{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T01:50:04Z","timestamp":1770688204763,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,15]]},"DOI":"10.1093\/hmg\/ddr463","type":"journal-article","created":{"date-parts":[[2011,10,8]],"date-time":"2011-10-08T01:57:23Z","timestamp":1318039043000},"page":"437-445","source":"Crossref","is-referenced-by-count":54,"title":["Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations"],"prefix":"10.1093","volume":"21","author":[{"given":"Belinda K.","family":"Cornes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiea Chuen","family":"Khor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monisha E.","family":"Nongpiur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Ting","family":"Tay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingfeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghavan","family":"Lavanya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueling","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yik Ying","family":"Teo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee-Seng","family":"Chia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Seielstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin L.","family":"Hibberd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seang-Mei","family":"Saw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E-Shyong","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jost B.","family":"Jonas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eranga N.","family":"Vithana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin","family":"Aung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,10,7]]},"reference":[{"key":"key\n\t\t\t\t20170522135402_DDR463C1","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1167\/iovs.08-3271","article-title":"Heritability of central corneal thickness in nuclear families","volume":"50","author":"Landers","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522135402_DDR463C2","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1167\/iovs.04-1497","article-title":"Central corneal thickness is highly heritable: the twin eye studies","volume":"46","author":"Toh","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522135402_DDR463C3","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1167\/iovs.08-1934","article-title":"Heritability of central corneal thickness in Chinese: the Guangzhou Twin Eye Study","volume":"49","author":"Zheng","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522135402_DDR463C4","doi-asserted-by":"crossref","first-page":"e1000947","DOI":"10.1371\/journal.pgen.1000947","article-title":"Common genetic variants near the Brittle Cornea Syndrome locus ZNF469 influence the blinding disease risk factor central corneal thickness","volume":"6","author":"Lu","year":"2010","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20170522135402_DDR463C5","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1093\/hmg\/ddq349","article-title":"New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8","volume":"19","author":"Vitart","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522135402_DDR463C6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/hmg\/ddq511","article-title":"Collagen-related genes influence the glaucoma risk factor, central corneal thickness","volume":"20","author":"Vithana","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522135402_DDR463C7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C8","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ophtha.2010.10.024","article-title":"Differences in rates of glaucoma among Asian Americans and other racial groups, and among various Asian ethnic groups","volume":"118","author":"Stein","year":"2011","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20170522135402_DDR463C9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/eye.2000.154","article-title":"Does ethnic origin influence the incidence or severity of keratoconus?","volume":"14","author":"Pearson","year":"2000","journal-title":"Eye (Lond.)"},{"key":"key\n\t\t\t\t20170522135402_DDR463C10","first-page":"132","article-title":"Penetrating keratoplasty for keratoconus","volume":"26","author":"Tay","year":"1997","journal-title":"Ann. Acad. Med. Singapore"},{"key":"key\n\t\t\t\t20170522135402_DDR463C11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00417-007-0760-9","article-title":"Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study","volume":"246","author":"Zhang","year":"2008","journal-title":"Graefes Arch Clin. Exp. Ophthalmol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C12","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/ni1001-939","article-title":"Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein","volume":"2","author":"Liu","year":"2001","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C13","doi-asserted-by":"crossref","first-page":"ra25","DOI":"10.1126\/scisignal.2000230","article-title":"Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling","volume":"2","author":"James","year":"2009","journal-title":"Sci. Signal."},{"key":"key\n\t\t\t\t20170522135402_DDR463C14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/24620","article-title":"Control of neural crest cell fate by the Wnt signalling pathway","volume":"396","author":"Dorsky","year":"1998","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522135402_DDR463C15","article-title":"Wnt\/beta-catenin pathway","volume":"2005","author":"Moon","year":"2005","journal-title":"Sci STKE"},{"key":"key\n\t\t\t\t20170522135402_DDR463C16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","article-title":"Wnt\/beta-catenin signaling in development and disease","volume":"127","author":"Clevers","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522135402_DDR463C17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ceb.2008.01.009","article-title":"Wnt\/beta-catenin signaling: new (and old) players and new insights","volume":"20","author":"Huang","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C18","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1242\/dev.02381","article-title":"Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium","volume":"133","author":"Mukhopadhyay","year":"2006","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522135402_DDR463C19","doi-asserted-by":"crossref","first-page":"38721","DOI":"10.1074\/jbc.M106871200","article-title":"Molecular cloning and expression of a human chondroitin synthase","volume":"276","author":"Kitagawa","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522135402_DDR463C20","doi-asserted-by":"crossref","first-page":"12346","DOI":"10.1016\/S0021-9258(19)86322-6","article-title":"Characterization and biosynthesis of proteoglycans of corneal stroma from rhesus