{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:46:22Z","timestamp":1790646382790,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mol. Genet."],"DOI":"10.1093\/hmg\/ddw133","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:23:41Z","timestamp":1462062221000},"page":"ddw133","source":"Crossref","is-referenced-by-count":8,"title":["Oxidative metabolism and Ca<sup>2+<\/sup>handling in isolated brain mitochondria and striatal neurons from R6\/2 mice, a model of Huntington\u2019s disease"],"prefix":"10.1093","author":[{"given":"James","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica J.","family":"Pellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Brustovetsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickolay","family":"Brustovetsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,4,30]]},"reference":[{"key":"2016052017213836000_ddw133v2.1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6448-9_5"},{"key":"2016052017213836000_ddw133v2.2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"2016052017213836000_ddw133v2.3","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90117-5"},{"key":"2016052017213836000_ddw133v2.4","doi-asserted-by":"publisher","DOI":"10.1002\/biof.162"},{"key":"2016052017213836000_ddw133v2.5","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv209"},{"key":"2016052017213836000_ddw133v2.6","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13165"},{"key":"2016052017213836000_ddw133v2.7","doi-asserted-by":"publisher","DOI":"10.1038\/78054"},{"key":"2016052017213836000_ddw133v2.8","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1523\/JNEUROSCI.19-03-00964.1999","article-title":"Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition","volume":"19","author":"Kim","year":"1999","journal-title":"J. Neurosci"},{"key":"2016052017213836000_ddw133v2.9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001475200"},{"key":"2016052017213836000_ddw133v2.10","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-013-1393-0"},{"key":"2016052017213836000_ddw133v2.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.12.030"},{"key":"2016052017213836000_ddw133v2.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81369-0"},{"key":"2016052017213836000_ddw133v2.13","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20680"},{"key":"2016052017213836000_ddw133v2.14","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0456"},{"key":"2016052017213836000_ddw133v2.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00585-4"},{"key":"2016052017213836000_ddw133v2.16","unstructured":"Lai, J.C.K. and Clark, J.B. (1989) In A.A. Boulton, G.B. Baker, R.F. Butterworth (eds.), Neuromethods. pp. 43\u201398."},{"key":"2016052017213836000_ddw133v2.17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0005-2744(69)90310-6","article-title":"The inhibition of succinate dehydrogenase by oxalacetate","volume":"191","author":"Wojtczak","year":"1969","journal-title":"Biochim. Biophys. Acta"},{"key":"2016052017213836000_ddw133v2.18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0005-2728(69)90192-3","article-title":"The inhibition by 2,4-dinitrophenol of the removal of oxaloacetate formed by the oxidation of succinate by rat-liver and -heart mitochondria","volume":"180","author":"Oestreicher","year":"1969","journal-title":"Biochim. Biophys. Acta"},{"key":"2016052017213836000_ddw133v2.19","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3721"},{"key":"2016052017213836000_ddw133v2.20","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2009"},{"key":"2016052017213836000_ddw133v2.21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04361.x"},{"key":"2016052017213836000_ddw133v2.22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081528"},{"key":"2016052017213836000_ddw133v2.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.12.007"},{"key":"2016052017213836000_ddw133v2.24","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.76.3.396"},{"key":"2016052017213836000_ddw133v2.25","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn404"},{"key":"2016052017213836000_ddw133v2.26","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000102"},{"key":"2016052017213836000_ddw133v2.27","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr475"},{"key":"2016052017213836000_ddw133v2.28","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2313"},{"key":"2016052017213836000_ddw133v2.29","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197404000-00008"},{"key":"2016052017213836000_ddw133v2.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.03.013"},{"key":"2016052017213836000_ddw133v2.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.09.010"},{"key":"2016052017213836000_ddw133v2.32","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0328-4"},{"key":"2016052017213836000_ddw133v2.33","doi-asserted-by":"crossref","unstructured":"Brustovetsky N. (2015) Mutant huntingtin and elusive defects in oxidative metabolism and mitochondrial calcium handling. Mol. Neurobiol., doi: 10.1007\/s12035-015-9188-0","DOI":"10.1007\/s12035-015-9188-0"},{"key":"2016052017213836000_ddw133v2.34","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington\u2019s disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci"},{"key":"2016052017213836000_ddw133v2.35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704704200"},{"key":"2016052017213836000_ddw133v2.36","doi-asserted-by":"crossref","first-page":"e00060","DOI":"10.1042\/AN20110009","article-title":"Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function","volume":"3","author":"Kim","year":"2011","journal-title":"ASN. Neuro"},{"key":"2016052017213836000_ddw133v2.37","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt242"},{"key":"2016052017213836000_ddw133v2.38","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7626"},{"key":"2016052017213836000_ddw133v2.39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06612.x"},{"key":"2016052017213836000_ddw133v2.40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0106-08.2008"},{"key":"2016052017213836000_ddw133v2.41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504749200"},{"key":"2016052017213836000_ddw133v2.42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07268.x"},{"key":"2016052017213836000_ddw133v2.43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212661200"},{"key":"2016052017213836000_ddw133v2.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.05.065"},{"key":"2016052017213836000_ddw133v2.45","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1432-1033.1996.0623w.x","article-title":"The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites","volume":"238","author":"Chernyak","year":"1996","journal-title":"Eur. J. Biochem"},{"key":"2016052017213836000_ddw133v2.46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702841200"},{"key":"2016052017213836000_ddw133v2.47","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00117-6"},{"key":"2016052017213836000_ddw133v2.48","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0723-y"},{"key":"2016052017213836000_ddw133v2.49","doi-asserted-by":"publisher","DOI":"10.1038\/nature03434"},{"key":"2016052017213836000_ddw133v2.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.02.007"},{"key":"2016052017213836000_ddw133v2.51","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq247"},{"key":"2016052017213836000_ddw133v2.52","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds516"},{"key":"2016052017213836000_ddw133v2.53","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt406"},{"key":"2016052017213836000_ddw133v2.54","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr024"},{"key":"2016052017213836000_ddw133v2.55","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.18.8195-8209.2004"},{"key":"2016052017213836000_ddw133v2.56","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00671.x"},{"key":"2016052017213836000_ddw133v2.57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702134200"},{"key":"2016052017213836000_ddw133v2.58","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1523\/JNEUROSCI.13-02-00623.1993","article-title":"Intracellular calcium levels during the period of delayed excitotoxicity","volume":"13","author":"Dubinsky","year":"1993","journal-title":"J. Neurosci"},{"key":"2016052017213836000_ddw133v2.59","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem"},{"key":"2016052017213836000_ddw133v2.60","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20336"},{"key":"2016052017213836000_ddw133v2.61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903546106"},{"key":"2016052017213836000_ddw133v2.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.03.017"},{"key":"2016052017213836000_ddw133v2.63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607263200"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/article\/25\/13\/2762\/2525758\/Oxidative-metabolism-and-Ca2-handling-in-isolated","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T13:00:08Z","timestamp":1655643608000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddw133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,30]]},"references-count":63,"alternative-id":["10.1093\/hmg\/ddw133"],"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddw133","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,30]]}}}