{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:25:17Z","timestamp":1781907917065,"version":"3.54.5"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"18","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["312557"],"award-info":[{"award-number":["312557"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"publisher","award":["PUTJD145"],"award-info":[{"award-number":["PUTJD145"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,15]]},"DOI":"10.1093\/hmg\/ddx246","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T07:09:47Z","timestamp":1498288187000},"page":"3585-3599","source":"Crossref","is-referenced-by-count":46,"title":["Gene expression profiling of puberty-associated genes reveals abundant tissue and sex-specific changes across postnatal development"],"prefix":"10.1093","volume":"26","author":[{"given":"Huayun","family":"Hou","sequence":"first","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liis","family":"Uusk\u00fcla-Reimand","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"},{"name":"Department of Gene Technology, Tallinn University of Technology, 12616 Tallinn, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisam","family":"Makarem","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Corre","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shems","family":"Saleh","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"},{"name":"Department of Computer Science, University of Toronto, Toronto, ON M5S 2E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Metcalf","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"},{"name":"Department of Computer Science, University of Toronto, Toronto, ON M5S 2E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R","family":"Palmert","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"},{"name":"Division of Endocrinology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada"},{"name":"Departments of Paediatrics and Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Wilson","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"key\n\t\t\t\t20180314004307_ddx246-B1","doi-asserted-by":"crossref","first-page":"S218","DOI":"10.1542\/peds.2007-1813G","article-title":"Public health implications of altered puberty timing","volume":"121 Suppl 3","author":"Golub","year":"2008","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/MED.0000000000000213","article-title":"The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity","volume":"23","author":"Cousminer","year":"2016","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B3","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1210\/jcem.86.6.7603","article-title":"Variation in the timing of puberty: clinical spectrum and genetic investigation","volume":"86","author":"Palmert","year":"2001","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2010.01.038","article-title":"Genetic determinants of pubertal timing in the general population","volume":"324","author":"Gajdos","year":"2010","journal-title":"Mol. Cell. Endocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1096-7192(03)00107-0","article-title":"Genetic approaches to stature, pubertal timing, and other complex traits","volume":"80","author":"Palmert","year":"2003","journal-title":"Mol. Genet. Metab"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/ajpa.20106","article-title":"Heritability of age at menarche in girls from the Fels Longitudinal Study","volume":"128","author":"Towne","year":"2005","journal-title":"Am. J. Phys. Anthropol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10519-007-9161-4","article-title":"The familial clustering of age at menarche in extended twin families","volume":"37","author":"van den Berg","year":"2007","journal-title":"Behav. Genet"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nrendo.2009.177","article-title":"The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism","volume":"5","author":"Bianco","year":"2009","journal-title":"Nat. Rev. Endocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B9","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/ng.714","article-title":"Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies","volume":"42","author":"Elks","year":"2010","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13545","article-title":"Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche","volume":"514","author":"Perry","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B11","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1093\/hmg\/ddu150","article-title":"Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty","volume":"23","author":"Cousminer","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B12","doi-asserted-by":"crossref","first-page":"8842.","DOI":"10.1038\/ncomms9842","article-title":"Shared genetic aetiology of puberty timing between sexes and with health-related outcomes","volume":"6","author":"Day","year":"2015","journal-title":"Nat. Commun"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B13","doi-asserted-by":"crossref","first-page":"R130.","DOI":"10.1186\/gb-2009-10-11-r130","article-title":"BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources","volume":"10","author":"Wu","year":"2009","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B14","doi-asserted-by":"crossref","first-page":"R33.","DOI":"10.1186\/gb-2005-6-4-r33","article-title":"Promoter features related to tissue specificity as measured by Shannon entropy","volume":"6","author":"Schug","year":"2005","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1210\/endo.142.1.7881","article-title":"Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays","volume":"142","author":"Dalkin","year":"2001","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1095\/biolreprod.115.129320","article-title":"Cell type-specific sexual dimorphism in pituitary gene expression during maturation","volume":"93","author":"Bjelobaba","year":"2015","journal-title":"Biol. Reprod"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ajhg.2010.08.018","article-title":"WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome","volume":"87","author":"Kim","year":"2010","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000125857","article-title":"Delayed