{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:21:36Z","timestamp":1789928496202,"version":"4.0.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"DOI":"10.1093\/hmg\/ddv070","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T07:18:21Z","timestamp":1424935101000},"page":"3181-3191","source":"Crossref","is-referenced-by-count":22,"title":["Blocking hyperactive androgen receptor signaling ameliorates cardiac and renal hypertrophy in Fabry mice"],"prefix":"10.1093","volume":"24","author":[{"given":"Jin-Song","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Li","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Wight-Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taniqua S.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Goetsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Forni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay W.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Schiffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"key\n\t\t\t\t20170503080330_DDV070C1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1056\/NEJM196705252762101","article-title":"Enzymatic defect in Fabry disease: ceramide trihexosidase deficiency","volume":"276","author":"Brady","year":"1967","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170503080330_DDV070C2","first-page":"3733","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Desnick","year":"2001"},{"key":"key\n\t\t\t\t20170503080330_DDV070C3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pharmthera.2009.01.003","article-title":"Fabry disease","volume":"122","author":"Schiffmann","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"key\n\t\t\t\t20170503080330_DDV070C4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev-med-090910-085119","article-title":"The Fabry cardiomyopathy: models for the cardiologist","volume":"62","author":"Weidemann","year":"2011","journal-title":"Annu. Rev. Med."},{"key":"key\n\t\t\t\t20170503080330_DDV070C5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF02926689","article-title":"Renal size in Fabry's disease","volume":"2","author":"Stiennon","year":"1980","journal-title":"Urol. Radiol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/GIM.0b013e31802d8321","article-title":"Heterozygous Fabry women are not just carriers, but have a significant burden of disease and impaired quality of life","volume":"9","author":"Wang","year":"2007","journal-title":"Genet. Med."},{"key":"key\n\t\t\t\t20170503080330_DDV070C7","first-page":"291","article-title":"Agalsidase alfa (Replagal) in the treatment of Anderson-Fabry disease","volume":"1","author":"Pastores","year":"2007","journal-title":"Biologics"},{"key":"key\n\t\t\t\t20170503080330_DDV070C8","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/CIRCULATIONAHA.108.794529","article-title":"Long-term effects of enzyme replacement therapy on fabry cardiomyopathy: evidence for a better outcome with early treatment","volume":"119","author":"Weidemann","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170503080330_DDV070C9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1681\/ASN.2012030316","article-title":"Agalsidase benefits renal histology in young patients with Fabry disease","volume":"24","author":"Tondel","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C10","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1161\/hc3801.096352","article-title":"Regional cerebral hyperperfusion and nitric oxide pathway dysregulation in Fabry disease: reversal by enzyme replacement therapy","volume":"104","author":"Moore","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170503080330_DDV070C11","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1681\/ASN.2008111190","article-title":"Decreased nitric oxide bioavailability in a mouse model of Fabry disease","volume":"20","author":"Shu","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C12","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1073\/pnas.0712309105","article-title":"Elevated globotriaosylsphingosine is a hallmark of Fabry disease","volume":"105","author":"Aerts","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503080330_DDV070C13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4161\/auto.6.5.11943","article-title":"Autophagosome maturation is impaired in Fabry disease","volume":"6","author":"Chevrier","year":"2010","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20170503080330_DDV070C14","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1073\/pnas.94.6.2540","article-title":"Alpha-galactosidase A deficient mice: a model of Fabry disease","volume":"94","author":"Ohshima","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503080330_DDV070C15","doi-asserted-by":"crossref","first-page":"22896","DOI":"10.1074\/jbc.M200347200","article-title":"Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart","volume":"277","author":"Matsui","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503080330_DDV070C16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/01.CIR.98.3.256","article-title":"Androgen receptors mediate hypertrophy in cardiac myocytes","volume":"98","author":"Marsh","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170503080330_DDV070C17","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0008-6363(02)00701-0","article-title":"Effect of testosterone on post-myocardial infarction remodeling and