{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:26:53Z","timestamp":1790792813676,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"DOI":"10.1093\/hmg\/ddt522","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T05:37:59Z","timestamp":1382506679000},"page":"1320-1332","source":"Crossref","is-referenced-by-count":64,"title":["Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation\u2013differentiation balance early in life and optic nerve degeneration at old age"],"prefix":"10.1093","volume":"23","author":[{"given":"Adriana I.","family":"Iglesias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri\u00ebt","family":"Springelkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herma","family":"van der Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lies-Anne","family":"Severijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najaf","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Oostra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel E. M.","family":"Kockx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam C. G. N.","family":"van den Hout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred F. J.","family":"van IJcken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 G.","family":"Uitterlinden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob M.","family":"Verdijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline C. W.","family":"Klaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Willemsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M.","family":"van Duijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"key\n\t\t\t\t20170503074055_DDT522C1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMra0804630","article-title":"Primary open-angle glaucoma","volume":"360","author":"Kwon","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170503074055_DDT522C2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/jmg.2010.083337","article-title":"Genetic architecture of open angle glaucoma and related determinants","volume":"48","author":"Ramdas","year":"2011","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1001\/archophthalmol.2010.373","article-title":"Lifestyle and risk of developing open-angle glaucoma: the Rotterdam study","volume":"129","author":"Ramdas","year":"2011","journal-title":"Arch. Ophthalmol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C4","doi-asserted-by":"crossref","first-page":"6875","DOI":"10.1167\/iovs.11-7376","article-title":"Ocular perfusion pressure and the incidence of glaucoma: real effect or artifact? The Rotterdam Study","volume":"52","author":"Ramdas","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170503074055_DDT522C5","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archopht.116.12.1640","article-title":"Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study","volume":"116","author":"Wolfs","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/archopht.1975.01010020670002","article-title":"Size of the physiologic cup of the optic nerve head. hereditary and environmental factors","volume":"93","author":"Schwartz","year":"1975","journal-title":"Arch. Ophthalmol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C7","doi-asserted-by":"crossref","first-page":"e55573","DOI":"10.1371\/journal.pone.0055573","article-title":"The heritability of glaucoma-related traits corneal hysteresis, central corneal thickness, intraocular pressure, and choroidal blood flow pulsatility","volume":"8","author":"Freeman","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170503074055_DDT522C8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1167\/iovs.03-0516","article-title":"Heritability of risk factors for primary open-angle glaucoma: the Beaver Dam Eye Study","volume":"45","author":"Klein","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170503074055_DDT522C9","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1167\/iovs.06-1519","article-title":"Genetic contributions to glaucoma: heritability of intraocular pressure, retinal nerve fiber layer thickness, and optic disc morphology","volume":"48","author":"van Koolwijk","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170503074055_DDT522C10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170503074055_DDT522C11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170503074055_DDT522C12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/hmg\/ddi068","article-title":"Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1","volume":"14","author":"Monemi","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C13","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1093\/hmg\/ddr382","article-title":"Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA","volume":"20","author":"Wiggs","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C14","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng.661","article-title":"Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma","volume":"42","author":"Thorleifsson","year":"2010","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/ng.824","article-title":"Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1","volume":"43","author":"Burdon","year":"2011","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C16","doi-asserted-by":"crossref","first-page":"e1000978","DOI":"10.1371\/journal.pgen.1000978","article-title":"A genome-wide association study of optic disc parameters","volume":"6","author":"Ramdas","year":"2010","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C17","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1093\/hmg\/ddr120","article-title":"Common genetic variants associated with open-angle glaucoma","volume":"20","author":"Ramdas","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C18","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1242\/dev.128.13.2497","article-title":"Math5 is required for retinal ganglion cell and optic nerve formation","volume":"128","author":"Brown","year":"2001","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503074055_DDT522C19","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1242\/dev.085886","article-title":"Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7","volume":"140","author":"Mao","year":"2013","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503074055_DDT522C20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/WNR.0b013e328355f260","article-title":"Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis","volume":"23","author":"Prasov","year":"2012","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t20170503074055_DDT522C21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0925-4773(99)00068-4","article-title":"Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary\/hypothalamic axis and the ventral optic stalk","volume":"84","author":"Jean","year":"1999","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t20170503074055_DDT522C22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/geno.1999.5916","article-title":"Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies","volume":"61","author":"Gallardo","year":"1999","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170503074055_DDT522C23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/geno.1996.0172","article-title":"Cloning of the human SIX1 gene and its assignment to chromosome 14","volume":"33","author":"Boucher","year":"1996","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170503074055_DDT522C24","doi-asserted-by":"crossref","first-page":"19033","DOI":"10.1074\/jbc.M011491200","article-title":"Pax3 is essential for skeletal myogenesis and the expression of Six1 and Eya2","volume":"276","author":"Ridgeway","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503074055_DDT522C25","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/genetics\/138.4.1137","article-title":"Sine