{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:16:52Z","timestamp":1776986212101,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,15]]},"DOI":"10.1093\/hmg\/ddx137","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T19:44:30Z","timestamp":1491507870000},"page":"2335-2345","source":"Crossref","is-referenced-by-count":42,"title":["CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish"],"prefix":"10.1093","volume":"26","author":[{"given":"Shanshan","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lincoln","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaojing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yu Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulton","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mugen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"key":"key\n\t\t\t\t20170605061912_ddx137-B1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1086\/381055","article-title":"Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26)","volume":"74","year":"2004","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B2","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1167\/iovs.09-3982","article-title":"CERKL mutations cause an autosomal recessive cone-rod dystrophy with inner retinopathy","volume":"50","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B3","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1167\/iovs.10-5797","article-title":"Homozygosity mapping in patients with cone-rod dystrophy: novel mutations and clinical characterizations","volume":"51","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B4","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1167\/iovs.07-0736","article-title":"A common founder mutation of CERKL underlies autosomal recessive retinal degeneration with early macular involvement among Yemenite Jews","volume":"48","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B5","first-page":"1960","article-title":"A missense mutation in the nuclear localization signal sequence of CERKL (p.R106S) causes autosomal recessive retinal degeneration","volume":"14","year":"2008","journal-title":"Mol. Vis"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B6","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1101\/gr.144105.112","article-title":"Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes","volume":"23","year":"2013","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B7","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1167\/iovs.07-0865","article-title":"CERKL mutations and associated phenotypes in seven Spanish families with autosomal recessive retinitis pigmentosa","volume":"49","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B8","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1001\/archophthalmol.2009.207","article-title":"Novel compound heterozygous mutations in CERKL cause autosomal recessive retinitis pigmentosa in a nonconsanguineous Chinese family","volume":"127","year":"2009","journal-title":"Arch. Ophthalmol"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B9","first-page":"369","article-title":"Rod-cone dystrophy with initially preserved visual acuity despite early macular involvement suggests recessive CERKL mutations","volume":"36","year":"2014","journal-title":"Ophthalmic Genet"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbalip.2004.11.012","article-title":"Characterization of a ceramide kinase-like protein","volume":"1687","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbrc.2008.06.002","article-title":"Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice","volume":"373","year":"2008","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B12","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.bbrc.2006.03.056","article-title":"Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein","volume":"343","year":"2006","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B13","first-page":"168","article-title":"Overexpression of CERKL, a gene responsible for retinitis pigmentosa in humans, protects cells from apoptosis induced by oxidative stress","volume":"15","year":"2009","journal-title":"Mol. Vis"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.exer.2012.10.014","article-title":"Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene","volume":"106","year":"2013","journal-title":"Exp. Eye Res"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B15","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bbadis.2014.04.009","article-title":"CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis","volume":"1842","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B16","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.bbadis.2012.04.004","article-title":"Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer","volume":"1822","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B17","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1167\/iovs.10-7101","article-title":"High transcriptional complexity of the retinitis pigmentosa CERKL gene in human and mouse","volume":"52","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrg2091","article-title":"Animal models of human disease: zebrafish swim into view","volume":"8","year":"2007","journal-title":"Nat. Rev. Genet"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B19","doi-asserted-by":"crossref","first-page":"e64048.","DOI":"10.1371\/journal.pone.0064048","article-title":"CERKL knockdown causes retinal degeneration in zebrafish","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B20","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nbt.1939","article-title":"Heritable gene targeting in zebrafish using customized TALENs","volume":"29","year":"2011","journal-title":"Nat. Biotechnol"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jneumeth.2003.12.015","article-title":"An inexpensive device for non-invasive electroretinography in small aquatic vertebrates","volume":"135","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/cne.10763","article-title":"Lazy eyes zebrafish mutation affects Muller glial cells, compromising photoreceptor function and causing partial blindness","volume":"463","year":"2003","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-12-384892-5.00006-2","article-title":"Analysis of the retina in the zebrafish model","volume":"100","year":"2010","journal-title":"Methods Cell Biol"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.preteyeres.2013.06.001","article-title":"Evolution of phototransduction, vertebrate photoreceptors and retina","volume":"36","year":"2013","journal-title":"Prog. Retin. Eye Res"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.exer.2014.01.010","article-title":"Understanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture","volume":"126","year":"2014","journal-title":"Exp. Eye Res"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1152\/physiol.00038.2009","article-title":"Phagocytosis of retinal rod and cone photoreceptors","volume":"25","year":"2010","journal-title":"Physiology (Bethesda)"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B27","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1074\/jbc.M107876200","article-title":"Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells","volume":"277","year":"2002","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B28","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B29","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1167\/iovs.12-9770","article-title":"Ceramide kinase-like (CERKL) interacts with neuronal calcium sensor proteins in the retina in a cation-dependent manner","volume":"53","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B30","doi-asserted-by":"crossref","first-page":"e87898.","DOI":"10.1371\/journal.pone.0087898","article-title":"CERKL, a retinal disease gene, encodes an mRNA-binding protein that localizes in compact and untranslated mRNPs associated with microtubules","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B31","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","year":"2005","journal-title":"Physiol. Rev"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.33.1.61","article-title":"The renewal of photoreceptor cell outer segments","volume":"33","year":"1967","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B33","first-page":"990","article-title":"Apoptotic photoreceptor degeneration in experimental retinal detachment","volume":"36","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20170605061912_ddx137-B34","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1167\/iovs.02-0438","article-title":"An RCS-like retinal dystrophy phenotype in mer knockout mice","volume":"44","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/12\/2335\/17658113\/ddx137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T20:15:22Z","timestamp":1503605722000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddx137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,7]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,4,7]]},"published-print":{"date-parts":[[2017,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx137","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,7]]}}}