{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:06:14Z","timestamp":1772046374649,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100007393","name":"AFM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,15]]},"DOI":"10.1093\/hmg\/ddy012","type":"journal-article","created":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T12:09:51Z","timestamp":1515240591000},"page":"954-968","source":"Crossref","is-referenced-by-count":16,"title":["Intravenous administration of scAAV9-Hexb normalizes lifespan and prevents pathology in Sandhoff disease mice"],"prefix":"10.1093","volume":"27","author":[{"given":"Natalia","family":"Niemir","sequence":"first","affiliation":[{"name":"INSERM U1151, Institut Necker Enfants Malades, Paris 75014, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rouvi\u00e8re","sequence":"additional","affiliation":[{"name":"INSERM U1151, Institut Necker Enfants Malades, Paris 75014, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurore","family":"Besse","sequence":"additional","affiliation":[{"name":"Centre of Research in Myology, Institut de Myologie, Sorbonne Universit\u00e9s, UPMC University Paris 06, Inserm UMRS974, GH Piti\u00e9 Salp\u00eatri\u00e8re, Paris 75013, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie T","family":"Vanier","sequence":"additional","affiliation":[{"name":"INSERM U820, Universit\u00e9 de Lyon, Facult\u00e9 de M\u00e9decine Lyon-Est, Lyon 69372, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Dmytrus","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London SE5 9RX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibaut","family":"Marais","sequence":"additional","affiliation":[{"name":"Centre of Research in Myology, Institut de Myologie, Sorbonne Universit\u00e9s, UPMC University Paris 06, Inserm UMRS974, GH Piti\u00e9 Salp\u00eatri\u00e8re, Paris 75013, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Astord","sequence":"additional","affiliation":[{"name":"Centre of Research in Myology, Institut de Myologie, Sorbonne Universit\u00e9s, UPMC University Paris 06, Inserm UMRS974, GH Piti\u00e9 Salp\u00eatri\u00e8re, Paris 75013, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Puech","sequence":"additional","affiliation":[{"name":"Service de Biochimie, M\u00e9tabolomique et Prot\u00e9omique, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris 75015, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganna","family":"Panasyuk","sequence":"additional","affiliation":[{"name":"INSERM U1151, Institut Necker Enfants Malades, Paris 75014, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London SE5 9RX, UK"},{"name":"Department of Pediatrics, Los Angeles Biomedical Research Institute, David Geffen School of Medicine, UCLA, Torrance, CA 90502, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Barkats","sequence":"additional","affiliation":[{"name":"Centre of Research in Myology, Institut de Myologie, Sorbonne Universit\u00e9s, UPMC University Paris 06, Inserm UMRS974, GH Piti\u00e9 Salp\u00eatri\u00e8re, Paris 75013, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Caillaud","sequence":"additional","affiliation":[{"name":"INSERM U1151, Institut Necker Enfants Malades, Paris 75014, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Service de Biochimie, M\u00e9tabolomique et Prot\u00e9omique, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris 75015, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"key\n\t\t\t\t20180305025512_ddy012-B1","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1111\/j.1471-4159.1971.tb00204.x","article-title":"Enzyme alterations and lipid storage in three variants of Tay-Sachs disease","volume":"18","author":"Sandhoff","year":"1971","journal-title":"J. Neurochem"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B2","first-page":"3827","volume-title":"Metabolic and Molecular Bases of Inherited Disease","author":"Gravel","year":"2001"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B3","doi-asserted-by":"crossref","first-page":"10927","DOI":"10.1016\/S0021-9258(18)60406-5","article-title":"Natural history and inherited disorders of a lysosomal enzyme, beta-hexosaminidase","volume":"264","author":"Neufeld","year":"1989","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng1095-170","article-title":"Mouse models of Tay\u2013Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism","volume":"11","author":"Sango","year":"1995","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/5.1.1","article-title":"Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases","volume":"5","author":"Phaneuf","year":"1996","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B6","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/hmg\/6.11.1879","article-title":"Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases","volume":"6","author":"Huang","year":"1997","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B7","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1073\/pnas.97.20.10954","article-title":"Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation","volume":"97","author":"Wada","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B8","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/brain\/awg089","article-title":"Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis","volume":"126","author":"Jeyakumar","year":"2003","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B9","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/mt.2011.27","article-title":"Therapeutic potential of intracerebroventricular replacement of modified human \u03b2-hexosaminidase B for GM2 