{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:59:20Z","timestamp":1791143960059,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"DOI":"10.1093\/hmg\/ddu416","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T05:49:19Z","timestamp":1407995359000},"page":"21-36","source":"Crossref","is-referenced-by-count":50,"title":["Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot\u2013Marie\u2013Tooth neuropathy"],"prefix":"10.1093","volume":"24","author":[{"given":"V\u00edctor","family":"L\u00f3pez Del Amo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Seco-Cervera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Garc\u00eda-Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Whitworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico V.","family":"Pallard\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ximo Ibo","family":"Galindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"key\n\t\t\t\t20170522162441_DDU416C1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1469-1809.2007.00412.x","article-title":"Charcot-Marie-Tooth disease: a clinico-genetic confrontation","volume":"72","year":"2008","journal-title":"Ann. Hum. Genet."},{"key":"key\n\t\t\t\t20170522162441_DDU416C2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/jim-51-05-14","article-title":"Molecular mechanisms, diagnosis, and rational approaches to management of and therapy for Charcot-Marie-Tooth disease and related peripheral neuropathies","volume":"51","year":"2003","journal-title":"J. Investig. Med."},{"key":"key\n\t\t\t\t20170522162441_DDU416C3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1385\/NMM:8:1-2:23","article-title":"Neuropathology of Charcot-Marie-Tooth and related disorders","volume":"8","year":"2006","journal-title":"Neuromolecular. Med."},{"key":"key\n\t\t\t\t20170522162441_DDU416C4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000343487","article-title":"Molecular genetics of Charcot-Marie-Tooth disease: from genes to genomes","volume":"3","year":"2012","journal-title":"Mol. Syndromol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tcb.2012.10.006","article-title":"Mitochondrial dynamics in neurodegeneration","volume":"23","year":"2013","journal-title":"Trends. Cell. Biol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C6","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00018-012-1066-6","article-title":"Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates","volume":"70","year":"2013","journal-title":"Cell. Mol. Life. Sci."},{"key":"key\n\t\t\t\t20170522162441_DDU416C7","article-title":"Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"key\n\t\t\t\t20170522162441_DDU416C8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbamcr.2012.02.012","article-title":"Mitochondrial morphology in mitophagy and macroautophagy","volume":"1833","year":"2013","journal-title":"Biochim. Biophys. Acta."},{"key":"key\n\t\t\t\t20170522162441_DDU416C9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuron.2005.06.018","article-title":"Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions","volume":"47","year":"2005","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522162441_DDU416C10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.nbd.2013.03.010","article-title":"Silencing of the Charcot-Marie-Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry","volume":"55","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522162441_DDU416C11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/hmg\/ddi121","article-title":"GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria","volume":"14","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522162441_DDU416C12","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1083\/jcb.200507087","article-title":"Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease","volume":"170","year":"2005","journal-title":"J. Cell. Biol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C13","doi-asserted-by":"crossref","first-page":"36777","DOI":"10.1074\/jbc.M111.260042","article-title":"Charcot-Marie-Tooth-related gene GDAP1 complements cell cycle delay at G2\/M phase in Saccharomyces Cerevisiae fis1 gene-defective cells","volume":"286","year":"2011","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522162441_DDU416C14","first-page":"176","article-title":"Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes","volume":"21","year":"2004","journal-title":"Mol. Biol. Evol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1750-1172-6-87","article-title":"A locus-specific database for mutations in GDAP1 allows analysis of genotype-phenotype correlations in Charcot-Marie-Tooth diseases type 4A and 2K","volume":"6","year":"2011","journal-title":"Orphanet. J. Rare. Dis."},{"key":"key\n\t\t\t\t20170522162441_DDU416C16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.expneurol.2009.05.003","article-title":"Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A","volume":"218","year":"2009","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.nmd.2012.04.001","article-title":"A French family with Charcot-Marie-Tooth disease related to simultaneous heterozygous MFN2 and GDAP1 mutations","volume":"22","year":"2012","journal-title":"Neuromuscul. Disord."},{"key":"key\n\t\t\t\t20170522162441_DDU416C18","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1007\/s10495-009-0347-5","article-title":"Recent advances in using Drosophila to model neurodegenerative diseases","volume":"14","year":"2009","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t20170522162441_DDU416C19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mcn.2012.08.007","article-title":"D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries","volume":"55","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"key\n\t\t\t\t20170522162441_DDU416C20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-genet-110711-155456","article-title":"Probing mechanisms that underlie human neurodegenerative diseases in Drosophila","volume":"46","year":"2012","journal-title":"Annu. Rev. Genet."