{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:20:57Z","timestamp":1792700457039,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"DOI":"10.1093\/hmg\/dds199","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T22:04:28Z","timestamp":1338329068000},"page":"3776-3784","source":"Crossref","is-referenced-by-count":328,"title":["Evidence for an oligogenic basis of amyotrophic lateral sclerosis"],"prefix":"10.1093","volume":"21","author":[{"given":"Marka","family":"van Blitterswijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"van Es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.M.","family":"Hennekam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Dooijes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"van Rheenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Medic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre R.","family":"Bourque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helenius J.","family":"Schelhaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke J.","family":"van der Kooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"de Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul I.W.","family":"de Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Veldink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard H.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"key":"key\n\t\t\t\t20170522140059_DDS199C1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1212\/01.wnl.0000296811.19811.db","article-title":"Genetics of familial amyotrophic lateral sclerosis","volume":"70","author":"Valdmanis","year":"2008","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522140059_DDS199C2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/WCO.0b013e32832ffbe3","article-title":"Recent advances in motor neuron disease","volume":"22","author":"Van Damme","year":"2009","journal-title":"Curr. Opin. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522140059_DDS199C4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"Dejesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522140059_DDS199C5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrneurol.2011.150","article-title":"Clinical genetics of amyotrophic lateral sclerosis: what do we really know?","volume":"7","author":"Andersen","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C6","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1136\/jnnp.2010.207464","article-title":"An estimate of amyotrophic lateral sclerosis heritability using twin data","volume":"81","author":"Al-Chalabi","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"key\n\t\t\t\t20170522140059_DDS199C7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/1531-8249(20010201)49:2<267::AID-ANA51>3.0.CO;2-D","article-title":"Compound heterozygous D90A and D96N SOD1 mutations in a recessive amyotrophic lateral sclerosis family","volume":"49","author":"Hand","year":"2001","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C8","doi-asserted-by":"crossref","first-page":"E1377","DOI":"10.1002\/humu.21241","article-title":"De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis","volume":"31","author":"DeJesus-Hernandez","year":"2010","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20170522140059_DDS199C9","doi-asserted-by":"crossref","first-page":"553.e23","DOI":"10.1016\/j.neurobiolaging.2010.05.016","article-title":"A de novo missense mutation of the FUS gene in a \u2018true\u2019 sporadic ALS case","volume":"32","author":"Chio","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170522140059_DDS199C10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1001\/archneurol.2010.351","article-title":"Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis","volume":"68","author":"Daoud","year":"2011","journal-title":"Arch. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C11","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/jmg.2010.077180","article-title":"SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations","volume":"47","author":"Millecamps","year":"2010","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t20170522140059_DDS199C12","doi-asserted-by":"crossref","first-page":"21777","DOI":"10.1073\/pnas.0902174106","article-title":"Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis","volume":"106","author":"Gros-Louis","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522140059_DDS199C13","doi-asserted-by":"crossref","first-page":"1924.e15","DOI":"10.1016\/j.neurobiolaging.2011.04.004","article-title":"SOD1 G93D sporadic amyotrophic lateral sclerosis (SALS) patient with rapid progression and concomitant novel ANG variant","volume":"32","author":"Luigetti","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170522140059_DDS199C14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3109\/17482968.2011.584629","article-title":"Keeping up with genetic discoveries in amyotrophic lateral sclerosis: the ALSoD and ALSGene databases","volume":"12","author":"Lill","year":"2011","journal-title":"Amyotroph. Lateral Scler."},{"key":"key\n\t\t\t\t20170522140059_DDS199C15","first-page":"45","article-title":"ALSODatabase: database of SOD1 (and other) gene mutations in ALS on the Internet. European FALS Group and ALSOD Consortium","volume":"1","author":"Radunovic","year":"1999","journal-title":"Amyotroph. Lateral Scler. Other Motor Neuron Disord."