{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:27:06Z","timestamp":1790515626677,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Molecular Genetics"],"published-print":{"date-parts":[[2012,12,1]]},"DOI":"10.1093\/hmg\/dds367","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T06:04:53Z","timestamp":1346825093000},"page":"5159-5173","source":"Crossref","is-referenced-by-count":78,"title":["Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts"],"prefix":"10.1093","volume":"21","author":[{"given":"M.","family":"Tatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Di Bartolomeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Cianfanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cecconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Salvioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,9,4]]},"reference":[{"issue":"3","key":"1_9411676","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1096\/fasebj.5.3.2001789","volume":"5","author":"O'Brien","year":"1991","journal-title":"The FASEB Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0892-6638","issn-type":"print"},{"issue":"17","key":"2_15854066","doi-asserted-by":"publisher","first-page":"9953","DOI":"10.1074\/jbc.270.17.9953","volume":"270","author":"Salvioli","year":"1995","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"1","key":"3_14541716","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0014-5793(93)81631-9","volume":"336","author":"Vaccaro","year":"1993","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3468","issn-type":"print"},{"issue":"1","key":"4_6568884","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0014-5793(00)01417-4","volume":"472","author":"Salvioli","year":"2000","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3468","issn-type":"print"},{"issue":"44","key":"5_29751063","doi-asserted-by":"publisher","first-page":"17394","DOI":"10.1073\/pnas.0704998104","volume":"104","year":"2007","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"6_15865736","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0065-2660(08)60202-3","volume":"32","author":"Beutler","year":"1995","journal-title":"Advances in genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0065-2660","issn-type":"print"},{"key":"7_43636002","first-page":"879","volume":"367","year":"1986","journal-title":"Biological chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/1431-6730","issn-type":"print"},{"issue":"19","key":"8_5524236","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/BF01716064","volume":"67","author":"Christomanou","year":"1989","journal-title":"Klinische Wochenschrift","ISSN":"https:\/\/id.crossref.org\/issn\/0023-2173","issn-type":"print"},{"issue":"1","key":"9_9497654","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0014-5793(91)80760-Z","volume":"284","author":"Schnabel","year":"1991","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3468","issn-type":"print"},{"issue":"1","key":"10_10185577","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01233949","volume":"19","author":"Rafi","year":"1993","journal-title":"Somatic cell and molecular genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0740-7750","issn-type":"print"},{"issue":"1","key":"11_10717814","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s004010050960","volume":"97","author":"P\u00a0\u00a0mpols","year":"1999","journal-title":"Acta neuropathologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6322","issn-type":"print"},{"issue":"2-3","key":"12_18929867","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s00439-005-1288-x","volume":"117","author":"Diaz-Font","year":"2005","journal-title":"Human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6717","issn-type":"print"},{"issue":"6","key":"13_30024264","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1399-0004.2007.00899.x","volume":"72","author":"Tylki-Szymanska","year":"2007","journal-title":"Clinical genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9163","issn-type":"print"},{"key":"14_37375947","first-page":"152","volume":"28","year":"2005","journal-title":"Journal of inherited metabolic disease","ISSN":"https:\/\/id.crossref.org\/issn\/0141-8955","issn-type":"print"},{"key":"15_37375948","first-page":"S147","volume":"47","year":"2009","journal-title":"International journal of clinical pharmacology and therapeutics","ISSN":"https:\/\/id.crossref.org\/issn\/0946-1965","issn-type":"print"},{"issue":"15","key":"16_37313688","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1093\/hmg\/ddq204","volume":"19","year":"2010","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"1","key":"17_38458712","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4161\/auto.7.1.13884","volume":"7","author":"Tatti","year":"2011","ISSN":"https:\/\/id.crossref.org\/issn\/1554-8635","issn-type":"print"},{"issue":"6","key":"18_19713246","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0002-9440(10)61253-9","volume":"167","author":"Koike","year":"2005","journal-title":"American Journal Of Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"issue":"12","key":"19_28486147","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1093\/hmg\/ddm100","volume":"16","year":"2007","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"3","key":"20_30383859","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.bbrc.2007.12.187","volume":"367","author":"Takamura","year":"2008","journal-title":"Biochemical and biophysical research communications","ISSN":"https:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"issue":"7","key":"21_36500680","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3468","issn-type":"print"},{"issue":"7-8","key":"22_17334325","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1515\/BC.2002.112","volume":"383","author":"Turk","year":"2002","journal-title":"Biological chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/1431-6730","issn-type":"print"},{"key":"23_33994578","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0076-6879(08)03606-9","volume":"452","author":"Vazquez","year":"2009","journal-title":"Methods in enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/0076-6879","issn-type":"print"},{"issue":"7300","key":"24_37418204","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/nature09076","volume":"465","author":"Yu","year":"2010","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"4","key":"25_39461576","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/ncb2204","volume":"13","author":"Korolchuk","year":"2011","journal-title":"Nature Cell Biology","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4679","issn-type":"print"},{"issue":"7","key":"26_31857514","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4161\/auto.6787","volume":"4","author":"Wang","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1554-8635","issn-type":"print"},{"issue":"1","key":"27_29541235","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/hmg\/ddm289","volume":"17","year":"2008","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"4","key":"28_21866275","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/ana.20807","volume":"59","author":"Fukuda","year":"2006","journal-title":"Annals of neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"issue":"5","key":"29_21329679","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1182\/blood.V96.5.1969","volume":"96","author":"Moran","year":"2000","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"1-2","key":"30_31574933","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cca.2008.06.018","volume":"396","author":"van Breemen","year":"2008","journal-title":"Clinica Chimica Acta","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3492","issn-type":"print"},{"issue":"18","key":"31_37559493","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1093\/hmg\/ddq273","volume":"19","year":"2010","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"key":"32_43636003","first-page":"540","volume":"175","year":"2009","journal-title":"American Journal Of Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"issue":"20","key":"33_10489569","doi-asserted-by":"publisher","first-page":"10954","DOI":"10.1073\/pnas.97.20.10954","volume":"97","author":"Wada","year":"2000","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"11","key":"34_17059821","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1093\/hmg\/11.11.1343","volume":"11","author":"Myerowitz","year":"2002","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"12","key":"35_23317896","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.1093\/emboj\/19.12.2786","volume":"19","author":"Tyynela","year":"2000","journal-title":"The EMBO Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"issue":"6","key":"36_22058779","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1093\/brain\/awl107","volume":"129","year":"2006","journal-title":"Brain","ISSN":"https:\/\/id.crossref.org\/issn\/0006-8950","issn-type":"print"},{"issue":"6","key":"37_19713246","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0002-9440(10)61253-9","volume":"167","year":"2005","journal-title":"American Journal Of Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"issue":"12","key":"38_19672992","doi-asserted-by":"publisher","first-page":"7883","DOI":"10.1073\/pnas.112632299","volume":"99","year":"2002","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"3","key":"39_37559028","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.2353\/ajpath.2010.100050","volume":"177","year":"2010","journal-title":"American Journal Of Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"issue":"11","key":"40_35716692","first-page":"3340","volume":"119","author":"Mareninova","year":"2009","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"3","key":"41_35850176","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1074\/jbc.M109.065813","volume":"285","year":"2010","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"4","key":"42_40783924","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ymgme.2011.08.024","volume":"104","author":"Jurecka","year":"2011","journal-title":"Molecular genetics and metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/1096-7192","issn-type":"print"},{"issue":"1","key":"43_38204550","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1083\/jcb.201002100","volume":"191","year":"2010","journal-title":"The Journal of Cell Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9525","issn-type":"print"},{"issue":"21","key":"44_23321245","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","volume":"19","author":"Kabeya","year":"2000","journal-title":"The EMBO Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"issue":"12","key":"45_18415716","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1016\/j.biocel.2004.05.009","volume":"36","author":"Tanida","year":"2004","journal-title":"The international journal of biochemistry &amp; cell biology","ISSN":"https:\/\/id.crossref.org\/issn\/1357-2725","issn-type":"print"},{"issue":"2","key":"46_30321319","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4161\/auto.5338","volume":"4","author":"Klionsky","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1554-8635","issn-type":"print"},{"issue":"6","key":"47_10837581","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/oxfordjournals.jbchem.a022396","volume":"125","author":"Yasuda","year":"1999","journal-title":"Journal of Biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-924X","issn-type":"print"},{"key":"48_43636004","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0076-6879(81)80043-2","volume":"80","year":"1981","journal-title":"METHODS ENZIMOL"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/21\/23\/5159\/1611540\/dds367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T05:51:53Z","timestamp":1594619513000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/dds367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,4]]},"references-count":48,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2012,11,6]]},"published-print":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/dds367","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,4]]}}}