{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:12:25Z","timestamp":1792163545428,"version":"4.4.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,1]]},"DOI":"10.1093\/hmg\/ddr242","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T11:53:35Z","timestamp":1307102015000},"page":"3356-3365","source":"Crossref","is-referenced-by-count":93,"title":["Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14"],"prefix":"10.1093","volume":"20","author":[{"given":"Kun","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun S.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni","family":"Singaraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona B.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"El-Husseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,6,2]]},"reference":[{"key":"key\n\t\t\t\t20170522133638_DDR242C1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4889(99)00075-0","article-title":"Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins","volume":"1451","author":"Resh","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522133638_DDR242C2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.conb.2005.08.001","article-title":"Modulation of neuronal protein trafficking and function by palmitoylation","volume":"15","author":"Huang","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"key\n\t\t\t\t20170522133638_DDR242C3","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neuron.2004.11.027","article-title":"Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins","volume":"44","author":"Huang","year":"2004","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522133638_DDR242C4","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522133638_DDR242C5","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.neuron.2004.12.005","article-title":"Identification of PSD-95 palmitoylating enzymes","volume":"44","author":"Fukata","year":"2004","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522133638_DDR242C6","doi-asserted-by":"crossref","first-page":"41268","DOI":"10.1074\/jbc.M206573200","article-title":"Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae","volume":"277","author":"Lobo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522133638_DDR242C7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1083\/jcb.200206120","article-title":"The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase","volume":"159","author":"Roth","year":"2002","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522133638_DDR242C8","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1096\/fj.08-127399","article-title":"Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity","volume":"23","author":"Huang","year":"2009","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170522133638_DDR242C9","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nn1702","article-title":"Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function","volume":"9","author":"Yanai","year":"2006","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522133638_DDR242C10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.nbd.2010.05.027","article-title":"Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease","volume":"40","author":"Huang","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522133638_DDR242C11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.neuro.29.051605.113042","article-title":"Trinucleotide repeat disorders","volume":"30","author":"Orr","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522133638_DDR242C12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tcb.2009.01.005","article-title":"Huntingtin as an essential integrator of intracellular vesicular trafficking","volume":"19","author":"Caviston","year":"2009","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20170522133638_DDR242C13","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1073\/pnas.92.19.8710","article-title":"Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies","volume":"92","author":"Gutekunst","year":"1995","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522133638_DDR242C14","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0896-6273(95)90346-1","article-title":"Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons","volume":"14","author":"DiFiglia","year":"1995","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522133638_DDR242C15","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0092-8674(95)90542-1","article-title":"Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes","volume":"81","author":"Nasir","year":"1995","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522133638_DDR242C16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.7618107","article-title":"Inactivation of the mouse Huntington's disease gene homolog Hdh","volume":"269","author":"Duyao","year":"1995","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522133638_DDR242C17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ng1095-155","article-title":"Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue","volume":"11","author":"Zeitlin","year":"1995","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522133638_DDR242C18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20071619","article-title":"Huntington's disease: from pathology and genetics to potential therapies","volume":"412","author":"Imarisio","year":"2008","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170522133638_DDR242C19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1083\/jcb.200601051","article-title":"Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase","volume":"174","author":"Fernandez-Hernando","year":"2006","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522133638_DDR242C20","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1093\/hmg\/11.23.2815","article-title":"HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis","volume":"11","author":"Singaraja","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522133638_DDR242C21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1128\/MCB.01144-08","article-title":"Identification of G protein {alpha} subunit-palmitoylating enzyme","volume":"29","author":"Tsutsumi","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522133638_DDR242C22","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2005.03605.x","article-title":"Wild-type huntingtin protects neurons from excitotoxicity","volume":"96","author":"Leavitt","year":"2006","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522133638_DDR242C23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/81593","article-title":"Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice","volume":"26","author":"Dragatsis","year":"2000","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522133638_DDR242C24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1471-4159.2003.01980.x","article-title":"Depletion of wild-type huntingtin in mouse models of neurologic