{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:13:17Z","timestamp":1782537197256,"version":"3.54.5"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"DOI":"10.1093\/hmg\/ddr452","type":"journal-article","created":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:26:44Z","timestamp":1317428804000},"page":"175-184","source":"Crossref","is-referenced-by-count":92,"title":["Dysfunctions in endosomal\u2013lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease"],"prefix":"10.1093","volume":"21","author":[{"given":"Rajat","family":"Puri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimitsu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,30]]},"reference":[{"key":"key\n\t\t\t\t20170522142325_DDR452C1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ajmg.1575","article-title":"Advances in the genetics of progressive myoclonus epilepsy","volume":"106","author":"Delgado-Escueta","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10038-005-0321-1","article-title":"Recent advances in the molecular basis of Lafora's progressive myoclonus epilepsy","volume":"51","author":"Ganesh","year":"2006","journal-title":"J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/humu.20954","article-title":"Lafora progressive myoclonus epilepsy: a meta-analysis of reported mutations in the first decade following the discovery of the EPM2A and NHLRC1 genes","volume":"30","author":"Singh","year":"2009","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20170522142325_DDR452C4","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/hmg\/11.11.1251","article-title":"Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice","volume":"11","author":"Ganesh","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C5","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.bbrc.2003.12.043","article-title":"The carbohydrate-binding domain of Lafora disease protein targets Lafora polyglucosan bodies","volume":"313","author":"Ganesh","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522142325_DDR452C6","doi-asserted-by":"crossref","first-page":"30412","DOI":"10.1074\/jbc.M606117200","article-title":"Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates","volume":"281","author":"Worby","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cmet.2011.01.017","article-title":"Phosphate incorporation during glycogen synthesis and Lafora disease","volume":"13","author":"Tagliabracci","year":"2011","journal-title":"Cell Metab."},{"key":"key\n\t\t\t\t20170522142325_DDR452C8","doi-asserted-by":"crossref","first-page":"33816","DOI":"10.1074\/jbc.M807428200","article-title":"Abnormal metabolism of glycogen phosphate as a cause for Lafora disease","volume":"283","author":"Tagliabracci","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C9","doi-asserted-by":"crossref","first-page":"25372","DOI":"10.1074\/jbc.M110.148668","article-title":"Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin","volume":"285","author":"DePaoli-Roach","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C10","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/ana.22156","article-title":"Glycogen hyperphosphorylation underlies lafora body formation","volume":"68","author":"Turnbull","year":"2010","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522142325_DDR452C11","doi-asserted-by":"crossref","first-page":"e5907","DOI":"10.1371\/journal.pone.0005907","article-title":"Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin","volume":"4","author":"Vernia","year":"2009","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170522142325_DDR452C12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/hmg\/ddn398","article-title":"The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system","volume":"18","author":"Garyali","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C13","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1242\/jcs.082800","article-title":"Malin and laforin are essential components of protein complex that protects cells from the thermal stress","volume":"124","author":"Sengupta","year":"2011","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170522142325_DDR452C14","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/hmg\/ddq190","article-title":"Laforin, the most common protein mutated in Lafora disease, regulates autophagy","volume":"19","author":"Aguado","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C15","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522142325_DDR452C16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nrd2272","article-title":"Potential therapeutic applications of autophagy","volume":"6","author":"Rubinsztein","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"key\n\t\t\t\t20170522142325_DDR452C17","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"mTOR regulation of autophagy","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170522142325_DDR452C18","doi-asserted-by":"crossref","first-page":"20036","DOI":"10.1074\/jbc.M702376200","article-title":"PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding","volume":"282","author":"Wang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1006\/mcne.2001.1051","article-title":"FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain","volume":"18","author":"Lim","year":"2001","journal-title":"Mol. Cell Neurosci."},{"key":"key\n\t\t\t\t20170522142325_DDR452C20","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/hmg\/11.12.1455","article-title":"Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice","volume":"11","author":"de Geest","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C21","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1523\/JNEUROSCI.6412-10.2011","article-title":"Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy","volume":"31","author":"Lee","year":"2011","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522142325_DDR452C22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0962-8924(03)00005-9","article-title":"At the acidic edge: emerging functions for lysosomal membrane proteins","volume":"13","author":"Eskelinen","year":"2003","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20170522142325_DDR452C23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","article-title":"Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy","volume":"27","author":"Eskelinen","year":"2006","journal-title":"Mol. Aspects Med."