{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:11:42Z","timestamp":1791353502206,"version":"4.3.1"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,15]]},"DOI":"10.1093\/hmg\/ddu506","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T02:49:45Z","timestamp":1413341385000},"page":"939-953","source":"Crossref","is-referenced-by-count":52,"title":["Deletion of OTX2 in neural ectoderm delays anterior pituitary development"],"prefix":"10.1093","volume":"24","author":[{"given":"Amanda H.","family":"Mortensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Schade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lamonerie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Camper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,10,14]]},"reference":[{"key":"key\n\t\t\t\t20170503080414_DDU506C1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1086\/430721","article-title":"Heterozygous mutations of OTX2 cause severe ocular malformations","volume":"76","author":"Ragge","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C2","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1210\/jc.2008-1189","article-title":"A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency","volume":"93","author":"Diaczok","year":"2008","journal-title":"J. Clin. Endocr. Metab."},{"key":"key\n\t\t\t\t20170503080414_DDU506C3","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1210\/jc.2008-0720","article-title":"OTX2 mutation in a patient with anophthalmia, short stature, and partial GH deficiency: functional studies using the IRBP, HESX1, and POU1F1 promoters","volume":"93","author":"Dateki","year":"2008","journal-title":"J. Clin. Endocr. Metab."},{"key":"key\n\t\t\t\t20170503080414_DDU506C4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/jc.2008-1219","article-title":"OTX2 loss of function mutation causes anophthalmia and combined pituitary hormone deficiency with a small anterior and ectopic posterior pituitary","volume":"94","author":"Tajima","year":"2009","journal-title":"J. Clin. Endocr. Metab."},{"key":"key\n\t\t\t\t20170503080414_DDU506C5","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1210\/jc.2009-1334","article-title":"Heterozygous orthodenticle homeobox 2 mutations are associated with variable pituitary phenotype","volume":"95","author":"Dateki","year":"2010","journal-title":"J. Clin. Endocr. Metab."},{"key":"key\n\t\t\t\t20170503080414_DDU506C6","first-page":"2442","article-title":"A rare de novo nonsense mutation in OTX2 causes early onset retinal dystrophy and pituitary dysfunction","volume":"15","author":"Henderson","year":"2009","journal-title":"Mol. Vis."},{"key":"key\n\t\t\t\t20170503080414_DDU506C7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.beem.2010.06.008","article-title":"Septo-optic dysplasia and other midline defects: the role of transcription factors: HESX1 and beyond","volume":"25","author":"McCabe","year":"2011","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"key\n\t\t\t\t20170503080414_DDU506C8","doi-asserted-by":"crossref","first-page":"E278","DOI":"10.1002\/humu.20869","article-title":"Novel heterozygous OTX2 mutations and whole gene deletions in anophthalmia, microphthalmia and coloboma","volume":"29","author":"Wyatt","year":"2008","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20170503080414_DDU506C9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/mgme.2000.3052","article-title":"Modifier genes convert \u201csimple\u201d Mendelian disorders to complex traits","volume":"71","author":"Dipple","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"key\n\t\t\t\t20170503080414_DDU506C10","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00439-010-0820-9","article-title":"A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency","volume":"127","author":"Ashkenazi-Hoffnung","year":"2010","journal-title":"Hum. Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C11","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1242\/dev.121.10.3279","article-title":"Forebrain and midbrain regions are deleted in Otx2-\/- mutants due to a defective anterior neuroectoderm specification during gastrulation","volume":"121","author":"Acampora","year":"1995","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C12","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1101\/gad.9.21.2646","article-title":"Mouse Otx2 functions in the formation and patterning of rostral head","volume":"9","author":"Matsuo","year":"1995","journal-title":"Gene Dev."},{"key":"key\n\t\t\t\t20170503080414_DDU506C13","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1242\/dev.129.18.4347","article-title":"Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice","volume":"129","author":"Hide","year":"2002","journal-title":"Development"},{"issue":"Suppl 2","key":"key\n\t\t\t\t20170503080414_DDU506C14","first-page":"101","article-title":"Genetics, gene expression and bioinformatics of the pituitary gland","volume":"71","author":"Davis","year":"2009","journal-title":"Horm. Res."},{"key":"key\n\t\t\t\t20170503080414_DDU506C15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0168-9525(01)02516-1","article-title":"Genomics boosts mouse molecular genetics","volume":"17","author":"Birchmeier","year":"2001","journal-title":"Trends Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1242\/dev.128.3.377","article-title":"Hedgehog signaling is required for pituitary gland development","volume":"128","author":"Treier","year":"2001","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1242\/dev.085290","article-title":"Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition","volume":"140","author":"Acampora","year":"2013","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C18","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1242\/dev.120.10.2979","article-title":"Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants","volume":"120","author":"Ang","year":"1994","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/dev.122.1.41","article-title":"Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo","volume":"122","author":"Hermesz","year":"1996","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/358687a0","article-title":"Nested expression domains of four homeobox genes in developing rostral brain","volume":"358","author":"Simeone","year":"1992","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503080414_DDU506C21","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1002\/j.1460-2075.1993.tb05935.x","article-title":"A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo","volume":"12","author":"Simeone","year":"1993","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170503080414_DDU506C22","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0960-9822(96)00753-1","article-title":"Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo","volume":"6","author":"Thomas","year":"1996","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C23","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1101\/gad.932601","article-title":"Temporal regulation of a paired-like homeodomain repressor\/TLE corepressor complex and a related activator is required for pituitary organogenesis","volume":"15","author":"Dasen","year":"2001","journal-title":"Gene Dev."