{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:13:35Z","timestamp":1791288815410,"version":"4.3.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,15]]},"DOI":"10.1093\/hmg\/ddt008","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T04:22:25Z","timestamp":1357964545000},"page":"1581-1600","source":"Crossref","is-referenced-by-count":149,"title":["Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis"],"prefix":"10.1093","volume":"22","author":[{"given":"J.","family":"Prause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Katona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schnizler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bushuven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dreier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Buchkremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Johann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Deschauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Troost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,1,11]]},"reference":[{"key":"key\n\t\t\t\t20170503072815_DDT008C1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0896-6273(01)00177-5","article-title":"Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases","volume":"29","author":"Sherman","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170503072815_DDT008C2","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1126\/science.1067122","article-title":"Toxic proteins in neurodegenerative disease","volume":"296","author":"Taylor","year":"2002","journal-title":"Science"},{"issue":"suppl","key":"key\n\t\t\t\t20170503072815_DDT008C3","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170503072815_DDT008C4","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1093\/emboj\/17.24.7151","article-title":"The ubiquitin-proteasome pathway: on protein death and cell life","volume":"17","author":"Ciechanover","year":"1998","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170503072815_DDT008C5","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/10.10.1049","article-title":"Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release","volume":"10","author":"Jana","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C6","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrm1742","article-title":"Opinion: what is the role of protein aggregation in neurodegeneration?","volume":"6","author":"Ross","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbrc.2006.01.136","article-title":"Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction","volume":"342","author":"Goswami","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170503072815_DDT008C8","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1093\/hmg\/9.13.2009","article-title":"Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity","volume":"9","author":"Jana","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ajmg.1320510114","article-title":"Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers","volume":"51","author":"Rosen","year":"1994","journal-title":"Am. J. Med. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503072815_DDT008C11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/jmg.2008.062463","article-title":"Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis","volume":"46","author":"Daoud","year":"2009","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11910-009-0030-9","article-title":"Recent advances in the genetics of amyotrophic lateral sclerosis","volume":"9","author":"Valdmanis","year":"2009","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"key\n\t\t\t\t20170503072815_DDT008C13","doi-asserted-by":"crossref","first-page":"30223","DOI":"10.1074\/jbc.M605049200","article-title":"Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB\/ALS8)","volume":"281","author":"Kanekura","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503072815_DDT008C14","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/jmg.2010.077180","article-title":"SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations","volume":"47","author":"Millecamps","year":"2010","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/ana.22274","article-title":"Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease","volume":"68","author":"Luty","year":"2010","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C16","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/ana.22534","article-title":"A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis","volume":"70","author":"Al-Saif","year":"2011","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0165-6147(92)90030-A","article-title":"A proposal for the classification of sigma binding sites","volume":"13","author":"Quirion","year":"1992","journal-title":"Trends Pharmacol. Sci."},{"key":"key\n\t\t\t\t20170503072815_DDT008C18","doi-asserted-by":"crossref","first-page":"8072","DOI":"10.1073\/pnas.93.15.8072","article-title":"Purification, molecular cloning, and expression of the mammalian sigma1-binding site","volume":"93","author":"Hanner","year":"1996","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503072815_DDT008C19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1126\/science.2832949","article-title":"Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems","volume":"240","author":"Su","year":"1988","journal-title":"Science"},{"key":"key\n\t\t\t\t20170503072815_DDT008C20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0278-5846(96)00160-1","article-title":"Neuroprotective and anti-amnesic potentials of sigma (sigma) receptor ligands","volume":"21","author":"Maurice","year":"1997","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"key\n\t\t\t\t20170503072815_DDT008C21","first-page":"788","article-title":"Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration","volume":"293","author":"Hayashi","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170503072815_DDT008C22","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.lfs.2005.05.009","article-title":"The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse","volume":"77","author":"Hayashi","year":"2005","journal-title":"Life Sci."