{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:20:31Z","timestamp":1773037231117,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"DOI":"10.1093\/hmg\/ddu233","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:37:34Z","timestamp":1400200654000},"page":"5102-5108","source":"Crossref","is-referenced-by-count":32,"title":["In vitro screen of prion disease susceptibility genes using the scrapie cell assay"],"prefix":"10.1093","volume":"23","author":[{"given":"Craig A.","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Poulter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hummerich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter-C.","family":"Kl\u00f6hn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parmjit","family":"Jat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Mead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Collinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"key\n\t\t\t\t20170522160340_DDU233C1","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/0140-6736(91)93128-V","article-title":"Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease","volume":"337","year":"1991","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170522160340_DDU233C2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/352340a0","article-title":"Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease","volume":"352","year":"1991","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522160340_DDU233C3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1083320","article-title":"Balancing selection at the prion protein gene consistent with prehistoric kuru-like epidemics","volume":"300","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522160340_DDU233C4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1474-4422(08)70265-5","article-title":"Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study","volume":"8","year":"2009","journal-title":"Lancet Neurol."},{"key":"key\n\t\t\t\t20170522160340_DDU233C5","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1093\/hmg\/ddr607","article-title":"Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP","volume":"21","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522160340_DDU233C6","first-page":"1487.e21","article-title":"Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk","volume":"33","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170522160340_DDU233C7","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1073\/pnas.101130398","article-title":"Identification of multiple quantitative trait loci linked to prion disease incubation period in mice","volume":"98","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522160340_DDU233C8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10048-002-0133-9","article-title":"Identification of genetic loci affecting mouse-adapted bovine spongiform encephalopathy incubation time in mice","volume":"4","year":"2002","journal-title":"Neurogenetics"},{"key":"key\n\t\t\t\t20170522160340_DDU233C9","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.1073\/pnas.121172098","article-title":"Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice","volume":"98","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522160340_DDU233C10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/geno.2000.6320","article-title":"Quantitative trait loci affecting prion incubation time in mice","volume":"69","year":"2000","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170522160340_DDU233C11","doi-asserted-by":"crossref","first-page":"13722","DOI":"10.1073\/pnas.1208917109","article-title":"Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice","volume":"109","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522160340_DDU233C12","doi-asserted-by":"crossref","first-page":"11666","DOI":"10.1073\/pnas.1834432100","article-title":"A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions","volume":"100","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522160340_DDU233C13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ncomms1282","article-title":"Rapid cell-surface prion protein conversion revealed using a novel cell system","volume":"2","year":"2011","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20170522160340_DDU233C14","first-page":"1897","article-title":"Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP","volume":"21","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522160340_DDU233C15","doi-asserted-by":"crossref","first-page":"e1000383","DOI":"10.1371\/journal.pgen.1000383","article-title":"HECTD2 is associated with susceptibility to mouse and human prion disease","volume":"5","year":"2009","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170522160340_DDU233C16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10048-009-0219-8","article-title":"A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse","volume":"11","year":"2010","journal-title":"Neurogenetics"},{"key":"key\n\t\t\t\t20170522160340_DDU233C17","doi-asserted-by":"crossref","first-page":"e54454","DOI":"10.1371\/journal.pone.0054454","article-title":"Sod1 deficiency reduces incubation time in mouse models of prion disease","volume":"8","year":"2013","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170522160340_DDU233C18","doi-asserted-by":"crossref","first-page":"e15019","DOI":"10.1371\/journal.pone.0015019","article-title":"The retinoic Acid receptor Beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse","volume":"5","year":"2010","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170522160340_DDU233C19","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1099\/vir.0.2008\/001255-0","article-title":"Genes contributing to prion pathogenesis","volume":"89","year":"2008","journal-title":"J. Gen. Virol."},{"key":"key\n\t\t\t\t20170522160340_DDU233C20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4161\/pri.5.1.14460","article-title":"Plasminogen: a cellular protein cofactor for PrP (Sc) propagation","volume":"5","year":"2011","journal-title":"Prion"},{"key":"key\n\t\t\t\t20170522160340_DDU233C21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-2836(03)00342-5","article-title":"Cooperative binding of dominant-negative prion protein to kringle domains","volume":"329","year":"2003","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170522160340_DDU233C22","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1128\/JVI.79.17.11225-11230.2005","article-title":"Role of plasminogen in propagation of scrapie","volume":"79","year":"2005","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170522160340_DDU233C23","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0092-8674(93)90360-3","article-title":"Mice devoid of PrP are resistant to scrapie","volume":"73","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522160340_DDU233C24","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/j.1460-2075.1996.tb00467.x","article-title":"Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie","volume":"15","year":"1996","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170522160340_DDU233C25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0092-8674(89)90608-9","article-title":"Transgenic mice expressing hamster prion protein produce species- specific scrapie infectivity and amyloid plaques","volume":"59","year":"1989","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522160340_DDU233C26","doi-asserted-by":"crossref","first-page":"9295","DOI":"10.1073\/pnas.151242598","article-title":"Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody","volume":"98","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522160340_DDU233C27","doi-asserted-by":"crossref","first-page":"14242","DOI":"10.1074\/jbc.M802257200","article-title":"Down-regulation of CIBZ, a novel substrate of caspase-3, induces apoptosis","volume":"283","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522160340_DDU233C28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ana.22308","article-title":"SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk","volume":"69","year":"2011","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522160340_DDU233C29","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/jnr.10353","article-title":"SCG10-related neuronal growth-associated proteins in neural development, plasticity, degeneration, and aging","volume":"70","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"key\n\t\t\t\t20170522160340_DDU233C30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0167-4781(99)00080-9","article-title":"Biochemical analysis of mouse FKBP60, a novel member of the FKPB family","volume":"1446","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522160340_DDU233C31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12035-011-8184-2","article-title":"Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration","volume":"44","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"key\n\t\t\t\t20170522160340_DDU233C32","doi-asserted-by":"crossref","first-page":"26687","DOI":"10.1074\/jbc.M110.182303","article-title":"Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-Synuclein aggregation","volume":"286","year":"2011","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522160340_DDU233C33","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/j.1600-0854.2008.00748.x","article-title":"Arp11 affects dynein-dynactin interaction and is essential for dynein function in Aspergillus nidulans","volume":"9","year":"2008","journal-title":"Traffic"},{"key":"key\n\t\t\t\t20170522160340_DDU233C34","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1138718","article-title":"A general model of prion strains and their pathogenicity","volume":"318","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522160340_DDU233C35","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1126\/science.1131864","article-title":"Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host","volume":"313","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522160340_DDU233C36","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nm1746","article-title":"Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation","volume":"14","year":"2008","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522160340_DDU233C37","article-title":"Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293 T cell-based systems","year":"2001","journal-title":"Curr. Protoc. Immunol."},{"key":"key\n\t\t\t\t20170522160340_DDU233C38","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/brain\/awl076","article-title":"Phenotypic heterogeneity in inherited prion disease (P102L) is associated with differential propagation of protease-resistant wild-type and mutant prion protein","volume":"129","year":"2006","journal-title":"Brain"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T14:20:19Z","timestamp":1565446819000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddu233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":38,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2014,5,15]]},"published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddu233","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]}}}