{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:27:32Z","timestamp":1767374852903},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Molecular Genetics"],"published-print":{"date-parts":[[2013,3,15]]},"DOI":"10.1093\/hmg\/dds509","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T09:32:35Z","timestamp":1354613555000},"page":"1074-1085","source":"Crossref","is-referenced-by-count":13,"title":["Mutations in human DNA polymerase \u00a0 confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients"],"prefix":"10.1093","volume":"22","author":[{"given":"C. D.","family":"Sohl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kasiviswanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. S.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,12,3]]},"reference":[{"key":"1_30270341","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1146\/annurev.med.59.053006.104646","volume":"59","author":"Copeland","year":"2008","journal-title":"Annual review of medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0066-4219","issn-type":"print"},{"issue":"2","key":"2_35813658","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2009.07.050","volume":"139","author":"Lee","year":"2009","journal-title":"Cell","ISSN":"http:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"3_30152289","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1021\/bi972685u","volume":"37","year":"1998","ISSN":"http:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"1","key":"4_21198125","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1074\/jbc.M509730200","volume":"281","year":"2006","journal-title":"Journal of Biological Chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"5_30286938","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1021\/bi980772w","volume":"37","year":"1998","ISSN":"http:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"6_30152290","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1021\/bi992104w","volume":"39","year":"2000","ISSN":"http:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"6","key":"7_29892836","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1542\/peds.2007-0391","volume":"120","author":"Haas","year":"2007","journal-title":"Pediatrics","ISSN":"http:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"key":"8_18217647","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev.biochem.72.121801.161455","volume":"73","author":"Kaguni","year":"2004","journal-title":"Annual review of biochemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0066-4154","issn-type":"print"},{"issue":"2","key":"9_21603872","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1021\/cr040463d","volume":"106","author":"Graziewicz","year":"2006","journal-title":"Chemical Reviews","ISSN":"http:\/\/id.crossref.org\/issn\/1520-6890","issn-type":"print"},{"issue":"2","key":"10_38291752","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00018-010-0530-4","volume":"68","author":"Stumpf","year":"2011","journal-title":"Cellular and molecular life sciences : CMLS","ISSN":"http:\/\/id.crossref.org\/issn\/1420-682X","issn-type":"print"},{"issue":"5","key":"11_36500804","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.bbapap.2010.01.007","volume":"1804","author":"Bailey","year":"2010","journal-title":"Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology","ISSN":"http:\/\/id.crossref.org\/issn\/0006-3002","issn-type":"print"},{"issue":"9437","key":"12_18309661","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0140-6736(04)16983-3","volume":"364","author":"Luoma","year":"2004","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"9","key":"13_35333248","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/jhg.2009.71","volume":"54","author":"Singh","year":"2009","journal-title":"Journal of human genetics","ISSN":"http:\/\/id.crossref.org\/issn\/1434-5161","issn-type":"print"},{"issue":"5","key":"14_37602559","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.mito.2010.05.015","volume":"10","author":"Rajender","year":"2010","ISSN":"http:\/\/id.crossref.org\/issn\/1872-8278","issn-type":"print"},{"issue":"4","key":"15_39078373","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.nmd.2010.12.008","volume":"21","author":"Smits","year":"2011","journal-title":"Neuromuscular disorders : NMD","ISSN":"http:\/\/id.crossref.org\/issn\/0960-8966","issn-type":"print"},{"key":"16_45242140","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1128\/AAC.01659-08","volume":"53","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy","ISSN":"http:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"issue":"10","key":"17_38569518","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1086\/513872","volume":"195","year":"2007","journal-title":"Journal of Infectious Diseases","ISSN":"http:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"issue":"1","key":"18_42394606","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1124\/mol.112.078758","volume":"82","year":"2012","journal-title":"Molecular Pharmacology","ISSN":"http:\/\/id.crossref.org\/issn\/0026-895X","issn-type":"print"},{"issue":"6","key":"19_38992726","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1093\/hmg\/ddq565","volume":"20","year":"2011","journal-title":"Human Molecular Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"36","key":"20_19576040","doi-asserted-by":"publisher","first-page":"31341","DOI":"10.1074\/jbc.M506762200","volume":"280","year":"2005","journal-title":"Journal of Biological Chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"29","key":"21_34932366","doi-asserted-by":"publisher","first-page":"19501","DOI":"10.1074\/jbc.M109.011940","volume":"284","year":"2009","journal-title":"Journal of Biological Chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"18","key":"22_19553685","doi-asserted-by":"publisher","first-page":"15225","DOI":"10.1074\/jbc.C200100200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"44","key":"23_37793806","doi-asserted-by":"publisher","first-page":"34191","DOI":"10.1074\/jbc.M110.156182","volume":"285","year":"2010","journal-title":"Journal