gangliosidosis","volume":"19","author":"Matsuoka","year":"2011","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B10","doi-asserted-by":"crossref","first-page":"9150","DOI":"10.1074\/jbc.M609304200","article-title":"Pyrimethamine as a potential pharmacological chaperone for late-onset forms of gm2 gangliosidosis","volume":"282","author":"Maegawa","year":"2007","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B11","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/ana.20242","article-title":"NSAIDs increase survival in the Sandhoff disease mouse: Synergy with N-butyldeoxynojirimycin","volume":"56","author":"Jeyakumar","year":"2004","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B12","doi-asserted-by":"crossref","first-page":"10373","DOI":"10.1073\/pnas.0603765103","article-title":"Effective gene therapy in an authentic model of Tay-Sachs-related diseases","volume":"103","author":"Cach\u00f3n-Gonz\u00e1lez","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B13","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/mt.2012.44","article-title":"Gene transfer corrects acute GM2 gangliosidosis\u2014potential therapeutic contribution of perivascular enzyme flow","volume":"20","author":"Cach\u00f3n-Gonz\u00e1lez","year":"2012","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B14","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/mt.2009.71","article-title":"Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons","volume":"17","author":"Duque","year":"2009","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nbt.1515","article-title":"Intravascular AAV9 preferentially targets neonatal-neurons and adult-astrocytes in CNS","volume":"27","author":"Foust","year":"2009","journal-title":"Nat. Biotechnol"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1126\/scitranslmed.3000830","article-title":"Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy","volume":"2","author":"Valori","year":"2010","journal-title":"Sci. Transl. Med"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nbt.1610","article-title":"Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN","volume":"28","author":"Foust","year":"2010","journal-title":"Nat. Biotechnol"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/hmg\/ddq514","article-title":"Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice","volume":"20","author":"Dominguez","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B19","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/mt.2011.34","article-title":"Correction of neurological disease of mucopolysaccharidosis IIIB in adult mice by rAAV9 trans-blood-brain barrier gene delivery","volume":"19","author":"Fu","year":"2011","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B20","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1172\/JCI66778","article-title":"Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy","volume":"123","author":"Haurigot","year":"2013","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B21","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1089\/hum.2012.029","article-title":"Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer","volume":"23","author":"Ruzo","year":"2012","journal-title":"Hum. Gene Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B22","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1093\/hmg\/ddv168","article-title":"Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan","volume":"24","author":"Weismann","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ymthe.2006.03.014","article-title":"Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8","volume":"14","author":"Inagaki","year":"2006","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/mt.2014.240","article-title":"Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates","volume":"23","author":"Walia","year":"2015","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/hum.2016.015","article-title":"Systemic gene transfer of a hexosaminidase variant using an scAAV9.47 vector corrects GM2 gangliosidosis in Sandhoff mice","volume":"27","author":"Osmon","year":"2016","journal-title":"Hum. Gene Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B26","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1172\/JCI119322","article-title":"Murine mucopolysaccharidosis type VII: long term therapeutic effects of enzyme replacement and enzyme replacement followed by bone marrow transplantation","volume":"99","author":"Sands","year":"1997","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B27","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0437941100","article-title":"Transgene produces massive overexpression of human \u03b2-glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors","volume":"100","author":"Vogler","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B28","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/hmg\/ddu727","article-title":"Biochemical, histological and functional correction of mucopolysaccharidosis Type IIIB by intra-cerebrospinal fluid gene therapy","volume":"24","author":"Ribera","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B29","first-page":"e86696.","article-title":"CNS-directed gene therapy for the treatment of neurologic and somatic mucopolysaccharidosis type II (Hunter syndrome)","volume":"9","author":"Motas","year":"2016","journal-title":"JCI Insight"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B30","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ymthe.2006.01.006","article-title":"Gene therapy for lysosomal storage