},{"key":"key\n\t\t\t\t20170522140059_DDS199C16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1212\/01.wnl.0000339487.84908.00","article-title":"A case of ALS-FTD in a large FALS pedigree with a K17I ANG mutation","volume":"72","author":"van Es","year":"2009","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522140059_DDS199C17","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1136\/jnnp.2009.181453","article-title":"Large-scale SOD1 mutation screening provides evidence for genetic heterogeneity in amyotrophic lateral sclerosis","volume":"81","author":"van Es","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"key\n\t\t\t\t20170522140059_DDS199C18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1001\/archneurol.2009.329","article-title":"FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands","volume":"67","author":"Groen","year":"2010","journal-title":"Arch. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C19","doi-asserted-by":"crossref","first-page":"R46","DOI":"10.1093\/hmg\/ddq137","article-title":"TDP-43 and FUS\/TLS: emerging roles in RNA processing and neurodegeneration","volume":"19","author":"Lagier-Tourenne","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522140059_DDS199C20","doi-asserted-by":"crossref","first-page":"R156","DOI":"10.1093\/hmg\/ddp303","article-title":"Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis","volume":"18","author":"Pesiridis","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522140059_DDS199C21","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/archneur.65.9.1185","article-title":"Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations","volume":"65","author":"Kuhnlein","year":"2008","journal-title":"Arch. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jns.2009.04.017","article-title":"Screening for TARDBP mutations in Japanese familial amyotrophic lateral sclerosis","volume":"284","author":"Kamada","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"key\n\t\t\t\t20170522140059_DDS199C23","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neurobiolaging.2010.06.017","article-title":"Large-scale screening of TARDBP mutation in amyotrophic lateral sclerosis in Japanese","volume":"33","author":"Iida","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170522140059_DDS199C24","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1212\/WNL.0b013e3181a55f7b","article-title":"Reduced frequency of ALS in an ethnically mixed population: a population-based mortality study","volume":"72","author":"Zaldivar","year":"2009","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522140059_DDS199C25","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1212\/01.wnl.0000258551.96893.6f","article-title":"Ethnic variation in the incidence of ALS: a systematic review","volume":"68","author":"Cronin","year":"2007","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522140059_DDS199C26","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s00415-009-5124-4","article-title":"Identification of novel angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis","volume":"256","author":"Fernandez-Santiago","year":"2009","journal-title":"J. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10048-007-0111-3","article-title":"Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis","volume":"9","author":"Gellera","year":"2008","journal-title":"Neurogenetics"},{"key":"key\n\t\t\t\t20170522140059_DDS199C28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ng1742","article-title":"ANG mutations segregate with familial and \u2018sporadic\u2019 amyotrophic lateral sclerosis","volume":"38","author":"Greenway","year":"2006","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522140059_DDS199C29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nmd.2007.07.003","article-title":"A novel angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy","volume":"18","author":"Conforti","year":"2008","journal-title":"Neuromuscul. Disord."},{"key":"key\n\t\t\t\t20170522140059_DDS199C30","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/ana.22611","article-title":"Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis","volume":"70","author":"van Es","year":"2011","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C31","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/cdd.2009.52","article-title":"Angiogenin protects motoneurons against hypoxic injury","volume":"16","author":"Sebastia","year":"2009","journal-title":"Cell Death. Differ."},{"key":"key\n\t\t\t\t20170522140059_DDS199C32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/ana.21221","article-title":"Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis","volume":"62","author":"Wu","year":"2007","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C33","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/hmg\/ddm095","article-title":"A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis","volume":"16","author":"Subramanian","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522140059_DDS199C34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/hmg\/ddm290","article-title":"Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension\/pathfinding and survival of motor neurons","volume":"17","author":"Subramanian","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522140059_DDS199C35","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3109\/17482960902721642","article-title":"D90A-SOD1 mutation in ALS: The first report of heterozygous Italian patients and unusual findings","volume":"11","author":"Giannini","year":"2010","journal-title":"Amyotroph. Lateral Scler."},{"key":"key\n\t\t\t\t20170522140059_DDS199C36","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1007\/s00415-010-5512-9","article-title":"The epidemiology of CuZn-SOD mutations in Germany: a study of 217 families","volume":"257","author":"Rabe","year":"2010","journal-title":"J. Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/ng0595-61","article-title":"Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase","volume":"10","author":"Andersen","year":"1995","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522140059_DDS199C38","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522140059_DDS199C39","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6","volume":"323","author":"Vance","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522140059_DDS199C40","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1212\/WNL.0b013e3181bbfeef","article-title":"Mutations in FUS cause FALS and SALS in French and French Canadian populations","volume":"73","author":"Belzil","year":"2009","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522140059_DDS199C41","doi-asserted-by":"crossref","first-page":"548.e1","DOI":"10.1016\/j.neurobiolaging.2009.11.017","article-title":"C-terminal FUS\/TLS mutations in familial and sporadic ALS in Germany","volume":"32","author":"Drepper","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170522140059_DDS199C42","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00401-009-0621-1","article-title":"Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation","volume":"119","author":"Tateishi","year":"2010","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C43","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1212\/WNL.0b013e3181bbff05","article-title":"Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort","volume":"73","author":"Ticozzi","year":"2009","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522140059_DDS199C44","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3109\/17482968.2010.539235","article-title":"FUS\/TLS gene mutations are the second most frequent cause of familial ALS in the Spanish population","volume":"12","author":"Syriani","year":"2011","journal-title":"Amyotroph. Lateral Scler."},{"key":"key\n\t\t\t\t20170522140059_DDS199C45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jns.2010.06.008","article-title":"A Japanese ALS6 family with mutation R521C in the FUS\/TLS gene: a clinical, pathological and genetic report","volume":"296","author":"Yamamoto-Watanabe","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"key\n\t\t\t\t20170522140059_DDS199C46","doi-asserted-by":"crossref","first-page":"550.e1","DOI":"10.1016\/j.neurobiolaging.2009.12.020","article-title":"FUS mutations in sporadic amyotrophic lateral sclerosis","volume":"32","author":"Lai","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170522140059_DDS199C47","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/mus.21665","article-title":"Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"42","author":"Rademakers","year":"2010","journal-title":"Muscle Nerve"},{"key":"key\n\t\t\t\t20170522140059_DDS199C48","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/jnnp.2009.194399","article-title":"FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis","volume":"81","author":"Blair","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"key\n\t\t\t\t20170522140059_DDS199C49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/jmg.2009.071027","article-title":"Mutations of FUS gene in sporadic amyotrophic lateral sclerosis","volume":"47","author":"Corrado","year":"2010","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t20170522140059_DDS199C50","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0b013e3182661d14","article-title":"Hexanucleotide repeat expansions in C9orf72 in the spectrum of motor neuron diseases","author":"van Rheenen","year":"2012","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522140059_DDS199C51","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph. Lateral Scler. Other Motor Neuron Disord."},{"issue":"Suppl","key":"key\n\t\t\t\t20170522140059_DDS199C52","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0022-510X(94)90191-0","article-title":"El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases\/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial \u2018Clinical limits of amyotrophic lateral sclerosis\u2019 workshop contributors","volume":"124","author":"Brooks","year":"1994","journal-title":"J. Neurol. Sci."},{"key":"key\n\t\t\t\t20170522140059_DDS199C53","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/jnnp.2011.244939","article-title":"Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology","volume":"82","author":"Huisman","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"key\n\t\t\t\t20170522140059_DDS199C54","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1474-4422(07)70222-3","article-title":"ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study","volume":"6","author":"van Es","year":"2007","journal-title":"Lancet Neurol."},{"key":"key\n\t\t\t\t20170522140059_DDS199C55","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522140059_DDS199C56","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1093\/nar\/25.14.2745","article-title":"PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing","volume":"25","author":"Nickerson","year":"1997","journal-title":"Nucleic Acids Res."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/21\/17\/3776\/17255996\/dds199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T05:58:33Z","timestamp":1503467913000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/dds199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,29]]},"references-count":56,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2012,5,29]]},"published-print":{"date-parts":[[2012,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/dds199","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717948023.793453084","asserted-by":"object"}]},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5,29]]}}}