{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:35:59Z","timestamp":1789947359457,"version":"4.0.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"10","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100005C"],"award-info":[{"award-number":["HHSN268201100005C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100006C"],"award-info":[{"award-number":["HHSN268201100006C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100007C"],"award-info":[{"award-number":["HHSN268201100007C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100008C"],"award-info":[{"award-number":["HHSN268201100008C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100009C"],"award-info":[{"award-number":["HHSN268201100009C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100010C"],"award-info":[{"award-number":["HHSN268201100010C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100011C"],"award-info":[{"award-number":["HHSN268201100011C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HSN268201100012C"],"award-info":[{"award-number":["HSN268201100012C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL087641"],"award-info":[{"award-number":["R01HL087641"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL59367"],"award-info":[{"award-number":["R01HL59367"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL086694"],"award-info":[{"award-number":["R01HL086694"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG004402"],"award-info":[{"award-number":["U01HG004402"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268200625226C"],"award-info":[{"award-number":["HHSN268200625226C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES010126"],"award-info":[{"award-number":["P30ES010126"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE11551"],"award-info":[{"award-number":["R01DE11551"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE021418"],"award-info":[{"award-number":["R01DE021418"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["UL1RR025005"],"award-info":[{"award-number":["UL1RR025005"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH Roadmap for Medical Research"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHA 1582\/3-1"],"award-info":[{"award-number":["SCHA 1582\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heinz Nixdorf Foundation"},{"name":"German Ministry of Education and Science"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Centre for Neurodegenerative DISEASES"},{"name":"Dr Offenbacher's Kenan Professorship funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mol. Genet."],"published-print":{"date-parts":[[2016,5,15]]},"DOI":"10.1093\/hmg\/ddw069","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T21:13:37Z","timestamp":1457558017000},"page":"2113-2129","source":"Crossref","is-referenced-by-count":126,"title":["Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease"],"prefix":"10.1093","volume":"25","author":[{"given":"Steven","family":"Offenbacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimon","family":"Divaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana P.","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie T.","family":"Marchesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Laudes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Munz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne S.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari E.","family":"North","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"2016101302472956000_25.10.2113.1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"2016101302472956000_25.10.2113.2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140202"},{"key":"2016101302472956000_25.10.2113.3","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.5.531"},{"key":"2016101302472956000_25.10.2113.4","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.1.23"},{"key":"2016101302472956000_25.10.2113.5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028004283.x"},{"key":"2016101302472956000_25.10.2113.6","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.5.293"},{"key":"2016101302472956000_25.10.2113.7","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.11.1699"},{"key":"2016101302472956000_25.10.2113.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2012.00663.x"},{"key":"2016101302472956000_25.10.2113.9","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12010"},{"key":"2016101302472956000_25.10.2113.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01534.x"},{"key":"2016101302472956000_25.10.2113.11","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12302"},{"key":"2016101302472956000_25.10.2113.12","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.174"},{"key":"2016101302472956000_25.10.2113.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01043.x"},{"key":"2016101302472956000_25.10.2113.14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt065"},{"key":"2016101302472956000_25.10.2113.15","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514544506"},{"key":"2016101302472956000_25.10.2113.16","doi-asserted-by":"publisher","DOI":"10.1534\/g3.113.008755"},{"key":"2016101302472956000_25.10.2113.17","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12154"},{"key":"2016101302472956000_25.10.2113.18","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512447951"},{"key":"2016101302472956000_25.10.2113.19","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12317"},{"key":"2016101302472956000_25.10.2113.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.022"},{"key":"2016101302472956000_25.10.2113.21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-151"},{"key":"2016101302472956000_25.10.2113.22","doi-asserted-by":"crossref","unstructured":"Liu F. , van der Lijn F. , Schurmann C. , Zhu G. , Chakravarty M.M. , Hysi P.G. , Wollstein A. , Lao O. , Bruijne M.D. , Ikram M.A. et al . (2012) A genome-wide association study identifies five loci influencing facial morphology in Europeans. PLoS Genet., 8, e1002932.","DOI":"10.1371\/journal.pgen.1002932"},{"key":"2016101302472956000_25.10.2113.