{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:54:09Z","timestamp":1790394849616,"version":"4.1.0"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"17","funder":[{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["382231"],"award-info":[{"award-number":["382231"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"DOI":"10.1093\/hmg\/ddx230","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T15:10:37Z","timestamp":1497280237000},"page":"3409-3420","source":"Crossref","is-referenced-by-count":78,"title":["Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy"],"prefix":"10.1093","volume":"26","author":[{"given":"Samantha L.","family":"Sison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa N.","family":"Patitucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Seminary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Villalon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L.","family":"Lorson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison D.","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"key\n\t\t\t\t20171012113122_ddx230-B1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","year":"1995","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s004390100473","article-title":"SMN gene duplication and the emergence of the SMN2 gene occurred in distinct hominids: SMN2 is unique to Homo sapiens","volume":"108","year":"2001","journal-title":"Hum. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B3","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0092-8674(00)80368-2","article-title":"The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis","volume":"90","year":"1997","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B4","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0092-8674(00)80367-0","article-title":"The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins","volume":"90","year":"1997","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B5","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1126\/science.1074962","article-title":"Essential role for the SMN complex in the specificity of snRNP assembly","volume":"298","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B6","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1523\/JNEUROSCI.2396-15.2016","article-title":"Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons","volume":"36","year":"2016","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B7","first-page":"1269","article-title":"The domain encoded by exon 2 of the survival motor neuron protein mediates nucleic acid binding","volume":"7","year":"1998","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B8","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. of Sci. USA"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ng0598-63","article-title":"SMN oligomerization defect correlates with spinal muscular atrophy severity","volume":"19","year":"1998","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B10","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","article-title":"A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2","volume":"8","year":"1999","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B11","first-page":"342","article-title":"The astrocyte odyssey","volume":"86","year":"2008","journal-title":"Prog. Neurobiol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1083\/jcb.131.2.453","article-title":"Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury","volume":"131","year":"1995","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","year":"2005","journal-title":"Glia"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B14","first-page":"53","article-title":"Recent developments in understanding oxidative mechanisms and contributions of glial cell activation, mitochondrial dysfunction, and lipids and signaling pathways to neurodegenerative diseases. Preface","volume":"41","year":"2010","journal-title":"Mol. Neurobiol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B15","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0166-2236(97)01139-9","article-title":"Reactive astrocytes: cellular and molecular cues to biological function","volume":"20","year":"1997","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1242\/jcs.018671","article-title":"TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages","volume":"121","year":"2008","journal-title":"J. Cell Sci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/glia.22428","article-title":"Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis","volume":"61","year":"2013","journal-title":"Glia"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.1086071","article-title":"Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice","volume":"302","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B19","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nn1885","article-title":"Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model","volume":"10","year":"2007","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B20","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.stem.2008.10.001","article-title":"Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells","volume":"3","year":"2008","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B21","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1169096","article-title":"Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice","volume":"323","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B22","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/glia.22522","article-title":"Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production","volume":"61","year":"2013","journal-title":"Glia"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/hmg\/ddv489","article-title":"SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons","volume":"25","year":"2016","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B24","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1093\/hmg\/ddv148","article-title":"Astrocytes influence the severity of spinal muscular atrophy","volume":"24","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B25","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1161\/01.STR.31.11.2670","article-title":"Release of glial tissue-specific proteins after acute stroke: A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein","volume":"31","year":"2000","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B26","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1212\/01.WNL.0000120550.00643.DC","article-title":"Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury","volume":"62","year":"2004","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tins.2015.04.003","article-title":"Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker","volume":"38","year":"2015","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.mcn.2006.11.005","article-title":"Pro-NGF secreted by astrocytes promotes motor neuron cell death","volume":"34","year":"2007","journal-title":"Mol. Cell. Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B29","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.3390\/molecules19056891","article-title":"Circulating miRNAs as biomarkers for neurodegenerative disorders","volume":"19","year":"2014","journal-title":"Molecules"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s13238-015-0168-y","article-title":"Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2","volume":"6","year":"2015","journal-title":"Protein & Cell"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B31","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/glia.22556","article-title":"Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia","volume":"61","year":"2013","journal-title":"Glia"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2013.11.015","article-title":"Neuroprotection by astrocytes in brain ischemia: importance of microRNAs","volume":"565","year":"2014","journal-title":"Neurosci. Lett"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B33","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1073\/pnas.230364197","article-title":"Survival motor neuron protein modulates neuron-specific apoptosis","volume":"97","year":"2000","journal-title":"Proc. Natl. Acad. of Sci. USA"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B34","doi-asserted-by":"crossref","first-page":"e39113.","DOI":"10.1371\/journal.pone.0039113","article-title":"Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.nbd.2008.05.014","article-title":"Restoring Bcl-x(L) levels benefits a mouse model of spinal muscular atrophy","volume":"31","year":"2008","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.kjms.2013.12.007","article-title":"Survival of motor neuron protein downregulates miR-9 expression in patients with spinal muscular atrophy","volume":"30","year":"2014","journal-title":"Kaohsiung J. Med. Sci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B37","first-page":"18312","article-title":"A perturbed microRNA expression pattern characterizes embryonic neural stem cells derived from a severe mouse model of spinal muscular atrophy (SMA)","volume":"16","year":"2015","journal-title":"Int. J. Med. Sci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B38","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/stem.2233","article-title":"MiR-375 is essential for human spinal motor neuron development and may be involved in motor neuron degeneration","volume":"34","year":"2016","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B39","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1093\/hmg\/ddw084","article-title":"Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy","volume":"25","year":"2016","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B40","article-title":"SMA human iPSC-derived motor neurons show perturbed differentiation and reduced miR-335-5p expression","volume":"17","year":"2016","journal-title":"Int. J. Mol. Sci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B41","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1093\/nar\/gkq1325","article-title":"Species-specific microRNA roles elucidated following astrocyte activation","volume":"39","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B42","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.jinorgbio.2011.05.012","article-title":"Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures","volume":"105","year":"2011","journal-title":"J. Inorg. Biochem"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2011.05.044","article-title":"Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells","volume":"499","year":"2011","journal-title":"Neurosci. Lett"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2010.09.079","article-title":"Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models","volume":"487","year":"2011","journal-title":"Neurosci. Lett"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nbt.3049","article-title":"Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes","volume":"33","year":"2015","journal-title":"Nat. Biotechnol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B47","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.200304128","article-title":"Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons","volume":"163","year":"2003","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B48","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","year":"2007","journal-title":"Nat. Cell Biol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B49","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/hmg\/ddi078","article-title":"SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN","volume":"14","year":"2005","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B50","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/mt.2016.145","article-title":"Optimization of morpholino antisense oligonucleotides targeting the intronic repressor element1 in spinal muscular atrophy","volume":"24","year":"2016","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B51","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/hmg\/ddp030","article-title":"Translational readthrough by the aminoglycoside geneticin (G418) modulates SMN stability in vitro and improves motor function in SMA mice in vivo","volume":"18","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B52","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1126\/science.1250127","article-title":"Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy","volume":"345","year":"2014","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B53","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1093\/hmg\/ddu169","article-title":"Defining the therapeutic window in a severe animal model of spinal muscular atrophy","volume":"23","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B54","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B55","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1074\/jbc.M307521200","article-title":"Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression","volume":"279","year":"2004","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B56","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1053\/j.gastro.2008.07.074","article-title":"GATA4 is essential for jejunal function in mice","volume":"135","year":"2008","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B57","doi-asserted-by":"crossref","first-page":"12573","DOI":"10.1073\/pnas.0400752101","article-title":"GATA4 is essential for formation of the proepicardium and regulates cardiogenesis","volume":"101","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B58","doi-asserted-by":"crossref","first-page":"e0157426.","DOI":"10.1371\/journal.pone.0157426","article-title":"An integrative transcriptomic analysis for identifying novel target genes corresponding to severity spectrum in spinal muscular atrophy","volume":"11","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B59","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/MCB.00626-12","article-title":"GATA-6 and NF-kappaB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction","volume":"33","year":"2013","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B60","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrn3024","article-title":"Not(ch) just development: Notch signalling in the adult brain","volume":"12","year":"2011","journal-title":"Nat. Rev. Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B61","doi-asserted-by":"crossref","first-page":"11424","DOI":"10.3390\/ijms140611424","article-title":"Notch signaling pathway is activated in motoneurons of spinal muscular atrophy","volume":"14","year":"2013","journal-title":"Int. J. Mol. Sci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B62","doi-asserted-by":"crossref","first-page":"e106818.","DOI":"10.1371\/journal.pone.0106818","article-title":"Transcriptome profiling of spinal muscular atrophy motor neurons derived from mouse embryonic stem cells","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B63","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1523\/JNEUROSCI.5775-11.2012","article-title":"Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction","volume":"32","year":"2012","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B64","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/hmg\/ddm379","article-title":"Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect","volume":"17","year":"2008","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B65","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.1523\/JNEUROSCI.3472-16.2017","article-title":"Decreased Motor Neuron Support by SMA Astrocytes due to Diminished MCP1 Secretion","volume":"37","year":"2017","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B66","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/pmic.201300495","article-title":"Proteomic analysis of mouse astrocytes and their secretome by a combination of FASP and StageTip-based, high pH, reversed-phase fractionation","volume":"14","year":"2014","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B67","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.7973664","article-title":"GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle","volume":"266","year":"1994","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B68","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","article-title":"GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons","volume":"260","year":"1993","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B69","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/mds.25344","article-title":"Trophic factor gene therapy for Parkinson's disease","volume":"28","year":"2013","journal-title":"Mov. Disord"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B70","first-page":"61.","article-title":"Trophic factors as modulators of motor neuron physiology and survival: implications for ALS therapy","volume":"8","year":"2014","journal-title":"Front. Cell. Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B71","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.expneurol.2004.08.012","article-title":"Motoneurons crave glial cell line-derived neurotrophic factor","volume":"190","year":"2004","journal-title":"Exp. Neurol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nbd.2016.09.008","article-title":"Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands","volume":"97","year":"2017","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B73","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.nbd.2012.04.014","article-title":"Astrocyte-derived GDNF is a potent inhibitor of microglial activation","volume":"47","year":"2012","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B74","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/NEN.0000000000000074","article-title":"Mechanisms involved in spinal cord central synapse loss in a mouse model of spinal muscular atrophy","volume":"73","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B75","doi-asserted-by":"crossref","first-page":"e44789.","DOI":"10.1371\/journal.pone.0044789","article-title":"MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B76","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1460-9568.2010.07122.x","article-title":"Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy","volume":"31","year":"2010","journal-title":"Eur. J. Neurosci"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B77","doi-asserted-by":"crossref","first-page":"e1005710.","DOI":"10.1371\/journal.pgen.1005710","article-title":"GDNF overexpression from the native locus reveals its role in the nigrostriatal dopaminergic system function","volume":"11","year":"2015","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B78","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/stem.1873","article-title":"Notch signaling regulates motor neuron differentiation of human embryonic stem cells","volume":"33","year":"2015","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B79","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3109\/01677060902878481","article-title":"Notch signaling is required for activity-dependent synaptic plasticity at the Drosophila neuromuscular junction","volume":"23","year":"2009","journal-title":"J. Neurogenet"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B80","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.stemcr.2015.11.004","article-title":"Neurite aggregation and calcium dysfunction in iPSC-derived sensory neurons with Parkinson's Disease-related LRRK2 G2019S mutation","volume":"5","year":"2015","journal-title":"Stem Cell Reports"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B81","doi-asserted-by":"crossref","first-page":"81.","DOI":"10.1186\/1471-213X-10-81","article-title":"Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors","volume":"10","year":"2010","journal-title":"BMC Dev. Biol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B82","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0165-0270(98)00126-5","article-title":"A new method for the rapid and long term growth of human neural precursor cells","volume":"85","year":"1998","journal-title":"J. Neurosci. Methods"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B83","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.scr.2013.01.009","article-title":"EZ spheres: A stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs","volume":"10","year":"2013","journal-title":"Stem Cell Res"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B84","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1073\/pnas.1300398110","article-title":"Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy","volume":"110","year":"2013","journal-title":"Proc. Natl. Acad. of Sci. USA"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B85","doi-asserted-by":"crossref","first-page":"15699","DOI":"10.1074\/jbc.M112.425066","article-title":"Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis","volume":"288","year":"2013","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B86","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","year":"2006","journal-title":"Curr. Proc. Cell Biol"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B87","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1093\/nar\/gkr148","article-title":"Analysis of microRNA turnover in mammalian cells following Dicer1 ablation","volume":"39","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20171012113122_ddx230-B88","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s12033-015-9885-y","article-title":"Improved RT-PCR assay to quantitate the pri-, pre-, and mature microRNAs with higher efficiency and accuracy","volume":"57","year":"2015","journal-title":"Mol. Biotechnol"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/17\/3409\/19544152\/ddx230.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T19:28:50Z","timestamp":1569439730000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/26\/17\/3409\/3868472\/Astrocyteproduced-miR146a-as-a-mediator-of-motor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,15]]},"references-count":88,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2017,6,15]]},"published-print":{"date-parts":[[2017,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx230","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,9,1]]},"published":{"date-parts":[[2017,6,15]]}}}