{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:47:13Z","timestamp":1789991233853,"version":"4.0.1"},"reference-count":140,"publisher":"Oxford University Press (OUP)","issue":"R2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1093\/hmg\/ddx273","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T19:09:52Z","timestamp":1501009792000},"page":"R139-R150","source":"Crossref","is-referenced-by-count":110,"title":["Optic neuropathies: the tip of the neurodegeneration iceberg"],"prefix":"10.1093","volume":"26","author":[{"given":"Valerio","family":"Carelli","sequence":"first","affiliation":[{"name":"IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy"},{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"La Morgia","sequence":"additional","affiliation":[{"name":"IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy"},{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred N.","family":"Ross-Cisneros","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo A.","family":"Sadun","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, CA 90033, USA"},{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"key\n\t\t\t\t20180314003308_ddx273-B1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","article-title":"Mitochondrial dysfunction as a cause of optic neuropathies","volume":"23","author":"Carelli","year":"2004","journal-title":"Prog. Ret. Eye Res"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","article-title":"Mitochondrial optic neuropathies -Disease mechanisms and therapeutic strategies","volume":"30","author":"Yu-Wai-Man","year":"2011","journal-title":"Prog. Ret. Eye Res"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B3","first-page":"266","article-title":"Ein ungewohnlicher Fall von hereditarer Amaurose","volume":"4","author":"Von Graefe","year":"1858","journal-title":"Arch. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B4","first-page":"249","article-title":"Uber hereditare und congenital-angelegte Sehnervenleiden","volume":"17","author":"Leber","year":"1871","journal-title":"Arch. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B5","first-page":"1","article-title":"Infantile optic atrophy with dominant mode of inheritance: a clinical and genetic study of 19 Danish families","volume":"37","author":"Kjer","year":"1959","journal-title":"Acta Ophthalmol. Scand"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1086\/346066","article-title":"The epidemiology of Leber hereditary optic neuropathy in the North East of England","volume":"72","author":"Yu-Wai-Man","year":"2003","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B7","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.ophtha.2013.04.022","article-title":"Dominant optic atrophy: novel OPA1 mutations and revised prevalence estimates","volume":"120","author":"Yu-Wai-Man","year":"2013","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B8","first-page":"461","article-title":"Meta-analysis of the prevalence of Leber hereditary optic neuropathy mtDNA mutations in Europe. Eur","volume":"22","author":"Mascialino","year":"2012","journal-title":"J. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B9","doi-asserted-by":"crossref","first-page":"46.","DOI":"10.1186\/1750-1172-7-46","article-title":"Dominant optic atrophy","volume":"7","author":"Lenaers","year":"2012","journal-title":"Orphanet J. Rare Dis"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B10","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.3201231","article-title":"Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy","volume":"242","author":"Wallace","year":"1988","journal-title":"Science"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"Alexander","year":"2000","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mcn.2012.08.004","article-title":"The optic nerve: a \u201cmito-window\u201d on mitochondrial neurodegeneration","volume":"55","author":"Maresca","year":"2013","journal-title":"Mol. Cell Neurosci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0197-0186(01)00129-2","article-title":"Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies","volume":"40","author":"Carelli","year":"2002","journal-title":"Neurochem. Int"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exer.2015.05.008","article-title":"Electrophysiological assessment of retinal ganglion cell function","volume":"141","author":"Porciatti","year":"2015","journal-title":"Exp. Eye Res"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B16","doi-asserted-by":"crossref","first-page":"155.","DOI":"10.1007\/s12551-011-0054-7","article-title":"Optical coherence tomography: fundamental principles, instrumental designs and biomedical applications","volume":"3","author":"Popescu","year":"2011","journal-title":"Biophys. Rev"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ophtha.2004.06.034","article-title":"Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy","volume":"112","author":"Barboni","year":"2005","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B18","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.ophtha.2009.12.042","article-title":"OPA1 mutations associated with dominant optic atrophy influence optic nerve head size","volume":"117","author":"Barboni","year":"2010","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.ajo.2014.05.034","article-title":"Early macular retinal ganglion cell loss in dominant optic atrophy: genotype-phenotype correlation","volume":"158","author":"Barboni","year":"2014","journal-title":"Am. J. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B20","doi-asserted-by":"crossref","first-page":"37332.","DOI":"10.1038\/srep37332","article-title":"Changes in choroidal thickness follow the RNFL changes in Leber's hereditary optic neuropathy","volume":"6","author":"Borrelli","year":"2016","journal-title":"Sci. Rep"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B21","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ophtha.2009.07.026","article-title":"Natural history of Leber's hereditary optic neuropathy: longitudinal analysis of the retinal nerve fiber layer by optical coherence tomography","volume":"117","author":"Barboni","year":"2010","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B22","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1136\/bjophthalmol-2015-307326","article-title":"Macular nerve fibre and ganglion cell layer changes in acute Leber's hereditary optic neuropathy","volume":"100","author":"Balducci","year":"2016","journal-title":"Br. J. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.dadm.2016.12.014","article-title":"Retinal thickness in Alzheimer's disease: a systematic review and meta-analysis","volume":"6","author":"den Haan","year":"2017","journal-title":"Alzheimers Dement. (Amst)"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B24","doi-asserted-by":"crossref","first-page":"e85718.","DOI":"10.1371\/journal.pone.0085718","article-title":"Retinal nerve fiber layer thickness changes in Parkinson disease: a meta-analysis","volume":"9","author":"Yu","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/mds.25741","article-title":"Venturing into the no-man's land of the retina in Parkinson's disease","volume":"29","author":"Bodis-Wollner","year":"2014","journal-title":"Mov. Disord"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00401-016-1625-2","article-title":"A neurodegenerative perspective on mitochondrial optic neuropathies","volume":"132","author":"Yu-Wai-Man","year":"2016","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10540-007-9045-0","article-title":"Mitochondrial optic neuropathies: how two genomes may kill the same cell type?","volume":"27","author":"Carelli","year":"2007","journal-title":"Biosci. Rep"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bbabio.2009.02.024","article-title":"Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders","volume":"1787","author":"Carelli","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B29","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1001\/archneur.62.5.730","article-title":"Severe impairment of complex I-driven adenosine triphosphate synthesis in Leber hereditary optic neuropathy cybrids","volume":"62","author":"Baracca","year":"2005","journal-title":"Arch. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B30","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/brain\/awh258","article-title":"Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines","volume":"127","author":"Beretta","year":"2004","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B31","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1742-4658.2004.04542.x","article-title":"Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber's hereditary optic neuropathy","volume":"272","author":"Floreani","year":"2005","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B32","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1074\/jbc.M110119200","article-title":"Cells bearing mutations causing Leber's hereditary optic neuropathy are sensitized to Fas-Induced apoptosis","volume":"277","author":"Danielson","year":"2002","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B33","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1074\/jbc.M210285200","article-title":"Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium","volume":"278","author":"Ghelli","year":"2003","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B34","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s10495-005-0742-5","article-title":"Caspase-independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G","volume":"10","author":"Zanna","year":"2005","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jcp.20950","article-title":"Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to ADOA pathogenesis","volume":"211","author":"Olichon","year":"2007","journal-title":"J. Cell. Physiol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/brain\/awm335","article-title":"OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion","volume":"131","author":"Zanna","year":"2008","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B37","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.bbadis.2012.07.002","article-title":"Defective mitochondrial fusion, altered respiratory function, and distorted cristae structure in skin fibroblasts with heterozygous OPA1 mutations","volume":"1822","author":"Agier","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrneurol.2014.228","article-title":"Disturbed mitochondrial dynamics and neurodegenerative disorders","volume":"11","author":"Burt\u00e9","year":"2015","journal-title":"Nat. Rev. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B39","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1083\/jcb.135.4.883","article-title":"In situ localization of mitochondrial DNA replication in intact mammalian cells","volume":"135","author":"Davis","year":"1996","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B40","doi-asserted-by":"crossref","first-page":"120079.","DOI":"10.1098\/rsob.120079","article-title":"Insights into the roles of local translation from the axonal transcriptome","volume":"2","author":"Deglincerti","year":"2012","journal-title":"Open Biol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2004.11.003","article-title":"The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses","volume":"119","author":"Li","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B42","doi-asserted-by":"crossref","first-page":"e11583","DOI":"10.7554\/eLife.11583","article-title":"Dendritic mitochondria reach stable positions during circuit development","volume":"5","author":"Faits","year":"2016","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/bjo.83.2.231","article-title":"Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina","volume":"83","author":"Andrews","year":"1999","journal-title":"Br. J. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B44","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/archopht.120.6.791","article-title":"The distribution of mitochondrial activity in relation to optic nerve structure","volume":"120","author":"Bristow","year":"2002","journal-title":"Arch. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B45","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/bjo.2003.027664","article-title":"The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head","volume":"88","author":"Barron","year":"2004","journal-title":"Br. J. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180314003308_ddx273-B47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B48","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/mds.26966","article-title":"Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease","volume":"32","author":"Giannoccaro","year":"2017","journal-title":"Mov. Disord"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B49","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2010.07.018","article-title":"ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death","volume":"142","author":"Radoshevich","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B50","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cell.2011.02.010","article-title":"PARIS (ZNF746) repression of PGC-1\u03b1 contributes to neurodegeneration in Parkinson's disease","volume":"144","author":"Shin","year":"2011","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B51","doi-asserted-by":"crossref","first-page":"11696","DOI":"10.1073\/pnas.1500624112","article-title":"Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration","volume":"112","author":"Stevens","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B52","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nm.3213","article-title":"Rev-erb-\u03b1 modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy","volume":"19","author":"Woldt","year":"2013","journal-title":"Nat. Med"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B53","doi-asserted-by":"crossref","first-page":"12833","DOI":"10.1523\/JNEUROSCI.0109-15.2015","article-title":"Mitochondrial quality control via the PGC1\u03b1-TFEB signaling pathway is compromised by Parkin Q311X mutation but independently restored by Rapamycin","volume":"35","author":"Siddiqui","year":"2015","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B54","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cmet.2016.11.003","article-title":"Transcription Factor EB Controls Metabolic Flexibility during Exercise","volume":"25","author":"Mansueto","year":"2017","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2016.23","article-title":"Mitonuclear communication in homeostasis and stress","volume":"17","author":"Quir\u00f3s","year":"2016","journal-title":"Nat. Rev. Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B56","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/brain\/awt343","article-title":"Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy","volume":"137","author":"Giordano","year":"2014","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B57","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/brain\/awq276","article-title":"Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy","volume":"134","author":"Giordano","year":"2011","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B58","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.bbamcr.2009.06.001","article-title":"Regulation of mitochondrial respiratory chain biogenesis by estrogens\/estrogen receptors and physiological, pathological and pharmacological implications","volume":"1793","author":"Chen","year":"2009","journal-title":"Biochim. Biophys Acta"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B59","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1167\/iovs.08-2913","article-title":"OPA1 deficiency associated with increased autophagy in retinal ganglion cells in a murine model of dominant optic atrophy","volume":"50","author":"White","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B60","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ana.24410","article-title":"Syndromic parkinsonism and dementia associated with OPA1 missense mutations","volume":"78","author":"Carelli","year":"2015","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1212\/WNL.0000000000003491","article-title":"Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations","volume":"88","author":"Liao","year":"2017","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B62","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.molcel.2013.01.036","article-title":"The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO","volume":"49","author":"M\u00fcller-Rischart","year":"2013","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B63","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1212\/WNL.0000000000002688","article-title":"The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy","volume":"86","author":"Dombi","year":"2016","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B64","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1093\/brain\/awq218","article-title":"Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy","volume":"133","author":"Williams","year":"2010","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B65","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/brain\/awr330","article-title":"Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity","volume":"135","author":"Williams","year":"2012","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nbd.2015.12.008","article-title":"Miro sculpts mitochondrial dynamics in neuronal health and disease","volume":"90","author":"Devine","year":"2016","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B67","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.celrep.2016.09.004","article-title":"Loss of dendritic complexity precedes neurodegeneration in a mouse model with disrupted mitochondrial distribution in mature dendrites","volume":"17","author":"L\u00f3pez-Dom\u00e9nech","year":"2016","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B68","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.brainres.2016.12.019","article-title":"Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model","volume":"1657","author":"Song","year":"2017","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B69","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1242\/jcs.053850","article-title":"The axonal transport of mitochondria","volume":"125","author":"Saxton","year":"2012","journal-title":"J. Cell Sci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B70","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.semcdb.2010.01.003","article-title":"Organellar vs cellular control of mitochondrial dynamics","volume":"21","author":"Hyde","year":"2010","journal-title":"Semin. Cell