{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:52:53Z","timestamp":1789559573200,"version":"build-2803163510"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,15]]},"DOI":"10.1093\/hmg\/ddx085","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T12:14:06Z","timestamp":1488543246000},"page":"1821-1838","source":"Crossref","is-referenced-by-count":29,"title":["Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog"],"prefix":"10.1093","volume":"26","author":[{"given":"Tara E.","family":"Crawford Parks","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Ravel-Chapuis","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Bondy-Chorney","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Renaud","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Jasmin","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"key\n\t\t\t\t20180314005255_ddx085-B1","volume-title":"eLS","author":"Lukong","year":"2012"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B2","doi-asserted-by":"crossref","first-page":"13129","DOI":"10.1074\/jbc.M312923200","article-title":"Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis","volume":"279","author":"Timchenko","year":"2004","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B3","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/hmg\/ddi162","article-title":"Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy","volume":"14","author":"Ho","year":"2005","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B4","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1093\/hmg\/ddq277","article-title":"CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1","volume":"19","author":"Ward","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B5","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1126\/science.1088583","article-title":"A muscleblind knockout model for myotonic dystrophy","volume":"302","author":"Kanadia","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B6","doi-asserted-by":"crossref","first-page":"11748","DOI":"10.1073\/pnas.0604970103","article-title":"Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy","volume":"103","author":"Kanadia","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B7","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1093\/hmg\/dds306","article-title":"Mouse model of muscleblind-like 1 overexpression: Skeletal muscle effects and therapeutic promise","volume":"21","author":"Chamberlain","year":"2012","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B8","doi-asserted-by":"crossref","first-page":"e33218.","DOI":"10.1371\/journal.pone.0033218","article-title":"Muscleblind-like 1 knockout mice reveal novel splicing defects in the myotonic dystrophy brain","volume":"7","author":"Suenaga","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/hmg\/ddq500","article-title":"HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects","volume":"20","author":"Hubers","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B10","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1093\/hmg\/ddp352","article-title":"p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR","volume":"18","author":"Farooq","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B11","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/hmg\/ddt191","article-title":"Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation","volume":"22","author":"Farooq","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nbd.2013.08.005","article-title":"Posttranscriptional regulation of SOD1 gene expression under oxidative stress: Potential role of ELAV proteins in sporadic ALS","volume":"60","author":"Milani","year":"2013","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B13","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1093\/hmg\/dds205","article-title":"The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth","volume":"21","author":"Fallini","year":"2012","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0092-8674(91)90138-O","article-title":"Staufen, a gene required to localize maternal RNAs in the Drosophila egg","volume":"66","author":"St Johnston","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)80504-8","article-title":"Inscuteable and staufen mediate asymmetric localization and segregation of prospero RNA during drosophila neuroblast cell divisions","volume":"90","author":"Li","year":"1997","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B16","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1101\/gad.12.12.1847","article-title":"Miranda mediates asymmetric protein and RNA localization in the developing nervous system","volume":"12","author":"Schuldt","year":"1998","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B17","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.10.17.2179","article-title":"Oskar protein interaction with Vasa represents an essential step in polar granule assembly","volume":"10","author":"Breitwieser","year":"1996","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B18","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1471-4159.2003.01883.x","article-title":"Localization of the RNA-binding proteins Staufen1 and Staufen2 at the mammalian neuromuscular junction","volume":"86","author":"B\u00e9langer","year":"2003","journal-title":"J. Neurochem"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B19","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1242\/jcs.115.16.3285","article-title":"Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles","volume":"115","author":"Duchaine","year":"2002","journal-title":"J. Cell Sci"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B20","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/MCB.19.3.2212","article-title":"A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum","volume":"19","author":"Mari\u00f3n","year":"1999","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B21","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1128\/MCB.19.3.2220","article-title":"Mammalian Staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum","volume":"19","author":"Wickham","year":"1999","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B22","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1523\/JNEUROSCI.19-01-00288.1999","article-title":"The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport","volume":"19","author":"Kiebler","year":"1999","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B23","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1091\/mbc.10.9.2945","article-title":"Microtubule-dependent recruitment of Staufen-green fluorescent protein into large RNA-containing granules and subsequent dendritic transport in living hippocampal neurons","volume":"10","author":"K\u00f6hrmann","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0896-6273(01)00493-7","article-title":"A role for a rat homolog of Staufen in the transport of RNA to neuronal dendrites","volume":"32","author":"Tang","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0896-6273(01)00508-6","article-title":"Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation","volume":"32","author":"Krichevsky","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B26","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1073\/pnas.0334355100","article-title":"Isolation and characterization of Staufen-containing ribonucleoprotein particles from rat brain","volume":"100","author":"Mallardo","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1101\/gad.1717309","article-title":"SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs","volume":"23","author":"Gong","year":"2009","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B28","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1016\/j.febslet.2012.07.068","article-title":"Agrin induces association of Chrna1 mRNA and nicotinic acetylcholine receptor in C2C12 myotubes","volume":"586","author":"Chang","year":"2012","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B29","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2443.2008.01189.x","article-title":"Stau1 