{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:16:41Z","timestamp":1793395001328,"version":"4.5.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG042178"],"award-info":[{"award-number":["AG042178"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG047812"],"award-info":[{"award-number":["AG047812"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Garrison Family Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mol. Genet."],"published-print":{"date-parts":[[2016,5,1]]},"DOI":"10.1093\/hmg\/ddw045","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T13:10:20Z","timestamp":1455801020000},"page":"1739-1753","source":"Crossref","is-referenced-by-count":139,"title":["Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease"],"prefix":"10.1093","volume":"25","author":[{"given":"Xiangling","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Manczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Hemachandra","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"2016070501483598000_25.9.1739.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00003"},{"key":"2016070501483598000_25.9.1739.2","first-page":"21","article-title":"Brain imaging and cognitive dysfunctions in Huntington's disease","volume":"31","author":"Montoya","year":"2006","journal-title":"J. Psychiatry. Neurosci."},{"key":"2016070501483598000_25.9.1739.3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.6.561"},{"key":"2016070501483598000_25.9.1739.4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.5.487"},{"key":"2016070501483598000_25.9.1739.5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"2016070501483598000_25.9.1739.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01415-0"},{"key":"2016070501483598000_25.9.1739.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2009.04.001"},{"key":"2016070501483598000_25.9.1739.8","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-1-19"},{"key":"2016070501483598000_25.9.1739.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1738"},{"key":"2016070501483598000_25.9.1739.10","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr024"},{"key":"2016070501483598000_25.9.1739.11","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq306"},{"key":"2016070501483598000_25.9.1739.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0328-4"},{"key":"2016070501483598000_25.9.1739.13","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000102"},{"key":"2016070501483598000_25.9.1739.14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn404"},{"key":"2016070501483598000_25.9.1739.15","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr475"},{"key":"2016070501483598000_25.9.1739.16","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2313"},{"key":"2016070501483598000_25.9.1739.17","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv429"},{"key":"2016070501483598000_25.9.1739.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.10.016"},{"key":"2016070501483598000_25.9.1739.19","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-008-8044-z"},{"key":"2016070501483598000_25.9.1739.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.10.011"},{"key":"2016070501483598000_25.9.1739.21","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.013"},{"key":"2016070501483598000_25.9.1739.22","doi-asserted-by":"crossref","first-page":"31372","DOI":"10.1155\/JBB\/2006\/31372","article-title":"Mitochondrial oxidative damage in aging and Alzheimer's disease:implications for mitochondrially targeted antioxidant therapeutics","volume":"2006","author":"Reddy","year":"2006","journal-title":"J. Biomed. Biotechnol."},{"key":"2016070501483598000_25.9.1739.23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbadis.2005.10.007","article-title":"Targeting antioxidants to mitochondria: a new therapeutic direction","volume":"1762","author":"Sheu","year":"2006","journal-title":"Biochim Biophys Acta."},{"key":"2016070501483598000_25.9.1739.24","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.47.120505.105110"},{"key":"2016070501483598000_25.9.1739.25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05627.x"},{"key":"2016070501483598000_25.9.1739.26","doi-asserted-by":"publisher","DOI":"10.1038\/nm1001-1111"},{"key":"2016070501483598000_25.9.1739.27","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0240fje"},{"key":"2016070501483598000_25.9.1739.28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301089200"},{"key":"2016070501483598000_25.9.1739.29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404003200"},{"key":"2016070501483598000_25.9.1739.30","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100564"},{"key":"2016070501483598000_25.9.1739.31","doi-asserted-by":"publisher","DOI":"10.1007\/BF02854898"},{"key":"2016070501483598000_25.9.1739.32","doi-asserted-by":"publisher","DOI":"10.1097\/01.mca.0000236285.71683.b6"},{"key":"2016070501483598000_25.9.1739.33","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080825"},{"key":"2016070501483598000_25.9.1739.34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609388200"},{"key":"2016070501483598000_25.9.1739.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04018.x"},{"key":"2016070501483598000_25.9.1739.36","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr381"},{"key":"2016070501483598000_25.9.1739.37","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr139"},{"key":"2016070501483598000_25.9.1739.38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804871105"},{"key":"2016070501483598000_25.9.1739.39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1357-09.2009"},{"key":"2016070501483598000_25.9.1739.40","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt247"},{"key":"2016070501483598000_25.9.1739.41","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds003"},{"key":"2016070501483598000_25.9.1739.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.09.005"},{"key":"2016070501483598000_25.9.1739.43","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt528"},{"key":"2016070501483598000_25.9.1739.44","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.18.8195-8209.2004"},{"key":"2016070501483598000_25.9.1739.45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70911"},{"key":"2016070501483598000_25.9.1739.46","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6242-0"},{"key":"2016070501483598000_25.9.1739.47","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410514"},{"key":"2016070501483598000_25.9.1739.48","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199901)45:1<25::AID-ART6>3.0.CO;2-E"},{"key":"2016070501483598000_25.9.1739.49","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1471-4159.2007.04996.x","article-title":"Mitochondrial NAD+-linked State 3 respiration and complex-I activity are compromised in the cerebral cortex of 3\u2013 nitropropionic acid-induced rat model of Huntington's disease","volume":"104","author":"Pandey","year":"2008","journal-title":"J. Neurochem."},{"key":"2016070501483598000_25.9.1739.50","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2799"},{"key":"2016070501483598000_25.9.1739.51","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.4.503"},{"key":"2016070501483598000_25.9.1739.52","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8010203"},{"key":"2016070501483598000_25.9.1739.53","first-page":"1","article-title":"Measurement of oxygen radicals and lipid peroxidation in neural tissues","volume":"7","author":"Hall","year":"2009","journal-title":"Curr. Protoc. Neurosci.,"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/25\/9\/1739\/7148535\/ddw045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:36:28Z","timestamp":1718354188000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddw045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,16]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,7,5]]},"published-print":{"date-parts":[[2016,5,1]]}},"alternative-id":["10.1093\/hmg\/ddw045"],"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddw045","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,16]]}}}