{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:51:06Z","timestamp":1790725866481,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.1093\/hmg\/ddx162","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T15:13:55Z","timestamp":1493046835000},"page":"2850-2863","source":"Crossref","is-referenced-by-count":139,"title":["Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo"],"prefix":"10.1093","volume":"26","author":[{"given":"Sander","family":"Beel","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Moisse","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Damme","sequence":"additional","affiliation":[{"name":"Biochemical Institute of the Christian-Albrechts University Kiel, D-24098 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"De Muynck","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Robberecht","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium"},{"name":"Department of Neurology, University Hospitals Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludo","family":"Van Den Bosch","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Saftig","sequence":"additional","affiliation":[{"name":"Biochemical Institute of the Christian-Albrechts University Kiel, D-24098 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, B-3000 Leuven, Belgium"},{"name":"Department of Neurology, University Hospitals Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"key\n\t\t\t\t20180314011251_ddx162-B1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1677\/joe.0.1580145","article-title":"Granulins: the structure and function of an emerging family of growth factors","volume":"158","author":"Bateman","year":"1998","journal-title":"J. Endocrinol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0092-8674(02)01141-8","article-title":"Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair","volume":"111","author":"Zhu","year":"2002","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12031-011-9553-z","article-title":"Cellular effects of progranulin in health and disease","volume":"45","author":"De Muynck","year":"2011","journal-title":"J. Mol. Neurosci"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B4","doi-asserted-by":"crossref","first-page":"e21023.","DOI":"10.1371\/journal.pone.0021023","article-title":"C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking","volume":"6","author":"Zheng","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.tins.2014.04.003","article-title":"Progranulin in neurodegenerative disease","volume":"37","author":"Petkau","year":"2014","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B6","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1002\/cne.22430","article-title":"Progranulin expression in the developing and adult murine brain","volume":"518","author":"Petkau","year":"2010","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1083\/jcb.200712039","article-title":"Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival","volume":"181","author":"Van Damme","year":"2008","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B8","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1172\/JCI63113","article-title":"Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury","volume":"122","author":"Martens","year":"2012","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B9","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B10","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","article-title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","volume":"442","author":"Cruts","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/brain\/awn352","article-title":"Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members","volume":"132","author":"Finch","year":"2009","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B12","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1212\/01.wnl.0000325058.10218.fc","article-title":"Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration","volume":"71","author":"Ghidoni","year":"2008","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B13","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ana.21621","article-title":"Serum biomarker for progranulin-associated frontotemporal lobar degeneration","volume":"65","author":"Sleegers","year":"2009","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B14","doi-asserted-by":"crossref","first-page":"200 e201","DOI":"10.1016\/j.neurobiolaging.2016.02.019","article-title":"Portuguese family with the co-occurrence of frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis phenotypes due to progranulin gene mutation","volume":"41","author":"Almeida","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B15","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ajhg.2012.04.021","article-title":"Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage","volume":"90","author":"Smith","year":"2012","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B16","first-page":"845","article-title":"Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis","volume":"127","author":"Gotzl","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B17","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1096\/fj.10-161471","article-title":"Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia","volume":"24","author":"Yin","year":"2010","journal-title":"faseb J"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B18","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/NEN.0b013e3181fc9aea","article-title":"Microglial upregulation of progranulin as a marker of motor neuron degeneration","volume":"69","author":"Philips","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B19","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2016.04.001","article-title":"Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation","volume":"165","author":"Lui","year":"2016","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B20","doi-asserted-by":"crossref","first-page":"78.","DOI":"10.1186\/s40478-014-0078-x","article-title":"Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice","volume":"2","author":"Tanaka","year":"2014","journal-title":"Acta Neuropathol. Commun"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.stemcr.2014.12.001","article-title":"Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia","volume":"4","author":"Raitano","year":"2015","journal-title":"Stem Cell Rep"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B22","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.celrep.2012.09.007","article-title":"Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects","volume":"2","author":"Almeida","year":"2012","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B23","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nm.3672","article-title":"Progranulin protects against amyloid beta deposition and toxicity in Alzheimer's disease mouse models","volume":"20","author":"Minami","year":"2014","journal-title":"Nat. Med"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B24","doi-asserted-by":"crossref","first-page":"e13368.","DOI":"10.1371\/journal.pone.0013368","article-title":"Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy","volume":"5","author":"Laird","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B25","doi-asserted-by":"crossref","first-page":"41.","DOI":"10.1186\/1750-1326-5-41","article-title":"Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1","volume":"5","author":"Chitramuthu","year":"2010","journal-title":"Mol. Neurodegener"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B26","doi-asserted-by":"crossref","first-page":"19579","DOI":"10.1523\/JNEUROSCI.4318-13.2013","article-title":"Progranulin deficiency promotes post-ischemic blood-brain barrier