{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:38:59Z","timestamp":1791344339914,"version":"4.3.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,15]]},"DOI":"10.1093\/hmg\/ddt097","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T23:27:17Z","timestamp":1362094037000},"page":"2451-2461","source":"Crossref","is-referenced-by-count":17,"title":["Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest"],"prefix":"10.1093","volume":"22","author":[{"given":"Emily A.","family":"Nizialek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charissa","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Mester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinn","family":"Downes-Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charis","family":"Eng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,27]]},"reference":[{"key":"key\n\t\t\t\t20170503072342_DDT097C1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"key\n\t\t\t\t20170503072342_DDT097C2","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.1038\/sj.onc.1209870","article-title":"Modifiers of risk of hereditary breast cancer","volume":"25","author":"Narod","year":"2006","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170503072342_DDT097C3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng.2007.53","article-title":"The emerging landscape of breast cancer susceptibility","volume":"40","author":"Stratton","year":"2008","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/B:BREA.0000003871.38587.8b","article-title":"Familial breast cancer: scope for more susceptibility genes?","volume":"82","author":"Hemminki","year":"2003","journal-title":"Breast Cancer Res. Treat."},{"key":"key\n\t\t\t\t20170503072342_DDT097C5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrc2037","article-title":"Cancer phenomics: RET and PTEN as illustrative models","volume":"7","author":"Zbuk","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170503072342_DDT097C6","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1038\/sj.onc.1209879","article-title":"Models of genetic susceptibility to breast cancer","volume":"25","author":"Antoniou","year":"2006","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170503072342_DDT097C7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1470-2045(11)70076-6","article-title":"Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence","volume":"12","author":"Zhang","year":"2011","journal-title":"Lancet Oncol."},{"key":"key\n\t\t\t\t20170503072342_DDT097C8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1158\/1078-0432.CCR-11-2283","article-title":"Lifetime cancer risks in individuals with germline PTEN mutations","volume":"18","author":"Tan","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20170503072342_DDT097C9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ajhg.2010.11.013","article-title":"A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands","volume":"88","author":"Tan","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ng0597-64","article-title":"Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome","volume":"16","author":"Liaw","year":"1997","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C11","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1073\/pnas.0705410105","article-title":"Killin is a p53-regulated nuclear inhibitor of DNA synthesis","volume":"105","author":"Cho","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503072342_DDT097C12","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1001\/jama.2010.1877","article-title":"Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome","volume":"304","author":"Bennett","year":"2010","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170503072342_DDT097C13","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/gcc.20887","article-title":"Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma","volume":"50","author":"Bennett","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"key\n\t\t\t\t20170503072342_DDT097C14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/msb.2011.14","article-title":"Determinants of translation efficiency and accuracy","volume":"7","author":"Gingold","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"key\n\t\t\t\t20170503072342_DDT097C15","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/nar\/28.1.292","article-title":"Codon usage tabulated from international DNA sequence databases: status for the year 2000","volume":"28","author":"Nakamura","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170503072342_DDT097C16","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/jnci\/djg050","article-title":"Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer","volume":"95","author":"Foulkes","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"key\n\t\t\t\t20170503072342_DDT097C17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1470-2045(07)70074-8","article-title":"Triple-negative breast cancer: therapeutic options","volume":"8","author":"Cleator","year":"2007","journal-title":"Lancet Oncol."},{"key":"key\n\t\t\t\t20170503072342_DDT097C18","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature08516","article-title":"Origins and functional impact of copy number variation in the human genome","volume":"464","author":"Conrad","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503072342_DDT097C19","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ng.238","article-title":"Integrated detection and population-genetic analysis of SNPs and copy number variation","volume":"40","author":"McCarroll","year":"2008","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.gde.2010.03.005","article-title":"Germline copy number variation and cancer risk","volume":"20","author":"Kuiper","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20170503072342_DDT097C21","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1053\/j.gastro.2010.08.063","article-title":"Germline epigenetic silencing of the tumor suppressor gene PTPRJ in early-onset familial colorectal cancer","volume":"139","author":"Venkatachalam","year":"2010","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170503072342_DDT097C22","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10549-012-2088-3","article-title":"Analysis of KLLN as a high-penetrance breast cancer predisposition gene","volume":"134","author":"Thompson","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"key\n\t\t\t\t20170503072342_DDT097C23","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1093\/emboj\/17.16.4657","article-title":"Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation","volume":"17","author":"Venkatachalam","year":"1998","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170503072342_DDT097C24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/hmg\/ddg055","article-title":"Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor","volume":"12","author":"Duan","year":"2003","journal-title":"Human Mol. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C25","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1186\/gb-2005-6-9-r75","article-title":"Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals","volume":"6","author":"Chamary","year":"2005","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20170503072342_DDT097C26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ng837","article-title":"BRCA1 regulates the G2\/M checkpoint by activating Chk1 kinase upon DNA damage","volume":"30","author":"Yarden","year":"2002","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C27","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1101\/gad.14.12.1448","article-title":"Chk1 is an essential kinase that is regulated by Atr and required for the G(2)\/M DNA damage checkpoint","volume":"14","author":"Liu","year":"2000","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170503072342_DDT097C28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1535-6108(03)00110-7","article-title":"Chk1 and Chk2 kinases in checkpoint control and cancer","volume":"3","author":"Bartek","year":"2003","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20170503072342_DDT097C29","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/hmg\/10.7.715","article-title":"\u2018Other\u2019 breast cancer susceptibility genes: searching for more holy grail","volume":"10","author":"Nathanson","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C30","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/nar\/26.1.362","article-title":"Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL","volume":"26","author":"Heinemeyer","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170503072342_DDT097C31","volume-title":"Current Protocols in Bioinformatics.","author":"Schug","year":"2002"},{"key":"key\n\t\t\t\t20170503072342_DDT097C32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/35099076","article-title":"The ETS-domain transcription factor family","volume":"2","author":"Sharrocks","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170503072342_DDT097C33","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1159\/000086981","article-title":"Reduced expression of PTEN protein and its prognostic implications in invasive ductal carcinoma of the breast","volume":"68","author":"Tsutsui","year":"2005","journal-title":"Oncology"},{"key":"key\n\t\t\t\t20170503072342_DDT097C34","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0002-9440(10)65227-3","article-title":"Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast","volume":"155","author":"Perren","year":"1999","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170503072342_DDT097C35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cell.2008.04.013","article-title":"Tenets of PTEN tumor suppression","volume":"133","author":"Salmena","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170503072342_DDT097C36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1124\/mi.11.2.11","article-title":"CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle","volume":"11","author":"Dent","year":"2011","journal-title":"Mol. Interv."},{"key":"key\n\t\t\t\t20170503072342_DDT097C37","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1172\/JCI58765","article-title":"Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models","volume":"122","author":"Ma","year":"2012","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170503072342_DDT097C38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","author":"TCGA Network","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503072342_DDT097C39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature11154","article-title":"Sequence analysis of mutations and translocations across breast cancer subtypes","volume":"486","author":"Banerji","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503072342_DDT097C40","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1126\/science.1145720","article-title":"The genomic landscapes of human breast and colorectal cancers","volume":"318","author":"Wood","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20170503072342_DDT097C41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s10549-011-1846-y","article-title":"Basal-like breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival","volume":"133","author":"Weigman","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"key\n\t\t\t\t20170503072342_DDT097C42","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10983","article-title":"The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups","volume":"486","author":"Curtis","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503072342_DDT097C43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1471-2407-6-92","article-title":"Genomic alterations identified by array comparative genomic hybridization as prognostic markers in tamoxifen-treated estrogen receptor-positive breast cancer","volume":"6","author":"Han","year":"2006","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20170503072342_DDT097C44","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/sj.bjc.6690115","article-title":"Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma","volume":"79","author":"Feilotter","year":"1999","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20170503072342_DDT097C45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1023\/A:1006273516976","article-title":"Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype","volume":"57","author":"Garcia","year":"1999","journal-title":"Breast Cancer Res. Treat."},{"key":"key\n\t\t\t\t20170503072342_DDT097C46","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ajhg.2008.07.011","article-title":"Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes","volume":"83","author":"Ni","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C47","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1158\/0008-5472.CAN-06-0772","article-title":"p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction","volume":"66","author":"Tang","year":"2006","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170503072342_DDT097C48","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/hmg\/ddq434","article-title":"Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53","volume":"20","author":"He","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503072342_DDT097C49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1517\/14622416.6.3.303","article-title":"Use of CEPH and non-CEPH lymphoblast cell lines in pharmacogenetic studies","volume":"6","author":"Shukla","year":"2005","journal-title":"Pharmacogenomics"},{"key":"key\n\t\t\t\t20170503072342_DDT097C50","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/sj.onc.1204177","article-title":"Cdc25-dependent activation of cyclin A\/cdk2 is blocked in G2 phase arrested cells independently of ATM\/ATR","volume":"20","author":"Goldstone","year":"2001","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170503072342_DDT097C51","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"key\n\t\t\t\t20170503072342_DDT097C52","doi-asserted-by":"crossref","first-page":"20007","DOI":"10.1073\/pnas.0710052104","article-title":"Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma","volume":"104","author":"Beroukhim","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503072342_DDT097C53","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/22\/12\/2451\/14139513\/ddt097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T18:25:20Z","timestamp":1644431120000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddt097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,27]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,2,27]]},"published-print":{"date-parts":[[2013,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddt097","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2,27]]}}}