function","volume":"57","author":"Nahrendorf","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"key\n\t\t\t\t20170503080330_DDV070C18","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.7403864","article-title":"Testosterone-mediated sexual dimorphism of mitochondria and lysosomes in mouse kidney proximal tubules","volume":"209","author":"Koenig","year":"1980","journal-title":"Science"},{"key":"key\n\t\t\t\t20170503080330_DDV070C19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.ph.51.030189.000411","article-title":"Androgen-regulated gene expression","volume":"51","author":"Berger","year":"1989","journal-title":"Annu. Rev. Physiol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1210\/er.2008-0025","article-title":"Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice","volume":"30","author":"Wang","year":"2009","journal-title":"Endocr. Rev."},{"key":"key\n\t\t\t\t20170503080330_DDV070C21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1210\/en.2004-1649","article-title":"Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors","volume":"147","author":"Singh","year":"2006","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170503080330_DDV070C22","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/diabetes.54.4.1000","article-title":"Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion","volume":"54","author":"Fan","year":"2005","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170503080330_DDV070C23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/edrv.23.2.0460","article-title":"Androgen receptor (AR) coregulators: an overview","volume":"23","author":"Heinlein","year":"2002","journal-title":"Endocr. Rev."},{"key":"key\n\t\t\t\t20170503080330_DDV070C24","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1210\/en.2006-1653","article-title":"Identification of androgen response elements in the insulin-like growth factor I upstream promoter","volume":"148","author":"Wu","year":"2007","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170503080330_DDV070C25","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1074\/jbc.M108855200","article-title":"The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3","volume":"277","author":"Chipuk","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503080330_DDV070C26","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1210\/endo.139.2.5763","article-title":"Identification of androgen-regulated genes in mouse kidney by representational difference analysis and random arbitrarily primed polymerase chain reaction","volume":"139","author":"Melia","year":"1998","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170503080330_DDV070C27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/toxsci\/66.1.82","article-title":"Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and\/or hAR for endocrine screening","volume":"66","author":"Hartig","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170503080330_DDV070C28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ymgme.2008.06.016","article-title":"Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells","volume":"95","author":"Shen","year":"2008","journal-title":"Mol. Genet. Metab."},{"key":"key\n\t\t\t\t20170503080330_DDV070C29","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1210\/mend-5-12-1921","article-title":"The promoter of the prostate-specific antigen gene contains a functional androgen responsive element","volume":"5","author":"Riegman","year":"1991","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C30","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.95.6.2979","article-title":"HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte","volume":"95","author":"Claycomb","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503080330_DDV070C31","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/14084","article-title":"Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases","volume":"1","author":"Puri","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C32","doi-asserted-by":"crossref","first-page":"13112","DOI":"10.1016\/S0021-9258(18)43014-1","article-title":"Testosterone effects on the induction and urinary excretion of mouse kidney glycosphingolipids associated with lysosomes","volume":"256","author":"McCluer","year":"1981","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503080330_DDV070C33","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1083\/jcb.201208152","article-title":"The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction","volume":"199","author":"Platt","year":"2012","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/path.3021","article-title":"The cellular pathology of lysosomal diseases","volume":"226","author":"Cox","year":"2012","journal-title":"J. Pathol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10545-008-1040-5","article-title":"Pathogenic cascades in lysosomal disease-Why so complex?","volume":"32","author":"Walkley","year":"2009","journal-title":"J. Inherit. Metab. Dis."