},{"key":"key\n\t\t\t\t20170503080414_DDU506C24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/477","article-title":"Mutations in the homeobox gene HESX1\/Hesx1 associated with septo-optic dysplasia in human and mouse","volume":"19","author":"Dattani","year":"1998","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C25","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1152\/physiolgenomics.00080.2011","article-title":"Candidate genes for panhypopituitarism identified by gene expression profiling","volume":"43","author":"Mortensen","year":"2011","journal-title":"Physiol. Genomics"},{"key":"key\n\t\t\t\t20170503080414_DDU506C26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(88)90037-2","article-title":"The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein","volume":"55","author":"Bodner","year":"1988","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170503080414_DDU506C27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/0888-7543(90)90050-5","article-title":"The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation","volume":"8","author":"Camper","year":"1990","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170503080414_DDU506C28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/347528a0","article-title":"Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1","volume":"347","author":"Li","year":"1990","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503080414_DDU506C29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1651-2227.1999.tb14401.x","article-title":"Combined pituitary hormone deficiency: role of Pit-1 and Prop-1","volume":"88","author":"Pfaffle","year":"1999","journal-title":"Acta Paediatr. Suppl."},{"key":"key\n\t\t\t\t20170503080414_DDU506C30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1515\/JPEM.1993.6.3-4.229","article-title":"Pit-1 and pituitary function","volume":"6","author":"Pfaffle","year":"1993","journal-title":"J. Pediatr. Endocrinol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1365-2265.2008.03326.x","article-title":"Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD)","volume":"70","author":"Kelberman","year":"2009","journal-title":"Clin. Endocrinol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1006\/bbrc.2000.3721","article-title":"FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development","volume":"277","author":"Ohuchi","year":"2000","journal-title":"Biochem. Bioph. Res. Co."},{"key":"key\n\t\t\t\t20170503080414_DDU506C33","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/dbio.2000.9732","article-title":"Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures","volume":"222","author":"Hebert","year":"2000","journal-title":"Dev. Biol"},{"key":"key\n\t\t\t\t20170503080414_DDU506C34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ydbio.2010.09.024","article-title":"Direct and indirect requirements of Shh\/Gli signaling in early pituitary development","volume":"348","author":"Wang","year":"2010","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12098-011-0614-7","article-title":"Phenotype-genotype correlations in congenital isolated growth hormone deficiency (IGHD)","volume":"79","author":"Alatzoglou","year":"2012","journal-title":"Indian J. Pediatr."},{"key":"key\n\t\t\t\t20170503080414_DDU506C36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exer.2013.03.007","article-title":"The homeobox gene Otx2 in development and disease","volume":"111","author":"Beby","year":"2013","journal-title":"Exp. Eye Res."},{"key":"key\n\t\t\t\t20170503080414_DDU506C37","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1242\/dev.00849","article-title":"Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration","volume":"130","author":"Liu","year":"2003","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C38","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/sj.embor.7400751","article-title":"Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout","volume":"7","author":"Fossat","year":"2006","journal-title":"EMBO. Rep."},{"key":"key\n\t\t\t\t20170503080414_DDU506C39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/cne.21529","article-title":"Fate mapping Nkx2.1-lineage cells in the mouse telencephalon","volume":"506","author":"Xu","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C41","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1210\/me.2003-0225","article-title":"TCF and Groucho-related genes influence pituitary growth and development","volume":"17","author":"Brinkmeier","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C42","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.127.3.483","article-title":"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis","volume":"127","author":"De Moerlooze","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ydbio.2007.02.001","article-title":"Noggin regulates Bmp4 activity during pituitary induction","volume":"305","author":"Davis","year":"2007","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C44","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ydbio.2007.08.046","article-title":"TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors","volume":"311","author":"Brinkmeier","year":"2007","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C45","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/dvdy.21511","article-title":"WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth","volume":"237","author":"Potok","year":"2008","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170503080414_DDU506C46","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1242\/dev.125.23.4835","article-title":"Formation of Rathke's pouch requires dual induction from the diencephalon","volume":"125","author":"Takuma","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C47","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/dev.125.6.1005","article-title":"Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary","volume":"125","author":"Ericson","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0925-4773(00)00393-2","article-title":"Fibroblast growth factor signaling is required for the proliferation and patterning of progenitor cells in the developing anterior pituitary","volume":"96","author":"Norlin","year":"2000","journal-title":"Mech. Develop."},{"key":"key\n\t\t\t\t20170503080414_DDU506C49","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1101\/gad.12.11.1691","article-title":"Multistep signaling requirements for pituitary organogenesis in vivo","volume":"12","author":"Treier","year":"1998","journal-title":"Gene. Dev."