},{"key":"key\n\t\t\t\t20170503072815_DDT008C23","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJM199403033300907","article-title":"Excitatory amino acids as a final common pathway for neurologic disorders","volume":"330","author":"Lipton","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170503072815_DDT008C24","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1161\/01.STR.32.7.1613","article-title":"Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production","volume":"32","author":"Goyagi","year":"2001","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20170503072815_DDT008C25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1213\/00000539-200302000-00043","article-title":"Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats","volume":"96","author":"Goyagi","year":"2003","journal-title":"Anesth. Analg."},{"key":"key\n\t\t\t\t20170503072815_DDT008C26","doi-asserted-by":"crossref","DOI":"10.1002\/0471142727.mb2803s71","article-title":"Establishment and culture of human skin fibroblasts","author":"Villegas","year":"2005","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuroscience.2009.03.067","article-title":"Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons","volume":"162","author":"Guzman-Lenis","year":"2009","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170503072815_DDT008C28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejphar.2012.01.030","article-title":"The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements","volume":"682","author":"Pal","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C29","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2174\/138161212799436476","article-title":"Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases","volume":"18","author":"Niitsu","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"key\n\t\t\t\t20170503072815_DDT008C30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuroscience.2010.02.022","article-title":"The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study","volume":"167","author":"Mavlyutov","year":"2010","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170503072815_DDT008C31","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.yexcr.2006.01.004","article-title":"Silencing of sigma-1 receptor induces cell death in human lens cells","volume":"312","author":"Wang","year":"2006","journal-title":"Exp. Cell Res."},{"key":"key\n\t\t\t\t20170503072815_DDT008C32","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1167\/iovs.07-1101","article-title":"sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation","volume":"49","author":"Tchedre","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170503072815_DDT008C33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00439-005-0031-y","article-title":"A common founder for amyotrophic lateral sclerosis type 8 (ALS8) in the Brazilian population","volume":"118","author":"Nishimura","year":"2005","journal-title":"Hum. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C34","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1399-0004.2009.01319.x","article-title":"The p.P56S mutation in the VAPB gene is not due to a single founder: the first European case","volume":"77","author":"Funke","year":"2010","journal-title":"Clin. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C35","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.03.006","article-title":"Rethinking ALS: the FUS about TDP-43","volume":"136","author":"Lagier-Tourenne","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170503072815_DDT008C36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.0305-1846.2003.00518.x","article-title":"Protein aggregation in motor neurone disorders","volume":"29","author":"Wood","year":"2003","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/syn.890150103","article-title":"Evidence for the cholinergic nature of C-terminals associated with subsurface cisterns in alpha-motoneurons of rat","volume":"15","author":"Nagy","year":"1993","journal-title":"Synapse"},{"key":"key\n\t\t\t\t20170503072815_DDT008C38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-0404.2005.00432.x","article-title":"Function of sigma1 receptors in Parkinson's disease","volume":"112","author":"Mishina","year":"2005","journal-title":"Acta Neurol. Scand."},{"key":"key\n\t\t\t\t20170503072815_DDT008C39","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170503072815_DDT008C40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12149-007-0094-z","article-title":"Low density of sigma1 receptors in early Alzheimer's disease","volume":"22","author":"Mishina","year":"2008","journal-title":"Ann. Nucl. Med."},{"key":"key\n\t\t\t\t20170503072815_DDT008C41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/1871524910909030190","article-title":"Imaging of sigma1 receptors in the human brain using PET and [11C]SA4503","volume":"9","author":"Toyohara","year":"2009","journal-title":"Centr. Nerv. Syst. Agents Med. Chem."