{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:20:06Z","timestamp":1791980406944,"version":"4.4.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"DOI":"10.1093\/hmg\/ddr139","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T21:06:09Z","timestamp":1301691969000},"page":"2495-2509","source":"Crossref","is-referenced-by-count":772,"title":["Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage"],"prefix":"10.1093","volume":"20","author":[{"given":"Maria","family":"Manczak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus J.","family":"Calkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Hemachandra","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,31]]},"reference":[{"key":"key\n\t\t\t\t20170522133326_DDR139C1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"key\n\t\t\t\t20170522133326_DDR139C2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1046\/j.1471-4159.1997.69010273.x","article-title":"Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal","volume":"69","author":"Keller","year":"1997","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522133326_DDR139C3","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1212\/WNL.49.4.918","article-title":"Cybrids in Alzheimer's disease: a cellular model of the disease?","volume":"49","author":"Swerdlow","year":"1997","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522133326_DDR139C4","article-title":"Mitochondria are a therapeutic target for neurodegenerative disease","author":"Reddy","year":"2010","journal-title":"Curr. Alzheimer Res."},{"key":"key\n\t\t\t\t20170522133326_DDR139C5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer's disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522133326_DDR139C6","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1038\/sj.emboj.7601253","article-title":"Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons","volume":"25","author":"Barsoum","year":"2006","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170522133326_DDR139C7","doi-asserted-by":"crossref","first-page":"17213","DOI":"10.1073\/pnas.0508575102","article-title":"Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent","volume":"102","author":"Greig","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522133326_DDR139C8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmed.2007.12.002","article-title":"Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease","volume":"14","author":"Reddy","year":"2008","journal-title":"Trends Mol. Med."},{"key":"key\n\t\t\t\t20170522133326_DDR139C9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170522133326_DDR139C10","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.neurobiolaging.2005.05.022","article-title":"Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease","volume":"26","author":"Gouras","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170522133326_DDR139C11","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.freeradbiomed.2009.02.006","article-title":"Epigenetics, oxidative stress, and Alzheimer disease","volume":"46","author":"Zawia","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"Suppl. 2","key":"key\n\t\t\t\t20170522133326_DDR139C12","doi-asserted-by":"crossref","first-page":"S499","DOI":"10.3233\/JAD-2010-100504","article-title":"Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline","volume":"20","author":"Reddy","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"key\n\t\t\t\t20170522133326_DDR139C13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0166-2236(00)01749-5","article-title":"Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?","volume":"24","author":"Klein","year":"2001","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20170522133326_DDR139C14","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.1834302100","article-title":"Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss","volume":"100","author":"Gong","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522133326_DDR139C15","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","article-title":"A beta oligomers\u2014a decade of discovery","volume":"101","author":"Walsh","year":"2007","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522133326_DDR139C16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-beta in Alzheimer's disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522133326_DDR139C17","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1111\/j.1742-4658.2010.07719.x","article-title":"Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins","volume":"277","author":"Pham","year":"2010","journal-title":"FEBS J."},{"key":"key\n\t\t\t\t20170522133326_DDR139C18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1001\/archneurol.2008.565","article-title":"A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease","volume":"66","author":"Xia","year":"2009","journal-title":"Arch. Neurol."},{"key":"key\n\t\t\t\t20170522133326_DDR139C19","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1523\/JNEUROSCI.4456-09.2010","article-title":"Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation","volume":"30","author":"Wu","year":"2010","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522133326_DDR139C20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature04533","article-title":"A specific amyloid-beta protein assembly in the brain impairs memory","volume":"440","author":"Lesn\u00e9","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522133326_DDR139C21","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522133326_DDR139C22","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/hmg\/ddl066","article-title":"Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression","volume":"15","author":"Manczak","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522133326_DDR139C23","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1096\/fj.05-3735fje","article-title":"Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease","volume":"19","author":"Caspersen","year":"2005","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170522133326_DDR139C24","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1523\/JNEUROSCI.1469-06.2006","article-title":"Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction","volume":"26","author":"Devi","year":"2006","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522133326_DDR139C25","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease","volume":"106","author":"Yao","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"Suppl. 2","key":"key\n\t\t\t\t20170522133326_DDR139C26","doi-asserted-by":"crossref","first-page":"S609","DOI":"10.3233\/JAD-2010-100564","article-title":"Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons","volume":"20","author":"Manczak","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"key\n\t\t\t\t20170522133326_DDR139C27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000113689","article-title":"Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice","volume":"5","author":"Eckert","year":"2008","journal-title":"Neurodegener. Dis."