{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:11:13Z","timestamp":1790745073225,"version":"4.1.0"},"reference-count":132,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS081303"],"award-info":[{"award-number":["NS081303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS094921, NS100055, NS101661 and NS098379"],"award-info":[{"award-number":["NS094921, NS100055, NS101661 and NS098379"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012312","name":"Robert Packard Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,15]]},"DOI":"10.1093\/hmg\/ddy047","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T20:10:41Z","timestamp":1517947841000},"page":"1366-1381","source":"Crossref","is-referenced-by-count":100,"title":["Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS\/FTD models"],"prefix":"10.1093","volume":"27","author":[{"given":"Eric N","family":"Anderson","sequence":"first","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Gochenaur","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Dietrich School of Arts and Science, University of Pittsburgh, Pittsburgh, PA 15260, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogan","family":"Grant","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishani","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Watkins","sequence":"additional","affiliation":[{"name":"Center for Biological Imaging, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA"},{"name":"Department of Cell Biology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Y","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udai Bhan","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA"},{"name":"Department of Neuroscience, Dietrich School of Arts and Science, University of Pittsburgh, Pittsburgh, PA 15260, USA"},{"name":"Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA"},{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"key\n\t\t\t\t20180403031348_ddy047-B1","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1097\/00001756-200107200-00009","article-title":"Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies","volume":"12","author":"Kuusisto","year":"2001","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00401-006-0192-3","article-title":"Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease","volume":"113","author":"Terni","year":"2007","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pneurobio.2011.11.005","article-title":"Emerging role of p62\/sequestosome-1 in the pathogenesis of Alzheimer's disease","volume":"96","author":"Salminen","year":"2012","journal-title":"Prog. Neurobiol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1365-2990.2002.00394.x","article-title":"Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation","volume":"28","author":"Kuusisto","year":"2002","journal-title":"Neuropathol. Appl. Neurobiol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","author":"Arai","year":"2006","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B7","doi-asserted-by":"crossref","first-page":"2527.e3","DOI":"10.1016\/j.neurobiolaging.2012.05.008","article-title":"UBQLN2\/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis","volume":"33","author":"Williams","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00401-012-1035-z","article-title":"Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism","volume":"124","author":"Keller","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00401-012-1050-0","article-title":"Mixed tau, TDP-43 and p62 pathology in FTLD associated with a C9ORF72 repeat expansion and p.Ala239Thr MAPT (tau) variant","volume":"125","author":"King","year":"2013","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B10","doi-asserted-by":"crossref","first-page":"18728.","DOI":"10.1038\/srep18728","article-title":"Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Abeta-peptide","volume":"6","author":"Meisl","year":"2016","journal-title":"Sci. Rep"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B11","doi-asserted-by":"crossref","first-page":"E6506","DOI":"10.1073\/pnas.1606791113","article-title":"Environmental and genetic factors support the dissociation between alpha-synuclein aggregation and toxicity","volume":"113","author":"Villar-Pique","year":"2016","journal-title":"Proc. Natl Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B12","first-page":"239","article-title":"Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease","volume":"20","author":"Gorell","year":"1999","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfr239","article-title":"The role of environmental exposures in neurodegeneration and neurodegenerative diseases","volume":"124","author":"Cannon","year":"2011","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neubiorev.2015.03.003","article-title":"Environmental factors as modulators of neurodegeneration: insights from gene-environment interactions in Huntington's disease","volume":"52","author":"Mo","year":"2015","journal-title":"Neurosci. Biobehav. Rev"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B15","doi-asserted-by":"crossref","first-page":"366.","DOI":"10.12688\/f1000research.7431.1","article-title":"Metals and neurodegeneration","volume":"5","author":"Chen","year":"2016","journal-title":"F1000Res"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B16","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1289\/ehp.0900580","article-title":"Workplace exposures and the risk of amyotrophic lateral sclerosis","volume":"117","author":"Fang","year":"2009","journal-title":"Environ. Health Perspect"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jns.2010.01.011","article-title":"Association of ALS with head injury, cigarette smoking and APOE genotypes","volume":"291","author":"Schmidt","year":"2010","journal-title":"J. Neurol. Sci"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parkreldis.2015.12.008","article-title":"Environmental risk factors and Parkinson's disease: an umbrella review of meta-analyses","volume":"23","author":"Bellou","year":"2016","journal-title":"Parkinsonism