oculis is a homeobox gene required for Drosophila visual system development","volume":"138","author":"Serikaku","year":"1994","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170503074055_DDT522C26","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1242\/dev.121.12.4045","article-title":"Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development","volume":"121","author":"Oliver","year":"1995","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503074055_DDT522C27","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1167\/iovs.10-6339","article-title":"Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population","volume":"52","author":"Fan","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170503074055_DDT522C28","doi-asserted-by":"crossref","first-page":"e39278","DOI":"10.1371\/journal.pone.0039278","article-title":"CDKN2B polymorphism is associated with primary open-angle glaucoma (POAG) in the Afro-Caribbean population of Barbados, West Indies","volume":"7","author":"Cao","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170503074055_DDT522C29","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ajo.2012.07.023","article-title":"CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States","volume":"155","author":"Pasquale","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C30","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1093\/hmg\/dds103","article-title":"A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma","volume":"21","author":"Osman","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C31","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.ophtha.2012.02.004","article-title":"Glaucoma risk alleles at CDKN2B-AS1 are associated with lower intraocular pressure, normal-tension glaucoma, and advanced glaucoma","volume":"119","author":"Burdon","year":"2012","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20170503074055_DDT522C32","doi-asserted-by":"crossref","first-page":"e33389","DOI":"10.1371\/journal.pone.0033389","article-title":"Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese","volume":"7","author":"Nakano","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170503074055_DDT522C33","doi-asserted-by":"crossref","first-page":"e1002654","DOI":"10.1371\/journal.pgen.1002654","article-title":"Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma","volume":"8","author":"Wiggs","year":"2012","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C34","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nature06084","article-title":"p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a","volume":"448","author":"Krimpenfort","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503074055_DDT522C35","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1126\/science.1073263","article-title":"Tissue-specific regulation of retinal and pituitary precursor cell proliferation","volume":"297","author":"Li","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170503074055_DDT522C36","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20170503074055_DDT522C37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nmeth0410-250","article-title":"Single-nucleotide evolutionary constraint scores highlight disease-causing mutations","volume":"7","author":"Cooper","year":"2010","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20170503074055_DDT522C38","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"Consortium","year":"2013","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.exer.2013.03.004","article-title":"Exon-level expression profiling of ocular tissues","volume":"111","author":"Wagner","year":"2013","journal-title":"Exp. Eye Res."},{"key":"key\n\t\t\t\t20170503074055_DDT522C40","doi-asserted-by":"crossref","first-page":"e1001310","DOI":"10.1371\/journal.pgen.1001310","article-title":"Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma","volume":"7","author":"Veth","year":"2011","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C41","doi-asserted-by":"crossref","first-page":"10643","DOI":"10.1073\/pnas.95.18.10643","article-title":"The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes","volume":"95","author":"Toy","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"key\n\t\t\t\t20170503074055_DDT522C42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0925-4773(99)00017-9","article-title":"Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development","volume":"83","author":"Lopez-Rios","year":"1999","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t20170503074055_DDT522C43","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ygeno.2005.03.002","article-title":"Expression analysis of SIX3 and SIX6 in human tissues reveals differences in expression and a novel correlation between the expression of SIX3 and the genes encoding isocitrate dehyhrogenase and cadherin 18","volume":"86","author":"Aijaz","year":"2005","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170503074055_DDT522C44","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0925-4773(99)00270-1","article-title":"Cloning and expression of xSix3, the Xenopus homologue of murine Six3","volume":"91","author":"Zhou","year":"2000","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t20170503074055_DDT522C45","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/dvdy.1148","article-title":"Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos","volume":"221","author":"Lagutin","year":"2001","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170503074055_DDT522C46","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1242\/dev.129.17.4057","article-title":"Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye","volume":"129","author":"Carl","year":"2002","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503074055_DDT522C47","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1387\/ijdb.041879ma","article-title":"Retinal stem cells in vertebrates: parallels and divergences","volume":"48","author":"Amato","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C48","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-213X-6-36","article-title":"Molecular characterization of retinal stem cells and their niches in adult zebrafish","volume":"6","author":"Raymond","year":"2006","journal-title":"BMC Dev. Biol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C49","first-page":"951","article-title":"The Tg(ccnb1:EGFP) transgenic zebrafish line labels proliferating cells during retinal development and regeneration","volume":"14","author":"Kassen","year":"2008","journal-title":"Mol. Vis."},{"key":"key\n\t\t\t\t20170503074055_DDT522C50","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ajmg.a.30126","article-title":"Analysis of the developmental SIX6 homeobox gene in patients with anophthalmia\/microphthalmia","volume":"129A","author":"Gallardo","year":"2004","journal-title":"Am. J. Med. Genet. A"},{"key":"key\n\t\t\t\t20170503074055_DDT522C51","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1167\/iovs.04-0641","article-title":"Absence of SIX6 mutations in microphthalmia, anophthalmia, and coloboma","volume":"45","author":"Aijaz","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170503074055_DDT522C52","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0092-8674(00)81963-7","article-title":"Giant eyes in Xenopus laevis by overexpression of XOptx2","volume":"98","author":"Zuber","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170503074055_DDT522C53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrg2091","article-title":"Animal models of human disease: zebrafish swim into view","volume":"8","author":"Lieschke","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1601-183X.2003.00053.x","article-title":"Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish?","volume":"3","author":"Guo","year":"2004","journal-title":"Genes Brain Behav."