{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:40:27Z","timestamp":1790894427732,"version":"4.1.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,15]]},"DOI":"10.1093\/hmg\/ddr033","type":"journal-article","created":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T02:05:29Z","timestamp":1296007529000},"page":"1560-1573","source":"Crossref","is-referenced-by-count":107,"title":["APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome"],"prefix":"10.1093","volume":"20","author":[{"given":"Stefania","family":"Trazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina Maria","family":"Mitrugno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Valli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Rizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Guidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Perini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Bartesaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Ciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,1,25]]},"reference":[{"key":"key\n\t\t\t\t20170522141746_DDR033C1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1212\/WNL.34.7.909","article-title":"Down's syndrome: is there a decreased population of neurons?","volume":"34","author":"Ross","year":"1984","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522141746_DDR033C2","first-page":"181","article-title":"Brain growth in Down syndrome subjects 15\u201322 weeks of gestational age and birth to 60 months","volume":"9","author":"Schmidt-Sidor","year":"1990","journal-title":"Clin. Neuropathol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/hipo.20308","article-title":"Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice","volume":"17","author":"Contestabile","year":"2007","journal-title":"Hippocampus"},{"key":"key\n\t\t\t\t20170522141746_DDR033C4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1750-3639.2007.00113.x","article-title":"Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome","volume":"18","author":"Guidi","year":"2008","journal-title":"Brain Pathol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C5","article-title":"Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with Down syndrome","author":"Guidi","journal-title":"Brain. Pathol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0361-9230(86)90076-6","article-title":"Genetic basis for a mouse model of Down syndrome","volume":"16","author":"Reeves","year":"1986","journal-title":"Brain Res. Bull."},{"key":"key\n\t\t\t\t20170522141746_DDR033C7","first-page":"263","article-title":"Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome","volume":"360","author":"Davisson","year":"1990","journal-title":"Prog. Clin. Biol. Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C8","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1073\/pnas.95.11.6256","article-title":"Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities","volume":"95","author":"Sago","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522141746_DDR033C9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000056997","article-title":"Ts65Dn\u2014localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome","volume":"93","author":"Akeson","year":"2001","journal-title":"Cytogenet. Cell Genet."},{"key":"key\n\t\t\t\t20170522141746_DDR033C10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1095-177","article-title":"A mouse model for Down syndrome exhibits learning and behaviour deficits","volume":"11","author":"Reeves","year":"1995","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522141746_DDR033C11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ajmg.10175","article-title":"Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome","volume":"107","author":"Richtsmeier","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"key\n\t\t\t\t20170522141746_DDR033C12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3940(95)12052-6","article-title":"A behavioral assessment of Ts65Dn mice: a putative Down syndrome model","volume":"199","author":"Escorihuela","year":"1995","journal-title":"Neurosci. Lett."},{"key":"key\n\t\t\t\t20170522141746_DDR033C13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0166-4328(97)81111-4","article-title":"Spatial memory deficits in segmental trisomic Ts65Dn mice","volume":"82","author":"Demas","year":"1996","journal-title":"Behav. Brain Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C14","doi-asserted-by":"crossref","first-page":"11483","DOI":"10.1523\/JNEUROSCI.3406-07.2007","article-title":"Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome","volume":"27","author":"Chakrabarti","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522141746_DDR033C15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/hmg\/9.2.195","article-title":"Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse","volume":"9","author":"Baxter","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522141746_DDR033C16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1750-3639.2008.00168.x","article-title":"Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome","volume":"19","author":"Contestabile","year":"2009","journal-title":"Brain Pathol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C17","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1073\/pnas.0510750103","article-title":"Defective cerebellar response to mitogenic Hedgehog signaling in Down syndrome mice","volume":"103","author":"Roper","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522141746_DDR033C18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1447-073x.2005.00096.x","article-title":"Signaling cascade coordinating growth of dorsal and ventral tissues of the vertebrate brain, with special reference to the involvement of Sonic Hedgehog signaling","volume":"80","author":"Ishibashi","year":"2005","journal-title":"Anat. Sci. Int."},{"key":"key\n\t\t\t\t20170522141746_DDR033C19","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0962-8924(02)02405-4","article-title":"Pathways and consequences: hedgehog signaling in human disease","volume":"12","author":"Mullor","year":"2002","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/dbio.1999.9311","article-title":"Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube","volume":"211","author":"Goodrich","year":"1999","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C21","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/nature00989","article-title":"Patched acts catalytically to suppress the activity of Smoothened","volume":"418","author":"Taipale","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522141746_DDR033C22","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1007\/PL00000654","article-title":"Hedgehog signalling in cancer","volume":"57","author":"Toftgard","year":"2000","journal-title":"Cell Mol. Life Sci."