{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:15:11Z","timestamp":1791180911310,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,15]]},"DOI":"10.1093\/hmg\/dds286","type":"journal-article","created":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T06:20:16Z","timestamp":1342246816000},"page":"4448-4459","source":"Crossref","is-referenced-by-count":61,"title":["Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice"],"prefix":"10.1093","volume":"21","author":[{"given":"Katherine V.","family":"Bricceno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Sampognaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Van Meerbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte J.","family":"Sumner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth H.","family":"Fischbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barrington G.","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,7,13]]},"reference":[{"key":"key\n\t\t\t\t20170522173236_DDS286C1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification of spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173236_DDS286C2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","article-title":"A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2","volume":"8","author":"Monani","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173236_DDS286C3","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","author":"Lorson","year":"1999","journal-title":"Proc. Natl Acad. Sci. U S A"},{"key":"key\n\t\t\t\t20170522173236_DDS286C4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/71709","article-title":"A mouse model for spinal muscular atrophy","volume":"24","author":"Hsieh-Li","year":"2000","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522173236_DDS286C5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s100480000090","article-title":"The survival motor neuron (SMN) protein: effect of exon loss and mutation on protein localization","volume":"3","author":"Le","year":"2000","journal-title":"Neurogenetics"},{"key":"key\n\t\t\t\t20170522173236_DDS286C6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ajmg.a.30251","article-title":"Homozygous SMN1 deletions in unaffected family members and modification of the phenotype by SMN2","volume":"130A","author":"Prior","year":"2004","journal-title":"Am. J. Med. Genet. A"},{"key":"key\n\t\t\t\t20170522173236_DDS286C7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/hmg\/ddi078","article-title":"SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN","volume":"14","author":"Le","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173236_DDS286C8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1172\/JCI29562","article-title":"Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy","volume":"117","author":"Avila","year":"2007","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170522173236_DDS286C9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.expneurol.2011.06.003","article-title":"Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis","volume":"231","author":"Yoo","year":"2011","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t20170522173236_DDS286C10","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1093\/hmg\/ddr288","article-title":"Increasing expression and decreasing degradation of SMN ameliorate the spinal muscular atrophy phenotype in mice","volume":"20","author":"Kwon","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173236_DDS286C11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/ana.21449","article-title":"Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition","volume":"64","author":"Narver","year":"2008","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522173236_DDS286C12","doi-asserted-by":"crossref","first-page":"227S","DOI":"10.1093\/jn\/129.1.227S","article-title":"Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states","volume":"129","author":"Lecker","year":"1999","journal-title":"J. Nutr."},{"key":"key\n\t\t\t\t20170522173236_DDS286C13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0026-0495(90)90113-Q","article-title":"Different mechanisms of increased proteolysis in atrophy induced by denervation or unweighting of rat soleus muscle","volume":"39","author":"Tischler","year":"1990","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20170522173236_DDS286C14","doi-asserted-by":"crossref","first-page":"12602","DOI":"10.1073\/pnas.95.21.12602","article-title":"Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway","volume":"95","author":"Solomon","year":"1998","journal-title":"Proc. Natl Acad. Sci. U S A."},{"key":"key\n\t\t\t\t20170522173236_DDS286C15","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522173236_DDS286C16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"Sandri","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173236_DDS286C17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1097-2765(04)00211-4","article-title":"The IGF-1\/PI3K\/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors","volume":"14","author":"Stitt","year":"2004","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522173236_DDS286C18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.09.027","article-title":"IKKbeta\/NF-kappaB activation causes severe muscle wasting in mice","volume":"119","author":"Cai","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173236_DDS286C19","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1091\/mbc.E08-07-0759","article-title":"A histone deacetylase 4\/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression","volume":"20","author":"Tang","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20170522173236_DDS286C20","doi-asserted-by":"crossref","first-page":"16977","DOI":"10.1073\/pnas.0601565103","article-title":"Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade","volume":"103","author":"Tang","year":"2006","journal-title":"Proc. Natl Acad. Sci. U S A"},{"key":"key\n\t\t\t\t20170522173236_DDS286C21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/364501a0","article-title":"Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene","volume":"364","author":"Hasty","year":"1993","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522173236_DDS286C22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2010.09.004","article-title":"Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases","volume":"143","author":"Moresi","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522173236_DDS286C23","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/jcb.23136","article-title":"Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle","volume":"112","author":"Macpherson","year":"2011","journal-title":"J. Cell Biochem."