{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:33:23Z","timestamp":1787736803613,"version":"build-2784847793"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,15]]},"DOI":"10.1093\/hmg\/ddr271","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T04:24:51Z","timestamp":1307679891000},"page":"3545-3553","source":"Crossref","is-referenced-by-count":27,"title":["Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1"],"prefix":"10.1093","volume":"20","author":[{"given":"M\u00f3nica","family":"Sancho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s E.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gortat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo J.","family":"Carbajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pineda-Lucena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Orz\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"P\u00e9rez-Pay\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"key":"key\n\t\t\t\t20170522130325_DDR271C1","doi-asserted-by":"crossref","first-page":"32608","DOI":"10.1074\/jbc.273.49.32608","article-title":"Inhibition of human caspases by peptide-based and macromolecular inhibitors","volume":"273","author":"Garcia-Calvo","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130325_DDR271C2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1124\/jpet.102.039651","article-title":"Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis","volume":"304","author":"Scott","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170522130325_DDR271C3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2004.08.019","article-title":"Apoptotic cells can induce compensatory cell proliferation through the JNK and the wingless signaling pathways","volume":"7","author":"Ryoo","year":"2004","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C4","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/81343","article-title":"Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation","volume":"6","author":"Zheng","year":"2000","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522130325_DDR271C5","volume-title":"Design of Caspase Inhibitors as Potential Clinical Agents","author":"O'Brien","year":"2009"},{"key":"key\n\t\t\t\t20170522130325_DDR271C6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1097-2765(02)00442-2","article-title":"Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation","volume":"9","author":"Acehan","year":"2002","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C7","doi-asserted-by":"crossref","first-page":"31199","DOI":"10.1074\/jbc.C000405200","article-title":"Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1","volume":"275","author":"Jiang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130325_DDR271C8","doi-asserted-by":"crossref","first-page":"50834","DOI":"10.1074\/jbc.M209369200","article-title":"Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis","volume":"277","author":"Martin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130325_DDR271C9","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1073\/pnas.1832501100","article-title":"Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease","volume":"100","author":"Wang","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522130325_DDR271C10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/417074a","article-title":"Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice","volume":"417","author":"Zhu","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522130325_DDR271C11","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1073\/pnas.191107398","article-title":"An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease","volume":"98","author":"Mochizuki","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522130325_DDR271C12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2165\/00003495-197509040-00005","article-title":"Minocycline: a review of its antibacterial and pharmacokinetic properties and therapeutic use","volume":"9","author":"Brogden","year":"1975","journal-title":"Drugs"},{"key":"key\n\t\t\t\t20170522130325_DDR271C13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/80538","article-title":"Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease","volume":"6","author":"Chen","year":"2000","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522130325_DDR271C14","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1227\/00006123-200106000-00051","article-title":"Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction","volume":"48","author":"Sanchez Mejia","year":"2001","journal-title":"Neurosurgery"},{"key":"key\n\t\t\t\t20170522130325_DDR271C15","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1523\/JNEUROSCI.21-08-02580.2001","article-title":"Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia","volume":"21","author":"Tikka","year":"2001","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522130325_DDR271C16","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrjanheikki","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522130325_DDR271C17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2008.09.040","article-title":"Minocycline and neurodegenerative diseases","volume":"196","author":"Kim","year":"2009","journal-title":"Behav. Brain Res."},{"key":"key\n\t\t\t\t20170522130325_DDR271C18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"key\n\t\t\t\t20170522130325_DDR271C19","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1046\/j.1471-4159.1999.0722415.x","article-title":"Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis","volume":"72","author":"Almer","year":"1999","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522130325_DDR271C20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(01)02324-2","article-title":"Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons","volume":"315","author":"Lin","year":"2001","journal-title":"Neurosci. Lett."},{"key":"key\n\t\t\t\t20170522130325_DDR271C21","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1073\/pnas.0306239101","article-title":"Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury","volume":"101","author":"Teng","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522130325_DDR271C22","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jacc.2003.09.050","article-title":"Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac\/DIABLO, and reduces the mitochondrial leakage of cytochrome c and smac\/DIABLO","volume":"43","author":"Scarabelli","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"key\n\t\t\t\t20170522130325_DDR271C23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbrc.2005.09.101","article-title":"Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis","volume":"337","author":"Castanares","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522130325_DDR271C24","doi-asserted-by":"crossref","first-page":"19948","DOI":"10.1074\/jbc.M313629200","article-title":"Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130325_DDR271C25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/sj.bjp.0706079","article-title":"Effects of minocycline on Fas-mediated fulminant hepatitis in mice","volume":"144","author":"Chu","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"key\n\t\t\t\t20170522130325_DDR271C26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2004.10.039","article-title":"Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline","volume":"505","author":"Cornet","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"key\n\t\t\t\t20170522130325_DDR271C27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.nbd.2006.09.008","article-title":"Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline","volume":"25","author":"Mansson","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522130325_DDR271C28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0962-8924(00)01853-5","article-title":"Huntington's disease: the challenge for cell biologists","volume":"10","author":"Tobin","year":"2000","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20170522130325_DDR271C29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20071619","article-title":"Huntington's disease: from pathology and genetics to potential therapies","volume":"412","author":"Imarisio","year":"2008","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170522130325_DDR271C30","doi-asserted-by":"crossref","first-page":"12784","DOI":"10.1073\/pnas.221451398","article-title":"Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis","volume":"98","author":"Kim","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522130325_DDR271C31","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/sj.mt.6300185","article-title":"Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates","volume":"15","author":"Palfi","year":"2007","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20170522130325_DDR271C32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature01301","article-title":"Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders","volume":"421","author":"Sanchez","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522130325_DDR271C33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0092-8674(00)80514-0","article-title":"Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo","volume":"90","author":"Scherzinger","year":"1997","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C34","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.chembiol.2010.08.014","article-title":"Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models","volume":"17","author":"Leyva","year":"2010","journal-title":"Chem. Biol."