenesis"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00774-009-0064-8","article-title":"Wnt signaling in bone metabolism","volume":"27","author":"Kubota","year":"2009","journal-title":"J. Bone Miner. Metab."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/15216540500137586","article-title":"The Wnt signaling pathway in retinal degenerations","volume":"57","author":"Hackam","year":"2005","journal-title":"IUBMB Life"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0022-3476(05)80129-5","article-title":"Late-onset ornithine transcarbamylase deficiency in male patients","volume":"117","author":"Finkelstein","year":"1990","journal-title":"J. Pediatr."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1742-4682-3-40","article-title":"In silico experimentation with a model of hepatic mitochondrial folate metabolism","volume":"3","author":"Nijhout","year":"2006","journal-title":"Theor. Biol. Med. Model."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C19","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1074\/jbc.M808281200","article-title":"Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism","volume":"284","author":"MacFarlane","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ntt.2004.12.007","article-title":"Human neural tube defects: developmental biology, epidemiology, and genetics","volume":"27","author":"Detrait","year":"2005","journal-title":"Neurotoxicol. Teratol."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1521-6934(03)00009-9","article-title":"Homocysteine and pregnancy","volume":"17","author":"Hague","year":"2003","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C22","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1517\/14656566.2.9.1449","article-title":"Homocysteine-lowering treatment: an overview","volume":"2","author":"van Guldener","year":"2001","journal-title":"Expert Opin. Pharmacother."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00335-001-3054-2","article-title":"Genetic and molecular control of folate-homocysteine metabolism in mutant mice","volume":"13","author":"Ernest","year":"2002","journal-title":"Mamm. Genome"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nm0197-60","article-title":"Inositol prevents folate-resistant neural tube defects in the mouse","volume":"3","author":"Greene","year":"1997","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C25","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.72","article-title":"Gene-environment interactions: folate metabolism and the embryonic nervous system","author":"Ross","year":"2010","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0042-6822(59)90043-1","article-title":"Plaque production by the polyoma virus","volume":"8","author":"Dulbecco","year":"1959","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C27","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1074\/jbc.M109.079855","article-title":"Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos","volume":"285","author":"Pike","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1096\/fj.01-0401rev","article-title":"S-Adenosylmethionine: a control switch that regulates liver function","volume":"16","author":"Mato","year":"2002","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C29","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/hep.21651","article-title":"WNT\/beta-catenin signaling in liver health and disease","volume":"45","author":"Thompson","year":"2007","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4161\/org.4.2.5855","article-title":"Wnt\/beta-catenin signaling in hepatic organogenesis","volume":"4","author":"Nejak-Bowen","year":"2008","journal-title":"Organogenesis"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1042\/BST0340330","article-title":"S-adenosylmethionine: jack of all trades and master of everything","volume":"34","author":"Loenen","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20031327","article-title":"A perspective of polyamine metabolism","volume":"376","author":"Wallace","year":"2003","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C33","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1096\/fj.09-130708","article-title":"Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools","volume":"23","author":"Bistulfi","year":"2009","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1749-6632.1998.tb10106.x","article-title":"Wnt signaling stabilizes the dual-function protein beta-catenin in diverse cell types","volume":"857","author":"Giarre","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C35","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/dvdy.20135","article-title":"Beta-catenin signaling marks the prospective site of primitive streak formation in the mouse embryo","volume":"231","author":"Mohamed","year":"2004","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C36","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data","volume":"31","author":"Irizarry","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"Suppl. 1","key":"key\n\t\t\t\t20170522141353_DDQ384C37","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1093\/bioinformatics\/18.suppl_1.S96","article-title":"Variance stabilization applied to microarray data calibration and to the quantification of differential expression","volume":"18","author":"Huber","year":"2002","journal-title":"Bioinformatics"},{"issue":"Suppl. 1","key":"key\n\t\t\t\t20170522141353_DDQ384C38","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1093\/bioinformatics\/18.suppl_1.S105","article-title":"A variance-stabilizing transformation for gene-expression microarray data","volume":"18","author":"Durbin","year":"2002","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C39","volume-title":"Posterior Probabilities of Alternative Linear Models","author":"Lempers","year":"1971"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C40","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1080\/01621459.1988.10478694","article-title":"Bayesian variable selection in linear regression","volume":"83","author":"Mitchell","year":"1988","journal-title":"J. Am. Stat. Assoc."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C41","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1080\/01621459.1993.10476353","article-title":"Variable selection via Gibbs sampling","volume":"88","author":"George","year":"1993","journal-title":"J. Am. Stat. Assoc."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C42","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1198\/016214505000000051","article-title":"Spike and slab gene selection for multigroup microarray data","volume":"100","author":"Ishwaran","year":"2005","journal-title":"J. Am. Stat. Assoc."},{"key":"key\n\t\t\t\t20170522141353_DDQ384C43","article-title":"Generalized ridge regression: geometry and computational solutions when p is larger than n","author":"Ishwaran","journal-title":"Roy. Stat. Soc. Ser. B Theor. Method"},{"key":"key\n\t\t\t\t20170522141353_DDQ384C44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/00401706.1970.10488634","article-title":"Ridge regression: Biased estimation for non-orthogonal problems","volume":"12","author":"Hoerl","year":"1970","journal-title":"Technometrics"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/19\/23\/4560\/17249715\/ddq384.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T01:15:08Z","timestamp":1503450908000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddq384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,15]]},"references-count":44,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2010,9,15]]},"published-print":{"date-parts":[[2010,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddq384","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.6690956.6885054","asserted-by":"object"}]},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9,15]]}}}