Relat. Disord"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1124\/jpet.110.174466","article-title":"Exposure to an environmental neurotoxicant hastens the onset of amyotrophic lateral sclerosis-like phenotype in human Cu2+\/Zn2+ superoxide dismutase 1 G93A mice: glutamate-mediated excitotoxicity","volume":"338","author":"Johnson","year":"2011","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.neuro.2009.07.010","article-title":"The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis","volume":"30","author":"Johnson","year":"2009","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B21","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1111\/j.1468-1331.2012.03723.x","article-title":"Trauma and amyotrophic lateral sclerosis: a case-control study from a population-based registry","volume":"19","author":"Pupillo","year":"2012","journal-title":"Eur. J. Neurol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B22","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1093\/ije\/20.Supplement_2.S28","article-title":"Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies","volume":"20","author":"Mortimer","year":"1991","journal-title":"Int. J. Epidemiol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B23","doi-asserted-by":"crossref","first-page":"e32768.","DOI":"10.1371\/journal.pone.0032768","article-title":"A high-density genome-wide association screen of sporadic ALS in US veterans","volume":"7","author":"Kwee","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ana.20882","article-title":"Head injury and Parkinson's disease risk in twins","volume":"60","author":"Goldman","year":"2006","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B25","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/aje\/kwm153","article-title":"Head injury and amyotrophic lateral sclerosis","volume":"166","author":"Chen","year":"2007","journal-title":"Am. J. Epidemiol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B26","doi-asserted-by":"crossref","first-page":"e00630.","DOI":"10.1002\/brb3.630","article-title":"Prevalence of potential sports-associated risk factors in Swiss amyotrophic lateral sclerosis patients","volume":"7","author":"Feddermann-Demont","year":"2017","journal-title":"Brain Behav"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B27","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1212\/WNL.61.6.750","article-title":"Excess incidence of ALS in young Gulf War veterans","volume":"61","author":"Haley","year":"2003","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.parkreldis.2005.11.007","article-title":"Amyotrophic lateral sclerosis in an Italian professional soccer player","volume":"12","author":"Vanacore","year":"2006","journal-title":"Parkinsonism Relat. Disord"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B29","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1212\/WNL.0b013e31826daf50","article-title":"Neurodegenerative causes of death among retired National Football League players","volume":"79","author":"Lehman","year":"2012","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/17482960802351029","article-title":"Clinical aspects of ALS in Gulf War veterans","volume":"10","author":"Kasarskis","year":"2009","journal-title":"Amyotroph. Lateral Scler"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000136648","article-title":"Amyotrophic lateral sclerosis among 1991 Gulf War veterans: evidence for a time-limited outbreak","volume":"31","author":"Horner","year":"2008","journal-title":"Neuroepidemiology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000083297","article-title":"Estimating the occurrence of amyotrophic lateral sclerosis among Gulf War (1990-1991) veterans using capture-recapture methods","volume":"24","author":"Coffman","year":"2005","journal-title":"Neuroepidemiology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B33","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1212\/01.WNL.0000069922.32557.CA","article-title":"Occurrence of amyotrophic lateral sclerosis among Gulf War veterans","volume":"61","author":"Horner","year":"2003","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B34","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/brain\/awh373","article-title":"Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players","volume":"128","author":"Chio","year":"2005","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B35","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/jnnp.2010.224501","article-title":"Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis","volume":"82","author":"Byrne","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B36","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Kiernan","year":"2011","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B37","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbadis.2006.01.004","article-title":"Genetics of familial and sporadic amyotrophic lateral sclerosis","volume":"1762","author":"Gros-Louis","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B38","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1086\/426001","article-title":"Complex genetics of amyotrophic lateral sclerosis. Am.","volume":"75","author":"Kunst","year":"2004","journal-title":"J. Hum. Genet"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/mus.10001","article-title":"Familial amyotrophic lateral sclerosis","volume":"25","author":"Hand","year":"2002","journal-title":"Muscle Nerve"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B40","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00401-011-0909-9","article-title":"Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans","volume":"122","author":"Johnson","year":"2011","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B41","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/NEN.0b013e3181ee7d85","article-title":"TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy","volume":"69","author":"McKee","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B42","first-page":"7","article-title":"Amyotrophic lateral sclerosis and environmental