{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:16:33Z","timestamp":1791227793171,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"DOI":"10.1093\/hmg\/ddu066","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T03:54:57Z","timestamp":1392782097000},"page":"3552-3565","source":"Crossref","is-referenced-by-count":39,"title":["Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy"],"prefix":"10.1093","volume":"23","author":[{"given":"Genki","family":"Tohnai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohide","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakatsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Ohtsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"key\n\t\t\t\t20170829063355_DDU066C1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrg1690","article-title":"Therapeutics development for triplet repeat expansion diseases","volume":"6","author":"Di Prospero","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170829063355_DDU066C2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2990.2007.00830.x","article-title":"Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy","volume":"33","author":"Adachi","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"key\n\t\t\t\t20170829063355_DDU066C3","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/brain\/awh381","article-title":"Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients","volume":"128","author":"Adachi","year":"2005","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170829063355_DDU066C4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/brain\/112.1.209","article-title":"X-linked recessive bulbospinal neuronopathy. A clinicopathological study","volume":"112","author":"Sobue","year":"1989","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170829063355_DDU066C5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jns.2007.08.012","article-title":"Spinal and bulbar muscular atrophy: skeletal muscle pathology in male patients and heterozygous females","volume":"264","author":"Soraru","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"key\n\t\t\t\t20170829063355_DDU066C6","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/brain\/awl096","article-title":"Natural history of spinal and bulbar muscular atrophy (SBMA): a study of 223 Japanese patients","volume":"129","author":"Atsuta","year":"2006","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170829063355_DDU066C7","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1093\/brain\/awp258","article-title":"Clinical features of spinal and bulbar muscular atrophy","volume":"132","author":"Rhodes","year":"2009","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170829063355_DDU066C8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.molcel.2010.10.001","article-title":"Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms","volume":"40","author":"Buchberger","year":"2010","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170829063355_DDU066C9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3109\/02656730903315823","article-title":"Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications","volume":"25","author":"Adachi","year":"2009","journal-title":"Int. J. Hyperthermia"},{"key":"key\n\t\t\t\t20170829063355_DDU066C10","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1172\/JCI57413","article-title":"Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease","volume":"121","author":"Labbadia","year":"2011","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170829063355_DDU066C11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/hmg\/11.5.515","article-title":"Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy","volume":"11","author":"Bailey","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170829063355_DDU066C12","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1111\/j.1742-4658.2010.07737.x","article-title":"CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates","volume":"277","author":"Stankiewicz","year":"2010","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20170829063355_DDU066C13","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170829063355_DDU066C14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170829063355_DDU066C15","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t20170829063355_DDU066C16","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1379\/CSC-51R.1","article-title":"Paeoniflorin, a novel heat shock protein-inducing compound","volume":"9","author":"Yan","year":"2004","journal-title":"Cell Stress Chaperones"},{"key":"key\n\t\t\t\t20170829063355_DDU066C17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainres.2011.04.011","article-title":"ASICs mediate the modulatory effect by paeoniflorin on alpha-synuclein autophagic degradation","volume":"1396","author":"Sun","year":"2011","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170829063355_DDU066C18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/10409238.2011.628970","article-title":"NF-Y and the transcriptional activation of CCAAT promoters","volume":"47","author":"Dolfini","year":"2012","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"key\n\t\t\t\t20170829063355_DDU066C19","doi-asserted-by":"crossref","first-page":"e35302","DOI":"10.1371\/journal.pone.0035302","article-title":"Role of the CCAAT-binding protein NFY in SCA17 pathogenesis","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170829063355_DDU066C20","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/hmg\/11.17.1967","article-title":"Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor","volume":"11","author":"Lieberman","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170829063355_DDU066C21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0896-6273(02)00834-6","article-title":"Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy","volume":"35","author":"Katsuno","year":"2002","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170829063355_DDU066C22","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms2417","article-title":"Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration","volume":"4","author":"Kondo","year":"2013","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20170829063355_DDU066C23","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1523\/JNEUROSCI.4522-06.2007","article-title":"The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes","volume":"27","author":"Tagawa","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170829063355_DDU066C24","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1474-4422(10)70182-4","article-title":"Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"9","author":"Katsuno","year":"2010","journal-title":"Lancet Neurol."},{"key":"key\n\t\t\t\t20170829063355_DDU066C25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1474-4422(10)70321-5","article-title":"Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial","volume":"10","author":"Fernandez-Rhodes","year":"2011","journal-title":"Lancet Neurol."},{"key":"key\n\t\t\t\t20170829063355_DDU066C26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.yfrne.2011.06.003","article-title":"Neurotoxic effects of androgens in spinal and bulbar muscular atrophy","volume":"32","author":"Parodi","year":"2011","journal-title":"Front. Neuroendocrinol."},{"key":"key\n\t\t\t\t20170829063355_DDU066C27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00401-010-0703-0","article-title":"Neurotoxic protein oligomerisation associated with polyglutamine diseases","volume":"120","author":"Hands","year":"2010","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170829063355_DDU066C28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/jb\/mvp119","article-title":"Molecular pathogenesis of protein misfolding diseases: pathological molecular environments versus quality control systems against misfolded proteins","volume":"146","author":"Naiki","year":"2009","journal-title":"J. Biochem."