{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:47:17Z","timestamp":1789505237421,"version":"build-2803163510"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"19","funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/63530\/2009"],"award-info":[{"award-number":["SFRH\/BPD\/63530\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["IF\/00094\/2013\/CP1173\/CT0005"],"award-info":[{"award-number":["IF\/00094\/2013\/CP1173\/CT0005"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UID\/CBQ\/04612\/2013"],"award-info":[{"award-number":["UID\/CBQ\/04612\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1093\/hmg\/ddx260","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T07:08:19Z","timestamp":1499152099000},"page":"3763-3775","source":"Crossref","is-referenced-by-count":36,"title":["Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity"],"prefix":"10.1093","volume":"26","author":[{"given":"Joana","family":"Branco-Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon\u00e7alo M.","family":"Po\u00e7as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Pires-Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaviano","family":"Giorgini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro M.","family":"Domingos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago F.","family":"Outeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"key\n\t\t\t\t20171011225014_ddx260-B1","first-page":"1","article-title":"Novel therapeutic strategies for the treatment of protein-misfolding diseases","volume":"9","year":"2007","journal-title":"Expert Rev. Mol. Med"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B2","doi-asserted-by":"crossref","first-page":"15005.","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1750-3639.1998.tb00196.x","article-title":"Transgenic mice in the study of polyglutamine repeat expansion diseases","volume":"8","year":"1998","journal-title":"Brain. Pathol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B5","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"The Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF02257483","article-title":"Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat","volume":"20","year":"1994","journal-title":"Somat. Cell Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B7","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1073\/pnas.97.4.1589","article-title":"Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins","volume":"97","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B8","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B9","article-title":"Chaperones in polyglutamine aggregation: beyond the Q-stretch","volume":"11","year":"2017","journal-title":"Front. Neurosci"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B10","doi-asserted-by":"crossref","first-page":"14993","DOI":"10.1074\/jbc.M112.446237","article-title":"The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin","volume":"288","year":"2013","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1021\/bi301325q","article-title":"Membrane interactions of the amphipathic amino terminus of huntingtin","volume":"52","year":"2013","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B12","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1093\/hmg\/ddm217","article-title":"Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity","volume":"16","year":"2007","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/hmg\/ddl440","article-title":"The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis","volume":"16","year":"2007","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ng1503","article-title":"Polyglutamine expansion of huntingtin impairs its nuclear export","volume":"37","year":"2005","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B15","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/hmg\/ddg156","article-title":"Huntingtin contains a highly conserved nuclear export signal","volume":"12","year":"2003","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B16","doi-asserted-by":"crossref","first-page":"20075","DOI":"10.1073\/pnas.1320626110","article-title":"Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation","volume":"110","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B17","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jmb.2011.12.010","article-title":"Slow amyloid nucleation via alpha-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments","volume":"415","year":"2012","journal-title":"J. Mol. Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B18","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.jmb.2009.12.017","article-title":"Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin","volume":"396","year":"2010","journal-title":"J. Mol. Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nsmb.1570","article-title":"Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism","volume":"16","year":"2009","journal-title":"Nat. Struct. Mol. Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nchembio0606-297","article-title":"Nucleation of huntingtin aggregation in cells","volume":"2","year":"2006","journal-title":"Nat. Chem. Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B21","doi-asserted-by":"crossref","first-page":"67.","DOI":"10.1186\/s13024-015-0063-2","article-title":"The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model","volume":"10","year":"2015","journal-title":"Mol. Neurodegener"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B22","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.neuron.2015.01.008","article-title":"N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice","volume":"85","year":"2015","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2014.11.035","article-title":"Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity","volume":"456","year":"2015","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B24","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/hmg\/dds554","article-title":"The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal","volume":"22","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B25","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1074\/jbc.M112.413575","article-title":"An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1","volume":"288","year":"2013","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2012.09.011","article-title":"Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties","volume":"424","year":"2012","journal-title":"J. Mol. Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B27","doi-asserted-by":"crossref","first-page":"25108","DOI":"10.1074\/jbc.M110.187591","article-title":"Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation","volume":"286","year":"2011","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B28","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/hmg\/ddr023","article-title":"Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation","volume":"20","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B29","doi-asserted-by":"crossref","first-page":"29427","DOI":"10.1074\/jbc.M109.013193","article-title":"Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity","volume":"284","year":"2009","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B30","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200909067","article-title":"IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome","volume":"187","year":"2009","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B31","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.neuron.2009.11.020","article-title":"Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice","volume":"64","year":"2009","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B32","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1074\/jbc.M412042200","article-title":"Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes","volume":"280","year":"2005","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1092194","article-title":"SUMO modification of Huntingtin and Huntington's disease pathology","volume":"304","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B34","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35099568","article-title":"Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila","volume":"413","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B35","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1093\/hmg\/ddt625","article-title":"Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions","volume":"23","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B36","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1073\/pnas.1114502109","article-title":"Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice","volume":"109","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nchembio.582","article-title":"Kinase inhibitors modulate huntingtin cell localization and toxicity","volume":"7","year":"2011","journal-title":"Nat. Chem. Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B38","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1523\/JNEUROSCI.2675-04.2004","article-title":"Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity","volume":"24","year":"2004","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B39","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.bbrc.2015.06.116","article-title":"Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKbeta","volume":"463","year":"2015","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B40","doi-asserted-by":"crossref","first-page":"e0121055.","DOI":"10.1371\/journal.pone.0121055","article-title":"Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin","volume":"10","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B41","doi-asserted-by":"crossref","first-page":"14610","DOI":"10.1073\/pnas.1301342110","article-title":"Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin","volume":"110","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B42","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1074\/jbc.M113.544312","article-title":"Dopamine D2 receptor relies upon PPM\/PP2C protein phosphatases to dephosphorylate huntingtin protein","volume":"289","year":"2014","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B43","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.neuint.2011.04.009","article-title":"FK506 ameliorates cell death features in Huntington's disease striatal cell models","volume":"59","year":"2011","journal-title":"Neurochem. Int"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B44","doi-asserted-by":"crossref","first-page":"33.","DOI":"10.1186\/1756-6606-2-33","article-title":"Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease","volume":"2","year":"2009","journal-title":"Mol. Brain"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B45","doi-asserted-by":"crossref","first-page":"11845","DOI":"10.1074\/jbc.M900639200","article-title":"Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro","volume":"284","year":"2009","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B46","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1523\/JNEUROSCI.3706-05.2006","article-title":"Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421","volume":"26","year":"2006","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/hmg\/ddu421","article-title":"Mutant huntingtin alters Tau phosphorylation and subcellular distribution","volume":"24","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B48","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.febslet.2011.11.019","article-title":"alpha-Synuclein modifies huntingtin aggregation in living cells","volume":"586","year":"2012","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B49","first-page":"RRN1210.","article-title":"Visualization of cell-to-cell transmission of mutant huntingtin oligomers","volume":"3","year":"2011","journal-title":"PLoS Curr"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B50","doi-asserted-by":"crossref","first-page":"e0155747.","DOI":"10.1371\/journal.pone.0155747","article-title":"Folding landscape of mutant huntingtin exon1: diffusible multimers, oligomers and fibrils, and no detectable monomer","volume":"11","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B51","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1093\/hmg\/ddu606","article-title":"alpha-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila","volume":"24","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B52","first-page":"577","article-title":"Alpha-synuclein overexpression promotes aggregation of mutant huntingtin","volume":"346(Pt 3)","year":"2000","journal-title":"Biochem. J"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B53","first-page":"1","article-title":"Mutant exon 1 Huntingtin aggregation is regulated by T3 phosphorylation-induced structural changes and crosstalk between T3 phosphorylation and acetylation at K6","volume":"56","year":"2017","journal-title":"Angew. Chem. Int. Ed"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B54","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/1531-8249(199912)46:6<842::AID-ANA6>3.0.CO;2-O","article-title":"Huntington aggregates may not predict neuronal death in Huntington's disease","volume":"46","year":"1999","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B55","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","year":"2004","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B56","doi-asserted-by":"crossref","first-page":"11402","DOI":"10.1073\/pnas.0503634102","article-title":"Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions","volume":"102","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B57","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1073\/pnas.0511256103","article-title":"Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases","volume":"103","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B58","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nchembio.1308","article-title":"Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration","volume":"9","year":"2013","journal-title":"Nat. Chem. Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1042\/BJ20121772","article-title":"Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle","volume":"456","year":"2013","journal-title":"Biochem. J"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B60","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/B978-0-12-396456-4.00012-2","article-title":"Protein phosphatases and Alzheimer's disease","volume":"106","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B61","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1046\/j.1471-4159.1995.65020732.x","article-title":"Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain","volume":"65","year":"1995","journal-title":"J. Neurochem"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B62","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1523\/JNEUROSCI.15-05-03375.1995","article-title":"Differential expression of protein phosphatase 1 isoforms in mammalian brain","volume":"15","year":"1995","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B63","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.chembiol.2008.01.005","article-title":"Activation of protein phosphatase 1 by a small molecule designed to bind to the enzyme's regulatory site","volume":"15","year":"2008","journal-title":"Chem. Biol"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B64","doi-asserted-by":"crossref","first-page":"10054","DOI":"10.1002\/anie.201204308","article-title":"Development of a peptide that selectively activates protein phosphatase-1 in living cells","volume":"51","year":"2012","journal-title":"Angew. Chem. Int. Ed"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B65","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1534\/genetics.115.180208","article-title":"The Transgenic RNAi Project at Harvard Medical School: resources and validation","volume":"201","year":"2015","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B66","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nmeth.1592","article-title":"A genome-scale shRNA resource for transgenic RNAi in Drosophila","volume":"8","year":"2011","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B67","first-page":"140","article-title":"Dissection of imaginal discs from 3rd instar Drosophila larvae","volume":"2","year":"2007","journal-title":"J. Vis. Exp"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B68","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","year":"2012","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","volume":"224","year":"2006","journal-title":"J. Microsc"},{"key":"key\n\t\t\t\t20171011225014_ddx260-B70","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1242\/dev.128.6.815","article-title":"A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia","volume":"128","year":"2001","journal-title":"Development"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/19\/3763\/19947623\/ddx260.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T02:45:30Z","timestamp":1719283530000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/26\/19\/3763\/3932276\/Protein-phosphatase-1-regulates-huntingtin-exon-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,7]]},"references-count":70,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2017,7,7]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx260","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/135954","asserted-by":"object"}]},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10,1]]},"published":{"date-parts":[[2017,7,7]]}}}