},{"key":"key\n\t\t\t\t20170503072815_DDT008C42","doi-asserted-by":"crossref","first-page":"9086","DOI":"10.1074\/jbc.272.14.9086","article-title":"Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance","volume":"272","author":"Bush","year":"1997","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503072815_DDT008C43","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1093\/hmg\/ddi312","article-title":"Endoplasmic reticulum stress compromises the ubiquitin-proteasome system","volume":"14","author":"Menendez-Benito","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C44","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1093\/brain\/awm190","article-title":"Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis","volume":"130","author":"Ilieva","year":"2007","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170503072815_DDT008C45","first-page":"754","article-title":"Stress signaling from the endoplasmic reticulum: a central player in the pathogenesis of amyotrophic lateral sclerosis","volume":"63","author":"Walker","year":"2011","journal-title":"IUBMB Life"},{"key":"key\n\t\t\t\t20170503072815_DDT008C46","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1073\/pnas.0509227103","article-title":"Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model","volume":"103","author":"Kikuchi","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503072815_DDT008C47","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1247\/csf.27.421","article-title":"Autophagosome formation in mammalian cells","volume":"27","author":"Mizushima","year":"2002","journal-title":"Cell Struct. Funct."},{"key":"key\n\t\t\t\t20170503072815_DDT008C48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C49","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00027.2001","article-title":"The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction","volume":"82","author":"Glickman","year":"2002","journal-title":"Physiol. Rev."},{"key":"key\n\t\t\t\t20170503072815_DDT008C50","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.bbrc.2006.02.104","article-title":"Curcumin enhances the polyglutamine-expanded truncated N-terminal huntingtin-induced cell death by promoting proteasomal malfunction","volume":"342","author":"Dikshit","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170503072815_DDT008C51","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1073\/pnas.94.3.855","article-title":"Activation of the cell death program by inhibition of proteasome function","volume":"94","author":"Drexler","year":"1997","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503072815_DDT008C52","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tcb.2008.12.002","article-title":"MAM: more than just a housekeeper","volume":"19","author":"Hayashi","year":"2009","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C53","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0306-4522(93)90029-F","article-title":"Caffeine-induced calcium release from internal stores in cultured rat sensory neurons","volume":"57","author":"Usachev","year":"1993","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170503072815_DDT008C54","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature02246","article-title":"The mitochondrial calcium uniporter is a highly selective ion channel","volume":"427","author":"Kirichok","year":"2004","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503072815_DDT008C55","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.cdd.4402072","article-title":"Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosis","volume":"14","author":"Zhang","year":"2007","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170503072815_DDT008C56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s13277-011-0248-4","article-title":"Cetuximab induces mitochondrial translocalization of EGFRvIII, but not EGFR: involvement of mitochondria in tumor drug resistance?","volume":"33","author":"Dreier","year":"2012","journal-title":"Tumour Biol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C57","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","article-title":"Regulation of cell death: the calcium-apoptosis link","volume":"4","author":"Orrenius","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C58","doi-asserted-by":"crossref","first-page":"23318","DOI":"10.1074\/jbc.M112.349142","article-title":"Expression of a truncated form of the endoplasmic reticulum chaperone protein, sigma-1 receptor, promotes mitochondrial energy depletion and apoptosis","volume":"287","author":"Shioda","year":"2012","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503072815_DDT008C59","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/s13311-012-0140-y","article-title":"Sigma-1R agonist improves motor function and motoneuron survival in ALS mice","volume":"9","author":"Mancuso","year":"2012","journal-title":"Neurotherapeutics"},{"key":"key\n\t\t\t\t20170503072815_DDT008C60","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2174\/156720511797633232","article-title":"Genetic polymorphisms in sigma-1 receptor and apolipoprotein E interact to influence the severity of Alzheimer's disease","volume":"8","author":"Huang","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"key\n\t\t\t\t20170503072815_DDT008C61","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000101990","article-title":"Sigma receptor type 1 gene variation in a group of Polish patients with Alzheimer's disease and mild cognitive impairment","volume":"23","author":"Maruszak","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"key\n\t\t\t\t20170503072815_DDT008C62","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/00019442-200512000-00005","article-title":"A variant of the sigma receptor type-1 gene is a protective factor for Alzheimer disease","volume":"13","author":"Uchida","year":"2005","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"key\n\t\t\t\t20170503072815_DDT008C63","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/01.STR.31.4.976","article-title":"Sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion","volume":"31","author":"Harukuni","year":"2000","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20170503072815_DDT008C64","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1097\/00001756-200508010-00018","article-title":"Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity","volume":"16","author":"Marrazzo","year":"2005","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t20170503072815_DDT008C65","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/BF00310025","article-title":"Presynaptic