puberty in the male Djungarian hamster: effect of short photoperiod or melatonin treatment on the GnRH neuronal system","volume":"54","author":"Buchanan","year":"1991","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-079X.1992.tb00029.x","article-title":"Melatonin secretion during adrenarche in normal human puberty and in pubertal disorders","volume":"12","author":"Cavallo","year":"1992","journal-title":"J. Pineal Res"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B20","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/dev.20605","article-title":"Human puberty: salivary melatonin profiles in constant conditions","volume":"54","author":"Crowley","year":"2012","journal-title":"Dev. Psychobiol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1095\/biolreprod2.2.216","article-title":"Delayed puberty in blinded anosmic female rats: role of the pineal gland","volume":"2","author":"Reiter","year":"1970","journal-title":"Biol. Reprod"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B22","first-page":"301","article-title":"Melatonin inhibits testosterone secretion by acting at hypothalamo-pituitary-gonadal axis in the rat","volume":"21","author":"Yilmaz","year":"2000","journal-title":"Neuro Endocrinol. Lett"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B23","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/ng.385","article-title":"Genome-wide association studies identify loci associated with age at menarche and age at natural menopause","volume":"41","author":"He","year":"2009","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/JOE-15-0360","article-title":"Sex-specific regulation of weight and puberty by the Lin28\/let-7 axis","volume":"228","author":"Corre","year":"2016","journal-title":"J. Endocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B25","doi-asserted-by":"crossref","first-page":"9.","DOI":"10.1186\/2042-6410-3-9","article-title":"Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood","volume":"3","author":"Conforto","year":"2012","journal-title":"Biol. Sex Differ"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(88)90037-2","article-title":"The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein","volume":"55","author":"Bodner","year":"1988","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1095\/biolreprod.103.026880","article-title":"The murine testicular transcriptome: characterizing gene expression in the testis during the progression of spermatogenesis","volume":"71","author":"Shima","year":"2004","journal-title":"Biol. Reprod"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B28","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1128\/MCB.21.4.1393-1403.2001","article-title":"Hepatocyte nuclear factor 4\u03b1 (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis","volume":"21","author":"Hayhurst","year":"2001","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0197-4580(86)90026-6","article-title":"LHRH neurons in the female C57BL\/6J mouse brain during reproductive aging: no loss up to middle age","volume":"7","author":"Hoffman","year":"1986","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/acel.12299","article-title":"Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity","volume":"14","author":"Satoh","year":"2015","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B31","first-page":"2579","article-title":"Visualizing Data using t-SNE","volume":"9","author":"Maaten","year":"2008","journal-title":"J. Mach. Learn. Res"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B32","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/ijo.2012.177","article-title":"Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis","volume":"37","author":"Prentice","year":"2013","journal-title":"Int. J. Obes. (Lond)"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B33","first-page":"1","article-title":"Transcriptome profiling of the developing postnatal mouse testis using next-generation sequencing","volume":"56","author":"Gong","year":"2012","journal-title":"Sci. China Life Sci"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B34","author":"Jost","year":"1948"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0012-1606(03)00391-9","article-title":"Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave","volume":"262","author":"Menke","year":"2003","journal-title":"Dev. Biol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B36","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMoa1302160","article-title":"Central precocious puberty caused by mutations in the imprinted gene MKRN3","volume":"368","author":"Abreu","year":"2013","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B37","doi-asserted-by":"crossref","first-page":"R131","DOI":"10.1530\/JME-14-0315","article-title":"A new pathway in the control of the initiation of puberty: the MKRN3 gene","volume":"54","author":"Abreu","year":"2015","journal-title":"J. Mol. Endocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B38","doi-asserted-by":"crossref","first-page":"129.","DOI":"10.1095\/biolreprod.112.102798","article-title":"Molecular profiling of postnatal development of the hypothalamus in female and male rats","volume":"87","author":"Walker","year":"2012","journal-title":"Biol. Reprod"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B39","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ygeno.2005.02.013","article-title":"Sexually dimorphic gene expression in the hypothalamus, pituitary gland, and cortex","volume":"85","author":"Nishida","year":"2005","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B40","article-title":"Transcriptomics reveals patterns of sexually dimorphic gene expression in an avian hypothalamic-pituitary-gonadal (HPG) axis","author":"MacManes","year":"2016","journal-title":"bioRxiv"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B41","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/MCB.06312-11","article-title":"Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver","volume":"32","author":"Zhang","year":"2012","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B42","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ng.593","article-title":"Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies","volume":"42","author":"Zhu","year":"2010","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B43","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2826.2009.01892.x","article-title":"Distribution of kisspeptin neurones in the adult female mouse brain","volume":"21","author":"Clarkson","year":"2009","journal-title":"J. Neuroendocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2826.2007.01558.x","article-title":"Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion","volume":"19","author":"Guti\u00e9rrez-Pascual","year":"2007","journal-title":"J. Neuroendocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B45","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1210\/me.2012-1405","article-title":"Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes","volume":"27","author":"Witham","year":"2013","journal-title":"Mol. Endocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mce.2016.07.039","article-title":"Role of the Kiss1\/Kiss1r system in the regulation of pituitary cell function","volume":"438","author":"Gahete","year":"2016","journal-title":"Mol. Cell. Endocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-5793(99)01473-8","article-title":"The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes","volume":"462","author":"Wechselberger","year":"1999","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B48","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/pbc.24825","article-title":"Neoplastic causes of abnormal puberty","volume":"61","author":"Wendt","year":"2014","journal-title":"Pediatr. Blood Cancer"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B49","doi-asserted-by":"crossref","first-page":"6412","DOI":"10.1073\/pnas.0914399107","article-title":"Genetic variation of melatonin productivity in laboratory mice under domestication","volume":"107","author":"Kasahara","year":"2010","journal-title":"Proc. Natl. Acad. Sci"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B50","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1046\/j.1460-9568.2000.00990.x","article-title":"Transcription factor dynamics and neuroendocrine signalling in the mouse pineal gland: a comparative analysis of melatonin-deficient C57BL mice and melatonin-proficient C3H mice","volume":"12","author":"Von Gall","year":"2000","journal-title":"Eur. J. Neurosci"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B51","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/978-1-4614-6199-9_19","article-title":"Kisspeptin and seasonality of reproduction","volume":"784","author":"Clarke","year":"2013","journal-title":"Adv. Exp. Med. Biol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B52","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1089\/dna.1994.13.1163","article-title":"The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary","volume":"13","author":"Seidah","year":"1994","journal-title":"DNA Cell Biol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B53","article-title":"Kisspeptin signaling in the amygdala modulates reproductive hormone secretion","author":"Comninos","year":"2015","journal-title":"Brain Struct. Funct"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B54","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1210\/en.2015-1366","article-title":"The posterodorsal medial amygdala regulates the timing of puberty onset in female rats","volume":"156","author":"Li","year":"2015","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S0954579410000660","article-title":"Quality of early family relationships and the timing and tempo of puberty: effects depend on biological sensitivity to context","volume":"23","author":"Ellis","year":"2011","journal-title":"Dev. Psychopathol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B56","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1542\/peds.2005-2939","article-title":"Increased risk of precocious puberty in internationally adopted children in Denmark","volume":"118","author":"Teilmann","year":"2006","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B57","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1037\/a0013065","article-title":"Impact of fathers on daughters\u2019 age at menarche: a genetically and environmentally controlled sibling study","volume":"44","author":"Tither","year":"2008","journal-title":"Dev. Psychol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B58","doi-asserted-by":"crossref","first-page":"371583.","DOI":"10.1155\/2014\/371583","article-title":"Nongenetic determinants of age at menarche: a systematic review","volume":"2014","author":"Yermachenko","year":"2014","journal-title":"BioMed Res. Int"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B59","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ni925","article-title":"Bcl11a is essential for normal lymphoid development","volume":"4","author":"Liu","year":"2003","journal-title":"Nat. Immunol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B60","doi-asserted-by":"crossref","first-page":"733.","DOI":"10.1016\/j.modgep.2004.03.009","article-title":"CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis","volume":"4","author":"Leid","year":"2004","journal-title":"Gene Expr. Patterns GEP"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B61","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1182\/blood-2012-12-472308","article-title":"LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo","volume":"122","author":"Lee","year":"2013","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B62","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1530\/JOE-11-0098","article-title":"Identification of estradiol\/ER\u03b1-regulated genes in the mouse