{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:54:04Z","timestamp":1792144444920,"version":"4.4.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,15]]},"DOI":"10.1093\/hmg\/dds379","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:31:30Z","timestamp":1347323490000},"page":"5280-5293","source":"Crossref","is-referenced-by-count":130,"title":["Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin\u2013proteasomal and autophagy systems"],"prefix":"10.1093","volume":"21","author":[{"given":"Haiqun","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Kast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan S.","family":"Steffan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,9,10]]},"reference":[{"key":"key\n\t\t\t\t20170522145854_DDS379C1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0166-2236(00)01609-X","article-title":"Transcriptional dysregulation in Huntington's disease","volume":"23","author":"Cha","year":"2000","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20170522145854_DDS379C2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-9525(03)00074-X","article-title":"Transcriptional abnormalities in Huntington disease","volume":"19","author":"Sugars","year":"2003","journal-title":"Trends Genet."},{"key":"key\n\t\t\t\t20170522145854_DDS379C3","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s00018-003-3013-z","article-title":"Polyglutamine diseases: a transcription disorder","volume":"60","author":"Okazawa","year":"2003","journal-title":"Cell Mol. Life Sci."},{"key":"key\n\t\t\t\t20170522145854_DDS379C4","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/jnr.21046","article-title":"Striatal specificity of gene expression dysregulation in Huntington's disease","volume":"84","author":"Thomas","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"key\n\t\t\t\t20170522145854_DDS379C5","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1126\/science.1073845","article-title":"Neurodegeneration. A glutamine-rich trail leads to transcription factors","volume":"296","author":"Freiman","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522145854_DDS379C6","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2005.10.030","article-title":"In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets","volume":"123","author":"Zhai","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522145854_DDS379C7","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35099568","article-title":"Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila","volume":"413","author":"Steffan","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522145854_DDS379C8","doi-asserted-by":"crossref","first-page":"10335","DOI":"10.1523\/JNEUROSCI.2599-04.2004","article-title":"Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease","volume":"24","author":"Ferrante","year":"2004","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522145854_DDS379C9","doi-asserted-by":"crossref","first-page":"19176","DOI":"10.1073\/pnas.0606373103","article-title":"ESET\/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease","volume":"103","author":"Ryu","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522145854_DDS379C10","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/hmg\/ddm064","article-title":"Modulation of nucleosome dynamics in Huntington's disease","volume":"16","author":"Stack","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522145854_DDS379C11","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd2681","article-title":"Therapeutic application of histone deacetylase inhibitors for central nervous system disorders","volume":"7","author":"Kazantsev","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"key\n\t\t\t\t20170522145854_DDS379C12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1517\/13543784.17.2.169","article-title":"Histone deacetylase inhibitors: possible implications for neurodegenerative disorders","volume":"17","author":"Hahnen","year":"2008","journal-title":"Expert Opin. Investig. Drugs"},{"key":"key\n\t\t\t\t20170522145854_DDS379C13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.canlet.2009.02.013","article-title":"Isoform-specific histone deacetylase inhibitors: the next step","volume":"280","author":"Balasubramanian","year":"2009","journal-title":"Cancer Lett."},{"key":"key\n\t\t\t\t20170522145854_DDS379C14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nchembio815","article-title":"Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia","volume":"2","author":"Herman","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"key\n\t\t\t\t20170522145854_DDS379C15","doi-asserted-by":"crossref","first-page":"35402","DOI":"10.1074\/jbc.M807045200","article-title":"Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases","volume":"283","author":"Chou","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145854_DDS379C16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.nbd.2012.01.016","article-title":"Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease","volume":"46","author":"Jia","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522145854_DDS379C17","doi-asserted-by":"crossref","first-page":"15564","DOI":"10.1073\/pnas.0804249105","article-title":"The HDAC inhibitor, 4b, ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice","volume":"105","author":"Thomas","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522145854_DDS379C18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/emboj.2009.364","article-title":"The IKK complex contributes to the induction of autophagy","volume":"29","author":"Criollo","year":"2010","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170522145854_DDS379C19","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1523\/JNEUROSCI.2675-04.2004","article-title":"Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity","volume":"24","author":"Khoshnan","year":"2004","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522145854_DDS379C20","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200909067","article-title":"IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome","volume":"187","author":"Thompson","year":"2009","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522145854_DDS379C21","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.neuron.2009.11.020","article-title":"Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice","volume":"64","author":"Gu","year":"2009","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522145854_DDS379C22","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.4161\/cc.9.17.12718","article-title":"Does Huntingtin play a role in selective macroautophagy","volume":"9","author":"Steffan","year":"2010","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170522145854_DDS379C23","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1073\/pnas.1114502109","article-title":"Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice","volume":"109","author":"Di Pardo","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522145854_DDS379C24","doi-asserted-by":"crossref","first-page":"16027","DOI":"10.1074\/jbc.M710606200","article-title":"Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice","volume":"283","author":"Orr","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145854_DDS379C25","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.292.5521.1552","article-title":"Impairment of the ubiquitin-proteasome system by protein aggregation","volume":"292","author":"Bence","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522145854_DDS379C26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1100\/tsw.2008.60","article-title":"The ubiquitin-proteasome pathway in Huntington's disease","volume":"8","author":"Finkbeiner","year":"2008","journal-title":"Sci. World J."