negatively regulates myogenic differentiation in C2C12 cells","volume":"13","author":"Yamaguchi","year":"2008","journal-title":"Genes Cells"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.bbrc.2011.11.133","article-title":"Stau1 regulates Dvl2 expression during myoblast differentiation","volume":"417","author":"Yamaguchi","year":"2012","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B31","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1091\/mbc.E14-04-0895","article-title":"The RNA-binding protein Staufen1 impairs myogenic differentiation via a c-myc-dependent mechanism","volume":"25","author":"Ravel-Chapuis","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1083\/jcb.201108113","article-title":"The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing","volume":"196","author":"Ravel-Chapuis","year":"2012","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B33","doi-asserted-by":"crossref","first-page":"42342","DOI":"10.1038\/srep42342","article-title":"Novel roles for Staufen1 in embryonal and alveolar rhabdomyosarcoma via c-myc- dependent and -independent events","volume":"7","author":"Crawford Parks","year":"2017","journal-title":"Sci. Rep"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B34","first-page":"2896","article-title":"Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene","volume":"8","author":"Sternberg","year":"1988","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B35","first-page":"5058","article-title":"E-Box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice","volume":"16","author":"Shield","year":"1996","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B36","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/dev.113.3.1017","article-title":"Developmental regulation of creatine kinase gene expression by myogenic factors in embryonic mouse and chick skeletal muscle","volume":"113","author":"Lyons","year":"1991","journal-title":"Development"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B37","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1128\/MCB.16.4.1649","article-title":"Analysis of muscle creatine kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice","volume":"16","author":"Donoviel","year":"1996","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B38","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1128\/MCB.13.5.2753","article-title":"Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle","volume":"13","author":"Amacher","year":"1993","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B39","doi-asserted-by":"crossref","first-page":"25.","DOI":"10.1186\/2044-5040-1-25","article-title":"Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer","volume":"1","author":"Tai","year":"2011","journal-title":"Skelet. Muscle"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/298294a0","article-title":"Fetal myosin heavy chains in regenerating muscle","volume":"298","author":"Sartore","year":"1982","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B41","doi-asserted-by":"crossref","first-page":"22.","DOI":"10.1186\/s13395-015-0046-6","article-title":"Developmental myosins: expression patterns and functional significance","volume":"5","author":"Schiaffino","year":"2015","journal-title":"Skelet. Muscle"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B42","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1093\/hmg\/ddp431","article-title":"Pharmacological activation of PPARbeta\/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice","volume":"18","author":"Miura","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B43","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1093\/hmg\/ddr265","article-title":"Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle","volume":"20","author":"Ljubicic","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B44","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/hmg\/ddu535","article-title":"Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation","volume":"24","author":"Al-Rewashdy","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/hmg\/ddv444","article-title":"Combinatorial Therapeutic Activation with Heparin and AICAR Stimulates Additive Effects on Utrophin A Expression in Dystrophic Muscles","volume":"25","author":"P\u00e9ladeau","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B46","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science (80-.)"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B47","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","article-title":"Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy","volume":"98","author":"Gomes","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B48","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1074\/jbc.M114.600916","article-title":"Histone deacetylase 6 is a FoxO transcription factor dependent effector in skeletal muscle atrophy","volume":"290","author":"Ratti","year":"2015","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B49","first-page":"95616","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases, MuRF1 and MAFbx\/Atrogin-1","author":"Bodine","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B50","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1158\/0008-5472.CAN-12-2522","article-title":"MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase","volume":"73","author":"Kaur","year":"2013","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B51","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1261\/rna.720308","article-title":"A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes","volume":"14","author":"Furic","year":"2008","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B52","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature14280","article-title":"hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1","volume":"519","author":"Sugimoto","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B53","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI118968","article-title":"Rapid publication muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin \u2013 proteasome proteolytic pathway by a mechanism including gene transcription","volume":"98","author":"Price","year":"1996","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B54","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0014-5793(94)80290-4","article-title":"Ubiquitin gene expression is increased in skeletal muscle of tumour-bearing rats","volume":"338","author":"Llovera","year":"1994","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B55","first-page":"E996","article-title":"Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma","volume":"268","author":"Baracos","year":"1995","journal-title":"Am. J. Physiol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B56","first-page":"5568","article-title":"Increased ATP-Ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats","volume":"54","author":"Temparis","year":"1994","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B57","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.nmd.2010.03.006","article-title":"Progressive skeletal muscle weakness in transgenic mice expressing CTG expansions is associated with the activation of the ubiquitin-proteasome pathway","volume":"20","author":"Vignaud","year":"2010","journal-title":"Neuromuscul. Disord"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B58","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.biocel.2013.06.010","article-title":"Molecular mechanisms of muscle atrophy in myotonic dystrophies","volume":"45","author":"Timchenko","year":"2013","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B59","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1096\/fj.05-5249fje","article-title":"Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1","volume":"20","author":"L\u00e9ger","year":"2006","journal-title":"faseb