},{"key":"key\n\t\t\t\t20170522141746_DDR033C23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1440-1754.2007.01104.x","article-title":"Switched-on Sonic hedgehog: a gene whose activity extends beyond fetal development\u2014to oncogenesis","volume":"43","author":"Arsic","year":"2007","journal-title":"J. Paediatr. Child Health"},{"key":"key\n\t\t\t\t20170522141746_DDR033C24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2184.2009.00587.x","article-title":"Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome","volume":"42","author":"Contestabile","year":"2009","journal-title":"Cell Prolif."},{"key":"key\n\t\t\t\t20170522141746_DDR033C25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s004120050256","article-title":"Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation","volume":"106","author":"Hendzel","year":"1997","journal-title":"Chromosoma"},{"key":"key\n\t\t\t\t20170522141746_DDR033C26","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522141746_DDR033C27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1750-3639.2008.00246.x","article-title":"Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome","volume":"20","author":"Bianchi","year":"2010","journal-title":"Brain Pathol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00441-008-0743-0","article-title":"Characterization of primary neurospheres generated from mouse ventral rostral hindbrain","volume":"336","author":"Osterberg","year":"2009","journal-title":"Cell Tissue Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C29","doi-asserted-by":"crossref","first-page":"14071","DOI":"10.1073\/pnas.182542899","article-title":"Small molecule modulation of Smoothened activity","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522141746_DDR033C30","first-page":"875","article-title":"The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas","volume":"19","author":"Cretnik","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"key\n\t\t\t\t20170522141746_DDR033C31","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.3748\/wjg.15.3799","article-title":"Methylation of PTCH1a gene in a subset of gastric cancers","volume":"15","author":"Du","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cancergencyto.2007.09.008","article-title":"Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas","volume":"180","author":"Pritchard","year":"2008","journal-title":"Cancer Genet. Cytogenet."},{"key":"key\n\t\t\t\t20170522141746_DDR033C33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mrrev.2008.02.004","article-title":"Epigenetic interplay between histone modifications and DNA methylation in gene silencing","volume":"659","author":"Vaissiere","year":"2008","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C34","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1073\/pnas.052410099","article-title":"Comprehensive analysis of CpG islands in human chromosomes 21 and 22","volume":"99","author":"Takai","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522141746_DDR033C35","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1073\/pnas.93.23.13333","article-title":"Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome","volume":"93","author":"Holtzman","year":"1996","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522141746_DDR033C36","first-page":"5","article-title":"AICD overexpression in neuro 2A cells regulates expression of PTCH1 and TRPC5","volume":"2011","author":"Raychaudhuri","year":"2011","journal-title":"Int. J. Alzheimers Dis"},{"key":"key\n\t\t\t\t20170522141746_DDR033C37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1126\/science.1058783","article-title":"A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60","volume":"293","author":"Cao","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522141746_DDR033C38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jnr.10845","article-title":"Inhibition of histone deacetylation enhances the neurotoxicity induced by the C-terminal fragments of amyloid precursor protein","volume":"75","author":"Kim","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C39","doi-asserted-by":"crossref","first-page":"8769","DOI":"10.1523\/JNEUROSCI.0534-10.2010","article-title":"Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome","volume":"30","author":"Bianchi","year":"2010","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522141746_DDR033C40","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1002\/jnr.22131","article-title":"Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres","volume":"87","author":"Moldrich","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C41","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0140-6736(02)07497-4","article-title":"Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study","volume":"359","author":"Bahn","year":"2002","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170522141746_DDR033C42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1159\/000236899","article-title":"A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells","volume":"31","author":"Bhattacharyya","year":"2009","journal-title":"Dev. Neurosci."},{"key":"key\n\t\t\t\t20170522141746_DDR033C43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nn983","article-title":"Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo","volume":"6","author":"Lai","year":"2003","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522141746_DDR033C44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1242\/dev.01567","article-title":"Sonic hedgehog controls stem cell behavior in the postnatal and adult brain","volume":"132","author":"Palma","year":"2005","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522141746_DDR033C45","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0896-6273(03)00561-0","article-title":"Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches","volume":"39","author":"Machold","year":"2003","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522141746_DDR033C46","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mod.2008.11.002","article-title":"A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog","volume":"126","author":"Roper","year":"2009","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t20170522141746_DDR033C47","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/pd.2316","article-title":"Abnormal Shh and FOXC2 expression correlates with aberrant lymphatic development in human fetuses with increased nuchal translucency","volume":"29","author":"de Mooij","year":"2009","journal-title":"Prenat. Diagn."