{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:21:39Z","timestamp":1768681299651,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,20]]},"DOI":"10.1093\/hmg\/ddu398","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T02:57:16Z","timestamp":1406861836000},"page":"6927-6934","source":"Crossref","is-referenced-by-count":44,"title":["A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis"],"prefix":"10.1093","volume":"23","author":[{"given":"Antonio","family":"Juli\u00e0","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugeni","family":"Dom\u00e8nech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Chaparro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valle","family":"Garc\u00eda-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Gomoll\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"Pan\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00edriam","family":"Ma\u00f1osa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Barreiro-De Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Garcia-Planella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Aguas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Esteve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan L.","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fcl","family":"Tortosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"L\u00f3pez-Lasanta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnald","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep L.","family":"Gelp\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres C.","family":"Garc\u00eda-Montero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Bertranpetit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin","family":"Absher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier P.","family":"Gisbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Marsal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,7,31]]},"reference":[{"key":"key\n\t\t\t\t20170522154613_DDU398C1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522154613_DDU398C2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522154613_DDU398C3","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1053\/j.gastro.2011.05.048","article-title":"HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn\u2019s disease","volume":"141","author":"Okada","year":"2011","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170522154613_DDU398C4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ncpgasthep0528","article-title":"Mechanisms of disease: pathogenesis of Crohn\u2019s disease and ulcerative colitis","volume":"3","author":"Sartor","year":"2006","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"key\n\t\t\t\t20170522154613_DDU398C5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"Anderson","year":"2011","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154613_DDU398C6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/ng.549","article-title":"Genome-wide association identifies multiple ulcerative colitis susceptibility loci","volume":"42","author":"McGovern","year":"2010","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154613_DDU398C7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ng.553","article-title":"Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)","volume":"42","author":"Franke","year":"2010","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154613_DDU398C8","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/ng.203","article-title":"Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease","volume":"40","author":"Kugathasan","year":"2008","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154613_DDU398C9","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/ng.489","article-title":"Common variants at five new loci associated with early-onset inflammatory bowel disease","volume":"41","author":"Imielinski","year":"2009","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154613_DDU398C10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng.275","article-title":"Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study","volume":"41","author":"Silverberg","year":"2009","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154613_DDU398C11","doi-asserted-by":"crossref","first-page":"e10693","DOI":"10.1371\/journal.pone.0010693","article-title":"Genetics and beyond\u2014the transcriptome of human monocytes and disease susceptibility","volume":"5","author":"Zeller","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170522154613_DDU398C12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature08903","article-title":"Transcriptome genetics using second generation sequencing in a Caucasian population","volume":"464","author":"Montgomery","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522154613_DDU398C13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature12531","article-title":"Transcriptome and genome sequencing uncovers functional variation in humans","volume":"501","author":"Lappalainen","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522154613_DDU398C14","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/gutjnl-2012-303333","article-title":"Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations","volume":"62","author":"Planell","year":"2013","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170522154613_DDU398C15","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1136\/gut.2008.148395","article-title":"Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis","volume":"57","author":"Noble","year":"2008","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170522154613_DDU398C16","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/ibd.20879","article-title":"Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data","volume":"15","author":"Olsen","year":"2009","journal-title":"Inflamm. Bowel. Dis."},{"key":"key\n\t\t\t\t20170522154613_DDU398C17","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/carcin\/bgs183","article-title":"Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model","volume":"33","author":"Tang","year":"2012","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170522154613_DDU398C18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1152\/physiolgenomics.00138.2010","article-title":"Temporal genomewide expression profiling of DSS colitis reveals novel inflammatory and angiogenesis genes similar to ulcerative colitis","volume":"43","author":"Fang","year":"2011","journal-title":"Physiol. Genomics"},{"key":"key\n\t\t\t\t20170522154613_DDU398C19","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/gutjnl-2012-302865","article-title":"A genome-wide association study on a southern European population identifies a new Crohn\u2019s disease susceptibility locus at RBX1-EP300","volume":"62","author":"Julia","year":"2012","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170522154613_DDU398C20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.crohns.2009.12.003","article-title":"The second European evidence-based Consensus on the diagnosis and management of Crohn\u2019s disease: definitions and diagnosis","volume":"4","author":"Van Assche","year":"2010","journal-title":"J. Crohns Colitis"},{"key":"key\n\t\t\t\t20170522154613_DDU398C21","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/1471-2105-11-264","article-title":"CNstream: a method for the identification and genotyping of copy number polymorphisms using Illumina microarrays","volume":"11","author":"Alonso","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20170522154613_DDU398C22","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522154613_DDU398C23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522154613_DDU398C24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"Purcell","year":"2003","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170522154613_DDU398C25","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/gepi.20533","article-title":"MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes","volume":"34","author":"Li","year":"2010","journal-title":"Genet. Epidemiol."},{"key":"key\n\t\t\t\t20170522154613_DDU398C26","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170522154613_DDU398C27","doi-asserted-by":"crossref","first-page":"e13085","DOI":"10.1371\/journal.pone.0013085","article-title":"Gene expression changes associated with resistance to intravenous corticosteroid therapy in children with severe ulcerative colitis","volume":"5","author":"Kabakchiev","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170522154613_DDU398C28","first-page":"D258","article-title":"The Gene Ontology (GO) database and informatics resource","volume":"32 Database issue","author":"Harris","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170522154613_DDU398C29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20170522154613_DDU398C30","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20170522154613_DDU398C31","doi-asserted-by":"crossref","first-page":"e1001046","DOI":"10.1371\/journal.pbio.1001046","article-title":"A user\u2019s guide to the encyclopedia of DNA elements (ENCODE)","volume":"9","year":"2011","journal-title":"PLoS Biol."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/23\/25\/6927\/13916478\/ddu398.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T04:51:01Z","timestamp":1503463861000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddu398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":31,"journal-issue":{"issue":"25","published-online":{"date-parts":[[2014,7,31]]},"published-print":{"date-parts":[[2014,12,20]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddu398","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}