{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:25:23Z","timestamp":1791059123697,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"DOI":"10.1093\/hmg\/ddt191","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:54:42Z","timestamp":1368060882000},"page":"3415-3424","source":"Crossref","is-referenced-by-count":55,"title":["Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation"],"prefix":"10.1093","volume":"22","author":[{"given":"Faraz","family":"Farooq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Abad\u00eda-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"MacKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah","family":"Hadwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Shamim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Holcik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"MacKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"key\n\t\t\t\t20170522150602_DDT191C1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1750-1172-6-71","article-title":"Spinal muscular atrophy","volume":"6","author":"D'Amico","year":"2011","journal-title":"Orphanet. J. Rare Dis."},{"key":"key\n\t\t\t\t20170522150602_DDT191C2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ejhg.2011.134","article-title":"Pan-ethnic carrier screening and prenatal diagnosis for spinal muscular atrophy: clinical laboratory analysis of >72,400 specimens","volume":"20","author":"Sugarman","year":"2012","journal-title":"Eur. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522150602_DDT191C4","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","author":"Lorson","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522150602_DDT191C5","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","article-title":"A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2","volume":"8","author":"Monani","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C6","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1093\/hmg\/ddp352","article-title":"p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR","volume":"18","author":"Farooq","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-5793(00)02084-6","article-title":"Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade","volume":"483","author":"Brook","year":"2000","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170522150602_DDT191C8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1074\/jbc.274.1.264","article-title":"p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes","volume":"274","author":"Dean","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522150602_DDT191C9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/MCB.23.2.425-436.2003","article-title":"p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts","volume":"23","author":"Frevel","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522150602_DDT191C10","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1074\/jbc.M005486200","article-title":"Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts","volume":"276","author":"Rutault","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522150602_DDT191C11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s000110050499","article-title":"Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase","volume":"48","author":"Wang","year":"1999","journal-title":"Inflamm. Res."},{"key":"key\n\t\t\t\t20170522150602_DDT191C12","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1242\/jcs.111.21.3145","article-title":"ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation","volume":"111","author":"Atasoy","year":"1998","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170522150602_DDT191C13","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1261\/rna.501707","article-title":"FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1","volume":"13","author":"David","year":"2007","journal-title":"RNA (New York, NY)"},{"key":"key\n\t\t\t\t20170522150602_DDT191C14","doi-asserted-by":"crossref","first-page":"15293","DOI":"10.1073\/pnas.95.26.15293","article-title":"HNS, a nuclear-cytoplasmic shuttling sequence in HuR","volume":"95","author":"Fan","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522150602_DDT191C15","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/emboj\/17.12.3448","article-title":"Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs","volume":"17","author":"Fan","year":"1998","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170522150602_DDT191C16","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1128\/MCB.00210-09","article-title":"p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)\/S checkpoint","volume":"29","author":"Lafarga","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522150602_DDT191C17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.taap.2007.04.007","article-title":"Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells","volume":"222","author":"Hsiao","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170522150602_DDT191C18","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/CAD.0b013e32833dada8","article-title":"Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines","volume":"21","author":"Park","year":"2010","journal-title":"Anti-Cancer Drugs"},{"key":"key\n\t\t\t\t20170522150602_DDT191C19","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.bbrc.2006.08.075","article-title":"Differential effect of celecoxib on tissue factor expression in human endothelial and vascular smooth muscle cells","volume":"349","author":"Steffel","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522150602_DDT191C20","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/hmg\/ddi078","article-title":"SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN","volume":"14","author":"Le","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C21","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1093\/hmg\/ddq147","article-title":"Spinal muscular atrophy: mechanisms and therapeutic strategies","volume":"19","author":"Lorson","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C22","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/carcin\/bgh076","article-title":"Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin","volume":"25","author":"Chun","year":"2004","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170522150602_DDT191C23","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1016\/j.bmcl.2005.05.107","article-title":"The molecular basis for coxib inhibition of p38alpha MAP kinase","volume":"15","author":"Sperandio da Silva","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"key\n\t\t\t\t20170522150602_DDT191C24","first-page":"213","article-title":"Selective COX-2 inhibitor regulates the MAP kinase signaling pathway in human osteoarthritic chondrocytes after induction of nitric oxide","volume":"15","author":"Takahashi","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"key\n\t\t\t\t20170522150602_DDT191C25","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1172\/JCI46276","article-title":"Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway","volume":"121","author":"Farooq","year":"2011","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170522150602_DDT191C26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1741-7015-7-14","article-title":"Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy","volume":"7","author":"Millino","year":"2009","journal-title":"BMC Med."