},{"key":"key\n\t\t\t\t20170522162441_DDU416C21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.110.003293","article-title":"Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery","volume":"63","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"key\n\t\t\t\t20170522162441_DDU416C22","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nn1910","article-title":"Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization","volume":"10","year":"2007","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522162441_DDU416C23","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1073\/pnas.0913485107","article-title":"Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin","volume":"107","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522162441_DDU416C24","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00726-011-0868-4","article-title":"Drosophila as a platform to predict the pathogenicity of novel aminoacyl-tRNA synthetase mutations in CMT","volume":"42","year":"2012","journal-title":"Amino Acids"},{"key":"key\n\t\t\t\t20170522162441_DDU416C25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.nbd.2014.01.021","article-title":"Human Rab7 mutation mimics features of Charcot-Marie-Tooth neuropathy type 2B in Drosophila","volume":"65","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522162441_DDU416C26","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ng2049","article-title":"Using FlyAtlas to identify better Drosophila melanogaster models of human disease","volume":"39","year":"2007","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522162441_DDU416C27","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/459927a","article-title":"Unlocking the secrets of the genome","volume":"459","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522162441_DDU416C28","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/S0960-9822(01)00393-1","article-title":"Cooperative action of antioxidant defense systems in Drosophila","volume":"11","year":"2001","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C29","first-page":"1017","article-title":"Sudan Black B treatment reduces autofluorescence and improves resolution of in situ hybridization specific fluorescent signals of brain sections","volume":"25","year":"2010","journal-title":"Histol. Histopathol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","year":"1993","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522162441_DDU416C31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nature05954","article-title":"A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila","volume":"448","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522162441_DDU416C32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0092-8674(00)81385-9","article-title":"Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye","volume":"87","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522162441_DDU416C33","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1126\/science.290.5498.1978","article-title":"Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1","volume":"290","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522162441_DDU416C34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF00215187","article-title":"Ultrastructure of capitate projections in the optic neuropil of Diptera","volume":"246","year":"1986","journal-title":"Cell Tissue Res."},{"key":"key\n\t\t\t\t20170522162441_DDU416C35","doi-asserted-by":"crossref","first-page":"10732","DOI":"10.1523\/JNEUROSCI.23-33-10732.2003","article-title":"Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals","volume":"23","year":"2003","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522162441_DDU416C36","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/ejn.12136","article-title":"Mixed miniature postsynaptic currents resulting from co-release of glycine and GABA recorded from glycinergic neurons in the neonatal respiratory network","volume":"37","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"key\n\t\t\t\t20170522162441_DDU416C37","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jmor.1051450307","article-title":"Mitochondrial changes in flight muscles of normal and flightless Drosophila melanogaster with age","volume":"145","year":"1975","journal-title":"J. Morphol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.mito.2012.01.004","article-title":"Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila","volume":"12","year":"2012","journal-title":"Mitochondrion"},{"key":"key\n\t\t\t\t20170522162441_DDU416C39","doi-asserted-by":"crossref","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","article-title":"Calcium, ATP, and ROS: a mitochondrial love-hate triangle","volume":"287","year":"2004","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C40","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ars.2006.8.1941","article-title":"Redox control of neural function: background, mechanisms, and significance","volume":"8","year":"2006","journal-title":"Antioxid. Redox. Signal."},{"key":"key\n\t\t\t\t20170522162441_DDU416C41","first-page":"136","article-title":"Effect of aging on glutathione metabolism. Protection by antioxidants","volume":"62","year":"1992","journal-title":"Free Radic. Aging"},{"key":"key\n\t\t\t\t20170522162441_DDU416C42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/hmg\/ddr450","article-title":"Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential","volume":"21","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522162441_DDU416C43","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.291.5504.643","article-title":"Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster","volume":"291","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522162441_DDU416C44","first-page":"467180","article-title":"Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives","volume":"2011","year":"2011","journal-title":"Oxid. Med. Cell. Longev."