{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T02:28:01Z","timestamp":1779157681698,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,15]]},"DOI":"10.1093\/hmg\/ddt176","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:33:55Z","timestamp":1366245235000},"page":"3227-3238","source":"Crossref","is-referenced-by-count":26,"title":["Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy"],"prefix":"10.1093","volume":"22","author":[{"given":"Jong-Min","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina I.","family":"Galkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Levantovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Fossale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Anne Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayalakshmi","family":"Srinidhi Mysore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn R.","family":"Coser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshi","family":"Shioda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Furia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Derry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac S.","family":"Kohane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihn Sik","family":"Seong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa C.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Gusella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcy E.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"key\n\t\t\t\t20170522152536_DDT176C1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","author":"HDCRG","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522152536_DDT176C2","first-page":"320","article-title":"On chorea","volume":"26","author":"Huntington","year":"1872","journal-title":"Med. Surg. Rep."},{"key":"key\n\t\t\t\t20170522152536_DDT176C3","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1136\/jnnp.47.12.1283","article-title":"Increased rate of suicide among patients with Huntington's disease","volume":"47","author":"Schoenfeld","year":"1984","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"key\n\t\t\t\t20170522152536_DDT176C4","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/ajmg.a.32901","article-title":"Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG)","volume":"149A","author":"Hendricks","year":"2009","journal-title":"Am. J. Med. Genet. A."},{"key":"key\n\t\t\t\t20170522152536_DDT176C5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","article-title":"A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length","volume":"65","author":"Langbehn","year":"2004","journal-title":"Clin. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C6","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/mds.21820","article-title":"Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats","volume":"23","author":"Semaka","year":"2008","journal-title":"Mov. Disord."},{"key":"key\n\t\t\t\t20170522152536_DDT176C7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng0893-398","article-title":"The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease","volume":"4","author":"Andrew","year":"1993","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ng0893-387","article-title":"Trinucleotide repeat length instability and age of onset in Huntington's disease","volume":"4","author":"Duyao","year":"1993","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/nbdi.1994.0019","article-title":"Huntington's disease CAG trinucleotide repeats in pathologically confirmed post-mortem brains","volume":"1","author":"Persichetti","year":"1994","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522152536_DDT176C10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng0893-393","article-title":"Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease","volume":"4","author":"Snell","year":"1993","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C11","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1212\/WNL.0b013e318249f683","article-title":"CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion","volume":"78","author":"Lee","year":"2012","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522152536_DDT176C12","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1093\/hmg\/ddi319","article-title":"HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism","volume":"14","author":"Seong","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/hmg\/ddp524","article-title":"Huntingtin facilitates polycomb repressive complex 2","volume":"19","author":"Seong","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmbi.2001.4624","article-title":"Comparison of ARM and HEAT protein repeats","volume":"309","author":"Andrade","year":"2001","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170522152536_DDT176C15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2202-3-15","article-title":"The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB\/Rel\/dorsal family transcription factor","volume":"3","author":"Takano","year":"2002","journal-title":"BMC Neurosci."},{"key":"key\n\t\t\t\t20170522152536_DDT176C16","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1073\/pnas.0504921102","article-title":"Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease","volume":"102","author":"Borovecki","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522152536_DDT176C17","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1093\/hmg\/ddr355","article-title":"Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative","volume":"20","author":"Fossale","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C18","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington's disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C19","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/hmg\/ddm133","article-title":"Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage","volume":"16","author":"Kuhn","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C20","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C21","doi-asserted-by":"crossref","first-page":"14424","DOI":"10.1073\/pnas.0703652104","article-title":"Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood","volume":"104","author":"Runne","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522152536_DDT176C22","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1523\/JNEUROSCI.2461-07.2007","article-title":"Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration","volume":"27","author":"Strand","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522152536_DDT176C23","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1093\/hmg\/ddr195","article-title":"HD CAG-correlated gene expression changes support a simple dominant gain of function","volume":"20","author":"Jacobsen","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF02257483","article-title":"Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat","volume":"20","author":"Ambrose","year":"1994","journal-title":"Somat. Cell Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C25","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/hmg\/2.10.1541","article-title":"Differential 3\u2019 polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression","volume":"2","author":"Lin","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/cem.887","article-title":"Mean squared error of prediction (MSEP) estimates for principal component regression (PCR) and partial least squares regression (PLSR)","volume":"18","author":"Mevik","year":"2004","journal-title":"J Chemometr"},{"key":"key\n\t\t\t\t20170522152536_DDT176C27","doi-asserted-by":"crossref","first-page":"13544","DOI":"10.1073\/pnas.0506577102","article-title":"Discovering statistically significant pathways in expression profiling studies","volume":"102","author":"Tian","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522152536_DDT176C28","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature06758","article-title":"Genetics of gene expression and its effect on disease","volume":"452","author":"Emilsson","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522152536_DDT176C29","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.copbio.2005.10.005","article-title":"Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits","volume":"16","author":"Schadt","year":"2005","journal-title":"Curr. Opin. Biotechnol."},{"key":"key\n\t\t\t\t20170522152536_DDT176C30","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/ng1589","article-title":"An integrative genomics approach to infer causal associations between gene expression and disease","volume":"37","author":"Schadt","year":"2005","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C31","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1093\/hmg\/11.17.1927","article-title":"Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1471-2350-7-71","article-title":"Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study","volume":"7","author":"Li","year":"2006","journal-title":"BMC Med. Genet."},{"key":"key\n\t\t\t\t20170522152536_DDT176C33","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","article-title":"Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset","volume":"101","author":"Wexler","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522152536_DDT176C34","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1176\/appi.ajp.2009.09070973","article-title":"Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder","volume":"167","author":"Perlis","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"key\n\t\t\t\t20170522152536_DDT176C35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/mcpr.1993.1034","article-title":"A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes","volume":"7","author":"Warner","year":"1993","journal-title":"Mol. Cell. Probes"},{"key":"key\n\t\t\t\t20170522152536_DDT176C36","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"key\n\t\t\t\t20170522152536_DDT176C37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/22\/16\/3227\/17259385\/ddt176.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T04:40:58Z","timestamp":1503463258000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddt176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,16]]},"references-count":37,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2013,4,16]]},"published-print":{"date-parts":[[2013,8,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddt176","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4,16]]}}}