{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:48:23Z","timestamp":1792622903089,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"DOI":"10.1093\/hmg\/ddr387","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T00:25:37Z","timestamp":1314750337000},"page":"4724-4731","source":"Crossref","is-referenced-by-count":136,"title":["Genome-wide association study of circulating retinol levels"],"prefix":"10.1093","volume":"20","author":[{"given":"Alison M.","family":"Mondul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Major","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn C.","family":"Cornelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"M\u00e4nnist\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Hazra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann W.","family":"Hsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin B.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Eliassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Reding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hendrickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmo","family":"Virtamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Chanock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius","family":"Albanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,30]]},"reference":[{"key":"key\n\t\t\t\t20170522154653_DDR387C1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mam.2005.10.001","article-title":"Carotenoid actions and their relation to health and disease","volume":"26","author":"Krinsky","year":"2005","journal-title":"Mol. Aspects Med."},{"key":"key\n\t\t\t\t20170522154653_DDR387C2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1350-9462(97)00001-3","article-title":"Xerophthalmia and vitamin A status","volume":"17","author":"Sommer","year":"1998","journal-title":"Prog. Retin. Eye Res."},{"key":"key\n\t\t\t\t20170522154653_DDR387C3","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/ajcn\/81.5.990","article-title":"Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men","volume":"81","author":"Sesso","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"key\n\t\t\t\t20170522154653_DDR387C4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/aje\/kwq429","article-title":"Serum retinol and risk of prostate cancer","volume":"173","author":"Mondul","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"key\n\t\t\t\t20170522154653_DDR387C5","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1093\/ajcn\/81.5.1034","article-title":"Genetic and environmental contributions to serum retinol and alpha-tocopherol concentrations: the Stanislas Family Study","volume":"81","author":"Gueguen","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"key\n\t\t\t\t20170522154653_DDR387C6","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ajcn\/69.5.931","article-title":"Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein","volume":"69","author":"Biesalski","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"key\n\t\t\t\t20170522154653_DDR387C7","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1073\/pnas.90.6.2375","article-title":"Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone","volume":"90","author":"Episkopou","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522154653_DDR387C8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ajhg.2008.12.019","article-title":"Common variation in the beta-carotene 15,15\u2032-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study","volume":"84","author":"Ferrucci","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C9","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/hmg\/ddq155","article-title":"Genome-wide association study of circulating vitamin D levels","volume":"19","author":"Ahn","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C10","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1093\/hmg\/ddr296","article-title":"Genome-wide association study identifies common variants associated with circulating vitamin E levels","volume":"20","author":"Major","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bbrc.2008.01.087","article-title":"Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes","volume":"368","author":"Jacobsson","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522154653_DDR387C12","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ng.685","article-title":"Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution","volume":"42","author":"Heid","year":"2010","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/1047-2797(94)90036-1","article-title":"The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. The ATBC Cancer Prevention Study Group","volume":"4","year":"1994","journal-title":"Ann. Epidemiol."},{"key":"key\n\t\t\t\t20170522154653_DDR387C14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mrfmmm.2005.06.013","article-title":"Methods for etiologic and early marker investigations in the PLCO trial","volume":"592","author":"Hayes","year":"2005","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170522154653_DDR387C15","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ng2075","article-title":"A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer","volume":"39","author":"Hunter","year":"2007","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C16","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1093\/hmg\/ddq156","article-title":"Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes","volume":"19","author":"Qi","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C17","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ng.429","article-title":"Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer","volume":"41","author":"Amundadottir","year":"2009","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ajhg.2009.09.012","article-title":"A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma","volume":"85","author":"Landi","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.91","article-title":"Multiple loci identified in a genome-wide association study of prostate cancer","volume":"40","author":"Thomas","year":"2008","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154653_DDR387C20","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/clinchem\/32.5.874","article-title":"Retinol, alpha-tocopherol, lycopene, and alpha- and beta-carotene simultaneously determined in plasma by isocratic liquid chromatography","volume":"32","author":"Milne","year":"1986","journal-title":"Clin. Chem."},{"key":"key\n\t\t\t\t20170522154653_DDR387C21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-4347(97)00140-0","article-title":"Simultaneous measurement of seven carotenoids, retinol and alpha-tocopherol in serum by high-performance liquid chromatography","volume":"694","author":"Steghens","year":"1997","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"key\n\t\t\t\t20170522154653_DDR387C22","volume-title":"The Retinoids: Biology, Chemistry, and Medicine","author":"Sporn","year":"1994"},{"key":"key\n\t\t\t\t20170522154653_DDR387C23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/ajcn\/76.1.172","article-title":"Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake","volume":"76","author":"El-Sohemy","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"key\n\t\t\t\t20170522154653_DDR387C24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.clinbiochem.2005.02.001","article-title":"Carotenoids, retinol and tocopherols in blood: comparability between serum and plasma (Li-heparin) values","volume":"38","author":"Olmedilla-Alonso","year":"2005","journal-title":"Clin. Biochem."},{"key":"key\n\t\t\t\t20170522154653_DDR387C25","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/clinchem\/40.3.411","article-title":"Retinol, alpha-tocopherol, lutein\/zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, trans-beta-carotene, and four retinyl esters in serum determined simultaneously by reversed-phase HPLC with multiwavelength detection","volume":"40","author":"Sowell","year":"1994","journal-title":"Clin. Chem."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/20\/23\/4724\/17253115\/ddr387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T21:53:12Z","timestamp":1592862792000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddr387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,30]]},"references-count":25,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2011,8,30]]},"published-print":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddr387","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8,30]]}}}