},{"key":"key\n\t\t\t\t20170522141746_DDR033C48","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0960-9822(99)80482-5","article-title":"Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1","volume":"9","author":"Ding","year":"1999","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C49","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522141746_DDR033C50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/dev.00182","article-title":"Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors","volume":"130","author":"Kenney","year":"2003","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522141746_DDR033C51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/gene.10004","article-title":"Genetic evidence that Sil is required for the Sonic Hedgehog response pathway","volume":"31","author":"Izraeli","year":"2001","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170522141746_DDR033C52","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ejhg.2008.176","article-title":"PTCH1 duplication in a family with microcephaly and mild developmental delay","volume":"17","author":"Derwinska","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522141746_DDR033C53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pneurobio.2008.05.002","article-title":"The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease","volume":"85","author":"Muller","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C54","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1158\/1078-0432.CCR-06-1736","article-title":"The hedgehog signaling pathway in cancer","volume":"12","author":"Evangelista","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C55","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1158\/0008-5472.CAN-08-0946","article-title":"Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice","volume":"69","author":"Ecke","year":"2009","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C56","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522141746_DDR033C57","doi-asserted-by":"crossref","first-page":"e11866","DOI":"10.1371\/journal.pone.0011866","article-title":"APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation","volume":"5","author":"Ghosal","year":"2010","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170522141746_DDR033C58","first-page":"117","article-title":"Segmental trisomy as a mouse model for Down syndrome","volume":"384","author":"Davisson","year":"1993","journal-title":"Prog. Clin. Biol. Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C59","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.2144\/03356st02","article-title":"Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome","volume":"35","author":"Liu","year":"2003","journal-title":"Biotechniques"},{"key":"key\n\t\t\t\t20170522141746_DDR033C60","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1523\/JNEUROSCI.16-23-07599.1996","article-title":"Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis","volume":"16","author":"Weiss","year":"1996","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522141746_DDR033C61","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1523\/JNEUROSCI.13-02-00820.1993","article-title":"Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse","volume":"13","author":"Takahashi","year":"1993","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522141746_DDR033C62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-3806(01)00294-2","article-title":"Disruption of cell cycle kinetics and cyclin-dependent kinase system by ethanol in cultured cerebellar granule progenitors","volume":"132","author":"Li","year":"2001","journal-title":"Brain Res. Dev. Brain Res."},{"key":"key\n\t\t\t\t20170522141746_DDR033C63","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522141746_DDR033C64","doi-asserted-by":"crossref","first-page":"10098","DOI":"10.1074\/jbc.M109.043711","article-title":"CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT\/glycogen synthase kinase-3beta\/beta-catenin signaling","volume":"285","author":"Trazzi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522141746_DDR033C65","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1083\/jcb.200505078","article-title":"Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain","volume":"171","author":"Ryan","year":"2005","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522141746_DDR033C66","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ng1719","article-title":"Evidence for an instructive mechanism of de novo methylation in cancer cells","volume":"38","author":"Keshet","year":"2006","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522141746_DDR033C67","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1073\/pnas.0601587103","article-title":"The mechanism of M.HhaI DNA C5 cytosine methyltransferase enzyme: a quantum mechanics\/molecular mechanics approach","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522141746_DDR033C68","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1046-2023(02)00006-3","article-title":"Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation","volume":"26","author":"Weinmann","year":"2002","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170522141746_DDR033C69","doi-asserted-by":"crossref","first-page":"18682","DOI":"10.1073\/pnas.0705524104","article-title":"Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis","volume":"104","author":"Liu","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/20\/8\/1560\/17255351\/ddr033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T02:12:24Z","timestamp":1637201544000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddr033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,25]]},"references-count":69,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,1,25]]},"published-print":{"date-parts":[[2011,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddr033","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,25]]}}}