{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:31:41Z","timestamp":1790271101247,"version":"4.1.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,15]]},"DOI":"10.1093\/hmg\/ddt052","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T03:51:16Z","timestamp":1360295476000},"page":"1994-2009","source":"Crossref","is-referenced-by-count":134,"title":["TFEB regulates lysosomal proteostasis"],"prefix":"10.1093","volume":"22","author":[{"given":"Wensi","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Savini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Ake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"di Ronza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sardiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Segatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"key\n\t\t\t\t20170522140100_DDT052C1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nrm1423","article-title":"The cell biology of lysosomal storage disorders","volume":"5","author":"Futerman","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1023\/B:BOLI.0000042959.44318.7c","article-title":"Correlation between enzyme activity and substrate storage in a cell culture model system for Gaucher disease","volume":"27","author":"Schueler","year":"2004","journal-title":"J. Inherit Metab. Dis."},{"key":"key\n\t\t\t\t20170522140100_DDT052C3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/humu.20676","article-title":"Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)","volume":"29","author":"Hruska","year":"2008","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20170522140100_DDT052C4","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/S0021-9258(17)42166-1","article-title":"Analysis of human acid beta-glucosidase by site-directed mutagenesis and heterologous expression","volume":"269","author":"Grace","year":"1994","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522140100_DDT052C5","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.biocel.2005.05.008","article-title":"Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease","volume":"37","author":"Schmitz","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C6","doi-asserted-by":"crossref","first-page":"21665","DOI":"10.1073\/pnas.1014376107","article-title":"Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl","volume":"107","author":"Lu","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522140100_DDT052C7","doi-asserted-by":"crossref","first-page":"15428","DOI":"10.1073\/pnas.192582899","article-title":"Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease","volume":"99","author":"Sawkar","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522140100_DDT052C8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1021\/jm060677i","article-title":"Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention","volume":"50","author":"Yu","year":"2007","journal-title":"J. Med. Chem."},{"key":"key\n\t\t\t\t20170522140100_DDT052C9","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1093\/hmg\/ddi240","article-title":"ER retention and degradation as the molecular basis underlying Gaucher disease heterogeneity","volume":"14","author":"Ron","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522140100_DDT052C10","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1146\/annurev.biochem.052308.114844","article-title":"Biological and chemical approaches to diseases of proteostasis deficiency","volume":"78","author":"Powers","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20170522140100_DDT052C11","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1371\/journal.pbio.0060026","article-title":"Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis","volume":"6","author":"Mu","year":"2008","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.cell.2008.06.037","article-title":"Chemical and biological approaches synergize to ameliorate protein-folding diseases","volume":"134","author":"Mu","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522140100_DDT052C13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nchembio.368","article-title":"Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis","volume":"6","author":"Ong","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/cb100321m","article-title":"Ca2+ homeostasis modulation enhances the amenability of L444P glucosylcerebrosidase to proteostasis regulation in patient-derived fibroblasts","volume":"6","author":"Wang","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C15","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.chembiol.2011.04.008","article-title":"Lacidipine remodels protein folding and Ca2+ homeostasis in Gaucher's disease fibroblasts: a mechanism to rescue mutant glucocerebrosidase","volume":"18","author":"Wang","year":"2011","journal-title":"Chem. Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C16","doi-asserted-by":"crossref","first-page":"43454","DOI":"10.1074\/jbc.M111.274332","article-title":"Inhibition of endoplasmic reticulum-associated degradation rescues native folding in loss of function protein misfolding diseases","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522140100_DDT052C17","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1086\/302925","article-title":"Analysis and classification of 304 mutant alleles in patients with type 1 and type 3 Gaucher disease","volume":"66","author":"Koprivica","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522140100_DDT052C18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/gte.1997.1.5","article-title":"Gaucher disease: gene frequencies and genotype\/phenotype correlations","volume":"1","author":"Grabowski","year":"1997","journal-title":"Genet. Test"},{"key":"key\n\t\t\t\t20170522140100_DDT052C19","doi-asserted-by":"crossref","first-page":"21200","DOI":"10.1073\/pnas.1119181109","article-title":"Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease","volume":"108","author":"Lu","year":"2011","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522140100_DDT052C20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522140100_DDT052C21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.genet.38.072902.092717","article-title":"Melanocytes and the microphthalmia transcription factor network","volume":"38","author":"Steingrimsson","year":"2004","journal-title":"Annu. Rev. Genet."