},{"key":"key\n\t\t\t\t20170503080414_DDU506C50","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mce.2013.06.026","article-title":"Gene dosage of Otx2 is important for fertility in male mice","volume":"377","author":"Larder","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C51","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1242\/dev.126.19.4295","article-title":"Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain","volume":"126","author":"Rhinn","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C52","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1002\/j.1460-2075.1992.tb05319.x","article-title":"Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex","volume":"11","author":"Simeone","year":"1992","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170503080414_DDU506C53","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000115037","article-title":"Fibroblast growth factor signaling in cranial suture development and pathogenesis","volume":"12","author":"Hajihosseini","year":"2008","journal-title":"Front. Oral Biol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C54","doi-asserted-by":"crossref","first-page":"e11673","DOI":"10.1371\/journal.pone.0011673","article-title":"Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration","volume":"5","author":"Beby","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170503080414_DDU506C55","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/me.2010-0271","article-title":"Deletion of otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism","volume":"25","author":"Diaczok","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C56","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1242\/dev.090860","article-title":"The transcription factor Otx2 regulates choroid plexus development and function","volume":"140","author":"Johansson","year":"2013","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C57","doi-asserted-by":"crossref","first-page":"7879","DOI":"10.1523\/JNEUROSCI.15-12-07879.1995","article-title":"Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon","volume":"15","author":"Robel","year":"1995","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170503080414_DDU506C58","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1242\/dev.124.18.3639","article-title":"Genetic control of brain morphogenesis through Otx gene dosage requirement","volume":"124","author":"Acampora","year":"1997","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C59","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/43670","article-title":"The caudal limit of Otx2 expression positions the isthmic organizer","volume":"401","author":"Broccoli","year":"1999","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503080414_DDU506C60","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1038\/emboj.2011.407","article-title":"FGF signalling inhibits neural induction in human embryonic stem cells","volume":"30","author":"Greber","year":"2011","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170503080414_DDU506C61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/B978-0-12-416021-7.00002-X","article-title":"Development of the medial hypothalamus: forming a functional hypothalamic-neurohypophyseal interface","volume":"106","author":"Pearson","year":"2013","journal-title":"Curr. Top. Dev. Biol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C62","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng0797-311","article-title":"Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome","volume":"16","author":"Bamshad","year":"1997","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C63","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/(SICI)1096-8628(19961111)65:4<325::AID-AJMG15>3.0.CO;2-W","article-title":"Clinical analysis of a large kindred with the Pallister ulnar-mammary syndrome","volume":"65","author":"Bamshad","year":"1996","journal-title":"Am. J. Med Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C64","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1242\/dev.094524","article-title":"Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis","volume":"140","author":"Trowe","year":"2013","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C65","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1242\/dev.125.7.1229","article-title":"Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH","volume":"125","author":"Acampora","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C66","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1242\/dev.126.4.743","article-title":"Functional equivalency between Otx2 and Otx1 in development of the rostral head","volume":"126","author":"Suda","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C67","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1242\/dev.128.13.2433","article-title":"Emx2 directs the development of diencephalon in cooperation with Otx2","volume":"128","author":"Suda","year":"2001","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C68","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1399-0004.2010.01450.x","article-title":"OTX2 microphthalmia syndrome: four novel mutations and delineation of a phenotype","volume":"79","author":"Schilter","year":"2011","journal-title":"Clin. Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C69","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/dvg.20398","article-title":"Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility","volume":"46","author":"Charles","year":"2008","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170503080414_DDU506C70","first-page":"622","article-title":"Cell-specific expression of the mouse glycoprotein hormone alpha-subunit gene requires multiple interacting DNA elements in transgenic mice and cultured cells","volume":"12","author":"Brinkmeier","year":"1998","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C71","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1210\/me.2004-0341","article-title":"Role of PROP1 in pituitary gland growth","volume":"19","author":"Ward","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170503080414_DDU506C72","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/hmg\/10.11.1141","article-title":"Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility","volume":"10","author":"Cushman","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170503080414_DDU506C73","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1242\/dev.129.2.329","article-title":"Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification","volume":"129","author":"Suh","year":"2002","journal-title":"Development"},{"key":"key\n\t\t\t\t20170503080414_DDU506C74","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1210\/en.2005-1080","article-title":"Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty","volume":"147","author":"Vesper","year":"2006","journal-title":"Endocrinology"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/24\/4\/939\/14143727\/ddu506.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T23:55:43Z","timestamp":1650412543000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddu506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,14]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,10,14]]},"published-print":{"date-parts":[[2015,2,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddu506","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10,14]]}}}