{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:10:48Z","timestamp":1777637448834,"version":"3.51.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/hmg\/ddx139","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T19:12:56Z","timestamp":1491851576000},"page":"2462-2471","source":"Crossref","is-referenced-by-count":44,"title":["BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction"],"prefix":"10.1093","volume":"26","author":[{"given":"Hadar","family":"Segal-Gavish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neta","family":"Gazit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Barhum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tali","family":"Ben-Zur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Taler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay Henry","family":"Hornfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Gil-Ad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Weizman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Slutsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minae","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Offen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Barzilay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"key\n\t\t\t\t20170617055141_ddx139-B1","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1017\/S0954579413000783","article-title":"Developmental mechanisms in the prodrome to psychosis","volume":"25","year":"2013","journal-title":"Dev. Psychopathol"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B2","first-page":"48.","article-title":"Gene-environment interactions in severe mental illness","volume":"5","year":"2014","journal-title":"Front. Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B3","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/schbul\/sbn117","article-title":"Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions","volume":"34","year":"2008","journal-title":"Schizophr. Bull"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/archgenpsychiatry.2011.1503","article-title":"Use and abuse of alcohol and illicit drugs in US adolescents: results of the National Comorbidity Survey-Adolescent Supplement","volume":"69","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B5","author":"EMCDDA","year":"2012"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1056\/NEJMp1614783","article-title":"Recreational Cannabis \u2014 Minimizing the Health Risks from Legalization","volume":"376","year":"2017","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B7","first-page":"879.","article-title":"Adverse health effects of marijuana use","volume":"371","year":"2014","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(07)61162-3","article-title":"Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review","volume":"370","year":"2007","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B9","doi-asserted-by":"crossref","first-page":"11.","DOI":"10.1136\/bmj.38267.664086.63","article-title":"Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people","volume":"330","year":"2005","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B10","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jpsychires.2012.11.009","article-title":"The impact of cannabis use on age of onset and clinical characteristics in first-episode psychotic patients. Data from the Psychosis Incident Cohort Outcome Study (PICOS)","volume":"47","year":"2013","journal-title":"J. Psychiatr. Res"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.schres.2014.04.023","article-title":"Change in cannabis use in the general population: a longitudinal study on the impact on psychotic experiences","volume":"157","year":"2014","journal-title":"Schizophr. Res"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S2215-0366(14)00117-5","article-title":"Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: A case-control study","volume":"2","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B13","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.pneurobio.2010.06.010","article-title":"Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia","volume":"92","year":"2010","journal-title":"Prog. Neurobiol"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B14","first-page":"54.","article-title":"Gone to Pot - A Review of the Association between Cannabis and Psychosis","volume":"5","year":"2014","journal-title":"Front. Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B15","first-page":"30","article-title":"Cannabis and cognitive dysfunction: parallels with endophenotypes of schizophrenia?","volume":"32","year":"2007","journal-title":"J. Psychiatry Neurosci"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B16","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1001\/jamapsychiatry.2015.1131","article-title":"Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence","volume":"72","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B17","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/hmg\/9.9.1415","article-title":"Disruption of two novel genes by a translocation co-segregating with schizophrenia","volume":"9","year":"2000","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B18","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/mp.2016.154","article-title":"DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia","volume":"21","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B19","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.neuropharm.2010.12.027","article-title":"DISC1-binding proteins in neural development, signalling and schizophrenia","volume":"62","year":"2012","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neubiorev.2014.07.001","article-title":"Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: impact of mouse models","volume":"45","year":"2014","journal-title":"Neurosci. Biobehav. Rev"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B21","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/sj.mp.4001574","article-title":"Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment","volume":"9","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B22","first-page":"1","article-title":"The potential of DISC1 protein as a therapeutic target for mental illness","volume":"8222","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.nbd.2015.06.006","article-title":"Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory","volume":"82","year":"2015","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B24","doi-asserted-by":"crossref","first-page":"12462","DOI":"10.1073\/pnas.1307925110","article-title":"Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness","volume":"110","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/15622975.2013.841993","article-title":"Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression","volume":"15","year":"2014","journal-title":"World J. Biol. Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1101\/lm.1650110","article-title":"Object recognition memory and the rodent hippocampus","volume":"17","year":"2010","journal-title":"Learn. Mem"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B27","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1126\/science.1150769","article-title":"Synaptic theory of working memory","volume":"319","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B28","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1471-4159.2005.03074.x","article-title":"In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol","volume":"93","year":"2005","journal-title":"J. Neurochem"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B29","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/cdd.2015.11","article-title":"The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K\/Akt\/mTORC1\/BDNF pathway","volume":"22","year":"2015","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B30","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1523\/JNEUROSCI.23-06-02371.2003","article-title":"Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus","volume":"23","year":"2003","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B31","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrn1925","article-title":"Gene-environment interactions in psychiatry: joining forces with neuroscience","volume":"7","year":"2006","journal-title":"Nat. Rev. Neurosci"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B32","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/npp.2012.24","article-title":"Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways","volume":"37","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S1461145711001854","article-title":"Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence","volume":"16","year":"2013","journal-title":"Int. J. Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2014.10.019","article-title":"Regulation of hippocampal synaptic plasticity by BDNF","volume":"1621","year":"2015","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B35","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1192\/bjp.bp.109.064220","article-title":"High-potency cannabis and the risk of psychosis","volume":"195","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B36","first-page":"101.","article-title":"Association of Cannabis Use during Adolescence, Prefrontal CB1 Receptor Signaling, and Schizophrenia","volume":"3","year":"2012","journal-title":"Front. Pharmacol"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B37","volume-title":"Anxiety-Related Behaviors in Mice","year":"2009"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bbr.2004.05.028","article-title":"Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer\u2019s disease","volume":"156","year":"2005","journal-title":"Behav. Brain Res"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B39","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/nn.2647","article-title":"Animal models of neuropsychiatric disorders","volume":"13","year":"2010","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B40","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbr.2011.07.049","article-title":"Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment","volume":"225","year":"2011","journal-title":"Behav. Brain Res"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B41","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2009.08.027","article-title":"Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood","volume":"206","year":"2010","journal-title":"Behav. Brain Res"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B42","doi-asserted-by":"crossref","first-page":"14501","DOI":"10.1073\/pnas.0704774104","article-title":"Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc","volume":"104","year":"2007","journal-title":"Natl. Acad. Sci. U S A"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B43","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nn.2433","article-title":"Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses","volume":"12","year":"2009","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B44","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuron.2015.12.034","article-title":"IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses","volume":"89","year":"2016","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B45","doi-asserted-by":"crossref","first-page":"e61.","DOI":"10.1038\/tp.2011.64","article-title":"Intracerebral adult stem cells transplantation increases brain-derived neurotrophic factor levels and protects against phencyclidine-induced social deficit in mice","volume":"1","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"key\n\t\t\t\t20170617055141_ddx139-B46","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nprot.2009.22","article-title":"Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors","volume":"4","year":"2009","journal-title":"Nat. Protoc"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/13\/2462\/17725773\/ddx139.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T21:54:02Z","timestamp":1569016442000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddx139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,11]]},"references-count":46,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2017,4,11]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx139","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,11]]}}}