},{"key":"key\n\t\t\t\t20170522140100_DDT052C22","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/hmg\/ddr306","article-title":"Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways","volume":"20","author":"Palmieri","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522140100_DDT052C23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","article-title":"Transcriptional activation of lysosomal exocytosis promotes cellular clearance","volume":"21","author":"Medina","year":"2011","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20170522140100_DDT052C24","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522140100_DDT052C25","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cell.2007.10.018","article-title":"LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase","volume":"131","author":"Reczek","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522140100_DDT052C26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1379\/1466-1268(1996)001<0109:IOMACC>2.3.CO;2","article-title":"Influence of molecular and chemical chaperones on protein folding","volume":"1","author":"Welch","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"key\n\t\t\t\t20170522140100_DDT052C27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1139\/o05-148","article-title":"Role of osmolytes as chemical chaperones during the refolding of aminoacylase","volume":"84","author":"Kim","year":"2006","journal-title":"Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1379\/1466-1268(1996)001<0117:CCCTMP>2.3.CO;2","article-title":"Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein","volume":"1","author":"Brown","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"key\n\t\t\t\t20170522140100_DDT052C29","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0022-2836(03)00368-1","article-title":"Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease","volume":"328","author":"Ferrao-Gonzales","year":"2003","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0003-2697(89)90115-2","article-title":"Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases","volume":"180","author":"Maley","year":"1989","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170522140100_DDT052C31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/BF02436006","article-title":"Characterization of glucocerebrosidase in Greek Gaucher disease patients: mutation analysis and biochemical studies","volume":"18","author":"Michelakakis","year":"1995","journal-title":"J. Inherit Metab. Dis."},{"key":"key\n\t\t\t\t20170522140100_DDT052C32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/excr.1997.3581","article-title":"Lysosomal biogenesis in lysosomal storage disorders","volume":"234","author":"Karageorgos","year":"1997","journal-title":"Exp. Cell Res."},{"key":"key\n\t\t\t\t20170522140100_DDT052C33","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1101\/gr.130435.111","article-title":"Identification of microRNA-regulated gene networks by expression analysis of target genes","volume":"22","author":"Gennarino","year":"2012","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170522140100_DDT052C34","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1093\/bioinformatics\/btq430","article-title":"Cytoscape Web: an interactive web-based network browser","volume":"26","author":"Lopes","year":"2010","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170522140100_DDT052C35","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522140100_DDT052C36","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbamcr.2008.09.018","article-title":"Proteomics of the lysosome","volume":"1793","author":"Lubke","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522140100_DDT052C37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1021\/cb600187q","article-title":"Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants","volume":"1","author":"Sawkar","year":"2006","journal-title":"ACS Chem. Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C38","doi-asserted-by":"crossref","first-page":"13478","DOI":"10.1074\/jbc.M308523200","article-title":"Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay\u2013Sachs and Sandhoff Patients","volume":"279","author":"Tropak","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522140100_DDT052C39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/jama.281.3.249","article-title":"Prevalence of lysosomal storage disorders","volume":"281","author":"Meikle","year":"1999","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170522140100_DDT052C40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1067\/mpd.2002.122394","article-title":"Inborn errors of metabolism in the Italian pediatric population: a national retrospective survey","volume":"140","author":"Dionisi-Vici","year":"2002","journal-title":"J. Pediatr."},{"key":"key\n\t\t\t\t20170522140100_DDT052C41","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cca.2005.07.022","article-title":"Blood oxidative stress markers in Gaucher disease patients","volume":"364","author":"Roversi","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"key\n\t\t\t\t20170522140100_DDT052C42","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ymgme.2010.06.018","article-title":"Oxidative stress in Niemann\u2013Pick disease, type C","volume":"101","author":"Fu","year":"2010","journal-title":"Mol. Genet. Metab."},{"key":"key\n\t\t\t\t20170522140100_DDT052C43","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4161\/auto.19469","article-title":"Autophagy in lysosomal storage disorders","volume":"8","author":"Lieberman","year":"2012","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20170522140100_DDT052C44","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1111\/j.1471-4159.2005.03534.x","article-title":"Defective calcium homeostasis in the cerebellum in a mouse model of Niemann\u2013Pick A disease","volume":"95","author":"Ginzburg","year":"2005","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522140100_DDT052C45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ceca.2007.12.005","article-title":"Mitochondrial Ca2+ homeostasis in lysosomal storage diseases","volume":"44","author":"Kiselyov","year":"2008","journal-title":"Cell Calcium"},{"key":"key\n\t\t\t\t20170522140100_DDT052C46","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/hmg\/ddm324","article-title":"ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones","volume":"17","author":"Wei","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522140100_DDT052C47","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(95)91688-1","article-title":"Gaucher's disease variant characterised by progressive calcification of heart valves and unique genotype","volume":"346","author":"Abrahamov","year":"1995","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170522140100_DDT052C48","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s00018-002-8458-y","article-title":"Gaucher disease: Perspectives on a prototype lysosomal disease","volume":"59","author":"Zhao","year":"2002","journal-title":"Cell Mol. Life Sci."},{"key":"key\n\t\t\t\t20170522140100_DDT052C49","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.genom.4.070802.110415","article-title":"Enzyme therapy for lysosomal storage disease: principles, practice, and prospects","volume":"4","author":"Grabowski","year":"2003","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"key\n\t\t\t\t20170522140100_DDT052C50","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2165\/00003495-200767180-00005","article-title":"Treatment of lysosomal storage disorders: progress with enzyme replacement therapy","volume":"67","author":"Rohrbach","year":"2007","journal-title":"Drugs"},{"key":"key\n\t\t\t\t20170522140100_DDT052C51","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev-genom-090711-163739","article-title":"Enzyme replacement therapy for lysosomal diseases: lessons from 20 years of experience and remaining challenges","volume":"13","author":"Desnick","year":"2012","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"key\n\t\t\t\t20170522140100_DDT052C52","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1371\/journal.pmed.0010021","article-title":"Enzyme replacement in Gaucher disease","volume":"1","author":"Beutler","year":"2004","journal-title":"PLoS Med."