{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:33:21Z","timestamp":1790415201322,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"DOI":"10.1093\/hmg\/ddx080","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T20:11:54Z","timestamp":1488399114000},"page":"2006-2017","source":"Crossref","is-referenced-by-count":41,"title":["Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice"],"prefix":"10.1093","volume":"26","author":[{"given":"S\u00e9verine","family":"Marcos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Monnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Rovira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Fouveaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Pitteloud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Ango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Dod\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Hardelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"key\n\t\t\t\t20170519062206_ddx080-B1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ejhg.2008.206","article-title":"Kallmann syndrome","volume":"17","year":"2009","journal-title":"Eur. J. Hum. Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nrendo.2015.112","article-title":"Expert consensus document: European consensus statement on congenital hypogonadotropic hypogonadism (pathogenesis, diagnosis and treatment)","volume":"11","year":"2015","journal-title":"Nat. Rev. Endocrinol"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/(SICI)1096-9861(19960311)366:3<547::AID-CNE12>3.0.CO;2-M","article-title":"Migration of luteinizing hormone-releasing hormone (LHRH) neurons in early human embryos","volume":"366","year":"1996","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0169-328X(89)90076-4","article-title":"Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome","volume":"6","year":"1989","journal-title":"Mol. Brain Res"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B5","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1172\/JCI43699","article-title":"Defective migration of neuroendocrine GnRH cells in human arrhinencephalic conditions","volume":"120","year":"2010","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B6","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1242\/dev.139444","article-title":"Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains","volume":"143","year":"2016","journal-title":"Development"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B7","first-page":"485","volume-title":"Epstein's Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis","year":"2016","edition":"3rd edn"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/353529a0","article-title":"A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules","volume":"353","year":"1991","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0092-8674(91)90193-3","article-title":"The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules","volume":"67","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B10","doi-asserted-by":"crossref","first-page":"8190","DOI":"10.1073\/pnas.89.17.8190","article-title":"X chromosome-linked Kallmann syndrome: stop mutations validate the candidate gene","volume":"89","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ng1122","article-title":"Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome","volume":"33","year":"2003","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B12","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1172\/JCI34538","article-title":"Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice","volume":"118","year":"2008","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B13","first-page":"1648","article-title":"Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2","volume":"2","year":"2006","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B14","doi-asserted-by":"crossref","first-page":"11524","DOI":"10.1073\/pnas.1102284108","article-title":"Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism","volume":"108","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B15","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ajhg.2014.08.006","article-title":"Mutations in FEZF1 cause Kallmann syndrome","volume":"95","year":"2014","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B16","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ajhg.2013.03.024","article-title":"Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness","volume":"92","year":"2013","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ajhg.2008.09.005","article-title":"Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome","volume":"83","year":"2008","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1399-0004.2008.01107.x","article-title":"CHD7 mutations in patients initially diagnosed with Kallmann syndrome: the clinical overlap with CHARGE syndrome","volume":"75","year":"2009","journal-title":"Clin. Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B19","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.1523\/JNEUROSCI.20-20-07691.2000","article-title":"Semaphorin 3A is required for guidance of olfactory axons in mice","volume":"20","year":"2000","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B20","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1523\/JNEUROSCI.22-10-04025.2002","article-title":"Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice","volume":"22","year":"2002","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B21","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1242\/dev.105544","article-title":"Semaphorin signalling during development","volume":"141","year":"2014","journal-title":"Development"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B22","doi-asserted-by":"crossref","first-page":"29120","DOI":"10.1074\/jbc.R115.687327","article-title":"Neuropilin functions as an essential cell surface receptor","volume":"290","year":"2015","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.neuron.2016.06.018","article-title":"Structural basis for plexin activation and regulation","volume":"91","year":"2016","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/338161a0","article-title":"Origin of luteinizing hormone-releasing hormone neurons","volume":"338","year":"1989","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B25","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1073\/pnas.86.20.8132","article-title":"Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode","volume":"86","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.903210102","article-title":"Immunocytochemical demonstration of neural cell adhesion molecule (NCAM) along the migration route of luteinizing hormone-releasing hormone (LHRH) neurons in mice","volume":"321","year":"1992","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B27","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1523\/JNEUROSCI.15-12-07769.1995","article-title":"The migration of luteinizing hormone-releasing hormone neurons in the developing rat is associated with a