{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:06:47Z","timestamp":1790795207219,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mol. Genet."],"DOI":"10.1093\/hmg\/ddw119","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T20:44:13Z","timestamp":1464986653000},"page":"ddw119","source":"Crossref","is-referenced-by-count":15,"title":["Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism"],"prefix":"10.1093","author":[{"given":"Ivan","family":"Gallotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Mazzarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Donato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C.","family":"Chaplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Zampi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio S.","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo A.","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bazzicalupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Di Schiavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"2016061019042144000_ddw119v2.1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.15.6.409"},{"key":"2016061019042144000_ddw119v2.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.08.005"},{"key":"2016061019042144000_ddw119v2.3","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1996.0010"},{"key":"2016061019042144000_ddw119v2.4","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(80)90847-8","article-title":"Classification of spinal muscular atrophies","volume":"1","author":"Pearn","year":"1980","journal-title":"Lancet"},{"key":"2016061019042144000_ddw119v2.5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90460-3"},{"key":"2016061019042144000_ddw119v2.6","doi-asserted-by":"publisher","DOI":"10.1038\/344540a0"},{"key":"2016061019042144000_ddw119v2.7","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.7.1177"},{"key":"2016061019042144000_ddw119v2.8","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.13.2525"},{"key":"2016061019042144000_ddw119v2.9","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.4858"},{"key":"2016061019042144000_ddw119v2.10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074962"},{"key":"2016061019042144000_ddw119v2.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80368-2"},{"key":"2016061019042144000_ddw119v2.12","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200304128"},{"key":"2016061019042144000_ddw119v2.13","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg157"},{"key":"2016061019042144000_ddw119v2.14","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2670"},{"key":"2016061019042144000_ddw119v2.15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003209"},{"key":"2016061019042144000_ddw119v2.16","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp310"},{"key":"2016061019042144000_ddw119v2.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.011"},{"key":"2016061019042144000_ddw119v2.18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.12.2133"},{"key":"2016061019042144000_ddw119v2.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9920"},{"key":"2016061019042144000_ddw119v2.20","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn320"},{"key":"2016061019042144000_ddw119v2.21","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.3.333"},{"key":"2016061019042144000_ddw119v2.22","doi-asserted-by":"publisher","DOI":"10.1007\/s10158-006-0027-x"},{"key":"2016061019042144000_ddw119v2.23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1536-12.2013"},{"key":"2016061019042144000_ddw119v2.24","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq459"},{"key":"2016061019042144000_ddw119v2.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2007.03.002"},{"key":"2016061019042144000_ddw119v2.26","doi-asserted-by":"publisher","DOI":"10.1038\/364337a0"},{"key":"2016061019042144000_ddw119v2.27","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1242\/dev.129.5.1283","article-title":"The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branching","volume":"129","author":"Rugarli","year":"2002","journal-title":"Development"},{"key":"2016061019042144000_ddw119v2.28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810359105"},{"key":"2016061019042144000_ddw119v2.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(99)00031-X"},{"key":"2016061019042144000_ddw119v2.30","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(77)90158-0"},{"key":"2016061019042144000_ddw119v2.31","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(83)90201-4"},{"key":"2016061019042144000_ddw119v2.32","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2068"},{"key":"2016061019042144000_ddw119v2.33","first-page":"28","article-title":"Nematode chitin synthases: gene structure, expression and function in Caenorhabditis elegans and the plant parasitic nematode Meloidogyne artiellia","volume":"266","author":"Veronico","year":"2001","journal-title":"MGG"},{"key":"2016061019042144000_ddw119v2.34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.21.11883"},{"key":"2016061019042144000_ddw119v2.35","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.12.3484"},{"key":"2016061019042144000_ddw119v2.36","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200611117"},{"key":"2016061019042144000_ddw119v2.37","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81182-4"},{"key":"2016061019042144000_ddw119v2.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.08.022"},{"key":"2016061019042144000_ddw119v2.39","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1355"},{"key":"2016061019042144000_ddw119v2.40","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065486"},{"key":"2016061019042144000_ddw119v2.41","doi-asserted-by":"publisher","DOI":"10.1101\/gad.482608"},{"key":"2016061019042144000_ddw119v2.42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108769200"},{"key":"2016061019042144000_ddw119v2.43","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155085"},{"key":"2016061019042144000_ddw119v2.44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001172"},{"key":"2016061019042144000_ddw119v2.45","doi-asserted-by":"publisher","DOI":"10.1038\/ng1534"},{"key":"2016061019042144000_ddw119v2.46","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807305787"},{"key":"2016061019042144000_ddw119v2.47","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200303168"},{"key":"2016061019042144000_ddw119v2.48","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1607007"},{"key":"2016061019042144000_ddw119v2.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.02.055"},{"key":"2016061019042144000_ddw119v2.50","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.56"},{"key":"2016061019042144000_ddw119v2.51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.52.35109"},{"key":"2016061019042144000_ddw119v2.52","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0982"},{"key":"2016061019042144000_ddw119v2.53","doi-asserted-by":"publisher","DOI":"10.1038\/nature01920"},{"key":"2016061019042144000_ddw119v2.54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910630107"},{"key":"2016061019042144000_ddw119v2.55","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds540"},{"key":"2016061019042144000_ddw119v2.56","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1637-06.2006"},{"key":"2016061019042144000_ddw119v2.57","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20031967725"},{"key":"2016061019042144000_ddw119v2.58","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2144\/02324bm01","article-title":"PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans","volume":"32","author":"Hobert","year":"2002","journal-title":"BioTechniques"},{"key":"2016061019042144000_ddw119v2.59","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1523\/JNEUROSCI.19-15-06225.1999","article-title":"Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein","volume":"19","author":"Eastman","year":"1999","journal-title":"J. Neurosci"},{"key":"2016061019042144000_ddw119v2.60","doi-asserted-by":"publisher","DOI":"10.1038\/nature01278"},{"key":"2016061019042144000_ddw119v2.61","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J"},{"key":"2016061019042144000_ddw119v2.62","doi-asserted-by":"crossref","unstructured":"Duerr J.S. (2006) Immunohistochemistry. WormBook, ed. The C. elegans Research Community, doi\/10.1895\/wormbook.1.105.1, http:\/\/www.wormbook.org.","DOI":"10.1895\/wormbook.1.105.1"},{"key":"2016061019042144000_ddw119v2.63","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/genetics\/141.3.977","article-title":"Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system","volume":"141","author":"Maduro","year":"1995","journal-title":"Genetics"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/article\/25\/12\/2564\/2525744\/Neuronspecific-knockdown-of-SMN1-causes-neuron","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T22:19:19Z","timestamp":1656627559000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddw119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":63,"alternative-id":["10.1093\/hmg\/ddw119"],"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddw119","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]}}}