},{"key":"key\n\t\t\t\t20170503080330_DDV070C36","doi-asserted-by":"crossref","first-page":"29661","DOI":"10.1074\/jbc.M411694200","article-title":"Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis","volume":"280","author":"Ikeda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503080330_DDV070C37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1440-1681.2007.04585.x","article-title":"Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure","volume":"34","author":"McMullen","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C38","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1093\/ndt\/gfs260","article-title":"The pathogenic role of the renal proximal tubular cell in diabetic nephropathy","volume":"27","author":"Tang","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"key\n\t\t\t\t20170503080330_DDV070C39","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/BJ20130825","article-title":"A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis","volume":"456","author":"Taguchi","year":"2013","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170503080330_DDV070C40","doi-asserted-by":"crossref","first-page":"e71694","DOI":"10.1371\/journal.pone.0071694","article-title":"Visualising androgen receptor activity in male and female mice","volume":"8","author":"Dart","year":"2013","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170503080330_DDV070C41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0303-7207(92)90221-Q","article-title":"Effects of pituitary hormones on the cell-specific expression of the KAP gene","volume":"89","author":"Meseguer","year":"1992","journal-title":"Mol. Cell. Endocrinol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C42","article-title":"Alpha-galactosidase A knockout mice: progressive organ pathology resembles the type 2 later-onset phenotype of fabry disease","author":"Bangari","year":"2015","journal-title":"Am. J. Pathol"},{"key":"key\n\t\t\t\t20170503080330_DDV070C43","doi-asserted-by":"crossref","first-page":"T131","DOI":"10.1530\/ERC-13-0472","article-title":"Androgen receptor phosphorylation: biological context and functional consequences","volume":"21","author":"Koryakina","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"key\n\t\t\t\t20170503080330_DDV070C44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.urolonc.2008.06.002","article-title":"Oncogenic activation of androgen receptor","volume":"27","author":"Kung","year":"2009","journal-title":"Urol. Oncol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0303-7207(96)03800-2","article-title":"Functional analysis of the human androgen receptor promoter","volume":"119","author":"Takane","year":"1996","journal-title":"Mol. Cell. Endocrinol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C46","first-page":"77","article-title":"Identification of 3\u2032,5\u2032-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter","volume":"8","author":"Mizokami","year":"1994","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C47","doi-asserted-by":"crossref","first-page":"33558","DOI":"10.1074\/jbc.M504461200","article-title":"Induction of androgen receptor expression by phosphatidylinositol 3-kinase\/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170503080330_DDV070C48","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1038\/sj.onc.1209366","article-title":"Complex regulation of human androgen receptor expression by Wnt signaling in prostate cancer cells","volume":"25","author":"Yang","year":"2006","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170503080330_DDV070C49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0090-4295(96)00117-3","article-title":"Agonist and antagonist activities of hydroxyflutamide and Casodex relate to androgen receptor stabilization","volume":"48","author":"Kemppainen","year":"1996","journal-title":"Urology"},{"key":"key\n\t\t\t\t20170503080330_DDV070C50","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.1168175","article-title":"Development of a second-generation antiandrogen for treatment of advanced prostate cancer","volume":"324","author":"Tran","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170503080330_DDV070C51","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.coph.2008.07.005","article-title":"Targeting the androgen receptor pathway in prostate cancer","volume":"8","author":"Chen","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"key\n\t\t\t\t20170503080330_DDV070C52","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1038\/mtna.2013.57","article-title":"HIV Tat domain improves cross-correction of human galactocerebrosidase in a gene- and flanking sequence-dependent manner","volume":"2","author":"Meng","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"key\n\t\t\t\t20170503080330_DDV070C53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4161\/oxim.1.1.6491","article-title":"Primary mouse renal tubular epithelial cells have variable injury tolerance to ischemic and chemical mediators of oxidative stress","volume":"1","author":"Breggia","year":"2008","journal-title":"Oxid. Med. Cell. Longev."},{"key":"key\n\t\t\t\t20170503080330_DDV070C54","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1194\/jlr.M017178","article-title":"Sex differences of urinary and kidney globotriaosylceramide and lyso-globotriaosylceramide in Fabry mice","volume":"52","author":"Durant","year":"2011","journal-title":"J. Lipid Res."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/24\/11\/3181\/14143508\/ddv070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T20:35:37Z","timestamp":1651350937000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddv070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,20]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,2,20]]},"published-print":{"date-parts":[[2015,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddv070","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2,20]]}}}