terminal loss from alpha-motoneurones following the retrograde axonal transport of diphtheria toxin","volume":"83","author":"Pullen","year":"1992","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C66","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1460-9568.2008.06602.x","article-title":"Increase in presynaptic territory of C-terminals on lumbar motoneurons of G93A SOD1 mice during disease progression","volume":"29","author":"Pullen","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"key\n\t\t\t\t20170503072815_DDT008C67","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0092-8674(01)00244-6","article-title":"Amyotrophic lateral sclerosis. Unfolding the toxicity of the misfolded","volume":"104","author":"Julien","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170503072815_DDT008C68","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nbd.2010.05.007","article-title":"Chaperone networks: tipping the balance in protein folding diseases","volume":"40","author":"Voisine","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170503072815_DDT008C69","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3109\/17482968.2011.641569","article-title":"Endoplasmic reticulum stress and the ER mitochondrial calcium cycle in amyotrophic lateral sclerosis","volume":"13","author":"Lautenschlaeger","year":"2012","journal-title":"Amyotroph. Lateral. Scler."},{"key":"key\n\t\t\t\t20170503072815_DDT008C70","doi-asserted-by":"crossref","first-page":"43156","DOI":"10.1074\/jbc.M112.380444","article-title":"The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones","volume":"287","author":"Hayashi","year":"2012","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503072815_DDT008C71","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1471-4159.2008.05857.x","article-title":"ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB","volume":"108","author":"Suzuki","year":"2009","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170503072815_DDT008C72","doi-asserted-by":"crossref","first-page":"40266","DOI":"10.1074\/jbc.M110.161398","article-title":"Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis","volume":"285","author":"Chen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503072815_DDT008C73","doi-asserted-by":"crossref","first-page":"9801","DOI":"10.1523\/JNEUROSCI.2661-07.2007","article-title":"Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates","volume":"27","author":"Teuling","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170503072815_DDT008C74","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/hmg\/ddr559","article-title":"VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis","volume":"21","author":"De Vos","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C75","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molmed.2009.01.001","article-title":"Calcium signaling and neurodegenerative diseases","volume":"15","author":"Bezprozvanny","year":"2009","journal-title":"Trends Mol. Med."},{"key":"key\n\t\t\t\t20170503072815_DDT008C76","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/hmg\/dds011","article-title":"Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria","volume":"21","author":"Morotz","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503072815_DDT008C77","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10565-007-0185-6","article-title":"Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture","volume":"23","author":"Canova","year":"2007","journal-title":"Cell Biol. Toxicol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C78","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/cr.2010.123","article-title":"Physiological levels of ATP negatively regulate proteasome function","volume":"20","author":"Huang","year":"2010","journal-title":"Cell Res."},{"key":"key\n\t\t\t\t20170503072815_DDT008C79","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1074\/jbc.M109.097345","article-title":"Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity","volume":"285","author":"Kim","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503072815_DDT008C80","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0014-2999(88)90527-4","article-title":"Novel antipsychotic drugs share high affinity for sigma receptors","volume":"155","author":"Largent","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C81","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"key\n\t\t\t\t20170503072815_DDT008C82","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.bbrc.2010.03.055","article-title":"Novel splice variants of the amyotrophic lateral sclerosis-associated gene VAPB expressed in human tissues","volume":"394","author":"Nachreiner","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170503072815_DDT008C83","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00313906","article-title":"Ethylene oxide polyneuropathy: clinical follow-up study with morphometric and electron microscopic findings in a sural nerve biopsy","volume":"232","author":"Schroder","year":"1985","journal-title":"J. Neurol."},{"key":"key\n\t\t\t\t20170503072815_DDT008C84","doi-asserted-by":"crossref","first-page":"29228","DOI":"10.1074\/jbc.M602629200","article-title":"Aspirin induces apoptosis through the inhibition of proteasome function","volume":"281","author":"Dikshit","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/22\/8\/1581\/14141001\/ddt008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T06:29:56Z","timestamp":1562567396000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddt008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,11]]},"references-count":84,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,1,11]]},"published-print":{"date-parts":[[2013,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddt008","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,11]]}}}