monkey","volume":"254","author":"Hassell","year":"1979","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522135402_DDR463C21","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0021-9258(18)94204-3","article-title":"Analysis of the proteoglycans synthesized by corneal explants from embryonic chicken. II. Structural characterization of the keratan sulfate and dermatan sulfate proteoglycans from corneal stroma","volume":"264","author":"Midura","year":"1989","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522135402_DDR463C22","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ajhg.2010.11.005","article-title":"Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling","volume":"87","author":"Tian","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522135402_DDR463C23","doi-asserted-by":"crossref","first-page":"8888","DOI":"10.1074\/jbc.M806590200","article-title":"Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan","volume":"284","author":"Zhang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522135402_DDR463C24","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1002\/dvdy.21579","article-title":"Development of the corneal stroma, and the collagen-proteoglycan associations that help define its structure and function","volume":"237","author":"Quantock","year":"2008","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522135402_DDR463C25","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0369-8114(01)00152-3","article-title":"Structure and function in extracellular matrices depend on interactions between anionic glycosaminoglycans","volume":"49","author":"Scott","year":"2001","journal-title":"Pathol. Biol. (Paris)"},{"key":"key\n\t\t\t\t20170522135402_DDR463C26","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s000180050048","article-title":"Independent modulation of collagen fibrillogenesis by decorin and lumican","volume":"57","author":"Neame","year":"2000","journal-title":"Cell Mol. Life Sci."},{"key":"key\n\t\t\t\t20170522135402_DDR463C27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.brainresbull.2009.08.017","article-title":"Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization","volume":"81","author":"Stagos","year":"2010","journal-title":"Brain Res. Bull."},{"key":"key\n\t\t\t\t20170522135402_DDR463C28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1242\/jcs.112.5.613","article-title":"The cellular basis of corneal transparency: evidence for \u2018corneal crystallins","volume":"112","author":"Jester","year":"1999","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170522135402_DDR463C29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.semcdb.2007.10.004","article-title":"The role of corneal crystallins in the cellular defense mechanisms against oxidative stress","volume":"19","author":"Lassen","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1350-9462(97)00004-9","article-title":"Gene sharing in lens and cornea: facts and implications","volume":"17","author":"Piatigorsky","year":"1998","journal-title":"Prog. Retin. Eye Res."},{"key":"key\n\t\t\t\t20170522135402_DDR463C31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/(SICI)1098-2264(199805)22:1<26::AID-GCC4>3.0.CO;2-9","article-title":"A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers","volume":"22","author":"Filippova","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"key\n\t\t\t\t20170522135402_DDR463C32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1074\/jbc.M109005200","article-title":"Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule","volume":"277","author":"Hamazaki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522135402_DDR463C33","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.biocel.2006.10.016","article-title":"Deletion of JAM-A causes morphological defects in the corneal epithelium","volume":"39","author":"Kang","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10384-007-0479-5","article-title":"Expression and distribution of junctional adhesion molecule-1 in the human cornea","volume":"51","author":"Chen","year":"2007","journal-title":"Jpn J. Ophthalmol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/09286580600878844","article-title":"Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay Eye Study (SiMES)","volume":"14","author":"Foong","year":"2007","journal-title":"Ophthalmic Epidemiol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/09286580903144738","article-title":"Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians","volume":"16","author":"Lavanya","year":"2009","journal-title":"Ophthalmic Epidemiol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ajo.2008.10.013","article-title":"Central corneal thickness and its associations with ocular and systemic factors: the Singapore Malay Eye Study","volume":"147","author":"Su","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170522135402_DDR463C38","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.ophtha.2007.08.021","article-title":"Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study","volume":"115","author":"Su","year":"2008","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20170522135402_DDR463C39","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ophtha.2007.07.006","article-title":"Comparative study of central corneal thickness measurement with slit-lamp optical coherence tomography and visante optical coherence tomography","volume":"115","author":"Li","year":"2008","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20170522135402_DDR463C40","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1093\/hmg\/ddr060","article-title":"Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area","volume":"20","author":"Khor","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522135402_DDR463C41","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522135402_DDR463C42","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522135402_DDR463C43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"R: a language for data analysis and graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"J. Comput. Graphical Stat."},{"key":"key\n\t\t\t\t20170522135402_DDR463C44","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1056\/NEJMoa0905606","article-title":"CISH and susceptibility to infectious diseases","volume":"362","author":"Khor","year":"2010","journal-title":"N. Engl. J. Med."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/21\/2\/437\/17256883\/ddr463.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T16:30:38Z","timestamp":1741797038000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddr463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,7]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,10,7]]},"published-print":{"date-parts":[[2012,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddr463","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10,7]]}}}