},{"key":"key\n\t\t\t\t20170522150602_DDT191C27","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1523\/JNEUROSCI.5775-11.2012","article-title":"Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction","volume":"32","author":"Gogliotti","year":"2012","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522150602_DDT191C28","doi-asserted-by":"crossref","first-page":"8703","DOI":"10.1523\/JNEUROSCI.0204-12.2012","article-title":"Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy","volume":"32","author":"Martinez","year":"2012","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522150602_DDT191C29","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/hmg\/ddm379","article-title":"Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect","volume":"17","author":"Gavrilina","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C30","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1172\/JCI29562","article-title":"Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy","volume":"117","author":"Avila","year":"2007","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170522150602_DDT191C31","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/hmg\/ddq023","article-title":"SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy","volume":"19","author":"Riessland","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature10485","article-title":"Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model","volume":"478","author":"Hua","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522150602_DDT191C33","doi-asserted-by":"crossref","first-page":"7633","DOI":"10.1523\/JNEUROSCI.0950-09.2009","article-title":"Oligonucleotide-mediated survival of motor neuron protein expression in CNS improves phenotype in a mouse model of spinal muscular atrophy","volume":"29","author":"Williams","year":"2009","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522150602_DDT191C34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nbt.1610","article-title":"Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN","volume":"28","author":"Foust","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20170522150602_DDT191C35","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/hmg\/ddq514","article-title":"Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice","volume":"20","author":"Dominguez","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C36","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI41615","article-title":"CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy","volume":"120","author":"Passini","year":"2010","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170522150602_DDT191C37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1126\/scitranslmed.3000830","article-title":"Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy","volume":"2","author":"Valori","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"key\n\t\t\t\t20170522150602_DDT191C38","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJMcibr1114629","article-title":"Sense in antisense therapy for spinal muscular atrophy","volume":"366","author":"MacKenzie","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170522150602_DDT191C39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nbt0310-235","article-title":"Genetic therapy for spinal muscular atrophy","volume":"28","author":"MacKenzie","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20170522150602_DDT191C40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2165\/00003088-200038030-00003","article-title":"Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor","volume":"38","author":"Davies","year":"2000","journal-title":"Clin. Pharmacokinet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mrfmmm.2007.09.003","article-title":"Dose-dependent reduction of 3,2\u2032-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib","volume":"638","author":"Ravoori","year":"2008","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170522150602_DDT191C42","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3109\/01480540903575691","article-title":"Pathological and biochemical effects of therapeutic and supratherapeutic doses of celecoxib in Wistar albino male rats","volume":"33","author":"Kockaya","year":"2010","journal-title":"Drug Chem. Toxicol."},{"key":"key\n\t\t\t\t20170522150602_DDT191C43","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1172\/JCI57291","article-title":"Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy","volume":"121","author":"Lutz","year":"2011","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170522150602_DDT191C44","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/hmg\/ddq021","article-title":"Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model","volume":"19","author":"Bowerman","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522150602_DDT191C45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1741-7015-10-24","article-title":"Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy","volume":"10","author":"Bowerman","year":"2012","journal-title":"BMC Med."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/22\/17\/3415\/17259372\/ddt191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T14:43:15Z","timestamp":1645022595000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddt191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,7]]},"references-count":45,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2013,5,7]]},"published-print":{"date-parts":[[2013,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddt191","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,7]]}}}