{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:57:04Z","timestamp":1772765824198,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Molecular Genetics"],"published-print":{"date-parts":[[2015,6,15]]},"DOI":"10.1093\/hmg\/ddv093","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T01:43:42Z","timestamp":1426124622000},"page":"3427-3439","source":"Crossref","is-referenced-by-count":28,"title":["A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS"],"prefix":"10.1093","volume":"24","author":[{"given":"S.","family":"Nagano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Masutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Urushitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,3,11]]},"reference":[{"issue":"6415","key":"1_10162536","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"issue":"5166","key":"2_15516824","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1126\/science.8209258","volume":"264","author":"Gurney","year":"1994","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"1","key":"3_16247268","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/ng0596-43","volume":"13","author":"Reaume","year":"1996","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"4","key":"4_16234275","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/00005072-199604000-00011","volume":"55","author":"Shibata","year":"1996","journal-title":"Journal of neuropathology and experimental neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3069","issn-type":"print"},{"issue":"2","key":"5_16704596","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0896-6273(00)80272-X","volume":"18","author":"Bruijn","year":"1997","journal-title":"Neuron","ISSN":"https:\/\/id.crossref.org\/issn\/0896-6273","issn-type":"print"},{"issue":"7","key":"6_34257588","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1089\/ars.2009.2536","volume":"11","author":"Chattopadhyay","year":"2009","journal-title":"Antioxidants & redox signaling","ISSN":"https:\/\/id.crossref.org\/issn\/1523-0864","issn-type":"print"},{"key":"7_18918875","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev.biochem.72.121801.161647","volume":"74","author":"Selverstone Valentine","year":"2005","journal-title":"Annual review of biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4154","issn-type":"print"},{"issue":"37","key":"8_46167367","doi-asserted-by":"publisher","first-page":"26480","DOI":"10.1074\/jbc.R113.467738","volume":"288","year":"2013","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"17","key":"9_19574128","doi-asserted-by":"publisher","first-page":"17266","DOI":"10.1074\/jbc.M500482200","volume":"280","year":"2005","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"45","key":"10_19687854","doi-asserted-by":"publisher","first-page":"15893","DOI":"10.1073\/pnas.0403979101","volume":"101","year":"2004","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"27","key":"11_28927019","doi-asserted-by":"publisher","first-page":"11263","DOI":"10.1073\/pnas.0704307104","volume":"104","year":"2007","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"49","key":"12_29550713","doi-asserted-by":"publisher","first-page":"35933","DOI":"10.1074\/jbc.M702941200","volume":"282","year":"2007","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"20","key":"13_34357626","doi-asserted-by":"publisher","first-page":"13940","DOI":"10.1074\/jbc.M809687200","volume":"284","year":"2009","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"7","key":"14_36498948","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.freeradbiomed.2010.01.008","volume":"48","author":"Kishigami","year":"2010","journal-title":"Free radical biology & medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0891-5849","issn-type":"print"},{"issue":"32","key":"15_40320352","doi-asserted-by":"publisher","first-page":"7057","DOI":"10.1021\/bi200614y","volume":"50","author":"Redler","year":"2011","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"16_50080525","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1038\/srep03275","volume":"3","year":"2013","ISSN":"https:\/\/id.crossref.org\/issn\/2045-2322","issn-type":"print"},{"issue":"8","key":"17_19566122","doi-asserted-by":"publisher","first-page":"5984","DOI":"10.1074\/jbc.M210419200","volume":"278","year":"2003","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"33","key":"18_19575842","doi-asserted-by":"publisher","first-page":"29771","DOI":"10.1074\/jbc.M504039200","volume":"280","year":"2005","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"35","key":"19_29260535","doi-asserted-by":"publisher","first-page":"14157","DOI":"10.1073\/pnas.0700477104","volume":"104","year":"2007","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"18","key":"20_22005391","doi-asserted-by":"publisher","first-page":"7142","DOI":"10.1073\/pnas.0602046103","volume":"103","year":"2006","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"18","key":"21_22005393","doi-asserted-by":"publisher","first-page":"7148","DOI":"10.1073\/pnas.0602048103","volume":"103","year":"2006","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"7","key":"22_44608122","doi-asserted-by":"publisher","first-page":"4970","DOI":"10.1074\/jbc.M112.414235","volume":"288","year":"2013","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"23_50080526","doi-asserted-by":"crossref","first-page":"e78060","DOI":"10.1371\/journal.pone.0078060","volume":"8","year":"2013","ISSN":"https:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"issue":"38","key":"24_29168107","doi-asserted-by":"publisher","first-page":"28087","DOI":"10.1074\/jbc.M704465200","volume":"282","year":"2007","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"2","key":"25_29879789","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1074\/jbc.M705657200","volume":"283","year":"2008","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"10","key":"26_28460802","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1016\/j.freeradbiomed.2007.02.004","volume":"42","author":"Watanabe","year":"2007","journal-title":"Free