},{"key":"key\n\t\t\t\t20170522145854_DDS379C27","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1093\/hmg\/ddh188","article-title":"Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases","volume":"13","author":"de Pril","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522145854_DDS379C28","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature06022","article-title":"Global changes to the ubiquitin system in Huntington's disease","volume":"448","author":"Bennett","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522145854_DDS379C29","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.1523\/JNEUROSCI.23-37-11653.2003","article-title":"Neuronal induction of the immunoproteasome in Huntington's disease","volume":"23","author":"Diaz-Hernandez","year":"2003","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522145854_DDS379C30","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1083\/jcb.200709080","article-title":"Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice","volume":"180","author":"Wang","year":"2008","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522145854_DDS379C31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature10353","article-title":"Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS\/dementia","volume":"477","author":"Deng","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522145854_DDS379C32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.brainresrev.2010.04.002","article-title":"Targets and consequences of protein SUMOylation in neurons","volume":"64","author":"Wilkinson","year":"2010","journal-title":"Brain Res. Rev."},{"key":"key\n\t\t\t\t20170522145854_DDS379C33","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1074\/jbc.M412042200","article-title":"Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes","volume":"280","author":"Jana","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145854_DDS379C34","doi-asserted-by":"crossref","first-page":"19385","DOI":"10.1074\/jbc.271.32.19385","article-title":"Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme","volume":"271","author":"Kalchman","year":"1996","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145854_DDS379C35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mcn.2006.09.006","article-title":"Ubiquitin-conjugating enzyme E2\u201325K increases aggregate formation and cell death in polyglutamine diseases","volume":"34","author":"de Pril","year":"2007","journal-title":"Mol. Cell Neurosci."},{"key":"key\n\t\t\t\t20170522145854_DDS379C36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1092194","article-title":"SUMO modification of Huntingtin and Huntington's disease pathology","volume":"304","author":"Steffan","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522145854_DDS379C37","doi-asserted-by":"crossref","first-page":"18030","DOI":"10.1073\/pnas.0408345102","article-title":"Apoptotic and autophagic cell death induced by histone deacetylase inhibitors","volume":"101","author":"Shao","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522145854_DDS379C38","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1073\/pnas.1204429109","article-title":"Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death","volume":"109","author":"Gammoh","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522145854_DDS379C39","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cell.2009.03.018","article-title":"Acetylation targets mutant huntingtin to autophagosomes for degradation","volume":"137","author":"Jeong","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522145854_DDS379C40","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.1523\/JNEUROSCI.1831-07.2007","article-title":"Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons","volume":"27","author":"Anne","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522145854_DDS379C41","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1534-5807(02)00188-0","article-title":"The IGF-1\/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt","volume":"2","author":"Humbert","year":"2002","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20170522145854_DDS379C42","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration","volume":"443","author":"Rubinsztein","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522145854_DDS379C43","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/ncb0910-836","article-title":"Selective autophagy: ubiquitin-mediated recognition and beyond","volume":"12","author":"Kraft","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170522145854_DDS379C44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nprot.2006.2","article-title":"T-maze alternation in the rodent","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20170522145854_DDS379C45","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/sj.npp.1300150","article-title":"Cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors","volume":"28","author":"Bontempi","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20170522145854_DDS379C46","doi-asserted-by":"crossref","first-page":"29427","DOI":"10.1074\/jbc.M109.013193","article-title":"Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity","volume":"284","author":"Aiken","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145854_DDS379C47","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1046\/j.1471-4159.2001.00027.x","article-title":"Clozapine increases apolipoprotein D expression in rodent brain: towards a mechanism for neuroleptic pharmacotherapy","volume":"76","author":"Thomas","year":"2001","journal-title":"J. Neurochem."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/21\/24\/5280\/17257420\/dds379.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T14:10:30Z","timestamp":1562163030000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/dds379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,10]]},"references-count":47,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2012,9,10]]},"published-print":{"date-parts":[[2012,12,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/dds379","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9,10]]}}}