J"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B60","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1093\/hmg\/dds286","article-title":"Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice","volume":"21","author":"Bricceno","year":"2012","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B61","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1111\/j.1582-4934.2009.00864.x","article-title":"Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures","volume":"13","author":"Chopard","year":"2009","journal-title":"J. Cell. Mol. Med"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B62","first-page":"465","article-title":"Sarcopenia and age-related changes in body composition and functional capacity","volume":"123","author":"Evans","year":"1993","journal-title":"Nutr. Res"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B63","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)93116-9","article-title":"Protein turnover in skeletal muscle","volume":"244","author":"Goldberg","year":"1969","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B64","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1096\/fj.02-0312com","article-title":"Patterns of gene expression in atrophying skeletal muscles: response to food deprivation","volume":"16","author":"Jagoe","year":"2002","journal-title":"faseb J"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10974-012-9288-7","article-title":"Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle","volume":"33","author":"Perera","year":"2012","journal-title":"J. Muscle Res. Cell Motil"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B66","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jmb.2008.03.049","article-title":"MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies","volume":"379","author":"Hirner","year":"2008","journal-title":"J. Mol. Biol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B67","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1097-2765(04)00211-4","article-title":"The IGF-1\/PI3K\/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors","volume":"14","author":"Stitt","year":"2004","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"Sandri","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B69","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1097\/01.ASN.0000127211.86206.E1","article-title":"Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase","volume":"15","author":"Lee","year":"2004","journal-title":"J. Am. Soc. Nephrol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B70","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2004.11.050","article-title":"Mammalian Staufen1 recruits Upf1 to specific mRNA 3\u2019UTRs so as to elicit mRNA decay","volume":"120","author":"Kim","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B71","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1038\/sj.emboj.7601712","article-title":"Staufen1 regulates diverse classes of mammalian transcripts","volume":"26","author":"Kim","year":"2007","journal-title":"embo J"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B72","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nature09701","article-title":"lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3\u2019 UTRs via Alu elements","volume":"470","author":"Gong","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B73","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1101\/gad.212639.112","article-title":"Control of myogenesis by rodent SINE-containing lncRNAs","volume":"27","author":"Wang","year":"2013","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B74","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nsmb.2739","article-title":"Staufen1 senses overall transcript secondary structure to regulate translation","volume":"21","author":"Ricci","year":"2013","journal-title":"Nat. Struct. Mol. Biol"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B75","first-page":"385","article-title":"Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3\u2019 end of a transcript encoding a protein kinase family member","volume":"69","author":"Brook","year":"1992","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B76","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1126\/science.1546326","article-title":"An unstable triplet repeat in a gene related to myotonic muscular dystrophy","volume":"255","author":"Fu","year":"1992","journal-title":"Science (80-.)"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B77","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1126\/science.1546325","article-title":"Myotonic dystrophy mutation: an unstable CTG repeat in the 3\u2019 untranslated region of the gene","volume":"255","author":"Mahadevan","year":"1992","journal-title":"Science (80-.)"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B78","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1042\/BST0371281","article-title":"Pathogenic mechanisms of myotonic dystrophy","volume":"37","author":"Lee","year":"2009","journal-title":"Biochem. Soc. Trans"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B79","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1074\/jbc.R800025200","article-title":"Mechanisms of RNA-mediated disease","volume":"284","author":"O\u2019Rourke","year":"2009","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B80","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1091\/mbc.E15-06-0356","article-title":"Staufen1 impairs stress granule formation in skeletal muscle cells from myotonic dystrophy type 1 patients","volume":"27","author":"Ravel-Chapuis","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B81","doi-asserted-by":"crossref","first-page":"e1005827.","DOI":"10.1371\/journal.pgen.1005827","article-title":"Staufen1 regulates multiple alternative splicing events either positively or negatively in DM1 indicating its role as a disease modifier","volume":"12","author":"Bondy-Chorney","year":"2016","journal-title":"PLOS Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B82","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1093\/hmg\/ddq226","article-title":"PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons","volume":"19","author":"Ning","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B83","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/mt.2014.209","article-title":"PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy","volume":"23","author":"Little","year":"2015","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B84","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/brain\/awq345","article-title":"Phosphatase and tensin homologue\/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis","volume":"134","author":"Kirby","year":"2011","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B85","doi-asserted-by":"crossref","first-page":"e1096.","DOI":"10.1038\/cddis.2014.55","article-title":"PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons","volume":"5","author":"Yang","year":"2014","journal-title":"Cell Death Dis"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B86","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1073\/pnas.90.7.3043","article-title":"An 83-nucleotide promoter of the acetylcholine receptor epsilon-subunit gene confers preferential synaptic expression in mouse muscle","volume":"90","author":"Duclert","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180314005255_ddx085-B87","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.1002220107","article-title":"Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise","volume":"107","author":"Valdez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/10\/1821\/24340371\/ddx085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T03:59:44Z","timestamp":1658721584000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/26\/10\/1821\/3084495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,24]]},"references-count":87,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,3,24]]},"published-print":{"date-parts":[[2017,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx085","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,5,15]]},"published":{"date-parts":[[2017,3,24]]}}}