radical biology & medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0891-5849","issn-type":"print"},{"issue":"6","key":"27_28827170","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1097\/01.jnen.0000263868.84188.3b","volume":"66","author":"Sasaki","year":"2007","journal-title":"Journal of neuropathology and experimental neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3069","issn-type":"print"},{"issue":"4","key":"28_45723956","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1258\/002367790780865976","volume":"24","author":"Yamate","year":"1990","journal-title":"Laboratory Animals","ISSN":"https:\/\/id.crossref.org\/issn\/0023-6772","issn-type":"print"},{"issue":"18","key":"29_19553778","doi-asserted-by":"publisher","first-page":"15923","DOI":"10.1074\/jbc.M112087200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"5778","key":"30_22205801","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1126\/science.1123511","volume":"312","author":"Boillee","year":"2006","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"3","key":"31_30990197","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nn2047","volume":"11","author":"Yamanaka","year":"2008","journal-title":"Nature neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/1097-6256","issn-type":"print"},{"issue":"7","key":"32_23597016","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1073\/pnas.0606201104","volume":"104","year":"2007","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"5","key":"33_36964959","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/j.1471-4159.2010.06683.x","volume":"113","author":"Gros-Louis","year":"2010","journal-title":"Journal of neurochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3042","issn-type":"print"},{"issue":"23","key":"34_19670247","doi-asserted-by":"publisher","first-page":"12571","DOI":"10.1073\/pnas.220417997","volume":"97","year":"2000","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"19","key":"35_34706843","doi-asserted-by":"publisher","first-page":"7774","DOI":"10.1073\/pnas.0902505106","volume":"106","year":"2009","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"36_50080527","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2046-2395-1-4","volume":"1","year":"2012","journal-title":"LONGEV HEALTHSPAN"},{"issue":"7","key":"37_10769159","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1073\/pnas.96.7.4131","volume":"96","author":"Takagi","year":"1999","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"39","key":"38_48300811","doi-asserted-by":"publisher","first-page":"26722","DOI":"10.1074\/jbc.M114.565333","volume":"289","year":"2014","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"14","key":"39_42171406","doi-asserted-by":"publisher","first-page":"5505","DOI":"10.1073\/pnas.1115009109","volume":"109","year":"2012","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"40_47358784","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/ncomms2417","volume":"4","year":"2013","ISSN":"https:\/\/id.crossref.org\/issn\/2041-1723","issn-type":"print"},{"issue":"3","key":"41_17803933","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0022-2836(03)00889-1","volume":"332","author":"DiDonato","year":"2003","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"20","key":"42_30558517","doi-asserted-by":"publisher","first-page":"13528","DOI":"10.1074\/jbc.M800564200","volume":"283","year":"2008","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"4","key":"43_41789154","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s11064-011-0679-8","volume":"37","author":"Chen","year":"2012","journal-title":"Neurochemical research","ISSN":"https:\/\/id.crossref.org\/issn\/0364-3190","issn-type":"print"},{"issue":"2","key":"44_21131038","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1093\/brain\/awh704","volume":"129","year":"2006","journal-title":"Brain","ISSN":"https:\/\/id.crossref.org\/issn\/0006-8950","issn-type":"print"},{"issue":"3","key":"45_41955674","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1471-4159.2012.07690.x","volume":"121","author":"Prudencio","year":"2012","journal-title":"Journal of neurochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3042","issn-type":"print"},{"issue":"13","key":"46_9902938","doi-asserted-by":"publisher","first-page":"6109","DOI":"10.1073\/pnas.89.13.6109","volume":"89","author":"Parge","year":"1992","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"11","key":"47_38342134","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1038\/nn.2660","volume":"13","author":"Bosco","year":"2010","journal-title":"Nature neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/1097-6256","issn-type":"print"},{"issue":"22","key":"48_14322531","doi-asserted-by":"publisher","first-page":"8044","DOI":"10.1073\/pnas.84.22.8044","volume":"84","author":"Epstein","year":"1987","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"49_11911553","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Analytical biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0003-2697","issn-type":"print"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/24\/12\/3427\/1723834\/ddv093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T22:10:18Z","timestamp":1566425418000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddv093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,11]]},"references-count":49,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,5,19]]},"published-print":{"date-parts":[[2015,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddv093","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,11]]}}}