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.11.017"},{"key":"2016101302472956000_25.10.2113.24","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2344"},{"key":"2016101302472956000_25.10.2113.25","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.110.120907"},{"key":"2016101302472956000_25.10.2113.26","unstructured":"Klein P. (1994) An Easy Guide to Factor Analysis. Taylor Francis Ltd, UK."},{"key":"2016101302472956000_25.10.2113.27","unstructured":"B\u00fcy\u00fck\u00f6zt\u00fcrk \u015e. (2004) Social sciences data analysis hand book, pp. 140\u2013175. Pegem Publishing, Ankara."},{"key":"2016101302472956000_25.10.2113.28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"2016101302472956000_25.10.2113.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.014"},{"key":"2016101302472956000_25.10.2113.30","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"2016101302472956000_25.10.2113.31","doi-asserted-by":"crossref","unstructured":"Segr\u00e8 A.V. , Groop L. , Mootha V.K. , Daly M.J. , Altshuler D. (2010) Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet., 6, e1001058.","DOI":"10.1371\/journal.pgen.1001058"},{"key":"2016101302472956000_25.10.2113.32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.114.000554"},{"key":"2016101302472956000_25.10.2113.33","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P052209"},{"key":"2016101302472956000_25.10.2113.34","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-012-1492-5"},{"key":"2016101302472956000_25.10.2113.35","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123579"},{"key":"2016101302472956000_25.10.2113.36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019306"},{"key":"2016101302472956000_25.10.2113.37","unstructured":"Belsley D.A. , Kuh E. , Welsch R.E. (2005) Regression Diagnostics: Identifying Influential Data and Sources of Collinearity. Wiley, New York, NY."},{"key":"2016101302472956000_25.10.2113.38","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080645"},{"key":"2016101302472956000_25.10.2113.39","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1407-9"},{"key":"2016101302472956000_25.10.2113.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.02.020"},{"key":"2016101302472956000_25.10.2113.41","doi-asserted-by":"crossref","unstructured":"Fredman G. , Oh S.F. , Ayilavarapu S. , Hasturk H. , Serhan C.N. , Van Dyke T.E. (2011) Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. PLoS One, 6, e24422.","DOI":"10.1371\/journal.pone.0024422"},{"key":"2016101302472956000_25.10.2113.42","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12015"},{"key":"2016101302472956000_25.10.2113.43","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1128\/IAI.60.6.2481-2487.1992","article-title":"Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis","volume":"60","author":"Tyagi","year":"1992","journal-title":"Infect. Immun."},{"key":"2016101302472956000_25.10.2113.44","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.8.1025"},{"key":"2016101302472956000_25.10.2113.45","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.66"},{"key":"2016101302472956000_25.10.2113.46","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070135"},{"key":"2016101302472956000_25.10.2113.47","doi-asserted-by":"publisher","DOI":"10.1177\/000456329703400205"},{"key":"2016101302472956000_25.10.2113.48","doi-asserted-by":"crossref","unstructured":"Tobin D.M. , Roca F.J. , Ray J.P. , Ko D.C. , Ramakrishnan L. (2013) An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. PLoS One, 8, e67828.","DOI":"10.1371\/journal.pone.0067828"},{"key":"2016101302472956000_25.10.2113.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.08.002"},{"key":"2016101302472956000_25.10.2113.50","doi-asserted-by":"crossref","unstructured":"Liu B. , Faller L.L. , Klitgord N. , Mazumdar V. , Ghodsi M. , Sommer D. , Gibbons T.R. , Treangen T.J. , Chang Y. , Li S. et al . (2012) Deep sequencing of the oral microbiome reveals signatures of periodontal disease. PLoS One, 7, e37919.","DOI":"10.1371\/journal.pone.0037919"},{"key":"2016101302472956000_25.10.2113.51","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2014.23"},{"key":"2016101302472956000_25.10.2113.52","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.041038-0"},{"key":"2016101302472956000_25.10.2113.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2013.06.001"},{"key":"2016101302472956000_25.10.2113.54","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.097803"},{"key":"2016101302472956000_25.10.2113.55","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060465"},{"key":"2016101302472956000_25.10.2113.56","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.6.782"},{"key":"2016101302472956000_25.10.2113.57","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"2016101302472956000_25.10.2113.58","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2003.03110.x"},{"key":"2016101302472956000_25.10.2113.59","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060047"},{"key":"2016101302472956000_25.10.2113.60","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-134"},{"key":"2016101302472956000_25.10.2113.61","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq419"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/25\/10\/2113\/18527331\/ddw069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:10:16Z","timestamp":1600283416000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddw069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,8]]},"references-count":61,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,13]]},"published-print":{"date-parts":[[2016,5,15]]}},"alternative-id":["10.1093\/hmg\/ddw069"],"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddw069","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,8]]}}}