Dev. Biol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B71","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.4161\/auto.26503","article-title":"MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age","volume":"9","author":"Ferree","year":"2013","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B72","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.neuron.2016.10.060","article-title":"The mammalian-specific protein Armcx1 regulates mitochondrial transport during axon regeneration","volume":"92","author":"Cartoni","year":"2016","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B73","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.celrep.2016.03.047","article-title":"The actin-binding protein \u03b1-Adducin is required for maintaining axon diameter","volume":"15","author":"Leite","year":"2016","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B74","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/brain\/awh310","article-title":"Neuropathology of white matter disease in Leber\u2019s hereditary optic neuropathy","volume":"128","author":"Kovacs","year":"2005","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B75","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1755-3768.1983.tb01424.x","article-title":"Histopathology of eye, optic nerve and brain in a case of dominant optic atrophy","volume":"61","author":"Kjer","year":"1983","journal-title":"Acta Ophthalmol. (Copenh)"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B76","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/0002-9394(79)90565-8","article-title":"A clinicopathologic study of autosomal dominant optic atrophy","volume":"88","author":"Johnston","year":"1979","journal-title":"Am. J. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B77","doi-asserted-by":"crossref","first-page":"20065","DOI":"10.1073\/pnas.1217113109","article-title":"Mouse mtDNA mutant model of Leber hereditary optic neuropathy","volume":"109","author":"Lin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B78","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/brain\/aws303","article-title":"The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse","volume":"135","author":"Sarzi","year":"2012","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B79","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3174\/ajnr.A4272","article-title":"Diffusion tensor imaging mapping of brain white matter pathology in mitochondrial optic neuropathies","volume":"36","author":"Manners","year":"2015","journal-title":"Am. J. Neuroradiol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B80","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/brain\/115.4.979","article-title":"Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation","volume":"115","author":"Harding","year":"1992","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B81","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/acn3.323","article-title":"A multiple sclerosis-like disorder in patients with OPA1 mutations","volume":"3","author":"Yu-Wai-Man","year":"2016","journal-title":"Ann. Clin. Transl. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B82","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1212\/01.wnl.0000307668.75233.35","article-title":"Myelin, mitochondria, and autoimmunity: what's the connection?","volume":"70","author":"Carelli","year":"2008","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B83","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.nbd.2013.06.010","article-title":"Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier","volume":"58","author":"Marella","year":"2013","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B84","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s10545-012-9492-z","article-title":"Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects: what we learned from 130 cases","volume":"35","author":"Koene","year":"2012","journal-title":"J. Inherit. Metab. Dis"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B85","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1523\/JNEUROSCI.3430-11.2012","article-title":"The energetics of CNS white matter","volume":"32","author":"Harris","year":"2012","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B86","first-page":"748","article-title":"Fine structure of experimental cyanide optic neuropathy","volume":"13","author":"Lessell","year":"1974","journal-title":"Invest. Ophthalmol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B87","first-page":"597","article-title":"Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity","volume":"39","author":"Ludwin","year":"1978","journal-title":"Lab. Invest"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B88","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2990.1982.tb00305.x","article-title":"Ethidium bromide induced demyelination in the spinal cord of the cat","volume":"8","author":"Blakemore","year":"1982","journal-title":"Neuropathol. Appl. Neurobiol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B89","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11314","article-title":"Oligodendroglia metabolically support axons and contribute to neurodegeneration","volume":"487","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B90","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature11007","article-title":"Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity","volume":"485","author":"F\u00fcnfschilling","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B91","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/glia.22965","article-title":"Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths","volume":"64","author":"Rinholm","year":"2016","journal-title":"Glia"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B92","doi-asserted-by":"crossref","first-page":"e24241.","DOI":"10.7554\/eLife.24241","article-title":"Monitoring ATP dynamics in electrically active white matter tracts","volume":"6","author":"Trevisiol","year":"2017","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B93","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12013-011-9174-8","article-title":"Hypothesis of an energetic function for myelin","volume":"61","author":"Morelli","year":"2011","journal-title":"Cell Biochem. Biophys"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B94","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/jcbfm.2012.148","article-title":"Is