diseases","volume":"13","author":"Sands","year":"2006","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B31","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.neuro.2007.01.014","article-title":"Extrapolating brain development from experimental species to humans","volume":"28","author":"Clancy","year":"2007","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B32","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1523\/JNEUROSCI.5746-12.2013","article-title":"Modeling transformations of neurodevelopmental sequences across mammalian species","volume":"33","author":"Workman","year":"2013","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fnmol.2015.00036","article-title":"Systemic AAVrh10 provides higher transgene expression than AAV9 in the brain and the spinal cord of neonatal mice","volume":"8","author":"Tanguy","year":"2015","journal-title":"Front. Mol. Neurosci"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B34","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/mt.2011.72","article-title":"Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates","volume":"19","author":"Gray","year":"2011","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B35","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/mt.2011.95","article-title":"AAV9: over the fence and into the woods","volume":"19","author":"Forsayeth","year":"2011","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B36","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/mt.2016.17","article-title":"Genotoxicity in mice following AAV gene delivery: a safety concern for human gene therapy?","volume":"24","author":"Chandler","year":"2016","journal-title":"Mol. Ther"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B37","first-page":"900","article-title":"Ganglioside GM2 N-acetyl-beta-D-galactosaminidase activity in cultured fibroblasts of late-infantile and adult GM2 gangliosidosis patients and of healthy probands with low hexosaminidase level","volume":"35","author":"Conzelmann","year":"1983","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B38","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/clinchem\/43.8.1325","article-title":"Diagnosis of lysosomal storage disorders: evaluation of lysosome-associated membrane protein LAMP-1 as a diagnostic marker","volume":"43","author":"Meikle","year":"1997","journal-title":"Clin. Chem"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B39","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.nbd.2004.02.010","article-title":"Regional and cellular neuropathology in the palmitoyl protein thioesterase-1 null mutant mouse model of infantile neuronal ceroid lipofuscinosis","volume":"16","author":"Bible","year":"2004","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.brainres.2004.07.030","article-title":"Late onset neurodegeneration in the Cln3-\/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation","volume":"1023","author":"Pontikis","year":"2004","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B41","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.nbd.2005.05.018","article-title":"Thalamocortical neuron loss and localized astrocytosis in the Cln3Deltaex7\/8 knock-in mouse model of Batten disease","volume":"20","author":"Pontikis","year":"2005","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B42","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B43","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ar.1092310411","article-title":"Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator","volume":"231","author":"West","year":"1991","journal-title":"Anat. Rec"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B44","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nbd.2006.09.001","article-title":"Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis","volume":"25","author":"Kielar","year":"2007","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B45","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1097\/NEN.0b013e3181ffe742","article-title":"Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7\/Ostm1","volume":"69","author":"Pressey","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B46","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2818.1999.00457.x","article-title":"The efficiency of systematic sampling in stereology\u2013reconsidered","volume":"193","author":"Gundersen","year":"1999","journal-title":"J. Microsc"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B47","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/hmg\/5.6.711","article-title":"Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids","volume":"5","author":"Fujita","year":"1996","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jneumeth.2007.09.002","article-title":"Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation","volume":"168","author":"Reid","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"key\n\t\t\t\t20180305025512_ddy012-B49","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF02533991","article-title":"Two procedures to remove polar contaminants from a crude brain lipid extract by using prepacked reversed-phase columns","volume":"22","author":"Kyrklund","year":"1987","journal-title":"Lipids"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/27\/6\/954\/24231743\/ddy012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T22:35:22Z","timestamp":1660257322000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/27\/6\/954\/4793002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,8]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,1,8]]},"published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy012","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3,15]]},"published":{"date-parts":[[2018,1,8]]}}}