transient, caudal projection of the vomeronasal nerve","volume":"15","year":"1995","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B28","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/hmg\/ddq468","article-title":"Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism","volume":"20","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B29","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1523\/JNEUROSCI.5075-06.2007","article-title":"Neuropilins and their ligands are important in the migration of gonadotropin-releasing hormone neurons","volume":"27","year":"2007","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B30","doi-asserted-by":"crossref","first-page":"e1002896","DOI":"10.1371\/journal.pgen.1002896","article-title":"SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome","volume":"8","year":"2012","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0896-6273(00)80869-7","article-title":"Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins","volume":"25","year":"2000","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/1097-0177(20010301)220:3<246::AID-DVDY1112>3.0.CO;2-2","article-title":"Differential expression of plexin-A subfamily members in the mouse nervous system","volume":"220","year":"2001","journal-title":"Dev. Dyn"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B33","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1002\/cne.22497","article-title":"Composition of the migratory mass during development of the olfactory nerve","volume":"518","year":"2010","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10735-007-9141-2","article-title":"Olfactory epithelium progenitors: insights from transgenic mice and in vitro biology","volume":"38","year":"2007","journal-title":"J. Mol. Histol"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B35","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1242\/bio.20135249","article-title":"Olfactory ensheathing glia are required for embryonic olfactory axon targeting and the migration of gonadotropin-releasing hormone neurons","volume":"2","year":"2013","journal-title":"Biol. Open"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B36","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.neuron.2006.10.032","article-title":"PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord","volume":"52","year":"2006","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B37","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0031-9384(87)90042-4","article-title":"Nipple attachment and survival in neonatal olfactory bulbectomized rats","volume":"40","year":"1987","journal-title":"Physiol. Behav"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B38","doi-asserted-by":"crossref","first-page":"36063","DOI":"10.1038\/srep36063","article-title":"Opposite-sex attraction in male mice requires testosterone-dependent regulation of adult olfactory bulb neurogenesis","volume":"6","year":"2016","journal-title":"Scientific Reports"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B39","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/humrep\/des022","article-title":"SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development","volume":"27","year":"2012","journal-title":"Hum. Reprod"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B40","first-page":"ra6","article-title":"Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization","volume":"5","year":"2012","journal-title":"Sci. Signal"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B41","doi-asserted-by":"crossref","first-page":"15610","DOI":"10.1073\/pnas.0906923106","article-title":"Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration","volume":"106","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B42","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrm1740","article-title":"Semaphorins command cells to move","volume":"6","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B43","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1007\/s00018-012-1019-0","article-title":"Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions","volume":"69","year":"2012","journal-title":"Cell Mol. Life. Sci"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B44","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0896-6273(01)00216-1","article-title":"Plexin A1 autoinhibition by the plexin sema domain","volume":"29","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B45","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1083\/jcb.200806160","article-title":"Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complex","volume":"183","year":"2008","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0896-6273(01)00478-0","article-title":"Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections","volume":"32","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0168-9525(94)90221-6","article-title":"A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material","volume":"10","year":"1994","journal-title":"Trends Genet"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B48","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","year":"1993","journal-title":"J. Mol. Biol"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B49","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gku989","article-title":"UniProt: a hub for protein information","volume":"43","author":"UniProt-consortium","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B50","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and Clustal X version 2.0","volume":"23","year":"2007","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B51","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1110\/ps.062416606","article-title":"Statistical potential for assessment and prediction of protein structures","volume":"15","year":"2006","journal-title":"Protein Sci"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B52","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera: a visualization system for exploratory research and analysis","volume":"25","year":"2004","journal-title":"J. Comput. Chem"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B53","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2: a multiple sequence alignment editor and analysis workbench","volume":"25","year":"2009","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170519062206_ddx080-B54","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0896-6273(00)80626-1","article-title":"Neuropilin-1 extracellular domains mediate semaphorin D\/III-induced growth cone collapse","volume":"21","year":"1998","journal-title":"Neuron"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/11\/2006\/17234604\/ddx080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T06:35:00Z","timestamp":1568874900000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddx080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,3,2]]},"published-print":{"date-parts":[[2017,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx080","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}