},{"key":"key\n\t\t\t\t20170522142325_DDR452C24","doi-asserted-by":"crossref","first-page":"21327","DOI":"10.1016\/S0021-9258(18)54636-6","article-title":"Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking","volume":"266","author":"Fukuda","year":"1991","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1523\/JNEUROSCI.16-01-00186.1996","article-title":"Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease","volume":"16","author":"Cataldo","year":"1996","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522142325_DDR452C26","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1523\/JNEUROSCI.17-11-04006.1997","article-title":"Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus","volume":"17","author":"Bednarski","year":"1997","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522142325_DDR452C27","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1523\/JNEUROSCI.20-18-06898.2000","article-title":"Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons","volume":"20","author":"Koike","year":"2000","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522142325_DDR452C28","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1093\/hmg\/ddn092","article-title":"Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin","volume":"17","author":"Chevalier-Larsen","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C29","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/brain\/awq341","article-title":"Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits","volume":"134","author":"Yang","year":"2011","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522142325_DDR452C30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.136.1.61","article-title":"The autophagic and endocytic pathways converge at the nascent autophagic vacuoles","volume":"136","author":"Liou","year":"1997","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20170522142325_DDR452C31","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ncb1007-1102","article-title":"Autophagosome formation: core machinery and adaptations","volume":"9","author":"Xie","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170522142325_DDR452C32","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1146\/annurev.biochem.78.081307.110540","article-title":"Mechanisms of endocytosis","volume":"78","author":"Doherty","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrm2728","article-title":"Rab GTPases as coordinators of vesicle traffic","volume":"10","author":"Stenmark","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522142325_DDR452C34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/physrev.00059.2009","article-title":"Role of Rab GTPases in membrane traffic and cell physiology","volume":"91","author":"Hutagalung","year":"2011","journal-title":"Physiol. Rev."},{"key":"key\n\t\t\t\t20170522142325_DDR452C35","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1242\/jcs.025726","article-title":"Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease","volume":"121","author":"Ravikumar","year":"2008","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170522142325_DDR452C36","doi-asserted-by":"crossref","first-page":"12110","DOI":"10.1074\/jbc.M809277200","article-title":"Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration","volume":"284","author":"Vanlandingham","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3233\/JAD-2004-6107","article-title":"The role of the endosomal\/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective","volume":"6","author":"Pasternak","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"key\n\t\t\t\t20170522142325_DDR452C38","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1093\/hmg\/ddp367","article-title":"Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing","volume":"18","author":"Wang","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C39","doi-asserted-by":"crossref","first-page":"22657","DOI":"10.1074\/jbc.M109.009688","article-title":"Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease","volume":"284","author":"Puri","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C40","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.1523\/JNEUROSCI.17-18-07053.1997","article-title":"Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse","volume":"17","author":"Irizarry","year":"1997","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522142325_DDR452C41","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.1074\/jbc.M110.105841","article-title":"Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity","volume":"285","author":"Susaki","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C42","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1093\/hmg\/ddr157","article-title":"Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice","volume":"20","author":"Vernia","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C43","doi-asserted-by":"crossref","first-page":"e1002037","DOI":"10.1371\/journal.pgen.1002037","article-title":"PTG depletion removes Lafora bodies and rescues the fatal epilepsy of lafora disease","volume":"7","author":"Turnbull","year":"2011","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C44","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1093\/hmg\/ddp196","article-title":"Deletions and missense mutations of EPM2A exacerbate