},{"key":"key\n\t\t\t\t20170522162441_DDU416C45","doi-asserted-by":"crossref","first-page":"13726","DOI":"10.1073\/pnas.260496697","article-title":"Genome-wide study of aging and oxidative stress response in Drosophila melanogaster","volume":"97","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522162441_DDU416C46","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1749-6632.2001.tb05653.x","article-title":"Exercise at old age: does it increase or alleviate oxidative stress?","volume":"928","year":"2001","journal-title":"Ann. NY. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522162441_DDU416C47","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s00391-004-0229-y","article-title":"Activity of antioxidant enzymes and concentration of lipid peroxidation products in selected tissues of mice of different ages, both healthy and melanoma-bearing","volume":"37","year":"2004","journal-title":"Z. Gerontol. Geriatr."},{"key":"key\n\t\t\t\t20170522162441_DDU416C48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2046-2395-2-14","article-title":"Life-long spontaneous exercise does not prolong lifespan but improves health span in mice","volume":"2","year":"2013","journal-title":"Longev. Healthspan."},{"key":"key\n\t\t\t\t20170522162441_DDU416C49","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1046\/j.1471-4159.1999.0721781.x","article-title":"Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene","volume":"72","year":"1999","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522162441_DDU416C50","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2009.09.011","article-title":"GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance","volume":"36","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522162441_DDU416C51","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1582-4934.2007.00158.x","article-title":"Cell expression of GDAP1 in the nervous system and pathogenesis of Charcot-Marie-Tooth type 4A disease","volume":"12","year":"2008","journal-title":"J. Cel. Mol. Med."},{"key":"key\n\t\t\t\t20170522162441_DDU416C52","doi-asserted-by":"crossref","first-page":"14696","DOI":"10.1523\/JNEUROSCI.2456-12.2012","article-title":"Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration","volume":"32","year":"2012","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522162441_DDU416C53","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10048-008-0166-9","article-title":"Mitochondrial complex I deficiency in GDAP1-related autosomal dominant Charcot-Marie-Tooth disease (CMT2K)","volume":"10","year":"2009","journal-title":"Neurogenetics"},{"key":"key\n\t\t\t\t20170522162441_DDU416C54","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/brain\/awt371","article-title":"The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease","volume":"137","year":"2014","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522162441_DDU416C55","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1117311","article-title":"A direct role for dual oxidase in Drosophila gut immunity","volume":"310","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522162441_DDU416C56","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0040-8166(87)90048-6","article-title":"Ultrastructure of the anal organ of Drosophila larva with reference to ion transport","volume":"19","year":"1987","journal-title":"Tissue Cell"},{"key":"key\n\t\t\t\t20170522162441_DDU416C57","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jinsphys.2012.01.008","article-title":"Immune and stress response \u2018cross-talk\u2019 in the Drosophila Malpighian tubule","volume":"58","year":"2012","journal-title":"J. Insect. Physiol."},{"key":"key\n\t\t\t\t20170522162441_DDU416C58","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1152\/physiolgenomics.00147.2009","article-title":"Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants","volume":"41","year":"2010","journal-title":"Physiol. Genomics."},{"key":"key\n\t\t\t\t20170522162441_DDU416C59","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/embor.2013.56","article-title":"Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission","volume":"14","year":"2013","journal-title":"EMBO. Rep."},{"key":"key\n\t\t\t\t20170522162441_DDU416C60","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/brb3.73","article-title":"A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease","volume":"2","year":"2012","journal-title":"Brain. Behav."},{"key":"key\n\t\t\t\t20170522162441_DDU416C61","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bbrc.2008.11.086","article-title":"The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process","volume":"378","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522162441_DDU416C62","article-title":"GFP and beta-galactosidase transformation vectors for promoter\/enhancer analysis in Drosophila","volume":"29","year":"2000","journal-title":"BioTechniques"},{"key":"key\n\t\t\t\t20170522162441_DDU416C63","first-page":"1383","article-title":"Preparation of Drosophila eye specimens for scanning electron microscopy","volume":"2011","year":"2011","journal-title":"Cold. Spring. Harb. Protoc."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T08:51:00Z","timestamp":1717231860000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddu416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,13]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,8,13]]},"published-print":{"date-parts":[[2015,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddu416","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,13]]}}}