myelin a mitochondrion?","volume":"33","author":"Harris","year":"2013","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B95","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s004010050873","article-title":"Focal accumulation of intra-axonal mitochondria in demyelination of the cat optic nerve","volume":"96","author":"Mutsaers","year":"1998","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B96","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/brain\/awp046","article-title":"Mitochondrial changes within axons in multiple sclerosis","volume":"132","author":"Mahad","year":"2009","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B97","doi-asserted-by":"crossref","first-page":"e1252304.","DOI":"10.1126\/science.1252304","article-title":"Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain","volume":"344","author":"Gibson","year":"2014","journal-title":"Science"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B98","first-page":"223","article-title":"Leber's hereditary optic neuropathy differentially affects smaller axons in the optic nerve","volume":"98","author":"Sadun","year":"2000","journal-title":"Trans. Am. Ophthalmol. Soc"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B99","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1523\/JNEUROSCI.4254-11.2012","article-title":"Why do axons differ in caliber?","volume":"32","author":"Perge","year":"2012","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B100","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1167\/iovs.12-10452","article-title":"Mathematically modeling the involvement of axons in Leber's hereditary optic neuropathy","volume":"53","author":"Pan","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B101","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrn.2016.159","article-title":"Functional diversity of astrocytes in neural circuit regulation","volume":"18","author":"Ben Haim","year":"2017","journal-title":"Nat. Rev. Neurosci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B102","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00401-015-1513-1","article-title":"Astrocytes: a central element in neurological diseases","volume":"131","author":"Pekny","year":"2016","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B103","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1073\/pnas.1404651111","article-title":"Transcellular degradation of axonal mitochondria","volume":"111","author":"Davis","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B104","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B105","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B106","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.1067262","article-title":"Phototransduction by retinal ganglion cells that set the circadian clock","volume":"295","author":"Berson","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B107","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1523\/JNEUROSCI.20-02-00600.2000","article-title":"A novel human opsin in the inner retina","volume":"20","author":"Provencio","year":"2000","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B108","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1002\/cne.24181","article-title":"Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity","volume":"525","author":"Hannibal","year":"2017","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B109","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1152\/jn.01066.2007","article-title":"Melanopsin ganglion cells use a membrane-associated rhabdomeric phototransduction cascade","volume":"99","author":"Graham","year":"2008","journal-title":"J. Neurophysiol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B110","doi-asserted-by":"crossref","first-page":"16094","DOI":"10.1523\/JNEUROSCI.4132-11.2011","article-title":"Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function","volume":"31","author":"Schmidt","year":"2011","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B111","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1002\/cne.23555","article-title":"Central projections of intrinsically photosensitive retinal ganglion cells in the macaque monkey","volume":"522","author":"Hannibal","year":"2014","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B112","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/cne.20970","article-title":"Central projections of melanopsin-expressing retinal ganglion cells in the mouse","volume":"497","author":"Hattar","year":"2006","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B113","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2017.04.046","article-title":"Melanopsin contributions to the representation of images in the early visual system","author":"Allen","year":"2017","journal-title":"Curr. Biol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B114","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1093\/brain\/awq155","article-title":"Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies","volume":"133","author":"La Morgia","year":"2010","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B115","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1167\/iovs.12-11137","article-title":"The pupil light reflex in Leber's hereditary optic neuropathy: evidence for preservation of melanopsin-expressing retinal ganglion cells","volume":"54","author":"Moura","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B116","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2017.04.003","article-title":"Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always","author":"Georg","year":"2017","journal-title":"Mitochondrion"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B117","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ana.24548","article-title":"Melanopsin retinal ganglion cell loss in Alzheimer disease","volume":"79","author":"La Morgia","year":"2016","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B118","author":"Yu-Wai-Man","year":"2017"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B119","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/brain\/awn269","article-title":"Visual system involvement in patients with Friedreich's