{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:15:40Z","timestamp":1791357340866,"version":"4.3.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"DOI":"10.1093\/hmg\/ddu238","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:37:34Z","timestamp":1400200654000},"page":"5147-5158","source":"Crossref","is-referenced-by-count":40,"title":["TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons"],"prefix":"10.1093","volume":"23","author":[{"given":"Linh","family":"Ngo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilda","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengdong","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan Shan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Zenker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen Sue Lyn","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Margaret","family":"Gunnersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Breuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Habgood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Anthony","family":"Keays","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian Ik-Tsen","family":"Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"key\n\t\t\t\t20170522152757_DDU238C1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2006.12.021","article-title":"Trekking across the brain: the journey of neuronal migration","volume":"128","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522152757_DDU238C2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tins.2009.09.003","article-title":"Molecular layers underlying cytoskeletal remodelling during cortical development","volume":"33","year":"2010","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.tins.2006.05.006","article-title":"The multipolar stage and disruptions in neuronal migration","volume":"29","year":"2006","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0079-6123(02)36008-4","article-title":"The origin and migration of cortical neurons","volume":"136","year":"2002","journal-title":"Prog. Brain Res."},{"key":"key\n\t\t\t\t20170522152757_DDU238C5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.neuro.31.060407.125536","article-title":"Establishment of axon-dendrite polarity in developing neurons","volume":"32","year":"2009","journal-title":"Annu. Rev. Neurosci"},{"key":"key\n\t\t\t\t20170522152757_DDU238C6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.neuro.25.112701.142932","article-title":"Molecular control of cortical dendrite development","volume":"25","year":"2002","journal-title":"Annu. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tcb.2009.03.009","article-title":"Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones","volume":"19","year":"2009","journal-title":"Trends Cell. Biol."},{"key":"key\n\t\t\t\t20170522152757_DDU238C8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1042\/BSR20100025","article-title":"Distinct alpha- and beta-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the \u2018multi-tubulin\u2019 hypothesis","volume":"30","year":"2010","journal-title":"Biosci. Rep."},{"key":"key\n\t\t\t\t20170522152757_DDU238C9","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/brain\/aws338","article-title":"Overlapping cortical malformations and mutations in TUBB2B and TUBA1A","volume":"136","year":"2013","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522152757_DDU238C10","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/ng.380","article-title":"Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria","volume":"41","year":"2009","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522152757_DDU238C11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2006.12.017","article-title":"Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans","volume":"128","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522152757_DDU238C12","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1093\/hmg\/ddq377","article-title":"Mutations in the neuronal ss-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defects","volume":"19","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152757_DDU238C13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cell.2009.12.011","article-title":"Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance","volume":"140","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522152757_DDU238C14","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ajhg.2014.03.009","article-title":"De novo mutations in the beta-tubulin gene TUBB2A cause simplified gyral patterning and infantile-onset epilepsy","volume":"94","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522152757_DDU238C15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/humu.20572","article-title":"Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A)","volume":"28","year":"2007","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20170522152757_DDU238C16","first-page":"1516","article-title":"Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown","volume":"23","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20170522152757_DDU238C17","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.celrep.2012.11.017","article-title":"Mutations in the beta-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities","volume":"2","year":"2012","journal-title":"Cell Rep."},{"key":"key\n\t\t\t\t20170522152757_DDU238C18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn1172","article-title":"Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases","volume":"7","year":"2004","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neuron.2005.08.032","article-title":"Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex","volume":"48","year":"2005","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522152757_DDU238C20","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1242\/dev.01209","article-title":"HGF regulates the development of cortical pyramidal dendrites","volume":"131","year":"2004","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522152757_DDU238C21","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/nn927","article-title":"BDNF release from single cells elicits local dendritic growth in nearby neurons","volume":"5","year":"2002","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C22","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/35104061","article-title":"Dendritic spines: structure, dynamics and regulation","volume":"2","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C23","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1523\/JNEUROSCI.23-07-02655.2003","article-title":"Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein)","volume":"23","year":"2003","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C24","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/hmg\/ddq276","article-title":"Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway","volume":"19","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152757_DDU238C25","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.tins.2004.05.001","article-title":"Patterns of neuronal migration in the embryonic cortex","volume":"27","year":"2004","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C26","doi-asserted-by":"crossref","first-page":"15726","DOI":"10.1523\/JNEUROSCI.1510-13.2013","article-title":"Zebrafish embryonic neurons transport messenger RNA to axons and growth cones in vivo","volume":"33","year":"2013","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C27","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1523\/JNEUROSCI.20-11-04165.2000","article-title":"Insulin-like growth factor I stimulates dendritic growth in primary somatosensory cortex","volume":"20","year":"2000","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/82900","article-title":"Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy","volume":"4","year":"2001","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrn3482","article-title":"Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction","volume":"14","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C30","doi-asserted-by":"crossref","first-page":"12120","DOI":"10.1523\/JNEUROSCI.2509-08.2008","article-title":"Microtubules in dendritic spine development","volume":"28","year":"2008","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C31","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1523\/JNEUROSCI.3074-08.2008","article-title":"Activity-dependent dynamic microtubule invasion of dendritic spines","volume":"28","year":"2008","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522152757_DDU238C32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuron.2008.11.013","article-title":"Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity","volume":"61","year":"2009","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522152757_DDU238C33","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1126\/science.283.5409.1931","article-title":"The role of local actin instability in axon formation","volume":"283","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522152757_DDU238C34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.200707042","article-title":"Microtubule stabilization specifies initial neuronal polarization","volume":"180","year":"2008","journal-title":"J. Cell. Biol."},{"key":"key\n\t\t\t\t20170522152757_DDU238C35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0896-6273(00)80777-1","article-title":"Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons","volume":"23","year":"1999","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522152757_DDU238C36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0896-6273(00)80778-3","article-title":"Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons","volume":"23","year":"1999","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522152757_DDU238C37","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/hmg\/8.9.1599","article-title":"Doublecortin, a stabilizer of microtubules","volume":"8","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152757_DDU238C38","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11011","article-title":"Patterns and rates of exonic de novo mutations in autism spectrum disorders","volume":"485","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522152757_DDU238C39","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09146","article-title":"Functional impact of global rare copy number variation in autism spectrum disorders","volume":"466","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522152757_DDU238C40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature07198","article-title":"Neurogenin 2 controls cortical neuron migration through regulation of Rnd2","volume":"455","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522152757_DDU238C41","article-title":"Ndfip1 Is Required for the Development of Pyramidal Neuron Dendrites and Spines in the Neocortex","year":"2013","journal-title":"Cereb. Cortex"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T14:20:20Z","timestamp":1565446820000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddu238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":41,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2014,5,15]]},"published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddu238","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]}}}