},{"key":"key\n\t\t\t\t20170522133326_DDR139C28","doi-asserted-by":"crossref","first-page":"20057","DOI":"10.1073\/pnas.0905529106","article-title":"Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice","volume":"106","author":"Rhein","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522133326_DDR139C29","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bbadis.2011.01.007","article-title":"Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons","volume":"1812","author":"Calkins","year":"2011","journal-title":"Biochim. Biophys. Acta."},{"key":"key\n\t\t\t\t20170522133326_DDR139C30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000283484","article-title":"Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons","volume":"7","author":"Wang","year":"2010","journal-title":"Neurodegener. Dis."},{"key":"key\n\t\t\t\t20170522133326_DDR139C31","doi-asserted-by":"crossref","first-page":"18670","DOI":"10.1073\/pnas.1006586107","article-title":"Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model","volume":"107","author":"Du","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522133326_DDR139C32","doi-asserted-by":"crossref","first-page":"19318","DOI":"10.1073\/pnas.0804871105","article-title":"Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl Acad. Sci .USA"},{"key":"key\n\t\t\t\t20170522133326_DDR139C33","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1523\/JNEUROSCI.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer's disease","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522133326_DDR139C34","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics\u2014fusion, fission, movement, and mitophagy\u2014in neurodegenerative diseases","volume":"18","author":"Chen","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522133326_DDR139C35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainresrev.2009.04.001","article-title":"Mitochondrial structural and functional dynamics in Huntington's disease","volume":"61","author":"Reddy","year":"2009","journal-title":"Brain Res. Rev."},{"key":"key\n\t\t\t\t20170522133326_DDR139C36","article-title":"Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases","author":"Reddy","year":"2010","journal-title":"Brain Res. Rev."},{"key":"key\n\t\t\t\t20170522133326_DDR139C37","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1083\/jcb.200903065","article-title":"The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice","volume":"186","author":"Wakabayashi","year":"2009","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522133326_DDR139C38","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ncb1907","article-title":"Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice","volume":"11","author":"Ishihara","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170522133326_DDR139C39","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage","volume":"20","author":"Shirendeb","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20170522133326_DDR139C40","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1167\/iovs.06-0573","article-title":"Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells","volume":"48","author":"Ju","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522133326_DDR139C41","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1523\/JNEUROSCI.5167-03.2004","article-title":"Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain","volume":"24","author":"Takahashi","year":"2004","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522133326_DDR139C42","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nm.1868","article-title":"Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease","volume":"14","author":"Du","year":"2008","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522133326_DDR139C43","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1091230","article-title":"ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease","volume":"304","author":"Lustbader","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522133326_DDR139C44","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer's disease","volume":"21","author":"Hirai","year":"2001","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522133326_DDR139C45","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/hmg\/ddh140","article-title":"Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease","volume":"13","author":"Reddy","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522133326_DDR139C46","doi-asserted-by":"crossref","first-page":"13145","DOI":"10.1073\/pnas.0806192105","article-title":"The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae","volume":"105","author":"Hansson Petersen","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522133326_DDR139C47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1750-3639.1991.tb00661.x","article-title":"Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections","volume":"1","author":"Braak","year":"1991","journal-title":"Brain Pathol."},{"key":"key\n\t\t\t\t20170522133326_DDR139C48","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jneumeth.2003.09.005","article-title":"The use of real-time PCR analysis in a gene expression study of Alzheimer's disease post-mortem brains","volume":"132","author":"Gutala","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"key\n\t\t\t\t20170522133326_DDR139C49","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1093\/hmg\/ddp331","article-title":"Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1\u201342 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease","volume":"18","author":"Manczak","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522133326_DDR139C50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/ijerph8010203","article-title":"Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31","volume":"8","author":"Reddy","year":"2011","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"key\n\t\t\t\t20170522133326_DDR139C51","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1073\/pnas.0813404106","article-title":"Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice","volume":"106","author":"Thakker","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522133326_DDR139C52","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1079469","article-title":"Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis","volume":"300","author":"Kayed","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522133326_DDR139C53","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","article-title":"Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1\u201342\/1\u201340 ratio in vitro and in vivo","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522133326_DDR139C54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/article\/20\/13\/2495\/2526989\/Impaired-mitochondrial-dynamics-and-abnormal","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T12:30:04Z","timestamp":1560083404000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddr139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,31]]},"references-count":54,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2011,3,31]]},"published-print":{"date-parts":[[2011,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddr139","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3,31]]}}}