pituitary","volume":"210","author":"Kim","year":"2011","journal-title":"J. Endocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B63","doi-asserted-by":"crossref","first-page":"e0159534","DOI":"10.1371\/journal.pone.0159534","article-title":"Loss of fertility in the absence of progesterone receptor expression in kisspeptin neurons of female mice","volume":"11","author":"A","year":"2016","journal-title":"PloS One"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B64","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.2528-03.2004","article-title":"The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival","volume":"24","author":"Sadakata","year":"2004","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B65","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0092-8674(91)90396-G","article-title":"The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor","volume":"65","author":"Soppet","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B66","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1074\/mcp.M400169-MCP200","article-title":"Automated yeast two-hybrid screening for nuclear receptor-interacting proteins","volume":"4","author":"Albers","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B67","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B68","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000077273","article-title":"Pituitary resistin gene expression: effects of age, gender and obesity","volume":"79","author":"Morash","year":"2004","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B69","doi-asserted-by":"crossref","first-page":"24.","DOI":"10.1186\/1741-7007-6-24","article-title":"Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary","volume":"6","author":"Sharov","year":"2008","journal-title":"BMC Biol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B70","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ng.3841","article-title":"Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk","volume":"49","author":"Day","year":"2017","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B71","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1093\/emboj\/17.23.6790","article-title":"Otx1 and Otx2 in the development and evolution of the mammalian brain","volume":"17","author":"Simeone","year":"1998","journal-title":"embo J"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B72","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/nn1155","article-title":"Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development","volume":"6","author":"Nishida","year":"2003","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B73","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1210\/er.2009-0008","article-title":"Genetic regulation of pituitary gland development in human and mouse","volume":"30","author":"Kelberman","year":"2009","journal-title":"Endocr. Rev"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B74","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1530\/EJE-12-0333","article-title":"A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve","volume":"167","author":"Gorbenko Del Blanco","year":"2012","journal-title":"Eur. J. Endocrinol"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B75","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nn.3319","article-title":"Epigenetic control of female puberty","volume":"16","author":"Lomniczi","year":"2013","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B76","doi-asserted-by":"crossref","first-page":"420747.","DOI":"10.1155\/2008\/420747","article-title":"Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes","volume":"2008","author":"Hruz","year":"2008","journal-title":"Adv. Bioinforma"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B77","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature13182","article-title":"A promoter-level mammalian expression atlas","volume":"507","author":"The FANTOM Consortium and the RIKEN PMI and CLST (dgt)","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B78","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1523\/JNEUROSCI.03-04-00832.1983","article-title":"Variations in number of dopamine neurons and tyrosine hydroxylase activity in hypothalamus of two mouse strains","volume":"3","author":"Baker","year":"1983","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B79","author":"Paxinos","year":"2004"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B80","doi-asserted-by":"crossref","first-page":"134.","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B81","doi-asserted-by":"crossref","first-page":"e51.","DOI":"10.1093\/nar\/gkr1259","article-title":"Correction of RT\u2013qPCR data for genomic DNA-derived signals with ValidPrime","volume":"40","author":"Laurell","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B82","author":"Wickham","year":"2009"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B83","author":"Krijthe","year":"2015"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B84","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkw199","article-title":"g:Profiler-a web server for functional interpretation of gene lists (2016 update)","volume":"44","author":"Reimand","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B85","author":"Martin","year":"2016"},{"key":"key\n\t\t\t\t20180314004307_ddx246-B86","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v062.i01","article-title":"TSclust: an r package for time series clustering","volume":"62","author":"Montero","year":"2014","journal-title":"J. Stat. Softw"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/18\/3585\/24339693\/ddx246.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T20:21:12Z","timestamp":1569529272000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/26\/18\/3585\/3895137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,27]]},"references-count":86,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2017,6,27]]},"published-print":{"date-parts":[[2017,9,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx246","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,9,15]]},"published":{"date-parts":[[2017,6,27]]}}}