},{"key":"key\n\t\t\t\t20170522130325_DDR271C35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/hmg\/ddi032","article-title":"Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis","volume":"14","author":"Sang","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522130325_DDR271C36","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1074\/jbc.274.17.11549","article-title":"An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9","volume":"274","author":"Zou","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130325_DDR271C37","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1097-2765(03)00051-0","article-title":"A unified model for apical caspase activation","volume":"11","author":"Boatright","year":"2003","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C38","doi-asserted-by":"crossref","first-page":"13664","DOI":"10.1073\/pnas.95.23.13664","article-title":"Oncogene-dependent apoptosis is mediated by caspase-9","volume":"95","author":"Fearnhead","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522130325_DDR271C39","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/sj.cdd.4401828","article-title":"Small molecule inhibitors of Apaf-1-related caspase- 3\/-9 activation that control mitochondrial-dependent apoptosis","volume":"13","author":"Malet","year":"2006","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170522130325_DDR271C40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0091-679X(01)66008-4","article-title":"Cell-free systems to study apoptosis","volume":"66","author":"Fearnhead","year":"2001","journal-title":"Methods Cell Biol."},{"key":"key\n\t\t\t\t20170522130325_DDR271C41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0092-8674(00)80085-9","article-title":"Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1008354229396","article-title":"Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water","volume":"18","author":"Dalvit","year":"2000","journal-title":"J. Biomol. NMR"},{"key":"key\n\t\t\t\t20170522130325_DDR271C43","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/anie.200390233","article-title":"NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors","volume":"42","author":"Meyer","year":"2003","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"key\n\t\t\t\t20170522130325_DDR271C44","doi-asserted-by":"crossref","first-page":"33489","DOI":"10.1074\/jbc.273.50.33489","article-title":"WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation","volume":"273","author":"Hu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130325_DDR271C45","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1097-2765(00)80095-7","article-title":"Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization","volume":"1","author":"Srinivasula","year":"1998","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C46","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1073\/pnas.220416197","article-title":"Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength","volume":"97","author":"Purring-Koch","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522130325_DDR271C47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s10495-008-0310-x","article-title":"A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint","volume":"14","author":"Mondragon","year":"2009","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t20170522130325_DDR271C48","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.molcel.2007.09.030","article-title":"Nonapoptotic role for Apaf-1 in the DNA damage checkpoint","volume":"28","author":"Zermati","year":"2007","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C49","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/hmg\/ddl017","article-title":"Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin","volume":"15","author":"Wang","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522130325_DDR271C50","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1242\/jcs.025726","article-title":"Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease","volume":"121","author":"Ravikumar","year":"2008","journal-title":"J. Cell. Sci."},{"key":"key\n\t\t\t\t20170522130325_DDR271C51","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.2741\/3517","article-title":"Mitochondria, Bcl-2 family proteins and apoptosomes: of worms, flies and men","volume":"14","author":"Colin","year":"2009","journal-title":"Front. Biosci."},{"key":"key\n\t\t\t\t20170522130325_DDR271C52","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1123480","article-title":"Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha","volume":"312","author":"Hetz","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522130325_DDR271C53","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1038\/onc.2008.309","article-title":"The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family","volume":"27","author":"Heath-Engel","year":"2008","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170522130325_DDR271C54","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bbamcr.2010.11.012","article-title":"Integrating stress signals at the endoplasmic reticulum: the BCL-2 protein family rheostat","volume":"1813","author":"Rodriguez","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522130325_DDR271C55","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.semcdb.2007.09.003","article-title":"The endoplasmic reticulum and the unfolded protein response","volume":"18","author":"Malhotra","year":"2007","journal-title":"Semin. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20170522130325_DDR271C56","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1074\/jbc.273.10.5841","article-title":"Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex","volume":"273","author":"Pan","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130325_DDR271C57","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/sj.cdd.4400729","article-title":"Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells","volume":"7","author":"Conus","year":"2000","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170522130325_DDR271C58","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1073\/pnas.96.17.9683","article-title":"Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1","volume":"96","author":"Moriishi","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522130325_DDR271C59","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/sj.cdd.4400665","article-title":"Bcl-xL does not inhibit the function of Apaf-1","volume":"7","author":"Newmeyer","year":"2000","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170522130325_DDR271C60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1097-2765(05)00021-3","article-title":"Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1","volume":"6","author":"Chau","year":"2000","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C61","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1016\/j.ejca.2010.06.011","article-title":"Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL","volume":"46","author":"Kutuk","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"key\n\t\t\t\t20170522130325_DDR271C62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molcel.2009.10.011","article-title":"Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis","volume":"36","author":"Autret","year":"2009","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522130325_DDR271C63","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nn.2709","article-title":"Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease","volume":"14","author":"D'Amelio","year":"2011","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522130325_DDR271C64","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/cdd.2008.28","article-title":"No death without life: vital functions of apoptotic effectors","volume":"15","author":"Galluzzi","year":"2008","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170522130325_DDR271C65","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/nature03465","article-title":"Structure of the apoptotic protease-activating factor 1 bound to ADP","volume":"434","author":"Riedl","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522130325_DDR271C66","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/meth.1999.0745","article-title":"Caspases: preparation and characterization","volume":"17","author":"Stennicke","year":"1999","journal-title":"Methods"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/20\/18\/3545\/17252801\/ddr271.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T11:54:11Z","timestamp":1560254051000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddr271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,9]]},"references-count":66,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2011,6,9]]},"published-print":{"date-parts":[[2011,9,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddr271","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6,9]]}}}