{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:28:58Z","timestamp":1791268138175,"version":"4.1.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mol. Genet."],"published-print":{"date-parts":[[2015,8,1]]},"DOI":"10.1093\/hmg\/ddv167","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T01:33:11Z","timestamp":1431048791000},"page":"4340-4352","source":"Crossref","is-referenced-by-count":40,"title":["<i>DLX4<\/i>is associated with orofacial clefting and abnormal jaw development"],"prefix":"10.1093","volume":"24","author":[{"given":"Di","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamali","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Prochazkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazel","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L.","family":"Gil-Da-Silva-Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Ling-Fung","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui-yan","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ophir","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bian","family":"Zhuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Slavotinek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"2015070608392105000_24.15.4340.1","doi-asserted-by":"publisher","DOI":"10.1597\/10-223"},{"key":"2015070608392105000_24.15.4340.2","doi-asserted-by":"publisher","DOI":"10.1597\/09-217"},{"key":"2015070608392105000_24.15.4340.3","doi-asserted-by":"publisher","DOI":"10.1038\/1294"},{"key":"2015070608392105000_24.15.4340.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032909"},{"key":"2015070608392105000_24.15.4340.5","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500612"},{"key":"2015070608392105000_24.15.4340.6","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.4.522"},{"key":"2015070608392105000_24.15.4340.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2014.04.003"},{"key":"2015070608392105000_24.15.4340.8","doi-asserted-by":"publisher","DOI":"10.1597\/10-178"},{"key":"2015070608392105000_24.15.4340.9","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31381"},{"key":"2015070608392105000_24.15.4340.10","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23867"},{"key":"2015070608392105000_24.15.4340.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00487.x"},{"key":"2015070608392105000_24.15.4340.12","doi-asserted-by":"publisher","DOI":"10.1242\/dev.080473"},{"key":"2015070608392105000_24.15.4340.13","doi-asserted-by":"crossref","unstructured":"Panganiban G. Rubenstein J.L. (2002) Developmental functions of the Distal-less\/Dlx homeobox genes. Development, 129, 4371\u20134386.","DOI":"10.1242\/dev.129.19.4371"},{"key":"2015070608392105000_24.15.4340.14","doi-asserted-by":"publisher","DOI":"10.1242\/dev.049700"},{"key":"2015070608392105000_24.15.4340.15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10858"},{"key":"2015070608392105000_24.15.4340.16","doi-asserted-by":"crossref","unstructured":"Akimenko M.A. Ekker M. Wegner J. Lin W. Westerfield M. (1994) Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. J. Neurosci., 14, 3475\u20133486.","DOI":"10.1523\/JNEUROSCI.14-06-03475.1994"},{"key":"2015070608392105000_24.15.4340.17","doi-asserted-by":"crossref","unstructured":"Solomon K.S. Fritz A. (2002) Concerted action of two dlx paralogs in sensory placode formation. Development, 129, 3127\u20133136.","DOI":"10.1242\/dev.129.13.3127"},{"key":"2015070608392105000_24.15.4340.18","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.4"},{"key":"2015070608392105000_24.15.4340.19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401912"},{"key":"2015070608392105000_24.15.4340.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0402-7"},{"key":"2015070608392105000_24.15.4340.21","unstructured":"Neufing P.J. Kalionis B. Horsfall D.J. Ricciardelli C. Stahl J. Vivekanandan S. Raymond W. Tilley W.D. (2013) Expression and localization of homeodomain proteins DLX4\/HB9 in normal and malignant human breast tissues. Anticancer Res., 23, 1479\u20131488."},{"key":"2015070608392105000_24.15.4340.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2008.07.004"},{"key":"2015070608392105000_24.15.4340.23","doi-asserted-by":"crossref","unstructured":"Kluk B.J. Fu Y. Formolo T.A. Zhang L. Hindle A.K. Man Y.G. Siegel R.S. Berg P.E. Deng C. McCaffrey T.A. (2010) BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer. Int. J. Biol. Sci., 6, 513\u2013524.","DOI":"10.7150\/ijbs.6.513"},{"key":"2015070608392105000_24.15.4340.24","unstructured":"Xian Y.S. Dang C.X. Yan C.X. Li H.P. Fu S.W. Wang Z.R. (2006) Clinicopathological significance of homeobox BP1 mRNA expression in lung cancer tissue. Nan Fang Yi Ke Da Xue Xue Bao, 26, 1173\u20131175."