of Biological Chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"36","key":"24_37377104","doi-asserted-by":"publisher","first-page":"28105","DOI":"10.1074\/jbc.M110.122283","volume":"285","year":"2010","journal-title":"Journal of Biological Chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"8","key":"25_18275378","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/nsmb805","volume":"11","author":"Graziewicz","year":"2004","journal-title":"Nature structural & molecular biology","ISSN":"http:\/\/id.crossref.org\/issn\/1545-9993","issn-type":"print"},{"issue":"21","key":"26_40520380","doi-asserted-by":"publisher","first-page":"9072","DOI":"10.1093\/nar\/gkr618","volume":"39","year":"2011","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"9","key":"27_33424766","doi-asserted-by":"publisher","first-page":"E150","DOI":"10.1002\/humu.20824","volume":"29","author":"Wong","year":"2008","journal-title":"Human mutation","ISSN":"http:\/\/id.crossref.org\/issn\/1059-7794","issn-type":"print"},{"issue":"11","key":"28_35228095","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1136\/jmg.2009.067686","volume":"46","year":"2009","journal-title":"Journal of Medical Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2593","issn-type":"print"},{"issue":"3","key":"29_23714773","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00431-006-0234-9","volume":"166","author":"de Vries","year":"2007","journal-title":"European journal of pediatrics","ISSN":"http:\/\/id.crossref.org\/issn\/0340-6199","issn-type":"print"},{"issue":"4","key":"30_18757608","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1093\/brain\/awh410","volume":"128","year":"2005","journal-title":"Brain","ISSN":"http:\/\/id.crossref.org\/issn\/0006-8950","issn-type":"print"},{"issue":"10","key":"31_40664592","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1136\/jmedgenet-2011-100222","volume":"48","year":"2011","journal-title":"Journal of Medical Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2593","issn-type":"print"},{"issue":"16","key":"32_31112113","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1093\/hmg\/ddn150","volume":"17","year":"2008","journal-title":"Human Molecular Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"7","key":"33_21945213","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1093\/brain\/awl088","volume":"129","year":"2006","journal-title":"Brain","ISSN":"http:\/\/id.crossref.org\/issn\/0006-8950","issn-type":"print"},{"key":"34_45229323","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1212\/WNL.0b013e3181b78488","volume":"73","year":"2009","journal-title":"OGPL Neurology"},{"issue":"2","key":"35_17220610","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/ana.10278","volume":"52","author":"Lamantea","year":"2002","journal-title":"Annals of neurology","ISSN":"http:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"issue":"8","key":"36_18275366","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/nsmb792","volume":"11","author":"Li","year":"2004","journal-title":"Nature structural & molecular biology","ISSN":"http:\/\/id.crossref.org\/issn\/1545-9993","issn-type":"print"},{"issue":"29","key":"37_40200823","doi-asserted-by":"publisher","first-page":"6376","DOI":"10.1021\/bi200280r","volume":"50","author":"Estep","year":"2011","ISSN":"http:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"13","key":"38_18266053","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"Pettersen","year":"2004","journal-title":"Journal of computational chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0192-8651","issn-type":"print"},{"issue":"11","key":"39_36681268","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1093\/hmg\/ddq089","volume":"19","year":"2010","journal-title":"Human Molecular Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"1","key":"40_17624367","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0022-2836(03)00405-4","volume":"329","author":"Lim","year":"2003","journal-title":"Journal of molecular biology","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"6","key":"41_40621721","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.mito.2011.08.003","volume":"11","author":"Kasiviswanathan","year":"2011","ISSN":"http:\/\/id.crossref.org\/issn\/1872-8278","issn-type":"print"},{"issue":"43","key":"42_19557572","doi-asserted-by":"publisher","first-page":"40479","DOI":"10.1074\/jbc.M205303200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"6","key":"43_22114091","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1086\/504303","volume":"78","author":"Longley","year":"2006","journal-title":"American journal of human genetics","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"26","key":"44_19548629","doi-asserted-by":"publisher","first-page":"23616","DOI":"10.1074\/jbc.M101114200","volume":"276","year":"2001","journal-title":"Journal of Biological Chemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"4","key":"45_36700819","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ymeth.2010.02.015","volume":"51","author":"Kasiviswanathan","year":"2010","journal-title":"Methods (San Diego, Calif.)","ISSN":"http:\/\/id.crossref.org\/issn\/1046-2023","issn-type":"print"},{"issue":"22","key":"46_29292366","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1093\/hmg\/ddm227","volume":"16","year":"2007","journal-title":"Human Molecular Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/22\/6\/1074\/1564392\/dds509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T08:39:47Z","timestamp":1503477587000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/dds509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,3]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,2,21]]},"published-print":{"date-parts":[[2013,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/dds509","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,3]]}}}