{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:20:43Z","timestamp":1790176843631,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mol. Genet."],"DOI":"10.1093\/hmg\/ddw117","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T20:44:13Z","timestamp":1464986653000},"page":"ddw117","source":"Crossref","is-referenced-by-count":9,"title":["Increased steroidogenesis promotes early-onset and severe vision loss in females with<i>OPA1<\/i>dominant optic atrophy"],"prefix":"10.1093","author":[{"given":"Emmanuelle","family":"Sarzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Seveno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Angebault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Milea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"R\u00f6nnb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Quil\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Grenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Caignard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Lacroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lavergne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Reynier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P","family":"Hamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Lenaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"2016061019042152000_ddw117v2.1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-46"},{"key":"2016061019042152000_ddw117v2.2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.108696.110"},{"key":"2016061019042152000_ddw117v2.3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200677200"},{"key":"2016061019042152000_ddw117v2.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.04.003"},{"key":"2016061019042152000_ddw117v2.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.04.012"},{"key":"2016061019042152000_ddw117v2.6","doi-asserted-by":"crossref","first-page":"e236.","DOI":"10.1093\/brain\/aws340","article-title":"Sensorineural hearing loss in OPA1-linked disorders","volume":"136(Pt 7)","author":"Leruez","year":"2013","journal-title":"Brain"},{"key":"2016061019042152000_ddw117v2.7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/brain\/awq007","article-title":"Multi-system neurological disease is common in patients with OPA1 mutations","volume":"133(Pt 3)","author":"Yu-Wai-Man","year":"2010","journal-title":"Brain"},{"key":"2016061019042152000_ddw117v2.8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24410"},{"key":"2016061019042152000_ddw117v2.9","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/brain\/aws303","article-title":"The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse","volume":"135(Pt 12)","author":"Sarzi","year":"2012","journal-title":"Brain"},{"key":"2016061019042152000_ddw117v2.10","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.134726"},{"key":"2016061019042152000_ddw117v2.11","doi-asserted-by":"crossref","unstructured":"Gaignard P. Savouroux S. Liere P. Pianos A. Th\u00e9rond P. Schumacher M. Slama A Guennoun R . (2015) Effect of sex differences on brain mitochondrial function and its suppression by ovariectomy and in aged mice. Endocrinology, en20141913.","DOI":"10.1210\/en.2014-1913"},{"key":"2016061019042152000_ddw117v2.12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/brain\/awq276","article-title":"Oestrogens ameliorate mitochondrial dysfunction in Leber\u2019s hereditary optic neuropathy","volume":"134(Pt 1)","author":"Giordano","year":"2011","journal-title":"Brain"},{"key":"2016061019042152000_ddw117v2.13","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1286.012"},{"key":"2016061019042152000_ddw117v2.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.04.014"},{"key":"2016061019042152000_ddw117v2.15","doi-asserted-by":"crossref","unstructured":"Sandoval H. Yao C.K. Chen K. Jaiswal M. Donti T. Lin Y.Q. Bayat V. Xiong B. Zhang K. David G . . (2014) Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. eLife, 3.","DOI":"10.7554\/eLife.03558"},{"key":"2016061019042152000_ddw117v2.16","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1159"},{"key":"2016061019042152000_ddw117v2.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.04.054"},{"key":"2016061019042152000_ddw117v2.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00448.x"},{"key":"2016061019042152000_ddw117v2.19","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.3.351"},{"key":"2016061019042152000_ddw117v2.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.008"},{"key":"2016061019042152000_ddw117v2.21","doi-asserted-by":"crossref","first-page":"70.","DOI":"10.1186\/1471-2350-10-70","article-title":"OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background","volume":"10","author":"Pierron","year":"2009","journal-title":"BMC Med. Genet"},{"key":"2016061019042152000_ddw117v2.22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1471-4159.1994.63010086.x","article-title":"Neurosteroidogenesis in rat retinas","volume":"63","author":"Guarneri","year":"1994","journal-title":"J. Neurochem"},{"key":"2016061019042152000_ddw117v2.23","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53630-3.00008-7"},{"key":"2016061019042152000_ddw117v2.24","doi-asserted-by":"publisher","DOI":"10.1126\/science.1243985"},{"key":"2016061019042152000_ddw117v2.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.02.008"},{"key":"2016061019042152000_ddw117v2.26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037926"},{"key":"2016061019042152000_ddw117v2.27","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1740435"},{"key":"2016061019042152000_ddw117v2.28","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000038304.62046.4C"},{"key":"2016061019042152000_ddw117v2.29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.9.3283"},{"key":"2016061019042152000_ddw117v2.30","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.003392"},{"key":"2016061019042152000_ddw117v2.31","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-7722.2003.00042.x"},{"key":"2016061019042152000_ddw117v2.32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306948101"},{"key":"2016061019042152000_ddw117v2.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2013.08.001"},{"key":"2016061019042152000_ddw117v2.34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3233\/JAD-2012-120283","article-title":"New evidence of mitochondria dysfunction in the female Alzheimer\u2019s disease brain: deficiency of estrogen receptor-beta","volume":"30","author":"Long","year":"2012","journal-title":"Journal of Alzheimer's Disease: JAD"},{"key":"2016061019042152000_ddw117v2.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2006.05.003"},{"key":"2016061019042152000_ddw117v2.36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0742380.x"},{"key":"2016061019042152000_ddw117v2.37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01229.x"},{"key":"2016061019042152000_ddw117v2.38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00191.x"},{"key":"2016061019042152000_ddw117v2.39","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1999.072"},{"key":"2016061019042152000_ddw117v2.40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1999.00407.x"},{"key":"2016061019042152000_ddw117v2.41","doi-asserted-by":"publisher","DOI":"10.1159\/000321118"},{"key":"2016061019042152000_ddw117v2.42","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0541"},{"key":"2016061019042152000_ddw117v2.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2009.05.001"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/article\/25\/12\/2539\/2525742\/Increased-steroidogenesis-promotes-earlyonset-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:45:59Z","timestamp":1568000759000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddw117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":43,"alternative-id":["10.1093\/hmg\/ddw117"],"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddw117","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]}}}