},{"key":"2015070608392105000_24.15.4340.25","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.168"},{"key":"2015070608392105000_24.15.4340.26","unstructured":"Hollington P. Neufing P. Kalionis B. Waring P. Bentel J. Wattchow D. Tilley W.D. (2004) Expression and localization of homeodomain proteins DLX4, HB9 and HB24 in malignant and benign human colorectal tissues. Anticancer Res., 24, 955\u2013962."},{"key":"2015070608392105000_24.15.4340.27","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8556"},{"key":"2015070608392105000_24.15.4340.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.11.005"},{"key":"2015070608392105000_24.15.4340.29","doi-asserted-by":"crossref","unstructured":"Acampora D. Merlo G.R. Paleari L. Zerega B. Postiglione M.P. Mantero S. Bober E. Barbieri O. Simeone A. Levi G. (1999) Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development, 126, 3795\u20133809.","DOI":"10.1242\/dev.126.17.3795"},{"key":"2015070608392105000_24.15.4340.30","doi-asserted-by":"crossref","unstructured":"Depew M.J. Liu J.K. Long J.E. Presley R. Meneses J.J. Pedersen R.A. Rubenstein J.L. (1999) Dlx5 regulates regional development of the branchial arches and sensory capsules. Development, 126, 3831\u20133846.","DOI":"10.1242\/dev.126.17.3831"},{"key":"2015070608392105000_24.15.4340.31","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Jacobo L. C\u00f3rdova-Fletes C. Ortiz-L\u00f3pez R. Rivas F. Saucedo-Carrasco C. Rojas-Mart\u00ednez A. (2013) Delineation of a de novo 7q21.3q31.1 deletion by CGH-SNP arrays in a girl with multiple congenital anomalies including severe glaucoma. Mol. Syndromol., 4, 285\u2013291.","DOI":"10.1159\/000353510"},{"key":"2015070608392105000_24.15.4340.32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004257"},{"key":"2015070608392105000_24.15.4340.33","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100556"},{"key":"2015070608392105000_24.15.4340.34","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23298"},{"key":"2015070608392105000_24.15.4340.35","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.7"},{"key":"2015070608392105000_24.15.4340.36","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.3.563"},{"key":"2015070608392105000_24.15.4340.37","doi-asserted-by":"crossref","unstructured":"Dong J. Amor D. Aldred M.J. Gu T. Escamilla M. MacDougall M. (2005) DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism. Am. J. Med. Genet., 133A, 138\u2013141.","DOI":"10.1002\/ajmg.a.30521"},{"key":"2015070608392105000_24.15.4340.38","doi-asserted-by":"publisher","DOI":"10.1159\/000322561"},{"key":"2015070608392105000_24.15.4340.39","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961016)65:2<109::AID-AJMG5>3.0.CO;2-N"},{"key":"2015070608392105000_24.15.4340.40","doi-asserted-by":"publisher","DOI":"10.1597\/04-200.1"},{"key":"2015070608392105000_24.15.4340.41","doi-asserted-by":"crossref","unstructured":"Weaver K.N. Rutledge K.D. Grant J.H. Robin N.H. (2010) Imperforate anus is a rare associated finding in blepharocheilodontic syndrome. Am. J. Med. Genet., 152A, 438\u2013440.","DOI":"10.1002\/ajmg.a.33207"},{"key":"2015070608392105000_24.15.4340.42","doi-asserted-by":"crossref","unstructured":"Freitas E.L. Martinhago C.D. Ramos E.S. Murray J.C. Gil-da-Silva-Lopes V.L. (2007) Preliminary molecular studies on blepharocheilodontic syndrome. Am. J. Med. Genet., 143A, 2757\u20132759.","DOI":"10.1002\/ajmg.a.32010"},{"key":"2015070608392105000_24.15.4340.43","doi-asserted-by":"crossref","unstructured":"Gil da Silva Lopes V.L. Guion-Almeida M.L. de Oliveira Rodini E.S. (2003) Blepharocheilodontic (BCD) syndrome: expanding the phenotype? Am. J. Med. Genet., 121A, 266\u2013270.","DOI":"10.1002\/ajmg.a.20223"},{"key":"2015070608392105000_24.15.4340.44","doi-asserted-by":"crossref","unstructured":"Zerucha T. St\u00fchmer T. Hatch G. Park B.K. Long Q. Yu G. Gambarotta A. Schultz J.R. Rubenstein J.L. Ekker M. (2000) A highly conserved enhancer in the Dlx5\/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain. J. Neurosci., 20, 709\u2013721.","DOI":"10.1523\/JNEUROSCI.20-02-00709.2000"},{"key":"2015070608392105000_24.15.4340.