ataxia","volume":"132","author":"Fortuna","year":"2009","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B120","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ajhg.2015.09.012","article-title":"Recessive mutations in RTN4IP1 cause isolated and syndromic optic neuropathies","volume":"97","author":"Angebault","year":"2015","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B121","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/brain\/awu069","article-title":"Narcolepsy is a common phenotype in HSAN IE and ADCA-DN","volume":"137","author":"Moghadam","year":"2014","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B122","doi-asserted-by":"crossref","first-page":"90.","DOI":"10.3389\/fgene.2015.00090","article-title":"DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?","volume":"6","author":"Maresca","year":"2015","journal-title":"Front. Genet"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B123","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM198608213150804","article-title":"Optic-nerve degeneration in Alzheimer's disease","volume":"315","author":"Hinton","year":"1986","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B124","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0161-6420(90)32621-0","article-title":"Optic nerve damage in Alzheimer's disease","volume":"97","author":"Sadun","year":"1990","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B125","doi-asserted-by":"crossref","first-page":"e0134750.","DOI":"10.1371\/journal.pone.0134750","article-title":"Optical coherence tomography in Alzheimer's disease: a meta-analysis","volume":"10","author":"Coppola","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B126","doi-asserted-by":"crossref","first-page":"162.","DOI":"10.3389\/fneur.2017.00162","article-title":"Retinal ganglion cells and circadian rhythms in Alzheimer's disease, Parkinson's disease, and beyond","volume":"8","author":"La Morgia","year":"2017","journal-title":"Front. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B127","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0161-6420(88)33176-3","article-title":"Chronic human glaucoma causing selectively greater loss of large optic nerve fibers","volume":"95","author":"Quigley","year":"1988","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B128","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/mds.26360","article-title":"Progressive retinal structure abnormalities in multiple system atrophy","volume":"30","author":"Mendoza-Santiesteban","year":"2015","journal-title":"Mov. Disord"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B129","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.ophtha.2015.02.030","article-title":"Intrinsically photosensitive retinal ganglion cell activity is associated with decreased sleep quality in patients with glaucoma","volume":"122","author":"Gracitelli","year":"2015","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B130","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1167\/iovs.16-19997","article-title":"Loss of melanopsin-expressing retinal ganglion cells in severely staged glaucoma patients","volume":"57","author":"Obara","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B131","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1468-1331.2012.03701.x","article-title":"Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern?","volume":"20","author":"La Morgia","year":"2013","journal-title":"Eur. J. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B132","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s00415-015-7869-2","article-title":"Optical coherence tomography findings in Huntington's disease: a potential biomarker of disease progression","volume":"262","author":"Kersten","year":"2015","journal-title":"J. Neurol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B133","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B134","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nbd.2015.09.008","article-title":"Mitochondrial dynamics and quality control in Huntington's disease","volume":"90","author":"Guedes-Dias","year":"2016","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B135","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00401-016-1613-6","article-title":"Ocular indicators of Alzheimer's: exploring disease in the retina","volume":"132","author":"Hart","year":"2016","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B136","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/brain\/awx088","article-title":"Real-time imaging of single neuronal cell apoptosis in patients with glaucoma","volume":"140","author":"Cordeiro","year":"2017","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B137","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd.2016.245","article-title":"Induced pluripotent stem cell technology: a decade of progress","volume":"16","author":"Shi","year":"2017","journal-title":"Nat. Rev. Drug Discov"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B138","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molmed.2017.02.007","article-title":"Disease modeling in stem cell-derived 3D organoid systems","volume":"23","author":"Dutta","year":"2017","journal-title":"Trends Mol. Med"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B139","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf9414","article-title":"Human tissues in a dish: The research and ethical implications of organoid technology","volume":"355","author":"Bredenoord","year":"2017","journal-title":"Science"},{"key":"key\n\t\t\t\t20180314003308_ddx273-B140","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.aal5060","article-title":"Regenerating optic pathways from the eye to the brain","volume":"356","author":"Laha","year":"2017","journal-title":"Science"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/26\/R2\/R139\/24338881\/ddx273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T10:14:32Z","timestamp":1602584072000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/26\/R2\/R139\/4036433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,26]]},"references-count":140,"journal-issue":{"issue":"R2","published-online":{"date-parts":[[2017,7,26]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddx273","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10,1]]},"published":{"date-parts":[[2017,7,26]]}}}