{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:22:00Z","timestamp":1790677320136,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"DOI":"10.1093\/hmg\/ddu489","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T04:36:31Z","timestamp":1412742991000},"page":"698-713","source":"Crossref","is-referenced-by-count":30,"title":["Co-ordinated brain and craniofacial development depend upon Patched1\/XIAP regulation of cell survival"],"prefix":"10.1093","volume":"24","author":[{"given":"Kazushi","family":"Aoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Trainor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"key\n\t\t\t\t20170522162424_DDU489C1","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1002\/ajmg.a.33454","article-title":"Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention","volume":"152A","year":"2010","journal-title":"Am. J. Med. Genet. A"},{"key":"key\n\t\t\t\t20170522162424_DDU489C2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1542\/peds.34.2.256","article-title":"The face predicts the brain: diagnostic significance of median facial anomalies for holoprosencephaly (arhinencephaly)","volume":"34","year":"1964","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20170522162424_DDU489C3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/ajmg.1320340232","article-title":"Perspectives on holoprosencephaly: part III. Spectra, distinctions, continuities, and discontinuities","volume":"34","year":"1989","journal-title":"Am. J. Med. Genet."},{"key":"key\n\t\t\t\t20170522162424_DDU489C4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajmg.10258","article-title":"Teratogenesis of holoprosencephaly","volume":"109","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"key\n\t\t\t\t20170522162424_DDU489C5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/bdra.20447","article-title":"Fetal ethanol exposure activates protein kinase A and impairs Shh expression in prechordal mesendoderm cells in the pathogenesis of holoprosencephaly","volume":"82","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0022-3476(83)80185-1","article-title":"Holoprosencephaly in infants of diabetic mothers","volume":"102","year":"1983","journal-title":"J. Pediatr."},{"key":"key\n\t\t\t\t20170522162424_DDU489C7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/1098-1004(200008)16:2<99::AID-HUMU2>3.0.CO;2-0","article-title":"Mutations in holoprosencephaly","volume":"16","year":"2000","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20170522162424_DDU489C8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.devcel.2005.12.014","article-title":"Divergence of hedgehog signal transduction mechanism between Drosophila and mammals","volume":"10","year":"2006","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20170522162424_DDU489C9","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.1139740","article-title":"Patched1 regulates hedgehog signaling at the primary cilium","volume":"317","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522162424_DDU489C11","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1101\/gad.1190304","article-title":"Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia","volume":"18","year":"2004","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522162424_DDU489C12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1242\/dev.026583","article-title":"A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm","volume":"136","year":"2009","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522162424_DDU489C13","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1242\/dev.126.21.4873","article-title":"The role of sonic hedgehog in normal and abnormal craniofacial morphogenesis","volume":"126","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522162424_DDU489C14","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","article-title":"Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity","volume":"75","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522162424_DDU489C15","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.243402","article-title":"Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity","volume":"16","year":"2002","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522162424_DDU489C16","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1002\/dvdy.22729","article-title":"Epigenetic integration of the developing brain and face","volume":"240","year":"2011","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522162424_DDU489C17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1196-357","article-title":"Mutations in the human Sonic Hedgehog gene cause holoprosencephaly","volume":"14","year":"1996","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522162424_DDU489C18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function","volume":"383","year":"1996","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522162424_DDU489C19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ydbio.2008.11.022","article-title":"Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis","volume":"327","year":"2009","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1085405","article-title":"Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog","volume":"301","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522162424_DDU489C21","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/ncb1880","article-title":"The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex","volume":"11","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nmeth762","article-title":"A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration","volume":"2","year":"2005","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20170522162424_DDU489C23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522162424_DDU489C24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","article-title":"The Bcl2 family: regulators of the cellular life-or-death switch","volume":"2","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170522162424_DDU489C25","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.1059108","article-title":"Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death","volume":"292","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522162424_DDU489C26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","article-title":"Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease cascade","volume":"91","year":"1997","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522162424_DDU489C27","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1097-2765(00)80095-7","article-title":"Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization","volume":"1","year":"1998","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522162424_DDU489C28","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrm1496","article-title":"Molecular mechanisms of caspase regulation during apoptosis","volume":"5","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C29","first-page":"225","article-title":"The primary cilium at the crossroads of mammalian hedgehog signaling","volume":"85","year":"2008","journal-title":"Curr. Top Dev. Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C30","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1038\/sj.onc.1210301","article-title":"Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling","volume":"26","year":"2007","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170522162424_DDU489C31","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cell.2009.08.021","article-title":"Caspases and kinases in a death grip","volume":"138","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522162424_DDU489C32","doi-asserted-by":"crossref","first-page":"6412","DOI":"10.1158\/0008-5472.CAN-05-2368","article-title":"The ERBB4\/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells","volume":"66","year":"2006","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170522162424_DDU489C33","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.3390\/ijms10073033","article-title":"Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2","volume":"10","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"key\n\t\t\t\t20170522162424_DDU489C34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molcel.2009.10.011","article-title":"Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis","volume":"36","year":"2009","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522162424_DDU489C35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/sj.cdd.4400957","article-title":"A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding","volume":"9","year":"2002","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170522162424_DDU489C36","doi-asserted-by":"crossref","first-page":"e18330","DOI":"10.1371\/journal.pone.0018330","article-title":"Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells","volume":"6","year":"2011","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170522162424_DDU489C37","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1021\/jm030420+","article-title":"Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database","volume":"47","year":"2004","journal-title":"J. Med. Chem."},{"key":"key\n\t\t\t\t20170522162424_DDU489C38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1242\/dev.129.2.361","article-title":"Hedgehog is required for murine yolk sac angiogenesis","volume":"129","year":"2002","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522162424_DDU489C39","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.devcel.2008.07.003","article-title":"Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly","volume":"15","year":"2008","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20170522162424_DDU489C40","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/ng.230","article-title":"Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein","volume":"40","year":"2008","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522162424_DDU489C41","doi-asserted-by":"crossref","first-page":"8460","DOI":"10.1073\/pnas.93.16.8460","article-title":"Defective forebrain development in mice lacking gp330\/megalin","volume":"93","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522162424_DDU489C42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/dvdy.23726","article-title":"Signaling by SHH rescues facial defects following blockade in the brain","volume":"241","year":"2012","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522162424_DDU489C43","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/dvdy.23764","article-title":"Neural crest cells pattern the surface cephalic ectoderm during FEZ formation","volume":"241","year":"2012","journal-title":"Developmental Dynamics"},{"key":"key\n\t\t\t\t20170522162424_DDU489C44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ydbio.2005.04.030","article-title":"Molecular interactions coordinating the development of the forebrain and face","volume":"284","year":"2005","journal-title":"Developmental Biology"},{"key":"key\n\t\t\t\t20170522162424_DDU489C45","doi-asserted-by":"crossref","first-page":"e1001623","DOI":"10.1371\/journal.pbio.1001623","article-title":"Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity","volume":"11","year":"2013","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C46","doi-asserted-by":"crossref","first-page":"18269","DOI":"10.1074\/jbc.M802156200","article-title":"Caspase cleavage of HER-2 releases a Bad-like cell death effector","volume":"283","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522162424_DDU489C47","first-page":"bap022","article-title":"Cildb: a knowledgebase for centrosomes and cilia","volume":"2009","year":"2009","journal-title":"Database (Oxford)"},{"key":"key\n\t\t\t\t20170522162424_DDU489C48","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.112.268946","article-title":"Mitochondrial control of cellular life, stress, and death","volume":"111","year":"2012","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t20170522162424_DDU489C49","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nrm3479","article-title":"Mitochondria: master regulators of danger signalling","volume":"13","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C50","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/ajmg.a.32027","article-title":"Cyclopia, aprosencephaly, and acardiac twinning: is hypoxia-ischemia a unifying mechanism?","volume":"143A","year":"2007","journal-title":"Am. J. Med. Genet. A"},{"key":"key\n\t\t\t\t20170522162424_DDU489C51","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1242\/dmm.011064","article-title":"The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos","volume":"6","year":"2013","journal-title":"Dis. Model Mech."},{"key":"key\n\t\t\t\t20170522162424_DDU489C52","first-page":"200","article-title":"The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy","volume":"34","year":"2012","journal-title":"Exp. Oncol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C53","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1126\/science.1098020","article-title":"The Hedgehog response network: sensors, switches, and routers","volume":"304","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522162424_DDU489C54","article-title":"ChIP-Seq: a method for global identification of regulatory elements in the genome","year":"2010","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C55","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.277.5329.1109","article-title":"Altered neural cell fates and medulloblastoma in mouse patched mutants","volume":"277","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522162424_DDU489C56","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","article-title":"Sonic hedgehog regulates growth and morphogenesis of the tooth","volume":"127","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522162424_DDU489C57","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0960-9822(98)70443-9","article-title":"Sonic hedgehog signaling is essential for hair development","volume":"8","year":"1998","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C58","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0076-6879(93)25025-W","article-title":"Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts","volume":"225","year":"1993","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170522162424_DDU489C59","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1440-169X.2008.01046.x","article-title":"Transferring genes into cultured mammalian embryos by electroporation","volume":"50","year":"2008","journal-title":"Dev. Growth Differ."},{"key":"key\n\t\t\t\t20170522162424_DDU489C60","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/aja.1001950404","article-title":"A series of normal stages in the development of the chick embryo. 1951","volume":"195","year":"1992","journal-title":"Dev. Dyn."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T08:13:00Z","timestamp":1650355980000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddu489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,6]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,10,6]]},"published-print":{"date-parts":[[2015,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddu489","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,6]]}}}