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Roy. Stat. Soc. B Met"},{"key":"key\n\t\t\t\t20180803083007_ddy040-B65","author":"Tenenbaum","year":"2017"},{"key":"key\n\t\t\t\t20180803083007_ddy040-B66","doi-asserted-by":"crossref","first-page":"23978","DOI":"10.1038\/srep23978","article-title":"ExtraPEG: a polyethylene glycol-based method for enrichment of extracellular vesicles","volume":"6","author":"Rider","year":"2016","journal-title":"Sci. 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