},{"key":"key\n\t\t\t\t20170522173236_DDS286C24","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1523\/JNEUROSCI.4434-08.2009","article-title":"Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice","volume":"29","author":"Kong","year":"2009","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522173236_DDS286C25","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ydbio.2011.05.667","article-title":"Muscles in a mouse model of spinal muscular atrophy show profound defects in neuromuscular development even in the absence of failure in neuromuscular transmission or loss of motor neurons","volume":"356","author":"Lee","year":"2011","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170522173236_DDS286C26","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1113\/jphysiol.2011.212845","article-title":"Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids","volume":"589","author":"Baehr","year":"2011","journal-title":"J. Physiol."},{"key":"key\n\t\t\t\t20170522173236_DDS286C27","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab."},{"key":"key\n\t\t\t\t20170522173236_DDS286C28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1101\/sqb.2008.73.064","article-title":"The molecular regulation of muscle stem cell function","volume":"73","author":"Rudnicki","year":"2008","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"key\n\t\t\t\t20170522173236_DDS286C29","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbrc.2011.10.036","article-title":"Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors","volume":"414","author":"Hagiwara","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522173236_DDS286C30","doi-asserted-by":"crossref","DOI":"10.1002\/ana.23582","article-title":"Glucose metabolism and pancreatic defects in spinal muscular atrophy","author":"Bowerman","year":"2012","journal-title":"Ann. Neurol.,"},{"key":"key\n\t\t\t\t20170522173236_DDS286C31","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.bbrc.2009.11.148","article-title":"Effect of diet on the survival and phenotype of a mouse model for spinal muscular atrophy","volume":"391","author":"Butchbach","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522173236_DDS286C32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/hmg\/ddr453","article-title":"Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy","volume":"21","author":"Ling","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173236_DDS286C33","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1093\/hmg\/ddn156","article-title":"Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy","volume":"17","author":"Kariya","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173236_DDS286C34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neuron.2010.12.032","article-title":"Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy","volume":"69","author":"Mentis","year":"2011","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522173236_DDS286C35","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2007.09.009","article-title":"The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle","volume":"6","author":"Clarke","year":"2007","journal-title":"Cell Metab."},{"key":"key\n\t\t\t\t20170522173236_DDS286C36","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200901052","article-title":"During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation","volume":"185","author":"Cohen","year":"2009","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522173236_DDS286C37","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jmb.2007.11.049","article-title":"Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis","volume":"376","author":"Koyama","year":"2008","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170522173236_DDS286C38","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/cvr\/cvp348","article-title":"Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms","volume":"85","author":"Mearini","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"key\n\t\t\t\t20170522173236_DDS286C39","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jmb.2005.05.021","article-title":"MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination","volume":"350","author":"Witt","year":"2005","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170522173236_DDS286C40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1741-7015-7-14","article-title":"Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy","volume":"7","author":"Millino","year":"2009","journal-title":"BMC Med."},{"key":"key\n\t\t\t\t20170522173236_DDS286C41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.nmd.2011.10.012","article-title":"Transgenic inactivation of murine myostatin does not decrease the severity of disease in a model of Spinal Muscular Atrophy","volume":"22","author":"Rindt","year":"2012","journal-title":"Neuromuscul. Disord."},{"key":"key\n\t\t\t\t20170522173236_DDS286C42","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/hmg\/ddn426","article-title":"Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy","volume":"18","author":"Rose","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173236_DDS286C43","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1093\/hmg\/ddp253","article-title":"Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice","volume":"18","author":"Sumner","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522173236_DDS286C44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12013-011-9175-7","article-title":"Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy","volume":"60","author":"Eddins","year":"2011","journal-title":"Cell Biochem. Biophys."},{"key":"key\n\t\t\t\t20170522173236_DDS286C45","doi-asserted-by":"crossref","first-page":"E591","DOI":"10.1152\/ajpendo.00073.2004","article-title":"IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1","volume":"287","author":"Sacheck","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/21\/20\/4448\/17256843\/dds286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T23:12:16Z","timestamp":1561936336000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/dds286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,13]]},"references-count":45,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2012,7,13]]},"published-print":{"date-parts":[[2012,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/dds286","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7,13]]}}}