},{"key":"key\n\t\t\t\t20170503074055_DDT522C55","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1242\/dev.123.1.263","article-title":"Mutations affecting development of the zebrafish retina","volume":"123","author":"Malicki","year":"1996","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503074055_DDT522C56","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/neu.10165","article-title":"Behavioral genetic approaches to visual system development and function in zebrafish","volume":"54","author":"Neuhauss","year":"2003","journal-title":"J. Neurobiol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.123.1.1","article-title":"The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio","volume":"123","author":"Haffter","year":"1996","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503074055_DDT522C58","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0896-6273(94)90308-5","article-title":"The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system","volume":"12","author":"Cheyette","year":"1994","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170503074055_DDT522C59","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1242\/dev.125.15.2973","article-title":"Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish","volume":"125","author":"Kobayashi","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503074055_DDT522C60","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1101\/gad.13.6.649","article-title":"Six3 overexpression initiates the formation of ectopic retina","volume":"13","author":"Loosli","year":"1999","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170503074055_DDT522C61","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0925-4773(00)00271-9","article-title":"Expanded retina territory by midbrain transformation upon overexpression of Six6 (Optx2) in Xenopus embryos","volume":"93","author":"Bernier","year":"2000","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t20170503074055_DDT522C62","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature02292","article-title":"Direct interaction of geminin and Six3 in eye development","volume":"427","author":"Del Bene","year":"2004","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503074055_DDT522C63","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1242\/dev.00185","article-title":"Six3 and Six6 activity is modulated by members of the groucho family","volume":"130","author":"Lopez-Rios","year":"2003","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503074055_DDT522C64","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ajo.2012.04.023","article-title":"Genetic investigation into the endophenotypic status of central corneal thickness and optic disc parameters in relation to open-angle glaucoma","volume":"154","author":"Dimasi","year":"2012","journal-title":"Am. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C65","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/371257a0","article-title":"p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest","volume":"371","author":"Hannon","year":"1994","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503074055_DDT522C66","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/stem.461","article-title":"Characterization of drCol 15a1b: a novel component of the stem cell niche in the zebrafish retina","volume":"28","author":"Gonzalez-Nunez","year":"2010","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20170503074055_DDT522C67","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.042308.113259","article-title":"From progenitors to differentiated cells in the vertebrate retina","volume":"25","author":"Agathocleous","year":"2009","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C68","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10654-011-9610-5","article-title":"The Rotterdam Study: 2012 objectives and design update","volume":"26","author":"Hofman","year":"2011","journal-title":"Eur. J. Epidemiol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C69","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/sj.ejhg.5201188","article-title":"Linkage disequilibrium in young genetically isolated Dutch population","volume":"12","author":"Aulchenko","year":"2004","journal-title":"Eur. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C70","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1046\/J.1469-1809.2005.00162.x","article-title":"The effect of genetic drift in a young genetically isolated population","volume":"69","author":"Pardo","year":"2005","journal-title":"Ann. Hum. Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C71","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF01664929","article-title":"Measurement variability in digital analysis of optic discs","volume":"85","author":"Rolando","year":"1994","journal-title":"Doc. Ophthalmol."},{"key":"key\n\t\t\t\t20170503074055_DDT522C72","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0161-6420(94)31090-6","article-title":"The prevalence of primary open-angle glaucoma in a population-based study in The Netherlands. The Rotterdam Study","volume":"101","author":"Dielemans","year":"1994","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20170503074055_DDT522C73","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ophtha.2010.01.034","article-title":"Incidence of glaucomatous visual field loss: a ten-year follow-up from the Rotterdam Study","volume":"117","author":"Czudowska","year":"2010","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20170503074055_DDT522C74","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170503074055_DDT522C75","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/bioinformatics\/btr613","article-title":"NARWHAL, a primary analysis pipeline for NGS data","volume":"28","author":"Brouwer","year":"2012","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170503074055_DDT522C76","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170503074055_DDT522C77","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170503074055_DDT522C78","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1101\/gr.073585.107","article-title":"EnsemblCompara GeneTrees: complete, duplication-aware phylogenetic trees in vertebrates","volume":"19","author":"Vilella","year":"2009","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170503074055_DDT522C79","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1371\/journal.pgen.0030078","article-title":"p53 activation by knockdown technologies","volume":"3","author":"Robu","year":"2007","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170503074055_DDT522C80","doi-asserted-by":"crossref","first-page":"W71","DOI":"10.1093\/nar\/gkm306","article-title":"Primer3Plus, an enhanced web interface to Primer3","volume":"35","author":"Untergasser","year":"2007","journal-title":"Nucleic Acid Res."},{"key":"key\n\t\t\t\t20170503074055_DDT522C81","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1242\/dev.128.20.3877","article-title":"Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant","volume":"128","author":"van de Water","year":"2001","journal-title":"Development"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/23\/5\/1320\/14142472\/ddt522.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T03:12:03Z","timestamp":1646881923000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddt522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,22]]},"references-count":81,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,10,22]]},"published-print":{"date-parts":[[2014,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddt522","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10,22]]}}}