{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:49:53Z","timestamp":1780109393669,"version":"3.54.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HD089932"],"award-info":[{"award-number":["R01HD089932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01GM098605"],"award-info":[{"award-number":["R01GM098605"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"DOI":"10.1093\/hmg\/ddy022","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T12:10:25Z","timestamp":1516104625000},"page":"1136-1149","source":"Crossref","is-referenced-by-count":30,"title":["CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice"],"prefix":"10.1093","volume":"27","author":[{"given":"Hironori","family":"Abe","sequence":"first","affiliation":[{"name":"Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris G","family":"Alavattam","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego H","family":"Castrillon","sequence":"additional","affiliation":[{"name":"Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishen","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA"},{"name":"Division of Experimental Hematology & Cancer Biology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA"},{"name":"Division of Experimental Hematology & Cancer Biology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi H","family":"Namekawa","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"key\n\t\t\t\t20181012112647422_ddy022-B1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/em.2850250609","article-title":"Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human","volume":"25","author":"Drost","year":"1995","journal-title":"Environ. Mol. Mutagen"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1073\/pnas.0912629107","article-title":"Rate, molecular spectrum, and consequences of human mutation","volume":"107","author":"Lynch","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.rbmo.2015.06.010","article-title":"Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility","volume":"31","author":"Gunes","year":"2015","journal-title":"Reprod. Biomed. Online"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1101\/gad.2021311","article-title":"Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications","volume":"25","author":"Polo","year":"2011","journal-title":"Genes. Dev"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.semcdb.2016.02.019","article-title":"Mechanisms of germ line genome instability","volume":"54","author":"Kim","year":"2016","journal-title":"Semin. Cell. Dev. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B7","doi-asserted-by":"crossref","first-page":"a016618","DOI":"10.1101\/cshperspect.a016618","article-title":"Meiotic recombination: the essence of heredity","volume":"7","author":"Hunter","year":"2015","journal-title":"Cold. Spring. Harb. Perspect. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-genet-120215-035111","article-title":"Control of meiotic crossovers: from double-strand break formation to designation","volume":"50","author":"Gray","year":"2016","journal-title":"Annu. Rev. Genet"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B9","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.1128\/MCB.25.16.7203-7215.2005","article-title":"Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage","volume":"25","author":"Barchi","year":"2005","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B10","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1242\/jcs.02466","article-title":"SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-\/- spermatocytes","volume":"118","author":"Bellani","year":"2005","journal-title":"J. Cell. Sci"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B11","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1101\/gad.219477.113","article-title":"ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing","volume":"27","author":"Royo","year":"2013","journal-title":"Genes. Dev"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B12","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1242\/dev.000018","article-title":"Meiotic sex chromosome inactivation","volume":"134","author":"Turner","year":"2007","journal-title":"Development"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B13","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s00018-012-0941-5","article-title":"Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways","volume":"69","author":"Ichijima","year":"2012","journal-title":"Cell. Mol. Life. Sci"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4161\/epi.5.4.11518","article-title":"DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis","volume":"5","author":"Inagaki","year":"2010","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1534-5807(03)00093-5","article-title":"H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis","volume":"4","author":"Fernandez-Capetillo","year":"2003","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B16","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1101\/gad.2030811","article-title":"MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells","volume":"25","author":"Ichijima","year":"2011","journal-title":"Genes. Dev"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B17","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.277.5331.1497","article-title":"Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25","volume":"277","author":"Sanchez","year":"1997","journal-title":"Science (New York, N.Y.)"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B18","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1101\/gad.14.12.1448","article-title":"Chk1 is an essential kinase that is regulated by Atr and required for the G(2)\/M DNA damage checkpoint","volume":"14","author":"Liu","year":"2000","journal-title":"Genes. Dev"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B19","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1101\/gad.14.12.1439","article-title":"Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-\/-) mice","volume":"14","author":"Takai","year":"2000","journal-title":"Genes. Dev"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccr.2004.06.015","article-title":"Chk1 is haploinsufficient for multiple functions critical to tumor suppression","volume":"6","author":"Lam","year":"2004","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B21","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.4161\/cc.20279","article-title":"Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes","volume":"11","author":"Chen","year":"2012","journal-title":"Cell Cycle (Georgetown, Tex.)"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1247671","article-title":"Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway","volume":"343","author":"Bolcun-Filas","year":"2014","journal-title":"Science (New York, N.Y"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B23","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.molcel.2017.07.027","article-title":"The DNA damage checkpoint eliminates mouse oocytes with chromosome synapsis failure","volume":"67","author":"Rinaldi","year":"2017","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B24","doi-asserted-by":"crossref","first-page":"e1005017","DOI":"10.1371\/journal.pgen.1005017","article-title":"The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes","volume":"11","author":"Pacheco","year":"2015","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.113.110502","article-title":"Toward a more precise and informative nomenclature describing fetal and neonatal male germ cells in rodents","volume":"89","author":"McCarrey","year":"2013","journal-title":"Biol. Reprod"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.113.110544","article-title":"Gonocytes, from the fifties to the present: is there a reason to change the name?","volume":"89","author":"Culty","year":"2013","journal-title":"Biol. Reprod"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0960-9822(06)00417-9","article-title":"Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes","volume":"7","author":"Flaggs","year":"1997","journal-title":"Curr. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B28","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1242\/dev.126078","article-title":"Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes","volume":"142","author":"Fedoriw","year":"2015","journal-title":"Development"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nprot.2010.195","article-title":"Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos","volume":"6","author":"Namekawa","year":"2011","journal-title":"Nat. Protoc"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B30","first-page":"e50819","article-title":"Slide preparation method to preserve three-dimensional chromatin architecture of testicular germ cells","volume":"83","author":"Namekawa","year":"2014","journal-title":"J. Vis. Exp"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cub.2005.11.066","article-title":"Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response","volume":"16","author":"Smits","year":"2006","journal-title":"Curr. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.molcel.2005.07.019","article-title":"Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway","volume":"19","author":"Zhang","year":"2005","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/dvg.20310","article-title":"Generation of a germ cell-specific mouse transgenic Cre line, Vasa-Cre","volume":"45","author":"Gallardo","year":"2007","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bdrc.20142","article-title":"Gonocytes, the forgotten cells of the germ cell lineage","volume":"87","author":"Culty","year":"2009","journal-title":"Birth. Defects. Res. C. Embryo. Today"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/nar\/gkr697","article-title":"Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication","volume":"40","author":"Sorensen","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B36","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.devcel.2015.01.014","article-title":"SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination","volume":"32","author":"Hasegawa","year":"2015","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05541","article-title":"Restoration of p53 function leads to tumour regression in vivo","volume":"445","author":"Ventura","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ydbio.2008.06.017","article-title":"Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth","volume":"321","author":"John","year":"2008","journal-title":"Dev. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B39","volume-title":"Histological and Histopathological Evaluation of the Testis","author":"Russell","year":"1990"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B40","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/aja.1000990307","article-title":"Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium","volume":"99","author":"Oakberg","year":"1956","journal-title":"Am. J. Anat"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B41","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.celrep.2016.09.073","article-title":"Elucidation of the Fanconi anemia protein network in meiosis and its function in the regulation of histone modifications","volume":"17","author":"Alavattam","year":"2016","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B42","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1111\/febs.13387","article-title":"DNA damage control: regulation and functions of checkpoint kinase 1","volume":"282","author":"Smits","year":"2015","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B43","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.cub.2004.11.032","article-title":"BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation","volume":"14","author":"Turner","year":"2004","journal-title":"Curr. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B44","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1083\/jcb.201311050","article-title":"BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis","volume":"205","author":"Broering","year":"2014","journal-title":"J. Cell. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B45","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ng837","article-title":"BRCA1 regulates the G2\/M checkpoint by activating Chk1 kinase upon DNA damage","volume":"30","author":"Yarden","year":"2002","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B46","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1101\/gad.291104","article-title":"Chk1 activation requires Rad9 S\/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1","volume":"18","author":"Furuya","year":"2004","journal-title":"Genes. Dev"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B47","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1128\/MCB.00492-06","article-title":"Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation","volume":"26","author":"Liu","year":"2006","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B48","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1101\/gad.202713.112","article-title":"RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids","volume":"26","author":"Sin","year":"2012","journal-title":"Genes. Dev"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B49","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1093\/hmg\/ddv244","article-title":"FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis","volume":"24","author":"Kato","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B50","doi-asserted-by":"crossref","first-page":"e1004954","DOI":"10.1371\/journal.pgen.1004954","article-title":"Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis","volume":"11","author":"Luo","year":"2015","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2007.12.013","article-title":"Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression","volume":"132","author":"Shimada","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B52","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.stem.2007.10.023","article-title":"Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest","volume":"2","author":"Takubo","year":"2008","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B53","doi-asserted-by":"crossref","first-page":"a012716","DOI":"10.1101\/cshperspect.a012716","article-title":"DNA damage sensing by the ATM and ATR kinases","volume":"5","author":"Marechal","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1083\/jcb.200710195","article-title":"Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation","volume":"182","author":"Mahadevaiah","year":"2008","journal-title":"J. Cell. Biol"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B55","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1126\/science.277.5331.1495","article-title":"Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase","volume":"277","author":"Furnari","year":"1997","journal-title":"Science (New York, N.Y.)"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B56","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1126\/science.2683079","article-title":"Checkpoints: controls that ensure the order of cell cycle events","volume":"246","author":"Hartwell","year":"1989","journal-title":"Science"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B57","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1023\/A:1018445520117","article-title":"A drying-down technique for the spreading of mammalian meiocytes from the male and female germline","volume":"5","author":"Peters","year":"1997","journal-title":"Chromosome Res"},{"key":"key\n\t\t\t\t20181012112647422_ddy022-B58","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/27\/7\/1136\/26033913\/ddy022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T17:10:11Z","timestamp":1660324211000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/27\/7\/1136\/4816202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,17]]},"references-count":58,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,1,17]]},"published-print":{"date-parts":[[2018,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy022","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4,1]]},"published":{"date-parts":[[2018,1,17]]}}}