disruption","volume":"33","author":"Jackman","year":"2013","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B27","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/brain\/awv079","article-title":"Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke","volume":"138","author":"Kanazawa","year":"2015","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B28","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s13238-010-0067-1","article-title":"Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3beta","volume":"1","author":"Gao","year":"2010","journal-title":"Protein Cell"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B29","doi-asserted-by":"crossref","first-page":"130.","DOI":"10.1186\/1471-2202-10-130","article-title":"Progranulin is expressed within motor neurons and promotes neuronal cell survival","volume":"10","author":"Ryan","year":"2009","journal-title":"BMC Neurosci"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B30","doi-asserted-by":"crossref","first-page":"2326 e2325","DOI":"10.1016\/j.neurobiolaging.2011.06.017","article-title":"Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling","volume":"32","author":"Xu","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B31","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1016\/j.neurobiolaging.2013.04.022","article-title":"The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding","volume":"34","author":"De Muynck","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B32","doi-asserted-by":"crossref","first-page":"33.","DOI":"10.1186\/1750-1326-7-33","article-title":"Progranulin regulates neuronal outgrowth independent of sortilin","volume":"7","author":"Gass","year":"2012","journal-title":"Mol. Neurodegener"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4695(199801)34:1<1::AID-NEU1>3.0.CO;2-C","article-title":"Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor","volume":"34","author":"Ferri","year":"1998","journal-title":"J. Neurobiol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B34","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1111\/j.1460-9568.2004.03802.x","article-title":"Galectin-1 in regenerating motoneurons","volume":"20","author":"McGraw","year":"2004","journal-title":"Eur. J. Neurosci"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B35","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.neurobiolaging.2013.03.027","article-title":"Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats","volume":"34","author":"Herdewyn","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B36","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1074\/mcp.M116.063636","article-title":"Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II","volume":"16","author":"Markmann","year":"2017","journal-title":"Mol. Cell Proteomics"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B37","first-page":"59","article-title":"The effect of temperature, acidification, and alkalization changes as well as ethanol on salivary cathepsin D activity","volume":"51 Suppl 1","author":"Karwowska","year":"2006","journal-title":"Adv. Med. Sci"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0022029901004757","article-title":"Thermal inactivation kinetics of bovine cathepsin D","volume":"68","author":"Hayes","year":"2001","journal-title":"J. Dairy Res"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B39","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1083\/jcb.201502029","article-title":"Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin","volume":"210","author":"Zhou","year":"2015","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.1199214","article-title":"The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice","volume":"332","author":"Tang","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B41","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1523\/JNEUROSCI.5336-12.2013","article-title":"Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells","volume":"33","author":"Chen","year":"2013","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B42","doi-asserted-by":"crossref","first-page":"69.","DOI":"10.1186\/s13024-016-0132-1","article-title":"Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling","volume":"11","author":"Altmann","year":"2016","journal-title":"Mol. Neurodegener"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B43","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1083\/jcb.201603079","article-title":"EphA2 is a functional receptor for the growth factor progranulin","volume":"215","author":"Neill","year":"2016","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuroscience.2013.06.049","article-title":"Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice","volume":"250","author":"Tanaka","year":"2013","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B45","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B46","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/brain\/awl107","article-title":"Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis","volume":"129","author":"Siintola","year":"2006","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B47","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/emboj\/20.11.2844","article-title":"Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1","volume":"20","author":"Rossi","year":"2001","journal-title":"embo J"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B48","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1073\/pnas.0609277104","article-title":"Developmental and adult phenotyping directly from mutant embryonic stem cells","volume":"104","author":"George","year":"2007","journal-title":"Proc. Natl Acad. Sci. U S A"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B49","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nbt0798-657","article-title":"Improved properties of FLP recombinase evolved by cycling mutagenesis","volume":"16","author":"Buchholz","year":"1998","journal-title":"Nat. Biotechnol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/A:1008868325009","article-title":"Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase","volume":"7","author":"Lallemand","year":"1998","journal-title":"Transgenic Res"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B51","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1002\/j.1460-2075.1995.tb00029.x","article-title":"Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells","volume":"14","author":"Saftig","year":"1995","journal-title":"embo J"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B52","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1002\/cne.22718","article-title":"Differential gene expression in the axotomized facial motor nucleus of presymptomatic SOD1 mice","volume":"519","author":"Mesnard","year":"2011","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B53","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1210\/endo.138.9.5418","article-title":"Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by cathepsin D","volume":"138","author":"Claussen","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B54","doi-asserted-by":"crossref","first-page":"168.","DOI":"10.1186\/1471-2105-6-168","article-title":"High-Throughput GoMiner, an \u2018industrial-strength\u2019 integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID)","volume":"6","author":"Zeeberg","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180314011251_ddx162-B55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/exnr.1999.7014","article-title":"Time course and age dependence of motor neuron death following facial nerve crush injury: role of fibroblast growth factor","volume":"157","author":"Kuzis","year":"1999","journal-title":"Exp. Neurol"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/15\/2850\/24340040\/ddx162.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T15:40:22Z","timestamp":1569080422000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/26\/15\/2850\/3768439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,26]]},"references-count":55,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2017,4,26]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx162","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,8,1]]},"published":{"date-parts":[[2017,4,26]]}}}