},{"key":"key\n\t\t\t\t20170522140100_DDT052C53","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1067\/mpd.2001.112171","article-title":"The efficacy of enzyme replacement therapy in patients with chronic neuronopathic Gaucher's disease","volume":"138","author":"Altarescu","year":"2001","journal-title":"J. Pediatr."},{"key":"key\n\t\t\t\t20170522140100_DDT052C54","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF00710053","article-title":"Neuropsychological outcomes of several storage diseases with and without bone marrow transplantation","volume":"18","author":"Shapiro","year":"1995","journal-title":"J. Inherit Metab. Dis."},{"key":"key\n\t\t\t\t20170522140100_DDT052C55","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00062752-199911000-00004","article-title":"Bone marrow transplantation for globoid cell leukodystrophy, adrenoleukodystrophy, metachromatic leukodystrophy, and Hurler syndrome","volume":"6","author":"Krivit","year":"1999","journal-title":"Curr. Opin. Hematol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C56","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00019052-199904000-00007","article-title":"Bone marrow transplantation as effective treatment of central nervous system disease in globoid cell leukodystrophy, metachromatic leukodystrophy, adrenoleukodystrophy, mannosidosis, fucosidosis, aspartylglucosaminuria, Hurler, Maroteaux-Lamy, and Sly syndromes, and Gaucher disease type III","volume":"12","author":"Krivit","year":"1999","journal-title":"Curr. Opin. Neurol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C57","first-page":"359","article-title":"Stem cell bone marrow transplantation in patients with metabolic storage diseases","volume":"49","author":"Krivit","year":"2002","journal-title":"Adv. Pediatr."},{"key":"key\n\t\t\t\t20170522140100_DDT052C58","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.2174\/138161211797247578","article-title":"Gene therapy for lysosomal storage diseases: progress, challenges and future prospects","volume":"17","author":"Seregin","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"key\n\t\t\t\t20170522140100_DDT052C59","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ymthe.2006.01.006","article-title":"Gene therapy for lysosomal storage diseases","volume":"13","author":"Sands","year":"2006","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20170522140100_DDT052C60","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1056\/NEJM198703053161002","article-title":"A mutation in the human glucocerebrosidase gene in neuronopathic Gaucher's disease","volume":"316","author":"Tsuji","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170522140100_DDT052C61","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1073\/pnas.85.7.2349","article-title":"Genetic heterogeneity in type 1 Gaucher disease: multiple genotypes in Ashkenazic and non-Ashkenazic individuals","volume":"85","author":"Tsuji","year":"1988","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522140100_DDT052C62","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.bi.60.070191.001353","article-title":"Lysosomal storage diseases","volume":"60","author":"Neufeld","year":"1991","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20170522140100_DDT052C63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0925-4439(94)00075-2","article-title":"Lysosomal storage diseases","volume":"1270","author":"Gieselmann","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522140100_DDT052C64","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004499","article-title":"Emergent properties of proteostasis in managing cystic fibrosis","volume":"3","author":"Balch","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C65","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention","volume":"319","author":"Balch","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522140100_DDT052C66","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.4161\/cc.8.24.10263","article-title":"Lysosomal enhancement: a CLEAR answer to cellular degradative needs","volume":"8","author":"Sardiello","year":"2009","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170522140100_DDT052C67","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4161\/auto.18658","article-title":"Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death","volume":"8","author":"Ma","year":"2012","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20170522140100_DDT052C68","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003799","article-title":"PGC-1\u03b1 rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function","volume":"4","author":"Tsunemi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"key\n\t\t\t\t20170522140100_DDT052C69","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1128\/MCB.00930-12","article-title":"Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-beta precursor protein","volume":"32","author":"Parr","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522140100_DDT052C70","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10059-012-0042-1","article-title":"Status of mTOR activity may phenotypically differentiate senescence and quiescence","volume":"33","author":"Cho","year":"2012","journal-title":"Mol. Cells"},{"key":"key\n\t\t\t\t20170522140100_DDT052C71","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/386779a0","article-title":"Nucleocytoplasmic transport: signals, mechanisms and regulation","volume":"386","author":"Nigg","year":"1997","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522140100_DDT052C72","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0898-6568(00)00077-2","article-title":"Nuclear targeting of proteins: how many different signals","volume":"12","author":"Christophe","year":"2000","journal-title":"Cell Signal."},{"key":"key\n\t\t\t\t20170522140100_DDT052C73","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2008","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20170522140100_DDT052C74","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/22\/10\/1994\/17258327\/ddt052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T02:46:01Z","timestamp":1644288361000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddt052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":74,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,2,7]]},"published-print":{"date-parts":[[2013,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddt052","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2,7]]}}}