factors","volume":"31","author":"Bozzoni","year":"2016","journal-title":"Funct. Neurol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B43","first-page":"181","article-title":"Risk factors for amyotrophic lateral sclerosis","volume":"7","author":"Ingre","year":"2015","journal-title":"Clin. Epidemiol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B44","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B45","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/hmg\/ddp534","article-title":"Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo","volume":"19","author":"Kabashi","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B46","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6","volume":"323","author":"Vance","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B47","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/jmg.2009.071027","article-title":"Mutations of FUS gene in sporadic amyotrophic lateral sclerosis","volume":"47","author":"Corrado","year":"2010","journal-title":"J. Med. Genet"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B48","doi-asserted-by":"crossref","first-page":"R46","DOI":"10.1093\/hmg\/ddq137","article-title":"TDP-43 and FUS\/TLS: emerging roles in RNA processing and neurodegeneration","volume":"19","author":"Lagier-Tourenne","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nn.3584","article-title":"State of play in amyotrophic lateral sclerosis genetics","volume":"17","author":"Renton","year":"2014","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B51","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B52","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1242\/jcs.038950","article-title":"Structural determinants of the cellular localization and shuttling of TDP-43","volume":"121","author":"Ayala","year":"2008","journal-title":"J. Cell Sci"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B53","doi-asserted-by":"crossref","first-page":"36337","DOI":"10.1074\/jbc.M104236200","article-title":"Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9","volume":"276","author":"Buratti","year":"2001","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B54","doi-asserted-by":"crossref","first-page":"28852","DOI":"10.1074\/jbc.M805376200","article-title":"TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing","volume":"283","author":"Bose","year":"2008","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neulet.2004.12.071","article-title":"Delocalization of the multifunctional RNA splicing factor TLS\/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads","volume":"379","author":"Belly","year":"2005","journal-title":"Neurosci. Lett"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainres.2012.02.059","article-title":"Misregulated RNA processing in amyotrophic lateral sclerosis","volume":"1462","author":"Polymenidou","year":"2012","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B57","doi-asserted-by":"crossref","first-page":"E736","DOI":"10.1073\/pnas.1222809110","article-title":"ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43","volume":"110","author":"Arnold","year":"2013","journal-title":"Proc. Natl Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B58","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1172\/JCI72723","article-title":"ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects","volume":"124","author":"Qiu","year":"2014","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B59","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1159\/000354170","article-title":"Role of stress granules and RNA-binding proteins in neurodegeneration: a mini-review","volume":"59","author":"Vanderweyde","year":"2013","journal-title":"Gerontology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B60","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1016\/j.neurobiolaging.2014.08.019","article-title":"Autophagy meets fused in sarcoma-positive stress granules","volume":"35","author":"Matus","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2007.12.003","article-title":"Stress granules: the Tao of RNA triage","volume":"33","author":"Anderson","year":"2008","journal-title":"Trends Biochem. Sci"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B62","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-cellbio-100913-013325","article-title":"Liquid-liquid phase separation in biology","volume":"30","author":"Hyman","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B64","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1091\/mbc.E04-08-0715","article-title":"Stress granule assembly is mediated by prion-like aggregation of TIA-1","volume":"15","author":"Gilks","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B65","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1002\/jcp.24395","article-title":"FUS\/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress","volume":"228","author":"Sama","year":"2013","journal-title":"J. Cell. Physiol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B66","doi-asserted-by":"crossref","first-page":"30.","DOI":"10.1186\/1750-1326-8-30","article-title":"Amyotrophic lateral sclerosis-linked FUS\/TLS alters stress granule assembly and dynamics","volume":"8","author":"Baron","year":"2013","journal-title":"Mol. Neurodegener"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B67","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1093\/hmg\/ddq335","article-title":"Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules","volume":"19","author":"Bosco","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B68","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2012.02.032","article-title":"TDP-43 aggregation in neurodegeneration: are stress granules the key?","volume":"1462","author":"Dewey","year":"2012","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B69","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1083\/jcb.201302044","article-title":"Stress granules as crucibles of ALS pathogenesis","volume":"201","author":"Li","year":"2013","journal-title":"J. Cell. Biol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B70","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2014.05.052","article-title":"Pathological stress granules in Alzheimer's disease","volume":"1584","author":"Ash","year":"2014","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B71","first-page":"47","article-title":"Physiological protein aggregation run amuck: stress granules and the genesis of neurodegenerative disease","volume":"17","author":"Wolozin","year":"2014","journal-title":"Discov. Med"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B72","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1093\/hmg\/dds526","article-title":"RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations","volume":"22","author":"Daigle","year":"2013","journal-title":"Hum Mol Genet."