unfolded protein response and apoptosis of neuronal cells induced by endoplasm reticulum stress","volume":"18","author":"Liu","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C45","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.4161\/auto.6.8.13307","article-title":"Laforin in autophagy: a possible link between carbohydrate and protein in Lafora disease?","volume":"6","author":"Puri","year":"2010","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20170522142325_DDR452C46","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1093\/hmg\/ddq407","article-title":"Sequestration of chaperones and proteasome into Lafora bodies and proteasomal dysfunction induced by Lafora disease-associated mutations of malin","volume":"19","author":"Rao","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C47","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.05.023","article-title":"p62 at the crossroads of autophagy, apoptosis, and cancer","volume":"137","author":"Moscat","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522142325_DDR452C48","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1083\/jcb.200907014","article-title":"Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes","volume":"186","author":"Simonsen","year":"2009","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522142325_DDR452C49","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.biopsych.2010.05.030","article-title":"Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression","volume":"68","author":"Ginsberg","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"key\n\t\t\t\t20170522142325_DDR452C50","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3233\/JAD-2010-101080","article-title":"Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease","volume":"22","author":"Ginsberg","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"key\n\t\t\t\t20170522142325_DDR452C51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.expneurol.2010.06.004","article-title":"Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP-43 in motor neuron disease","volume":"225","author":"Matej","year":"2010","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t20170522142325_DDR452C52","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0002-9440(10)64538-5","article-title":"Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations","volume":"157","author":"Cataldo","year":"2000","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170522142325_DDR452C53","doi-asserted-by":"crossref","first-page":"31261","DOI":"10.1074\/jbc.M304122200","article-title":"Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production","volume":"278","author":"Grbovic","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C54","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neurobiolaging.2004.09.018","article-title":"Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases","volume":"26","author":"Nixon","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170522142325_DDR452C55","doi-asserted-by":"crossref","first-page":"6874","DOI":"10.1074\/jbc.M509939200","article-title":"The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain","volume":"281","author":"Mattera","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C56","doi-asserted-by":"crossref","first-page":"21334","DOI":"10.1074\/jbc.M401022200","article-title":"The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes","volume":"279","author":"Dong","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142325_DDR452C57","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/cdd.2009.144","article-title":"Essential role of the unfolded protein response regulator GRP78\/BiP in protection from neuronal apoptosis","volume":"17","author":"Wang","year":"2010","journal-title":"Cell. Death Differ."},{"key":"key\n\t\t\t\t20170522142325_DDR452C58","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/ng1591","article-title":"Dynein mutations impair autophagic clearance of aggregate-prone proteins","volume":"37","author":"Ravikumar","year":"2005","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C59","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1023\/A:1007675508413","article-title":"The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review","volume":"25","author":"Nixon","year":"2000","journal-title":"Neurochem. Res."},{"key":"key\n\t\t\t\t20170522142325_DDR452C60","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.ejhg.5201300","article-title":"Loss of lysosomal association of cystatin B proteins representing progressive myoclonus epilepsy, EPM1, mutations","volume":"13","author":"Alakurtti","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C61","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1093\/hmg\/ddn124","article-title":"A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome","volume":"17","author":"Balreira","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522142325_DDR452C62","volume-title":"Histochemistry, Theoretical and Applied.","author":"Pearse","year":"1960","edition":"2nd edn."},{"key":"key\n\t\t\t\t20170522142325_DDR452C63","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1111\/j.1471-4159.2008.05317.x","article-title":"Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis","volume":"105","author":"Kabashi","year":"2008","journal-title":"J. Neurochem."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/21\/1\/175\/17255869\/ddr452.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T11:47:49Z","timestamp":1638964069000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddr452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,30]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,9,30]]},"published-print":{"date-parts":[[2012,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddr452","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9,30]]}}}