{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:25:35Z","timestamp":1789410335699,"version":"build-2803163510"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"DOI":"10.1093\/hmg\/ddu274","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T04:35:21Z","timestamp":1401856521000},"page":"5597-5614","source":"Crossref","is-referenced-by-count":67,"title":["Peroxidasin is essential for eye development in the mouse"],"prefix":"10.1093","volume":"23","author":[{"given":"Xiaohe","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Sabrautzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Horsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gailus-Durner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Beckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hrab\u011b de Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Graw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,3]]},"reference":[{"key":"key\n\t\t\t\t20170522134313_DDU274C1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/ICO.0b013e31820cd2ab","article-title":"Clinical features of anterior segment dysgenesis associated with congenital corneal opacities","volume":"31","year":"2012","journal-title":"Cornea"},{"key":"key\n\t\t\t\t20170522134313_DDU274C2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/ICU.0b013e328349412b","article-title":"Genetics of anterior segment dysgenesis disorders","volume":"22","year":"2011","journal-title":"Curr. Opin. Ophthalmol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ana.21191","article-title":"COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and stroke","volume":"62","year":"2007","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C4","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ajo.2012.11.028","article-title":"Variants of anterior segment dysgenesis and cerebral involvement in a large family with a novel COL4A1 mutation","volume":"155","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C5","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1096\/fj.04-3019com","article-title":"Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye","volume":"19","year":"2005","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170522134313_DDU274C6","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ajhg.2011.08.005","article-title":"Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma","volume":"89","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522134313_DDU274C7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/dvdy.20226","article-title":"Xenopus tropicalis peroxidasin gene is expressed within the developing neural tube and pronephric kidney","volume":"232","year":"2005","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522134313_DDU274C8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gep.2008.09.004","article-title":"Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo","volume":"9","year":"2009","journal-title":"Gene Expr. Patterns"},{"key":"key\n\t\t\t\t20170522134313_DDU274C9","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1006\/bbrc.1999.1123","article-title":"Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene","volume":"261","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522134313_DDU274C10","first-page":"6448","article-title":"A novel melanoma gene (MG50) encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes","volume":"60","year":"2000","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170522134313_DDU274C11","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.freeradbiomed.2008.09.009","article-title":"Identification and characterization of VPO1, a new animal heme-containing peroxidase","volume":"45","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170522134313_DDU274C12","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1002\/j.1460-2075.1994.tb06649.x","article-title":"Peroxidasin: a novel enzyme-matrix protein of Drosophila development","volume":"13","year":"1994","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170522134313_DDU274C13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2353\/ajpath.2009.080693","article-title":"Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney","volume":"175","year":"2009","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C14","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1242\/dev.049189","article-title":"The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration","volume":"137","year":"2010","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522134313_DDU274C15","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nchembio.1038","article-title":"Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis","volume":"8","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C16","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1128\/IAI.06337-11","article-title":"Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acid","volume":"80","year":"2012","journal-title":"Infect. Immun."},{"key":"key\n\t\t\t\t20170522134313_DDU274C17","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.freeradbiomed.2011.07.004","article-title":"Role of VPO1, a newly identified heme-containing peroxidase, in ox-LDL induced endothelial cell apoptosis","volume":"51","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170522134313_DDU274C18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tcm.2012.11.002","article-title":"Vascular peroxidase 1: a novel enzyme in promoting oxidative stress in cardiovascular system","volume":"23","year":"2013","journal-title":"Trends Cardiovasc. Med."},{"key":"key\n\t\t\t\t20170522134313_DDU274C19","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/78146","article-title":"Genome-wide, large-scale production of mutant mice by ENU mutagenesis","volume":"25","year":"2000","journal-title":"Nat, Genet."},{"key":"key\n\t\t\t\t20170522134313_DDU274C20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00335-012-9415-1","article-title":"Innovations in phenotyping of mouse models in the German Mouse Clinic","volume":"23","year":"2012","journal-title":"Mamm. Genome"},{"key":"key\n\t\t\t\t20170522134313_DDU274C21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ydbio.2006.09.021","article-title":"Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage","volume":"302","year":"2007","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C22","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0012-1606(87)90227-2","article-title":"Differential regulation of gamma-crystallin genes during mouse lens development","volume":"119","year":"1987","journal-title":"Dev Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C23","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1242\/dev.128.24.5075","article-title":"FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1\/2) signalling","volume":"128","year":"2001","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522134313_DDU274C24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-2443.1996.11011.x","article-title":"The master control gene for morphogenesis and evolution of the eye","volume":"1","year":"1996","journal-title":"Genes Cells"},{"key":"key\n\t\t\t\t20170522134313_DDU274C25","first-page":"343","article-title":"Eye development","volume":"90C","year":"2010","journal-title":"Curr. Top. Dev. Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.preteyeres.2012.04.002","article-title":"Pax6: a multi-level regulator of ocular development","volume":"31","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"key\n\t\t\t\t20170522134313_DDU274C27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/gad.14.2.245","article-title":"A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle","volume":"14","year":"2000","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522134313_DDU274C28","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.1128\/MCB.25.20.8854-8863.2005","article-title":"Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice","volume":"25","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1387\/ijdb.130193jg","article-title":"Pitx3 directly regulates Foxe3 during early lens development","volume":"57","year":"2013","journal-title":"Int. J. Dev. Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0945-053X(02)00014-8","article-title":"Collagen IV in the developing lens capsule","volume":"21","year":"2002","journal-title":"Matrix Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0092-8674(00)80078-1","article-title":"Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities","volume":"86","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522134313_DDU274C32","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/dvdy.21528","article-title":"PAX6 dosage effects on corneal development, growth, and wound healing","volume":"237","year":"2008","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522134313_DDU274C33","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1167\/iovs.10-6726","article-title":"Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation","volume":"52","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522134313_DDU274C34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-213X-8-59","article-title":"Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance","volume":"8","year":"2008","journal-title":"BMC Dev. Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C35","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/dbio.2000.9699","article-title":"Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor","volume":"222","year":"2000","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C36","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1242\/dev.000117","article-title":"Foxe view of lens development and disease","volume":"134","year":"2007","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522134313_DDU274C37","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.exer.2006.01.022","article-title":"Focus on molecules: FoxE3","volume":"84","year":"2007","journal-title":"Exp. Eye Res."},{"key":"key\n\t\t\t\t20170522134313_DDU274C38","first-page":"145","article-title":"Collagen IV mRNA expression during development of the mouse retina: an in situ hybridization study","volume":"34","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522134313_DDU274C39","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1167\/iovs.04-1419","article-title":"Embryonic synthesis of the inner limiting membrane and vitreous body","volume":"46","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522134313_DDU274C40","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1093\/hmg\/ddi348","article-title":"Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy","volume":"14","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522134313_DDU274C41","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1534\/genetics.106.064733","article-title":"Type IV procollagen missense mutations associated with defects of the eye, vascular stability, the brain, kidney function and embryonic or postnatal viability in the mouse, Mus musculus: an extension of the Col4a1 allelic series and the identification of the first two Col4a2 mutant alleles","volume":"175","year":"2007","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170522134313_DDU274C42","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/hmg\/ddm024","article-title":"Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis","volume":"16","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522134313_DDU274C43","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/hmg\/ddt560","article-title":"Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations","volume":"23","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522134313_DDU274C44","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1126\/science.1109418","article-title":"Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly","volume":"308","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522134313_DDU274C45","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMoa053727","article-title":"Role of COL4A1 in small-vessel disease and hemorrhagic stroke","volume":"354","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170522134313_DDU274C46","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/ana.22682","article-title":"COL4A1 mutations in patients with sporadic late-onset intracerebral hemorrhage","volume":"71","year":"2012","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ajhg.2011.11.022","article-title":"COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke","volume":"90","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522134313_DDU274C48","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1050-1738(96)00110-7","article-title":"Pax3, neural crest and cardiovascular development","volume":"6","year":"1996","journal-title":"Trends Cardiovasc. Med."},{"key":"key\n\t\t\t\t20170522134313_DDU274C49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0070-2153(10)90010-0","article-title":"Eye development","volume":"90","year":"2010","journal-title":"Curr. Top. Dev. Biol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1089\/jop.1989.5.353","article-title":"Prevention of lens protein-induced ocular inflammation with cyclooxygenase and lipoxygenase inhibitors","volume":"5","year":"1989","journal-title":"J. Ocul. Pharmacol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/jop.1992.8.309","article-title":"Inhibitory effect of tetrandrine on lens proteins-induced ocular inflammation in rabbits","volume":"8","year":"1992","journal-title":"J. Ocul. Pharmacol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C52","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","year":"2011","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170522134313_DDU274C53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0027-5107(85)90136-8","article-title":"Induction of gene mutations in mice: the multiple endpoint approach","volume":"150","year":"1985","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170522134313_DDU274C54","doi-asserted-by":"crossref","first-page":"W496","DOI":"10.1093\/nar\/gki430","article-title":"ARTS: a web-based tool for the set-up of high-throughput genome-wide mapping panels for the SNP genotyping of mouse mutants","volume":"33","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170522134313_DDU274C55","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170522134313_DDU274C56","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1167\/iovs.04-1407","article-title":"Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promotors","volume":"46","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522134313_DDU274C57","doi-asserted-by":"crossref","first-page":"16690","DOI":"10.1074\/jbc.M113.463315","article-title":"High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner","volume":"288","year":"2013","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522134313_DDU274C58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0076-6879(06)11009-5","article-title":"TM4 microarray software suite","volume":"411","year":"2006","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170522134313_DDU274C59","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522134313_DDU274C60","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/pmic.200700725","article-title":"Systematic gene expression profiling of mouse model series reveals coexpressed genes","volume":"8","year":"2008","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20170522134313_DDU274C61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","year":"2002","journal-title":"Nucleic Acids Res."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T21:43:53Z","timestamp":1649195033000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddu274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,3]]},"references-count":61,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2014,6,3]]},"published-print":{"date-parts":[[2014,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddu274","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,3]]}}}