diseases","volume":"87","author":"Zhang","year":"2003","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522133638_DDR242C25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1086\/318207","article-title":"Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo","volume":"68","author":"Leavitt","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522133638_DDR242C26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522133638_DDR242C27","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1523\/JNEUROSCI.3920-03.2004","article-title":"Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor","volume":"24","author":"Baquet","year":"2004","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522133638_DDR242C28","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1523\/JNEUROSCI.2461-07.2007","article-title":"Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration","volume":"27","author":"Strand","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522133638_DDR242C29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1385\/MN:28:3:259","article-title":"Wild-type huntingtin plays a role in brain development and neuronal survival","volume":"28","author":"Reiner","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"key\n\t\t\t\t20170522133638_DDR242C30","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington's disease","volume":"6","author":"Cattaneo","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522133638_DDR242C31","doi-asserted-by":"crossref","first-page":"21366","DOI":"10.1074\/jbc.M110.105601","article-title":"6-Phosphogluconate dehydrogenase mechanism: evidence for allosteric modulation by substrate","volume":"285","author":"Hanau","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522133638_DDR242C32","doi-asserted-by":"crossref","first-page":"15916","DOI":"10.1074\/jbc.M511007200","article-title":"Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522133638_DDR242C33","first-page":"pe48","article-title":"Huntingtin: alive and well and working in middle management","volume":"207","author":"MacDonald","year":"2003","journal-title":"Sci. STKE"},{"key":"key\n\t\t\t\t20170522133638_DDR242C34","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1371\/journal.pgen.0030082","article-title":"Huntingtin interacting proteins are genetic modifiers of neurodegeneration","volume":"3","author":"Kaltenbach","year":"2007","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170522133638_DDR242C35","doi-asserted-by":"crossref","first-page":"24713","DOI":"10.1074\/jbc.M103501200","article-title":"Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95","volume":"276","author":"Sun","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522133638_DDR242C36","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s00018-005-5084-5","article-title":"Synaptic dysfunction in Huntington's disease: a new perspective","volume":"62","author":"Smith","year":"2005","journal-title":"Cell Mol. Life Sci."},{"key":"key\n\t\t\t\t20170522133638_DDR242C37","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1007\/s00018-006-6242-0","article-title":"Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies","volume":"63","author":"Borrell-Pages","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"key\n\t\t\t\t20170522133638_DDR242C38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522133638_DDR242C39","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.1073\/pnas.0610628104","article-title":"Huntingtin facilitates dynein\/dynactin-mediated vesicle transport","volume":"104","author":"Caviston","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522133638_DDR242C40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-6273(03)00594-4","article-title":"Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila","volume":"40","author":"Gunawardena","year":"2003","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522133638_DDR242C41","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522133638_DDR242C42","doi-asserted-by":"crossref","first-page":"8808","DOI":"10.1074\/jbc.M109.075028","article-title":"Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease","volume":"285","author":"Landles","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522133638_DDR242C43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/nen.0b013e318040b2c8","article-title":"Characterization of huntingtin pathologic fragments in human Huntington disease, transgenic mice, and cell models","volume":"66","author":"Schilling","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"key\n\t\t\t\t20170522133638_DDR242C44","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1523\/JNEUROSCI.2071-10.2010","article-title":"Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo","volume":"30","author":"Graham","year":"2010","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522133638_DDR242C45","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","article-title":"Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin","volume":"125","author":"Graham","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522133638_DDR242C46","doi-asserted-by":"crossref","first-page":"31141","DOI":"10.1074\/jbc.M504113200","article-title":"DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras","volume":"280","author":"Swarthout","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522133638_DDR242C47","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bbalip.2006.03.010","article-title":"Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins","volume":"1761","author":"Ohno","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522133638_DDR242C48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncb735","article-title":"Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi","volume":"4","author":"Gervais","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170522133638_DDR242C49","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07605","article-title":"Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation","volume":"456","author":"Kang","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522133638_DDR242C50","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.cell.2006.03.042","article-title":"Global analysis of protein palmitoylation in yeast","volume":"125","author":"Roth","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522133638_DDR242C51","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2144\/04362RR02","article-title":"Labeling and quantifying sites of protein palmitoylation","volume":"36","author":"Drisdel","year":"2004","journal-title":"Biotechniques"},{"key":"key\n\t\t\t\t20170522133638_DDR242C52","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/yea.320110408","article-title":"Studies on the transformation of intact yeast cells by the LiAc\/SS-DNA\/PEG procedure","volume":"11","author":"Gietz","year":"1995","journal-title":"Yeast"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/article\/20\/17\/3356\/2527002\/Wildtype-HTT-modulates-the-enzymatic-activity-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T10:52:52Z","timestamp":1560250372000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddr242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,2]]},"references-count":52,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2011,6,2]]},"published-print":{"date-parts":[[2011,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddr242","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6,2]]}}}