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Lett."},{"key":"key\n\t\t\t\t20170503081456_DDU726C74","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1534\/genetics.107.072280","article-title":"In vivo functional specificity and homeostasis of Drosophila 14-3-3 proteins","volume":"177","author":"Acevedo","year":"2007","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170503081456_DDU726C75","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0012-1606(88)90139-X","article-title":"The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages","volume":"126","author":"Robinow","year":"1998","journal-title":"Dev. 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