},{"key":"key\n\t\t\t\t20180403031348_ddy047-B73","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1093\/hmg\/ddr150","article-title":"A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43","volume":"20","author":"Lanson","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B74","doi-asserted-by":"crossref","first-page":"e61576.","DOI":"10.1371\/journal.pone.0061576","article-title":"Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo","volume":"8","author":"Scaramuzzino","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B75","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2012.01.039","article-title":"FUS-related proteinopathies: lessons from animal models","volume":"1462","author":"Lanson","year":"2012","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20180403031348_ddy047-B76","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1073\/pnas.1219643110","article-title":"Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration","volume":"110","author":"Xu","year":"2013","journal-title":"Proc. Natl Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B77","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s13238-011-1065-7","article-title":"Expression of human FUS protein in Drosophila leads to progressive neurodegeneration","volume":"2","author":"Chen","year":"2011","journal-title":"Protein Cell"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B78","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2013.07.038","article-title":"Altered ribostasis: rNA-protein granules in degenerative disorders","volume":"154","author":"Ramaswami","year":"2013","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B79","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tcb.2016.05.004","article-title":"Principles and properties of stress granules","volume":"26","author":"Protter","year":"2016","journal-title":"Trends Cell Biol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B80","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1212\/WNL.0b013e3182343365","article-title":"Conjoint pathologic cascades mediated by ALS\/FTLD-U linked RNA-binding proteins TDP-43 and FUS","volume":"77","author":"Ito","year":"2011","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B81","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s004010050923","article-title":"RNA sequestration to pathological lesions of neurodegenerative diseases","volume":"96","author":"Ginsberg","year":"1998","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B82","first-page":"e52905 (","article-title":"A method to inflict closed head traumatic brain injury in Drosophila","author":"Katzenberger","year":"2015","journal-title":"J. Vis. Exp"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B83","doi-asserted-by":"crossref","first-page":"E4152","DOI":"10.1073\/pnas.1316895110","article-title":"A Drosophila model of closed head traumatic brain injury","volume":"110","author":"Katzenberger","year":"2013","journal-title":"Proc. Natl Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B84","doi-asserted-by":"crossref","first-page":"e12068","DOI":"10.7554\/eLife.12068","article-title":"A genome-wide resource for the analysis of protein localisation in Drosophila","volume":"5","author":"Sarov","year":"2016","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B85","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1242\/dev.127.8.1715","article-title":"Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling","volume":"127","author":"Pazman","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B86","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/gtc.12023","article-title":"Both G3BP1 and G3BP2 contribute to stress granule formation","volume":"18","author":"Matsuki","year":"2013","journal-title":"Genes Cells"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B87","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1091\/mbc.E06-12-1079","article-title":"Inhibition of the ubiquitin-proteasome system induces stress granule formation","volume":"18","author":"Mazroui","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B88","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1101\/gad.461107","article-title":"The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response","volume":"21","author":"Kwon","year":"2007","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B89","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1097\/01.CCM.0000169883.41245.23","article-title":"Ubiquitin immunoreactivity in cerebrospinal fluid after traumatic brain injury: clinical and experimental findings","volume":"33","author":"Majetschak","year":"2005","journal-title":"Crit. Care Med"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B90","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1083\/jcb.200711108","article-title":"Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain","volume":"180","author":"Nezis","year":"2008","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B91","doi-asserted-by":"crossref","first-page":"572","DOI":"10.4161\/auto.7.6.14943","article-title":"p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects","volume":"7","author":"Bartlett","year":"2011","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B92","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4161\/auto.5173","article-title":"Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness","volume":"4","author":"Clark","year":"2008","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B93","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuroscience.2011.03.021","article-title":"Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice","volume":"184","author":"Luo","year":"2011","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B94","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1089\/neu.2005.22.750","article-title":"Closed