},{"key":"key\n\t\t\t\t20170829063355_DDU066C29","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1471-4159.2009.06302.x","article-title":"The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies","volume":"110","author":"Bauer","year":"2009","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170829063355_DDU066C30","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1523\/JNEUROSCI.23-06-02203.2003","article-title":"Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein","volume":"23","author":"Adachi","year":"2003","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170829063355_DDU066C31","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nm878","article-title":"Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy","volume":"9","author":"Katsuno","year":"2003","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170829063355_DDU066C32","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nm1298","article-title":"17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration","volume":"11","author":"Waza","year":"2005","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170829063355_DDU066C33","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nm1547","article-title":"ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor","volume":"13","author":"Yang","year":"2007","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170829063355_DDU066C34","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/nm.2791","article-title":"Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2","volume":"18","author":"Miyazaki","year":"2012","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170829063355_DDU066C35","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2119\/molmed.2012.00271","article-title":"Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy","volume":"18","author":"Rinaldi","year":"2012","journal-title":"Mol. Med."},{"key":"key\n\t\t\t\t20170829063355_DDU066C36","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1523\/JNEUROSCI.0388-10.2010","article-title":"Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy","volume":"30","author":"Katsuno","year":"2010","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170829063355_DDU066C37","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/emboj.2008.23","article-title":"Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor","volume":"27","author":"Yamanaka","year":"2008","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170829063355_DDU066C38","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1093\/brain\/awr146","article-title":"Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor","volume":"134","author":"Huang","year":"2011","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170829063355_DDU066C39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio.1140","article-title":"Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation","volume":"9","author":"Wang","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"key\n\t\t\t\t20170829063355_DDU066C40","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/hmg\/10.14.1511","article-title":"Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice","volume":"10","author":"Cummings","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170829063355_DDU066C41","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/brain\/aws022","article-title":"Suppression of protein aggregation by chaperone modification of high molecular weight complexes","volume":"135","author":"Labbadia","year":"2012","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170829063355_DDU066C42","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/brain\/aws343","article-title":"Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy","volume":"136","author":"Malik","year":"2013","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170829063355_DDU066C43","doi-asserted-by":"crossref","first-page":"e51069","DOI":"10.1371\/journal.pone.0051069","article-title":"Hsp40 gene therapy exerts therapeutic effects on polyglutamine disease mice via a non-cell autonomous mechanism","volume":"7","author":"Popiel","year":"2012","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170829063355_DDU066C44","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/embo-reports\/kve246","article-title":"CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein","volume":"2","author":"Murata","year":"2001","journal-title":"EMBO Rep."},{"key":"key\n\t\t\t\t20170829063355_DDU066C45","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1523\/JNEUROSCI.3001-05.2005","article-title":"CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo","volume":"25","author":"Miller","year":"2005","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170829063355_DDU066C46","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.1242-07.2007","article-title":"CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model","volume":"27","author":"Adachi","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170829063355_DDU066C47","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1093\/hmg\/ddp115","article-title":"Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy","volume":"18","author":"Montie","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170829063355_DDU066C48","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1523\/JNEUROSCI.3021-12.2013","article-title":"p62\/SQSTM1 differentially removes thetoxic mutant androgen receptor via autophagy and inclusionformation in a spinal and bulbar muscular atrophy mouse model","volume":"33","author":"Doi","year":"2013","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170829063355_DDU066C49","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1093\/hmg\/ddt052","article-title":"TFEB regulates lysosomal proteostasis","volume":"22","author":"Song","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170829063355_DDU066C50","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","article-title":"Transcriptional activation of lysosomal exocytosis promotes cellular clearance","volume":"21","author":"Medina","year":"2011","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20170829063355_DDU066C51","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1128\/MCB.00930-12","article-title":"Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-beta precursor protein","volume":"32","author":"Parr","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170829063355_DDU066C52","doi-asserted-by":"crossref","first-page":"142ra197","DOI":"10.1126\/scitranslmed.3003799","article-title":"PGC-1alpha rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function","volume":"4","author":"Tsunemi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"key\n\t\t\t\t20170829063355_DDU066C53","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1093\/hmg\/ddt527","article-title":"Transcriptional activation of TFEB\/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy","volume":"23","author":"Chua","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170829063355_DDU066C54","article-title":"Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy","author":"Tanaka","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170829063355_DDU066C55","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/hmg\/10.10.1039","article-title":"Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death","volume":"10","author":"Adachi","year":"2001","journal-title":"Hum. Mol. Genet."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/23\/13\/3552\/19638259\/ddu066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T19:15:40Z","timestamp":1565205340000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/23\/13\/3552\/661078\/Paeoniflorin-eliminates-a-mutant-AR-via"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,18]]},"references-count":55,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2014,2,18]]},"published-print":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddu066","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,18]]}}}