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.07.029"},{"key":"2015070608392105000_24.15.4340.46","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4458"},{"key":"2015070608392105000_24.15.4340.47","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20106"},{"key":"2015070608392105000_24.15.4340.48","doi-asserted-by":"publisher","DOI":"10.1086\/422475"},{"key":"2015070608392105000_24.15.4340.49","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181833793"},{"key":"2015070608392105000_24.15.4340.50","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2003)040<0071:CGMSOC>2.0.CO;2"},{"key":"2015070608392105000_24.15.4340.51","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.8.2505-2514.2002"},{"key":"2015070608392105000_24.15.4340.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00716-8"},{"key":"2015070608392105000_24.15.4340.53","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1766"},{"key":"2015070608392105000_24.15.4340.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.03.007"},{"key":"2015070608392105000_24.15.4340.55","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00124-7"},{"key":"2015070608392105000_24.15.4340.56","unstructured":"Gallagher E.R. Ratisoontorn C. Cunningham M.L . Saethre-Chotzen Syndrome. In Pagon R.A. Adam M.P. Bird T.D. Dolan C.R. Fong C.T. Stephens K. (eds), GeneReviews\u2122 [Internet]. University of Washington, Seattle, Seattle (WA), 1993\u20132013. 2003 May 16."},{"key":"2015070608392105000_24.15.4340.57","doi-asserted-by":"publisher","DOI":"10.1597\/08-088.1"},{"key":"2015070608392105000_24.15.4340.58","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1102581"},{"key":"2015070608392105000_24.15.4340.59","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh233"},{"key":"2015070608392105000_24.15.4340.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.02.002"},{"key":"2015070608392105000_24.15.4340.61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035347"},{"key":"2015070608392105000_24.15.4340.62","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01676"},{"key":"2015070608392105000_24.15.4340.63","doi-asserted-by":"publisher","DOI":"10.1242\/dev.073197"},{"key":"2015070608392105000_24.15.4340.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.08.014"},{"key":"2015070608392105000_24.15.4340.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.10.017"},{"key":"2015070608392105000_24.15.4340.66","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00445"},{"key":"2015070608392105000_24.15.4340.67","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22713"},{"key":"2015070608392105000_24.15.4340.68","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22051"},{"key":"2015070608392105000_24.15.4340.69","doi-asserted-by":"publisher","DOI":"10.1242\/dev.094938"},{"key":"2015070608392105000_24.15.4340.70","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds477"},{"key":"2015070608392105000_24.15.4340.71","doi-asserted-by":"crossref","unstructured":"Yahyavi M. Abouzeid H. Gawdat G. de Preux A.S. Xiao T. Bardakjian T. Schneider A. Choi A. Jorgenson E. Baier H. (2013) ALDH1A3 loss of function causes bilateral anophthalmia\/microphthalmia and hypoplasia of the optic nerve and optic chiasm. Hum. Mol. Genet., 2, 3250\u20133258.","DOI":"10.1093\/hmg\/ddt179"},{"key":"2015070608392105000_24.15.4340.72","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603"},{"key":"2015070608392105000_24.15.4340.73","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-100918"},{"key":"2015070608392105000_24.15.4340.74","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0810-575"},{"key":"2015070608392105000_24.15.4340.75","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"2015070608392105000_24.15.4340.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.09.020"},{"key":"2015070608392105000_24.15.4340.77","doi-asserted-by":"publisher","DOI":"10.1080\/10520290701333558"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/24\/15\/4340\/17262606\/ddv167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T13:58:41Z","timestamp":1651931921000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddv167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":77,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2015,7,6]]},"published-print":{"date-parts":[[2015,8,1]]}},"alternative-id":["10.1093\/hmg\/ddv167"],"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddv167","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]}}}