head injury induces upregulation of Beclin 1 at the cortical site of injury","volume":"22","author":"Diskin","year":"2005","journal-title":"J. Neurotrauma"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B95","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1101\/pdb.prot080333","article-title":"Monitoring autophagic flux using Ref(2)P, the Drosophila p62 ortholog","volume":"2014","author":"DeVorkin","year":"2014","journal-title":"Cold Spring Harb. Protoc"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B96","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.cell.2013.05.037","article-title":"Eukaryotic stress granules are cleared by autophagy and Cdc48\/VCP function","volume":"153","author":"Buchan","year":"2013","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B97","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.4161\/15548627.2014.981787","article-title":"Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury","volume":"10","author":"Sarkar","year":"2014","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B98","doi-asserted-by":"crossref","first-page":"423.","DOI":"10.3389\/fncel.2015.00423","article-title":"Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?","volume":"9","author":"Aulas","year":"2015","journal-title":"Front. Cell. Neurosci"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B99","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1471-4159.2009.06383.x","article-title":"TDP-43 is recruited to stress granules in conditions of oxidative insult","volume":"111","author":"Colombrita","year":"2009","journal-title":"J. Neurochem"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B100","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1128\/MCB.01279-10","article-title":"TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor","volume":"31","author":"Dewey","year":"2011","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B101","doi-asserted-by":"crossref","first-page":"2353.","DOI":"10.1001\/jama.2017.16687","article-title":"Chronic traumatic encephalopathy in football players-reply","volume":"318","author":"McKee","year":"2017","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B102","doi-asserted-by":"crossref","first-page":"12596","DOI":"10.1073\/pnas.221303298","article-title":"A conditional tissue-specific transgene expression system using inducible GAL4","volume":"98","author":"Osterwalder","year":"2001","journal-title":"Proc. Natl Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B103","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neuroscience.2004.12.025","article-title":"Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease","volume":"132","author":"Crowther","year":"2005","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B104","doi-asserted-by":"crossref","DOI":"10.3791\/3795","article-title":"Methods to assay Drosophila behavior","author":"Nichols","year":"2012","journal-title":"J. Vis. Exp"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF03402040","article-title":"The molecular mechanism of autophagy","volume":"9","author":"Wang","year":"2003","journal-title":"Mol. Med"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B106","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1016\/j.neurobiolaging.2014.07.026","article-title":"Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons","volume":"35","author":"Ryu","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B107","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/cdd.2010.115","article-title":"Negative regulation of autophagy","volume":"17","author":"Liang","year":"2010","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B108","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/milmed\/168.2.143","article-title":"Motor axonal injury and amyotrophic lateral sclerosis: risk assessment using a reverse probability analysis technique","volume":"168","author":"Riggs","year":"2003","journal-title":"Mil. Med"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B109","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/milmed\/166.8.731","article-title":"The latency between traumatic axonal injury and the onset of amyotrophic lateral sclerosis in young adult men","volume":"166","author":"Riggs","year":"2001","journal-title":"Mil. Med"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1001\/archneur.1996.00550030031019","article-title":"Amyotrophic lateral sclerosis, heterogeneous susceptibility, trauma, and epidemiology","volume":"53","author":"Riggs","year":"1996","journal-title":"Arch. Neurol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B111","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00002826-199506000-00008","article-title":"Trauma, axonal injury, and amyotrophic lateral sclerosis: a clinical correlate of a neuropharmacologic model","volume":"18","author":"Riggs","year":"1995","journal-title":"Clin. Neuropharmacol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B112","doi-asserted-by":"crossref","first-page":"205.","DOI":"10.1001\/archneur.1985.04060030015004","article-title":"Trauma and amyotrophic lateral sclerosis","volume":"42","author":"Riggs","year":"1985","journal-title":"Arch. Neurol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B113","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0059-14.2015","article-title":"Acute traumatic brain injury does not exacerbate amyotrophic lateral sclerosis in the SOD1 (G93A) rat model (1,2,3)","volume":"2","author":"Thomsen","year":"2015","journal-title":"eNeuro"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B114","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/17482968.2012.660954","article-title":"Is head trauma a risk factor for amyotrophic lateral sclerosis? An evidence based review","volume":"13","author":"Armon","year":"2012","journal-title":"Amyotroph. Lateral Scler"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B115","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0022-510X(92)90241-C","article-title":"Mechanical trauma as a risk factor in classic amyotrophic lateral sclerosis: lack of epidemiologic evidence","volume":"113","author":"Kurland","year":"1992","journal-title":"J. Neurol. Sci"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B116","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1212\/WNL.45.3.555","article-title":"Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease","volume":"45","author":"Mayeux","year":"1995","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B117","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0304-3940(88)90081-X","article-title":"Ubiquitin deposits in anterior horn cells in motor neurone disease","volume":"93","author":"Leigh","year":"1988","journal-title":"Neurosci. Lett"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B118","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00401-012-1022-4","article-title":"The genetics and neuropathology of amyotrophic lateral sclerosis","volume":"124","author":"Al-Chalabi","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B119","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1523\/JNEUROSCI.4988-09.2010","article-title":"Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis","volume":"30","author":"Barmada","year":"2010","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B120","doi-asserted-by":"crossref","first-page":"13302","DOI":"10.1074\/jbc.M800342200","article-title":"Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation","volume":"283","author":"Winton","year":"2008","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B121","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.brainres.2009.09.105","article-title":"Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper\/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)","volume":"1305","author":"Volkening","year":"2009","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B122","doi-asserted-by":"crossref","first-page":"e13250.","DOI":"10.1371\/journal.pone.0013250","article-title":"Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue","volume":"5","author":"Liu-Yesucevitz","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B123","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pharmthera.2016.11.010","article-title":"Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders","volume":"172","author":"Hasegawa","year":"2017","journal-title":"Pharmacol. Ther"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B124","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1021\/la404710w","article-title":"Self-assembling properties of peptides derived from TDP-43 C-terminal fragment","volume":"30","author":"Saini","year":"2014","journal-title":"Langmuir"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B125","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1002\/cbic.201100427","article-title":"Delineation of the core aggregation sequences of TDP-43 C-terminal fragment","volume":"12","author":"Saini","year":"2011","journal-title":"Chembiochem"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B126","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.nbd.2016.08.007","article-title":"In vitro prion-like behaviour of TDP-43 in ALS","volume":"96","author":"Smethurst","year":"2016","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B127","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1074\/jbc.M113.516492","article-title":"Intranuclear aggregation of mutant FUS\/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis","volume":"289","author":"Nomura","year":"2014","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B128","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.expneurol.2017.09.011","article-title":"Reversible induction of TDP-43 granules in cortical neurons after traumatic injury","volume":"299","author":"Wiesner","year":"2018","journal-title":"Exp. Neurol"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B129","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neulet.2009.11.055","article-title":"Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system","volume":"469","author":"Wang","year":"2010","journal-title":"Neurosci. Lett"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B130","doi-asserted-by":"crossref","first-page":"30524","DOI":"10.1074\/jbc.M603337200","article-title":"Degradation of amyotrophic lateral sclerosis-linked mutant Cu, Zn-superoxide dismutase proteins by macroautophagy and the proteasome","volume":"281","author":"Kabuta","year":"2006","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B131","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1440-1789.2010.01129.x","article-title":"An autopsied case of sporadic adult-onset amyotrophic lateral sclerosis with FUS-positive basophilic inclusions","volume":"31","author":"Matsuoka","year":"2011","journal-title":"Neuropathology"},{"key":"key\n\t\t\t\t20180403031348_ddy047-B132","doi-asserted-by":"crossref","first-page":"e17808","DOI":"10.1371\/journal.pone.0017808","article-title":"TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch\/MAP1B levels and synaptic microtubules organization","volume":"6","author":"Godena","year":"2011","journal-title":"PLoS One"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/27\/8\/1366\/24527062\/ddy047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T00:05:16Z","timestamp":1660435516000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/27\/8\/1366\/4844881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":132,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,2,8]]},"published-print":{"date-parts":[[2018,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy047","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4,15]]},"published":{"date-parts":[[2018,2,8]]}}}